{"id":"https://openalex.org/W2058094904","doi":"https://doi.org/10.1038/ncomms6444","title":"Fc gamma receptor-TLR cross-talk elicits pro-inflammatory cytokine production by human M2 macrophages","display_name":"Fc gamma receptor-TLR cross-talk elicits pro-inflammatory cytokine production by human M2 macrophages","publication_year":2014,"publication_date":"2014-11-13","ids":{"openalex":"https://openalex.org/W2058094904","doi":"https://doi.org/10.1038/ncomms6444","mag":"2058094904","pmid":"https://pubmed.ncbi.nlm.nih.gov/25392121","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4243215"},"language":"en","primary_location":{"id":"doi:10.1038/ncomms6444","doi":"https://doi.org/10.1038/ncomms6444","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms6444","pdf_url":"https://www.nature.com/articles/ncomms6444.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/ncomms6444.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028443244","display_name":"Lisa T.C. Vogelpoel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Lisa T. C. Vogelpoel","raw_affiliation_strings":["Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands","Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]},{"raw_affiliation_string":"Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023689698","display_name":"Ivo S. Hansen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ivo S. Hansen","raw_affiliation_strings":["Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands","Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]},{"raw_affiliation_string":"Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050087953","display_name":"Theo Rispens","orcid":"https://orcid.org/0000-0001-9600-1312","observed_orcids":["https://orcid.org/0000-0001-9600-1312"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I3020210244","display_name":"Sanquin","ror":"https://ror.org/01fm2fv39","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I3020210244"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Theo Rispens","raw_affiliation_strings":["Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, 1006 AN Amsterdam, The Netherlands","Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, 1006 AN, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, 1006 AN Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I3020210244","https://openalex.org/I887064364"]},{"raw_affiliation_string":"Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, 1006 AN, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I3020210244","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032434394","display_name":"Femke J. M. Muller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Femke J. M. Muller","raw_affiliation_strings":["Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands","Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]},{"raw_affiliation_string":"Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113935325","display_name":"Toni M.M. van Capel","orcid":"https://orcid.org/0009-0005-9403-9866","observed_orcids":["https://orcid.org/0009-0005-9403-9866"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Toni M. M. van Capel","raw_affiliation_strings":["Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands","Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]},{"raw_affiliation_string":"Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044229910","display_name":"Maureen C. Turina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Maureen C. Turina","raw_affiliation_strings":["Department of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands","Department of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]},{"raw_affiliation_string":"Department of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066144728","display_name":"Joost B. Vos","orcid":"https://orcid.org/0000-0003-0088-4275","observed_orcids":["https://orcid.org/0000-0003-0088-4275"]},"institutions":[{"id":"https://openalex.org/I911458345","display_name":"Amsterdam UMC Location Vrije Universiteit Amsterdam","ror":"https://ror.org/00q6h8f30","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833","https://openalex.org/I911458345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Joost B. Vos","raw_affiliation_strings":["1] Immunaffect B.V., 1404 AK Bussum, The Netherlands [2] Department of Molecular Cell Biology and Immunology, Free University Medical Center, 1007 MB Amsterdam, The Netherlands","Immunaffect B.V., Bussum, 1404 AK, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1] Immunaffect B.V., 1404 AK Bussum, The Netherlands [2] Department of Molecular Cell Biology and Immunology, Free University Medical Center, 1007 MB Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I911458345"]},{"raw_affiliation_string":"Immunaffect B.V., Bussum, 1404 AK, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046625022","display_name":"Dominique Baeten","orcid":"https://orcid.org/0000-0002-0121-5543","observed_orcids":["https://orcid.org/0000-0002-0121-5543","https://orcid.org/0000-0002-1291-1755"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Dominique L. P. Baeten","raw_affiliation_strings":["Department of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands","Department of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]},{"raw_affiliation_string":"Department of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111564794","display_name":"Martien L. Kapsenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Martien L. Kapsenberg","raw_affiliation_strings":["Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands","Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]},{"raw_affiliation_string":"Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003825284","display_name":"Esther C. de Jong","orcid":"https://orcid.org/0000-0003-0410-3018","observed_orcids":["https://orcid.org/0000-0003-0410-3018"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Esther C. de Jong","raw_affiliation_strings":["Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands","Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]},{"raw_affiliation_string":"Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026990397","display_name":"Jeroen den Dunnen","orcid":"https://orcid.org/0000-0002-7199-8619","observed_orcids":["https://orcid.org/0000-0002-7199-8619"]},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Jeroen den Dunnen","raw_affiliation_strings":["Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands","Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]},{"raw_affiliation_string":"Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5026990397"],"corresponding_institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":5.0457,"has_fulltext":true,"cited_by_count":179,"citation_normalized_percentile":{"value":0.96323475,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"5","issue":"1","first_page":"5444","last_page":"5444"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.6079000234603882,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.6079000234603882,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.227400004863739,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.04439999908208847,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/m2-macrophages","display_name":"M2 macrophages","score":0.9430000185966492},{"id":"https://openalex.org/keywords/fc-gamma-receptor","display_name":"Fc gamma receptor","score":0.8180000185966492},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.8790000081062317},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8529999852180481},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8519999980926514},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":1.0},{"id":"https://openalex.org/keywords/th17-response","display_name":"Th17 response","score":0.8500000238418579},{"id":"https://openalex.org/keywords/fcgammariia","display_name":"Fc\u03b3RIIa","score":0.9810000061988831},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cytokine-transcription","display_name":"cytokine gene transcription","score":0.9229999780654907},{"id":"https://openalex.org/keywords/anti-inflammatory-macrophages","display_name":"anti-inflammatory macrophages","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7889856100082397},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6329758763313293},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6162195205688477},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.4992942810058594},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.49008047580718994},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.48401662707328796},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4518151581287384},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.4381507635116577},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4293662905693054},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34197425842285156},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33698660135269165},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3274664282798767},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.320283979177475},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.15992403030395508},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.07108861207962036},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05667421221733093},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017452","descriptor_name":"Receptors, IgG","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020170","descriptor_name":"Caspase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020239","descriptor_name":"Receptor Cross-Talk","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D058504","descriptor_name":"Th17 Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1038/ncomms6444","doi":"https://doi.org/10.1038/ncomms6444","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms6444","pdf_url":"https://www.nature.com/articles/ncomms6444.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3225831","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4243215","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25392121","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25392121","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4243215","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4243215/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/3e0dfd89-2d11-40b3-815f-a5ab68ef4cc3","doi":null,"is_oa":false,"landing_page_url":"https://research.vumc.nl/en/publications/3e0dfd89-2d11-40b3-815f-a5ab68ef4cc3","pdf_url":null,"source":{"id":"https://openalex.org/S7407055350","display_name":"Amsterdam UMC (VU Amsterdam) - Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vogelpoel, L T C, Hansen, I S, Rispens, T, Muller, F J M, van Capel, T M M, Turina, M C, Vos, J B, Baeten, D L P, Kapsenberg, ML, de Jong, E C & den Dunnen, J 2014, 'Fc gamma receptor-TLR cross-talk elicits pro-inflammatory cytokine production by human M2 macrophages', Nature Communications, vol. 5, 5444. https://doi.org/10.1038/ncomms6444","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/5da7827d-88b3-4327-b1c1-ecce48f7d16a","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/fc-gamma-receptortlr-crosstalk-elicits-proinflammatory-cytokine-production-by-human-m2-macrophages(5da7827d-88b3-4327-b1c1-ecce48f7d16a).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature communications, 5. Nature Publishing Group","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6444","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/ncomms6444","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/081d5c83-98b0-499c-bed8-bd46a895a3bc","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/081d5c83-98b0-499c-bed8-bd46a895a3bc","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Vogelpoel, L T C, Hansen, I S, Rispens, T, Muller, F J M, van Capel, T M M, Turina, M C, Vos, J B, Baeten, D L P, Kapsenberg, M L, de Jong, E C, den Dunnen, J & Kapsenberg, ML 2014, 'Fc gamma receptor-TLR cross-talk elicits pro-inflammatory cytokine production by human M2 macrophages', Nature communications, vol. 5, 5444, pp. 5444. https://doi.org/10.1038/ncomms6444","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vumc:oai:pure.atira.dk:publications/3e0dfd89-2d11-40b3-815f-a5ab68ef4cc3","doi":null,"is_oa":false,"landing_page_url":"https://research.vumc.nl/en/publications/3e0dfd89-2d11-40b3-815f-a5ab68ef4cc3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, 5:5444. Nature Publishing Group","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/ncomms6444","doi":"https://doi.org/10.1038/ncomms6444","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms6444","pdf_url":"https://www.nature.com/articles/ncomms6444.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2058094904.pdf","grobid_xml":"https://content.openalex.org/works/W2058094904.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1967369695","https://openalex.org/W1979982103","https://openalex.org/W1980354779","https://openalex.org/W1980794593","https://openalex.org/W1985859986","https://openalex.org/W1987535382","https://openalex.org/W2012680181","https://openalex.org/W2022917731","https://openalex.org/W2023218072","https://openalex.org/W2024483802","https://openalex.org/W2030644977","https://openalex.org/W2036261151","https://openalex.org/W2038026702","https://openalex.org/W2047159240","https://openalex.org/W2052549355","https://openalex.org/W2061123122","https://openalex.org/W2065210647","https://openalex.org/W2069096810","https://openalex.org/W2070855360","https://openalex.org/W2071430851","https://openalex.org/W2074249273","https://openalex.org/W2075901113","https://openalex.org/W2076437861","https://openalex.org/W2078975569","https://openalex.org/W2079857881","https://openalex.org/W2082991836","https://openalex.org/W2098966232","https://openalex.org/W2106171259","https://openalex.org/W2109956181","https://openalex.org/W2110826367","https://openalex.org/W2114769428","https://openalex.org/W2115694552","https://openalex.org/W2118084423","https://openalex.org/W2119194984","https://openalex.org/W2123665246","https://openalex.org/W2131872753","https://openalex.org/W2143660712","https://openalex.org/W2151948277","https://openalex.org/W2156724379","https://openalex.org/W2165241753","https://openalex.org/W2170119271"],"related_works":["https://openalex.org/W2160609829","https://openalex.org/W2788931403","https://openalex.org/W2939607606","https://openalex.org/W2139379942","https://openalex.org/W2766287142","https://openalex.org/W2076437861","https://openalex.org/W1996786164","https://openalex.org/W2146212434","https://openalex.org/W1999055902","https://openalex.org/W4409118704"],"abstract_inverted_index":{"M2":[0,18,36,70,142],"macrophages":[1,19,37,71],"suppress":[2],"inflammation":[3,39,43,133],"in":[4,20,56,92,134],"numerous":[5],"disorders,":[6],"including":[7],"tumour":[8],"formation,":[9],"infection":[10],"and":[11,51,80,82,116],"obesity.":[12],"However,":[13],"the":[14,21,57,138],"exact":[15],"role":[16,91],"of":[17,23,41,59,69,75,96,141],"context":[22,58],"several":[24],"other":[25],"diseases":[26,60],"is":[27],"still":[28],"largely":[29],"undefined.":[30],"We":[31],"here":[32],"show":[33],"that":[34,123],"human":[35],"promote":[38],"instead":[40],"suppressing":[42],"on":[44,99,104],"simultaneous":[45],"exposure":[46],"to":[47,131],"complexed":[48],"IgG":[49],"(c-IgG)":[50],"TLR":[52],"ligands,":[53],"as":[54,62],"occurs":[55],"such":[61],"rheumatoid":[63],"arthritis":[64],"(RA).":[65],"c-IgG-TLR":[66],"ligand":[67],"co-stimulation":[68,101],"selectively":[72,111],"amplifies":[73,112],"production":[74],"pro-inflammatory":[76,97],"cytokines":[77,98],"TNF-\u03b1,":[78],"IL-1\u03b2":[79],"IL-6":[81],"promotes":[83],"Th17":[84],"responses,":[85],"which":[86,110],"all":[87],"play":[88],"a":[89],"critical":[90],"RA":[93],"pathology.":[94],"Induction":[95],"c-IgG":[100],"mainly":[102],"depends":[103],"Fc":[105],"gamma":[106],"receptor":[107],"IIa":[108],"(Fc\u03b3RIIa),":[109],"cytokine":[113],"gene":[114],"transcription":[115],"induces":[117],"caspase-1":[118],"activation.":[119],"These":[120],"data":[121],"indicate":[122],"Fc\u03b3R-TLR":[124],"cross-talk":[125],"may":[126],"be":[127],"targeted":[128],"for":[129],"treatment":[130],"attenuate":[132],"RA,":[135],"by":[136],"restoring":[137],"anti-inflammatory":[139],"function":[140],"macrophages.":[143]},"counts_by_year":[{"year":2026,"cited_by_count":18},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":21},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":15}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
