{"id":"https://openalex.org/W2058094487","doi":"https://doi.org/10.1159/000146508","title":"Effects of Nicotine on the Fertility, Cytology and Life Span of Male Rats","display_name":"Effects of Nicotine on the Fertility, Cytology and Life Span of Male Rats","publication_year":1988,"publication_date":"1988-01-01","ids":{"openalex":"https://openalex.org/W2058094487","doi":"https://doi.org/10.1159/000146508","mag":"2058094487","pmid":"https://pubmed.ncbi.nlm.nih.gov/3369287"},"language":"en","primary_location":{"id":"doi:10.1159/000146508","doi":"https://doi.org/10.1159/000146508","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000146508","pdf_url":null,"source":{"id":"https://openalex.org/S4394735558","display_name":"Cells Tissues Organs","issn_l":"1422-6405","issn":["1422-6405","1422-6421"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells Tissues Organs","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020573231","display_name":"Alphonse Riesenfeld","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]},{"id":"https://openalex.org/I39694355","display_name":"Hunter College","ror":"https://ror.org/00g2xk477","country_code":"US","type":"education","lineage":["https://openalex.org/I39694355"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alphonse Riesenfeld","raw_affiliation_strings":["Department of Anthropology, Hunter College of the City University of New York, N.Y","Department of Anthropology, Hunter College of the City University of New York and Institute of Applied Biology, New York, N.Y"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anthropology, Hunter College of the City University of New York, N.Y","institution_ids":["https://openalex.org/I174216632","https://openalex.org/I39694355"]},{"raw_affiliation_string":"Department of Anthropology, Hunter College of the City University of New York and Institute of Applied Biology, New York, N.Y","institution_ids":["https://openalex.org/I174216632","https://openalex.org/I39694355"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015363585","display_name":"Heidi Oliva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324220072","display_name":"Mount Sinai Hospital","ror":"https://ror.org/01zkyz108","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1320796813","https://openalex.org/I1324220072"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heidi Oliva","raw_affiliation_strings":["Department of Pathology, Mt. Sinai Hospital, New York, N.Y, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Mt. Sinai Hospital, New York, N.Y, USA","institution_ids":["https://openalex.org/I1324220072"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.15722882,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"131","issue":"2","first_page":"171","last_page":"176"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.7324000000953674,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.7324000000953674,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.15150000154972076,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nicotine","display_name":"nicotine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/male-fertility","display_name":"male fertility","score":0.9269999861717224},{"id":"https://openalex.org/keywords/male-infertility","display_name":"male infertility","score":0.5860000252723694},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.699999988079071},{"id":"https://openalex.org/keywords/inflammatory-processes","display_name":"inflammatory processes","score":0.453000009059906},{"id":"https://openalex.org/keywords/lymphocytes","display_name":"lymphocytes","score":0.8960000276565552},{"id":"https://openalex.org/keywords/polymorphonuclear-leukocytes","display_name":"polymorphonuclear leukocytes","score":0.9760000109672546},{"id":"https://openalex.org/keywords/cytology","display_name":"cytology","score":0.8199999928474426},{"id":"https://openalex.org/keywords/lifespan","display_name":"lifespan","score":0.9210000038146973},{"id":"https://openalex.org/keywords/longevity","display_name":"longevity","score":0.5929999947547913},{"id":"https://openalex.org/keywords/fisher-rats","display_name":"Fisher rats","score":0.824999988079071},{"id":"https://openalex.org/keywords/reproductive-toxicity","display_name":"reproductive toxicity","score":0.4560000002384186}],"concepts":[{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.9012693166732788},{"id":"https://openalex.org/C518429986","wikidata":"https://www.wikidata.org/wiki/Q964401","display_name":"Fertility","level":3,"score":0.695256233215332},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.5648285746574402},{"id":"https://openalex.org/C2988516024","wikidata":"https://www.wikidata.org/wiki/Q441195","display_name":"Life span","level":2,"score":0.5348507165908813},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.49965333938598633},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48905977606773376},{"id":"https://openalex.org/C18823058","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cytology","level":2,"score":0.4715682864189148},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46672454476356506},{"id":"https://openalex.org/C2777688143","wikidata":"https://www.wikidata.org/wiki/Q179399","display_name":"Infertility","level":3,"score":0.45348095893859863},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.308016836643219},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.20115023851394653},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.10826292634010315},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005298","descriptor_name":"Fertility","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007248","descriptor_name":"Infertility, Male","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013223","descriptor_name":"Statistics as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000146508","doi":"https://doi.org/10.1159/000146508","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000146508","pdf_url":null,"source":{"id":"https://openalex.org/S4394735558","display_name":"Cells Tissues Organs","issn_l":"1422-6405","issn":["1422-6405","1422-6421"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells Tissues Organs","raw_type":"journal-article"},{"id":"pmid:3369287","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3369287","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta anatomica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1969202049","https://openalex.org/W2138637126","https://openalex.org/W2748487211","https://openalex.org/W1556296571","https://openalex.org/W1981695960","https://openalex.org/W2281154322","https://openalex.org/W1571516802","https://openalex.org/W2271701111","https://openalex.org/W2169646340","https://openalex.org/W2031852318"],"abstract_inverted_index":{"Contrary":[0],"to":[1,81,104],"an":[2,112],"earlier":[3,66,143],"opinion":[4],"that":[5,28,43,74],"nicotine":[6,82,162,244],"has":[7],"no":[8],"effect":[9,45,242],"on":[10],"the":[11,18,29,33,44,92,96,123,128,135,153,158,178,185,216,249],"fertility":[12],"of":[13,32,95,115,188,243],"male":[14,23,50,85,145,171,190,213,226],"animals":[15,34],"or":[16,254],"humans,":[17],"present":[19,97],"experimental":[20],"study":[21],"using":[22],"inbred":[24],"Fisher":[25,54],"rats":[26,55,191],"demonstrates":[27],"reproductive":[30],"capacity":[31],"is":[35,46,61,88,131,155,164,167,192,201,219,251],"greatly":[36],"reduced":[37],"when":[38,161],"injected":[39,57],"with":[40,58,64],"nicotine,":[41],"and":[42,68,173,257],"much":[47,142],"greater":[48,79,193,220],"in":[49,52,62,125,134,144,157,169,195,203,207,211,224,231],"than":[51,83,194,206,223,230],"female":[53,75,105,159,196,233],"similarly":[56],"nicotine.":[59],"This":[60],"accord":[63],"some":[65,170,212],"histological":[67],"morphological":[69],"studies":[70],"which":[71],"have":[72,77],"shown":[73],"rodents":[76],"a":[78],"tolerance":[80],"their":[84,208,225,232],"counterparts.":[86,234],"It":[87],"also":[89],"confirmed":[90],"by":[91,111],"cytologic":[93],"observations":[94,100],"study.":[98,260],"These":[99],"show":[101],"that,":[102],"similar":[103],"rats,":[106,146,172,198,215],"inflammatory":[107,139,174],"processes,":[108],"as":[109,181],"evidenced":[110],"increased":[113],"number":[114],"lymphocytes":[116],"and/or":[117],"polymorphonuclear":[118],"leukocytes,":[119],"are":[120,148,246],"responsible":[121],"for":[122,177,237],"decrease":[124],"fertility.":[126],"However,":[127,184],"cytological":[129],"profile":[130],"profoundly":[132],"different":[133],"two":[136],"sexes:":[137],"virulent":[138],"conditions":[140,175],"begin":[141],"they":[147],"more":[149],"frequent":[150],"and,":[151],"whereas":[152],"condition":[154],"reversible":[156],"animal":[160],"treatment":[163,245],"discontinued,":[165],"it":[166,200],"not":[168,221],"persist":[176],"entire":[179],"life":[180,186,217],"does":[182],"infertility.":[183],"span":[187,218],"nicotine-treated":[189,197,214],"although":[199],"shorter":[202],"both":[204],"sexes":[205],"respective":[209],"controls;":[210],"only":[222],"controls":[227],"but":[228,248],"even":[229],"Possible":[235],"explanations":[236],"this":[238],"apparently":[239],"paradoxical":[240],"life-prolonging":[241],"reviewed,":[247],"evidence":[250],"either":[252],"conflicting":[253],"insufficiently":[255],"established":[256],"requires":[258],"further":[259]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}