{"id":"https://openalex.org/W2058091920","doi":"https://doi.org/10.1095/biolreprod32.2.309","title":"An Analysis of the Age-Related Decline in Testicular Steroidogenesis in the Rat","display_name":"An Analysis of the Age-Related Decline in Testicular Steroidogenesis in the Rat","publication_year":1985,"publication_date":"1985-03-01","ids":{"openalex":"https://openalex.org/W2058091920","doi":"https://doi.org/10.1095/biolreprod32.2.309","mag":"2058091920","pmid":"https://pubmed.ncbi.nlm.nih.gov/3986266"},"language":"en","primary_location":{"id":"doi:10.1095/biolreprod32.2.309","doi":"https://doi.org/10.1095/biolreprod32.2.309","is_oa":false,"landing_page_url":"https://doi.org/10.1095/biolreprod32.2.309","pdf_url":null,"source":{"id":"https://openalex.org/S130598054","display_name":"Biology of Reproduction","issn_l":"0006-3363","issn":["0006-3363","1529-7268"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Reproduction","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108466949","display_name":"Yuhzo Kinoshita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210138181","display_name":"UPMC Montefiore","ror":"https://ror.org/03bzbh797","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769","https://openalex.org/I4210138181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuhzo Kinoshita","raw_affiliation_strings":["Department of Medicine, Montefiore Hospital, and the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Montefiore Hospital, and the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210138181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109004777","display_name":"Yotsuo Higashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210138181","display_name":"UPMC Montefiore","ror":"https://ror.org/03bzbh797","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769","https://openalex.org/I4210138181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yotsuo Higashi","raw_affiliation_strings":["Department of Medicine, Montefiore Hospital, and the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Montefiore Hospital, and the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210138181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087822746","display_name":"Stephen J. Winters","orcid":"https://orcid.org/0000-0003-3721-7388","observed_orcids":["https://orcid.org/0000-0003-3721-7388"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210138181","display_name":"UPMC Montefiore","ror":"https://ror.org/03bzbh797","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769","https://openalex.org/I4210138181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen J. Winters","raw_affiliation_strings":["Department of Medicine, Montefiore Hospital, and the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Montefiore Hospital, and the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210138181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110723007","display_name":"Hiroyuki Oshima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210138181","display_name":"UPMC Montefiore","ror":"https://ror.org/03bzbh797","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769","https://openalex.org/I4210138181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiroyuki Oshima","raw_affiliation_strings":["Department of Medicine, Montefiore Hospital, and the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Montefiore Hospital, and the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210138181"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071645670","display_name":"Philip Troen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210138181","display_name":"UPMC Montefiore","ror":"https://ror.org/03bzbh797","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769","https://openalex.org/I4210138181"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Philip Troen","raw_affiliation_strings":["Department of Medicine, Montefiore Hospital, and the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Montefiore Hospital, and the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210138181"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071645670"],"corresponding_institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210138181"],"apc_list":{"value":4605,"currency":"USD","value_usd":4605},"apc_paid":null,"fwci":2.642,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.89256404,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"32","issue":"2","first_page":"309","last_page":"314"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.8008000254631042,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.8008000254631042,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.1906999945640564,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6140000224113464},{"id":"https://openalex.org/keywords/testicular-steroidogenesis","display_name":"testicular steroidogenesis","score":0.9539999961853027},{"id":"https://openalex.org/keywords/leydig-cells","display_name":"Leydig cells","score":0.7820000052452087},{"id":"https://openalex.org/keywords/testosterone-production","display_name":"testosterone production","score":0.7200000286102295},{"id":"https://openalex.org/keywords/17alpha-hydroxylase","display_name":"17\u03b1-hydroxylase","score":0.9169999957084656},{"id":"https://openalex.org/keywords/c17-20-lyase","display_name":"C17,20-lyase","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.9359999895095825},{"id":"https://openalex.org/keywords/gonadotropin-deficiency","display_name":"gonadotropin deficiency","score":0.8809999823570251},{"id":"https://openalex.org/keywords/age-related-decline","display_name":"age-related decline","score":0.6610000133514404},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.3149999976158142}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8840376138687134},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8705874085426331},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7775503396987915},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.6943221092224121},{"id":"https://openalex.org/C2778782382","wikidata":"https://www.wikidata.org/wiki/Q409770","display_name":"Gonadotropin","level":3,"score":0.5154605507850647},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.49149954319000244},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.44562825560569763},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.42336326837539673},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2679162621498108},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.15332555770874023},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12640824913978577},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.04495188593864441}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000446","descriptor_name":"Aldehyde-Lyases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008861","descriptor_name":"Microsomes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013254","descriptor_name":"Steroid 17-alpha-Hydroxylase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1095/biolreprod32.2.309","doi":"https://doi.org/10.1095/biolreprod32.2.309","is_oa":false,"landing_page_url":"https://doi.org/10.1095/biolreprod32.2.309","pdf_url":null,"source":{"id":"https://openalex.org/S130598054","display_name":"Biology of Reproduction","issn_l":"0006-3363","issn":["0006-3363","1529-7268"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Reproduction","raw_type":"journal-article"},{"id":"pmid:3986266","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3986266","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of reproduction","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7095128696","https://openalex.org/W1603943057","https://openalex.org/W2101571848","https://openalex.org/W86393565","https://openalex.org/W266714568","https://openalex.org/W2075122070","https://openalex.org/W1993235359","https://openalex.org/W2099738367","https://openalex.org/W2033243487","https://openalex.org/W2414743281"],"abstract_inverted_index":{"The":[0,59,77],"effect":[1],"of":[2,55,61,79,90,98,103,142,178],"aging":[3,185],"in":[4,27,47,74,108,132,135,169,175,198],"rats":[5,49,137],"on":[6],"serum":[7],"and":[8,16,35,41,64,92],"intratesticular":[9],"testosterone":[10,23,45,133],"levels,":[11],"microsomal":[12,17],"steroidogenic":[13],"enzyme":[14],"activities":[15,118],"cytochrome":[18,70,199],"P-450":[19],"was":[20],"studied.":[21],"Serum":[22],"levels":[24,46,102],"were":[25,50,119,122],"highest":[26],"11-wk-old":[28,104],"rats,":[29],"declined":[30,37,94],"at":[31],"age":[32,91,99],"16":[33,88],"wk":[34,86,89],"further":[36],"between":[38],"ages":[39],"7":[40],"21":[42,96],"mo.":[43],"Intratesticular":[44],"21-mo-old":[48,75],"significantly":[51,73],"lower":[52],"than":[53],"those":[54],"the":[56,101,130,155,161,173,176,196],"other":[57,188],"groups.":[58],"activity":[60,78],"17":[62,80,179],"alpha-hydroxylase":[63,180],"C17-20":[65,182],"lyase,":[66],"as":[67,69,147,193,195],"well":[68,194],"P-450,":[71],"decreased":[72,143],"rats.":[76,171],"beta-hydroxysteroid":[81],"oxidoreductase":[82],"increased":[83],"from":[84],"11":[85],"to":[87,100,181],"then":[93],"by":[95],"mo":[97],"animals.":[105],"Similar":[106],"changes":[107],"delta":[109,114],"5-3,3-hydroxysteroid":[110],"dehydrogenase":[111],"coupled":[112],"with":[113,184],"5-delta":[115],"4":[116],"isomerase":[117],"observed,":[120],"but":[121],"not":[123],"statistically":[124],"significant.":[125],"These":[126],"results":[127,153],"suggest":[128],"that":[129,157,187],"decline":[131,174],"production":[134],"old":[136,170],"is":[138,160],"predominantly":[139],"a":[140],"result":[141],"oxygenase":[144],"activity.":[145],"Inasmuch":[146],"oxygenases":[148],"are":[149],"gonadotropin":[150,158],"dependent,":[151],"our":[152],"support":[154],"hypothesis":[156],"deficiency":[159],"major":[162],"factor":[163],"responsible":[164],"for":[165],"Leydig":[166],"cell":[167],"dysfunction":[168],"Further,":[172],"ratio":[177],"lyase":[183],"suggests":[186],"factors":[189],"affect":[190],"these":[191],"enzymes":[192],"reduction":[197],"P-450.":[200]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}