{"id":"https://openalex.org/W2058078629","doi":"https://doi.org/10.1007/bf00454780","title":"Modulation of interleukin 2 activity by lymphocyte-derived tetrahydrobiopterin","display_name":"Modulation of interleukin 2 activity by lymphocyte-derived tetrahydrobiopterin","publication_year":1985,"publication_date":"1985-06-01","ids":{"openalex":"https://openalex.org/W2058078629","doi":"https://doi.org/10.1007/bf00454780","mag":"2058078629","pmid":"https://pubmed.ncbi.nlm.nih.gov/3875040"},"language":"en","primary_location":{"id":"doi:10.1007/bf00454780","doi":"https://doi.org/10.1007/bf00454780","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00454780","pdf_url":null,"source":{"id":"https://openalex.org/S44783556","display_name":"Die Naturwissenschaften","issn_l":"0028-1042","issn":["0028-1042","1432-1904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Naturwissenschaften","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050792493","display_name":"Irmgard Ziegler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"I. Ziegler","raw_affiliation_strings":["Institut f\u00fcr Toxikologie und Biochemie der Gesellschaft f\u00fcr Strahlen- und Umweltforschung, D-8000, M\u00fcnchen","Institut f\u00fcr Toxikologie und Biochemie der Gesellschaft f\u00fcr Strahlen- und Umweltforschung, M\u00fcnchen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut f\u00fcr Toxikologie und Biochemie der Gesellschaft f\u00fcr Strahlen- und Umweltforschung, D-8000, M\u00fcnchen","institution_ids":["https://openalex.org/I3018134672"]},{"raw_affiliation_string":"Institut f\u00fcr Toxikologie und Biochemie der Gesellschaft f\u00fcr Strahlen- und Umweltforschung, M\u00fcnchen","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"middle","author":{"id":null,"display_name":"U. Schwul\ufffdra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U. Schwul\ufffdra","raw_affiliation_strings":["Biotest Serum-Institut, Offenbach"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotest Serum-Institut, Offenbach","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113574292","display_name":"H.\u2010H. Sonneborn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. -H. Sonneborn","raw_affiliation_strings":["Biotest Serum-Institut, D-6050, Offenbach","Biotest Serum-Institut, Offenbach"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotest Serum-Institut, D-6050, Offenbach","institution_ids":[]},{"raw_affiliation_string":"Biotest Serum-Institut, Offenbach","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043324387","display_name":"Werner M\u00fcller","orcid":"https://orcid.org/0000-0002-1297-9725","observed_orcids":["https://orcid.org/0000-0002-1297-9725"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"W. J. P. M\ufffdller","raw_affiliation_strings":["Genetisches Institut der Universit\u00e4t, K\u00f6ln"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetisches Institut der Universit\u00e4t, K\u00f6ln","institution_ids":["https://openalex.org/I180923762"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":1.0592,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.77152064,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"6","first_page":"330","last_page":"331"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.44119998812675476,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.44119998812675476,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.32100000977516174,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.04500000178813934,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9509999752044678},{"id":"https://openalex.org/keywords/tetrahydrobiopterin","display_name":"tetrahydrobiopterin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/lymphocytes","display_name":"lymphocytes","score":0.8700000047683716},{"id":"https://openalex.org/keywords/biopterin","display_name":"biopterin","score":0.42399999499320984}],"concepts":[{"id":"https://openalex.org/C2776145790","wikidata":"https://www.wikidata.org/wiki/Q419808","display_name":"Tetrahydrobiopterin","level":4,"score":0.7708083391189575},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.5100308060646057},{"id":"https://openalex.org/C123079801","wikidata":"https://www.wikidata.org/wiki/Q750240","display_name":"Modulation (music)","level":2,"score":0.4763201177120209},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.44333988428115845},{"id":"https://openalex.org/C2777371288","wikidata":"https://www.wikidata.org/wiki/Q410130","display_name":"Interleukin 2","level":3,"score":0.4292910695075989},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3966860771179199},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3160671889781952},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1942765712738037},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.17003175616264343},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.14813381433486938},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.1159924864768982},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.10563954710960388},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.09924164414405823},{"id":"https://openalex.org/C107038049","wikidata":"https://www.wikidata.org/wiki/Q35986","display_name":"Aesthetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001708","descriptor_name":"Biopterins","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D001708","descriptor_name":"Biopterins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011621","descriptor_name":"Pteridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/bf00454780","doi":"https://doi.org/10.1007/bf00454780","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00454780","pdf_url":null,"source":{"id":"https://openalex.org/S44783556","display_name":"Die Naturwissenschaften","issn_l":"0028-1042","issn":["0028-1042","1432-1904"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Naturwissenschaften","raw_type":"journal-article"},{"id":"pmid:3875040","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3875040","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Die Naturwissenschaften","raw_type":"Journal Article"},{"id":"pmh:oai:opus-zb.helmholtz-muenchen.de:41448","doi":null,"is_oa":false,"landing_page_url":"https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=41448","pdf_url":null,"source":{"id":"https://openalex.org/S4377196115","display_name":"Site cant be reached","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Naturwissenschaften 72, 330-331 (1985)","raw_type":"article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/bfbd07ab-635b-497e-9a13-8f432fe4a1dc","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/bfbd07ab-635b-497e-9a13-8f432fe4a1dc","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ziegler, I, Schwul\u00e9ra, U, Sonneborn, H H & M\u00fcller, W J 1985, 'Modulation of interleukin 2 activity by lymphocyte-derived tetrahydrobiopterin', Naturwissenschaften, vol. 72, no. 6, pp. 330-1.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1967570594","https://openalex.org/W2006194820","https://openalex.org/W2027581129","https://openalex.org/W2036463932","https://openalex.org/W2165233139","https://openalex.org/W2166920850"],"related_works":["https://openalex.org/W2888914223","https://openalex.org/W2889105787","https://openalex.org/W4240457682","https://openalex.org/W4234723793","https://openalex.org/W1974269271","https://openalex.org/W3127287762","https://openalex.org/W2048102416","https://openalex.org/W2888870997","https://openalex.org/W4249282238","https://openalex.org/W2889447291"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}