{"id":"https://openalex.org/W2058068338","doi":"https://doi.org/10.1016/s0006-8993(98)00411-9","title":"Ontogeny of altered synaptic function in a rat model of chronic temporal lobe epilepsy","display_name":"Ontogeny of altered synaptic function in a rat model of chronic temporal lobe epilepsy","publication_year":1998,"publication_date":"1998-07-01","ids":{"openalex":"https://openalex.org/W2058068338","doi":"https://doi.org/10.1016/s0006-8993(98)00411-9","mag":"2058068338","pmid":"https://pubmed.ncbi.nlm.nih.gov/9675275"},"language":"en","primary_location":{"id":"doi:10.1016/s0006-8993(98)00411-9","doi":"https://doi.org/10.1016/s0006-8993(98)00411-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0006-8993(98)00411-9","pdf_url":null,"source":{"id":"https://openalex.org/S96638545","display_name":"Brain Research","issn_l":"0006-8993","issn":["0006-8993","1872-6240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064431117","display_name":"Patrick S. Mangan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]},{"id":"https://openalex.org/I4210134211","display_name":"University of Virginia Medical Center","ror":"https://ror.org/046kb4y45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794","https://openalex.org/I4210134211"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick S Mangan","raw_affiliation_strings":["Department of Neurology, Box 394, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Box 394, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA","institution_ids":["https://openalex.org/I2799765794","https://openalex.org/I4210134211","https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091560019","display_name":"Edward H. Bertram","orcid":"https://orcid.org/0000-0002-1922-195X","observed_orcids":["https://orcid.org/0000-0002-1922-195X"]},"institutions":[{"id":"https://openalex.org/I2799765794","display_name":"University of Virginia Health System","ror":"https://ror.org/00wn7d965","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794"]},{"id":"https://openalex.org/I4210134211","display_name":"University of Virginia Medical Center","ror":"https://ror.org/046kb4y45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799765794","https://openalex.org/I4210134211"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Edward H Bertram","raw_affiliation_strings":["Department of Neurology, Box 394, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Box 394, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA","institution_ids":["https://openalex.org/I2799765794","https://openalex.org/I4210134211","https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5091560019"],"corresponding_institution_ids":["https://openalex.org/I2799765794","https://openalex.org/I4210134211","https://openalex.org/I51556381"],"apc_list":{"value":3360,"currency":"USD","value_usd":3360},"apc_paid":null,"fwci":0.2486,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.59091524,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"799","issue":"2","first_page":"183","last_page":"196"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-temporal-lobe-epilepsy","display_name":"chronic temporal lobe epilepsy","score":0.9750000238418579},{"id":"https://openalex.org/keywords/status-epilepticus","display_name":"status epilepticus","score":0.8619999885559082},{"id":"https://openalex.org/keywords/silent-period","display_name":"silent period","score":0.7630000114440918},{"id":"https://openalex.org/keywords/ca1-pyramidal-neurons","display_name":"CA1 pyramidal neurons","score":0.9480000138282776},{"id":"https://openalex.org/keywords/inhibitory-postsynaptic-potentials","display_name":"inhibitory postsynaptic potentials","score":0.8870000243186951},{"id":"https://openalex.org/keywords/gaba-a-receptor","display_name":"GABAA receptor","score":0.9089999794960022},{"id":"https://openalex.org/keywords/gabab-receptors","display_name":"GABAB receptors","score":0.9929999709129333},{"id":"https://openalex.org/keywords/presynaptic-inhibition","display_name":"presynaptic inhibition","score":0.9350000023841858},{"id":"https://openalex.org/keywords/neuronal-hyperexcitability","display_name":"neuronal hyperexcitability","score":0.777999997138977},{"id":"https://openalex.org/keywords/zolpidem","display_name":"zolpidem","score":0.9509999752044678},{"id":"https://openalex.org/keywords/epileptiform-activity","display_name":"epileptiform activity","score":0.7269999980926514},{"id":"https://openalex.org/keywords/synaptic-development","display_name":"synaptic development","score":0.4309999942779541},{"id":"https://openalex.org/keywords/seizure-onset","display_name":"seizure onset","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.7330858707427979},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.6622798442840576},{"id":"https://openalex.org/C2777341932","wikidata":"https://www.wikidata.org/wiki/Q980709","display_name":"Status epilepticus","level":3,"score":0.6605291366577148},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.6232978105545044},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.552963137626648},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5431721210479736},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5423300266265869},{"id":"https://openalex.org/C2781291010","wikidata":"https://www.wikidata.org/wiki/Q178580","display_name":"Period (music)","level":2,"score":0.5184006690979004},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.516867458820343},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.48590222001075745},{"id":"https://openalex.org/C2781099131","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal lobe","level":3,"score":0.4824838936328888},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.44345518946647644},{"id":"https://openalex.org/C2777771985","wikidata":"https://www.wikidata.org/wiki/Q210021","display_name":"gamma-Aminobutyric acid","level":3,"score":0.4116392433643341},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41124042868614197},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3979806900024414},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3957310616970062},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3541959226131439},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.303205668926239},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077334","descriptor_name":"Zolpidem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004833","descriptor_name":"Epilepsy, Temporal Lobe","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004833","descriptor_name":"Epilepsy, Temporal Lobe","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017729","descriptor_name":"Presynaptic Terminals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018080","descriptor_name":"Receptors, GABA-B","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0006-8993(98)00411-9","doi":"https://doi.org/10.1016/s0006-8993(98)00411-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0006-8993(98)00411-9","pdf_url":null,"source":{"id":"https://openalex.org/S96638545","display_name":"Brain Research","issn_l":"0006-8993","issn":["0006-8993","1872-6240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research","raw_type":"journal-article"},{"id":"pmid:9675275","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9675275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8910489657","display_name":"Mechanisms of Epileptogenesis","funder_award_id":"R01NS025605","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G999886459","display_name":null,"funder_award_id":"NS-25605","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W579657397","https://openalex.org/W1520163941","https://openalex.org/W1548516628","https://openalex.org/W1561389266","https://openalex.org/W1574757902","https://openalex.org/W1723579215","https://openalex.org/W1971778378","https://openalex.org/W1975667962","https://openalex.org/W1986725771","https://openalex.org/W1992724281","https://openalex.org/W1997068771","https://openalex.org/W2003834071","https://openalex.org/W2005273920","https://openalex.org/W2006383186","https://openalex.org/W2011926683","https://openalex.org/W2013104408","https://openalex.org/W2023823540","https://openalex.org/W2026172017","https://openalex.org/W2034474299","https://openalex.org/W2036527748","https://openalex.org/W2037997999","https://openalex.org/W2039200004","https://openalex.org/W2040184330","https://openalex.org/W2041203007","https://openalex.org/W2043915063","https://openalex.org/W2048145476","https://openalex.org/W2060509553","https://openalex.org/W2064703428","https://openalex.org/W2065882361","https://openalex.org/W2069226362","https://openalex.org/W2069831153","https://openalex.org/W2070042187","https://openalex.org/W2073890361","https://openalex.org/W2076302671","https://openalex.org/W2079526829","https://openalex.org/W2079793054","https://openalex.org/W2081453079","https://openalex.org/W2085235923","https://openalex.org/W2089846552","https://openalex.org/W2091195494","https://openalex.org/W2092700031","https://openalex.org/W2093428018","https://openalex.org/W2122848258","https://openalex.org/W2123252791","https://openalex.org/W2132239248","https://openalex.org/W2159635826","https://openalex.org/W2290923177","https://openalex.org/W2309556032","https://openalex.org/W2310004793","https://openalex.org/W2396372558","https://openalex.org/W2399177825","https://openalex.org/W2409336322","https://openalex.org/W2409927356","https://openalex.org/W2410053025","https://openalex.org/W2411076096","https://openalex.org/W2412716133","https://openalex.org/W2413963224","https://openalex.org/W2416186588","https://openalex.org/W2423462652","https://openalex.org/W2432611742","https://openalex.org/W2443450049","https://openalex.org/W4239594659","https://openalex.org/W4242228024","https://openalex.org/W7052051445"],"related_works":["https://openalex.org/W2040184330","https://openalex.org/W2399177825","https://openalex.org/W4242228024","https://openalex.org/W1979510713","https://openalex.org/W4394749480","https://openalex.org/W4360977567","https://openalex.org/W2296961855","https://openalex.org/W2416186588","https://openalex.org/W2339933008","https://openalex.org/W2309556032"],"abstract_inverted_index":null,"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
