{"id":"https://openalex.org/W2058045835","doi":"https://doi.org/10.1159/000073663","title":"Effect of the Antidepressant Desipramine on Cytosolic Ca2+ Movement and Proliferation in Human Osteosarcoma Cells","display_name":"Effect of the Antidepressant Desipramine on Cytosolic Ca2+ Movement and Proliferation in Human Osteosarcoma Cells","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W2058045835","doi":"https://doi.org/10.1159/000073663","mag":"2058045835","pmid":"https://pubmed.ncbi.nlm.nih.gov/14624059"},"language":"en","primary_location":{"id":"doi:10.1159/000073663","doi":"https://doi.org/10.1159/000073663","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000073663","pdf_url":null,"source":{"id":"https://openalex.org/S106137443","display_name":"Pharmacology","issn_l":"0031-7012","issn":["0031-7012","1423-0313"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054056894","display_name":"Chung\u2010Ren Jan","orcid":"https://orcid.org/0000-0003-2805-8418","observed_orcids":["https://orcid.org/0000-0003-2805-8418"]},"institutions":[{"id":"https://openalex.org/I4210152230","display_name":"Kaohsiung Veterans General Hospital","ror":"https://ror.org/04jedda80","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210152230"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chung-Ren Jan","raw_affiliation_strings":["Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan/ROC","Medical Education and Research,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan/ROC","institution_ids":["https://openalex.org/I4210152230"]},{"raw_affiliation_string":"Medical Education and Research,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110057284","display_name":"Yih\u2010Chau Lu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yih-Chau Lu","raw_affiliation_strings":["Orthopedic Surgery,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Orthopedic Surgery,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110257620","display_name":"Li\u2010Ling Tseng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li-Ling Tseng","raw_affiliation_strings":["Dentistry,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dentistry,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036563270","display_name":"Bang\u2010Ping Jiann","orcid":"https://orcid.org/0000-0001-6345-2475","observed_orcids":["https://orcid.org/0000-0001-6345-2475"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bang-Ping Jiann","raw_affiliation_strings":["Surgery, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102169018","display_name":"Hong\u2010Tai Chang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong-Tai Chang","raw_affiliation_strings":["Surgery, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080741317","display_name":"Jue\u2010Long Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152230","display_name":"Kaohsiung Veterans General Hospital","ror":"https://ror.org/04jedda80","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210152230"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jue-Long Wang","raw_affiliation_strings":["Rehabilitation, Kaohsiung Veterans General Hospital, Kaohsiung, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rehabilitation, Kaohsiung Veterans General Hospital, Kaohsiung, and","institution_ids":["https://openalex.org/I4210152230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090296644","display_name":"Wei\u2010Chuan Chen","orcid":"https://orcid.org/0000-0001-8937-5391","observed_orcids":["https://orcid.org/0000-0001-8937-5391"]},"institutions":[{"id":"https://openalex.org/I4210141770","display_name":"Pingtung Christian Hospital","ror":"https://ror.org/04bnbsh26","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210141770"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wei-Chuan Chen","raw_affiliation_strings":["Department of Surgery, Ping Tung Christian Hospital, PingTung,Taiwan/ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Ping Tung Christian Hospital, PingTung,Taiwan/ROC","institution_ids":["https://openalex.org/I4210141770"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105358006","display_name":"Jong\u2010Khing Huang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jong-Khing Huang","raw_affiliation_strings":["Surgery, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7737,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.65551839,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"69","issue":"4","first_page":"190","last_page":"196"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.5952000021934509,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.5952000021934509,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.1599999964237213,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.016499999910593033,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/desipramine","display_name":"desipramine","score":1.0},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.7979999780654907},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.9449999928474426},{"id":"https://openalex.org/keywords/mg-63-cells","display_name":"MG-63 cells","score":0.9399999976158142},{"id":"https://openalex.org/keywords/extracellular-calcium-influx","display_name":"extracellular calcium influx","score":0.8479999899864197},{"id":"https://openalex.org/keywords/calcium-release","display_name":"calcium release","score":0.6069999933242798},{"id":"https://openalex.org/keywords/sarco-endoplasmic-reticulum-ca2-atpase","display_name":"sarco/endoplasmic reticulum Ca2+-ATPase","score":0.9070000052452087},{"id":"https://openalex.org/keywords/thapsigargin","display_name":"thapsigargin","score":0.972000002861023},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7590000033378601},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8809999823570251},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.6190000176429749},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.8489999771118164}],"concepts":[{"id":"https://openalex.org/C2780250439","wikidata":"https://www.wikidata.org/wiki/Q423288","display_name":"Desipramine","level":4,"score":0.8849126100540161},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.7528338432312012},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.7451472878456116},{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.6070995926856995},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.48901495337486267},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4719730317592621},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.387786328792572},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.37411564588546753},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.28050804138183594},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23254477977752686},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21725451946258545},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16006100177764893},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09815490245819092},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.07154244184494019}],"mesh":[{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003891","descriptor_name":"Desipramine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010738","descriptor_name":"Type C Phospholipases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D010738","descriptor_name":"Type C Phospholipases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016257","descriptor_name":"Fura-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019284","descriptor_name":"Thapsigargin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1159/000073663","doi":"https://doi.org/10.1159/000073663","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000073663","pdf_url":null,"source":{"id":"https://openalex.org/S106137443","display_name":"Pharmacology","issn_l":"0031-7012","issn":["0031-7012","1423-0313"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology","raw_type":"journal-article"},{"id":"pmid:14624059","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14624059","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W169114245","https://openalex.org/W202834474","https://openalex.org/W264813646","https://openalex.org/W985114652","https://openalex.org/W1574660002","https://openalex.org/W1970982006","https://openalex.org/W1972161620","https://openalex.org/W1974507976","https://openalex.org/W1981919734","https://openalex.org/W1996820102","https://openalex.org/W2001483615","https://openalex.org/W2009413648","https://openalex.org/W2011041415","https://openalex.org/W2016148363","https://openalex.org/W2016810594","https://openalex.org/W2023285411","https://openalex.org/W2041256074","https://openalex.org/W2041769658","https://openalex.org/W2057665893","https://openalex.org/W2058577152","https://openalex.org/W2063535351","https://openalex.org/W2070832223","https://openalex.org/W2072748076","https://openalex.org/W2077226786","https://openalex.org/W2083874542","https://openalex.org/W2086486507","https://openalex.org/W2089947504","https://openalex.org/W2095955574","https://openalex.org/W2123823383","https://openalex.org/W2141260882","https://openalex.org/W2150942343","https://openalex.org/W2164620653","https://openalex.org/W2184821927","https://openalex.org/W2204081136","https://openalex.org/W2262929701","https://openalex.org/W2294013910","https://openalex.org/W2297772915"],"related_works":["https://openalex.org/W2015388796","https://openalex.org/W2131280101","https://openalex.org/W2185942463","https://openalex.org/W1558348085","https://openalex.org/W264813646","https://openalex.org/W2591196521","https://openalex.org/W2545271273","https://openalex.org/W2064376944","https://openalex.org/W2287977695","https://openalex.org/W2006118245"],"abstract_inverted_index":{"In":[0,61],"human":[1],"osteosarcoma":[2],"MG63":[3],"cells,":[4],"the":[5,68,80],"effect":[6,82],"of":[7,30,49,67,83,101,126,130],"desipramine,":[8],"an":[9,65,99],"antidepressant,":[10],"on":[11,85],"intracellular":[12,153],"Ca(2+)":[13,51,58,150,154],"concentration":[14],"([Ca(2+)](i))":[15],"was":[16,43,53,87],"measured":[17],"by":[18,45,47,56,146],"using":[19],"fura-2.":[20],"Desipramine":[21],"(>10":[22],"micromol/l)":[23],"caused":[24,73],"a":[25,33,74],"rapid":[26],"and":[27,124,132,152,156],"sustained":[28],"rise":[29,42],"[Ca(2+)](i)":[31,41,76,86,96,108,143],"in":[32,144],"concentration-dependent":[34],"manner":[35],"(EC(50)":[36],"=":[37],"200":[38,133],"micromol/l).":[39],"Desipramine-induced":[40],"prevented":[44],"80%":[46],"removal":[48],"extracellular":[50,149],"but":[52,121],"not":[54,105,117],"altered":[55],"voltage-gated":[57],"channel":[59],"blockers.":[60],"Ca(2+)-free":[62],"medium,":[63],"thapsigargin,":[64],"inhibitor":[66,100],"endoplasmic":[69],"reticulum":[70],"(ER)":[71],"Ca(2+)-ATPase,":[72],"monophasic":[75],"rise,":[77],"after":[78],"which":[79],"increasing":[81],"desipramine":[84,92,115,140],"abolished;":[88],"also,":[89],"pretreatment":[90],"with":[91,112],"partly":[93],"reduced":[94],"thapsigargin-induced":[95],"increase.":[97],"U73122,":[98],"phospholipase":[102],"C,":[103],"did":[104,116],"affect":[106],"desipramine-induced":[107],"rise.":[109],"Overnight":[110],"incubation":[111],"10":[113],"micromol/l":[114],"alter":[118],"cell":[119],"proliferation,":[120],"killed":[122],"32":[123],"89%":[125],"cells":[127],"at":[128,159],"concentrations":[129],"100":[131],"micromol/l,":[134],"respectively.":[135],"These":[136],"findings":[137],"suggest":[138],"that":[139],"rapidly":[141],"increases":[142],"osteoblasts":[145],"stimulating":[147],"both":[148],"influx":[151],"release,":[155],"is":[157],"cytotoxic":[158],"high":[160],"concentrations.":[161]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}