{"id":"https://openalex.org/W2058043554","doi":"https://doi.org/10.1073/pnas.97.7.3352","title":"APC mutations in sporadic colorectal tumors: A mutational \u201chotspot\u201d and interdependence of the \u201ctwo hits\u201d","display_name":"APC mutations in sporadic colorectal tumors: A mutational \u201chotspot\u201d and interdependence of the \u201ctwo hits\u201d","publication_year":2000,"publication_date":"2000-03-28","ids":{"openalex":"https://openalex.org/W2058043554","doi":"https://doi.org/10.1073/pnas.97.7.3352","mag":"2058043554","pmid":"https://pubmed.ncbi.nlm.nih.gov/10737795","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/16243"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.97.7.3352","doi":"https://doi.org/10.1073/pnas.97.7.3352","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.97.7.3352","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/16243","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111857924","display_name":"Andrew Rowan","orcid":"https://orcid.org/0000-0003-1926-9707","observed_orcids":["https://orcid.org/0000-0003-1926-9707"]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. J. Rowan","raw_affiliation_strings":["Molecular and Population Genetics Laboratory, Imperial Cancer\r Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, United\r Kingdom; and Cancer and Immunogenetics Laboratory,\r Imperial Cancer Research Fund, Institute of Molecular Medicine, John\r Radcliffe Hospital, Oxford OX3 9DZ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Population Genetics Laboratory, Imperial Cancer\r Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, United\r Kingdom; and Cancer and Immunogenetics Laboratory,\r Imperial Cancer Research Fund, Institute of Molecular Medicine, John\r Radcliffe Hospital, Oxford OX3 9DZ, United Kingdom","institution_ids":["https://openalex.org/I2802742124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107901299","display_name":"H. Lamlum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"H. Lamlum","raw_affiliation_strings":["Molecular and Population Genetics Laboratory, Imperial Cancer\r Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, United\r Kingdom; and Cancer and Immunogenetics Laboratory,\r Imperial Cancer Research Fund, Institute of Molecular Medicine, John\r Radcliffe Hospital, Oxford OX3 9DZ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Population Genetics Laboratory, Imperial Cancer\r Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, United\r Kingdom; and Cancer and Immunogenetics Laboratory,\r Imperial Cancer Research Fund, Institute of Molecular Medicine, John\r Radcliffe Hospital, Oxford OX3 9DZ, United Kingdom","institution_ids":["https://openalex.org/I2802742124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050974875","display_name":"Mohammad Ilyas","orcid":"https://orcid.org/0000-0001-7949-7504","observed_orcids":["https://orcid.org/0000-0001-7949-7504"]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. Ilyas","raw_affiliation_strings":["Molecular and Population Genetics Laboratory, Imperial Cancer\r Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, United\r Kingdom; and Cancer and Immunogenetics Laboratory,\r Imperial Cancer Research Fund, Institute of Molecular Medicine, John\r Radcliffe Hospital, Oxford OX3 9DZ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Population Genetics Laboratory, Imperial Cancer\r Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, United\r Kingdom; and Cancer and Immunogenetics Laboratory,\r Imperial Cancer Research Fund, Institute of Molecular Medicine, John\r Radcliffe Hospital, Oxford OX3 9DZ, United Kingdom","institution_ids":["https://openalex.org/I2802742124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049383372","display_name":"James Wheeler","orcid":"https://orcid.org/0000-0002-8145-624X","observed_orcids":["https://orcid.org/0000-0002-8145-624X"]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. Wheeler","raw_affiliation_strings":["Molecular and Population Genetics Laboratory, Imperial Cancer\r Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, United\r Kingdom; and Cancer and Immunogenetics Laboratory,\r Imperial Cancer Research Fund, Institute of Molecular Medicine, John\r Radcliffe Hospital, Oxford OX3 9DZ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Population Genetics Laboratory, Imperial Cancer\r Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, United\r Kingdom; and Cancer and Immunogenetics Laboratory,\r Imperial Cancer Research Fund, Institute of Molecular Medicine, John\r Radcliffe Hospital, Oxford OX3 9DZ, United Kingdom","institution_ids":["https://openalex.org/I2802742124"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J. Straub","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. Straub","raw_affiliation_strings":["Molecular and Population Genetics Laboratory, Imperial Cancer\r Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, United\r Kingdom; and Cancer and Immunogenetics Laboratory,\r Imperial Cancer Research Fund, Institute of Molecular Medicine, John\r Radcliffe Hospital, Oxford OX3 9DZ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Population Genetics Laboratory, Imperial Cancer\r Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, United\r Kingdom; and Cancer and Immunogenetics Laboratory,\r Imperial Cancer Research Fund, Institute of Molecular Medicine, John\r Radcliffe Hospital, Oxford OX3 9DZ, United Kingdom","institution_ids":["https://openalex.org/I2802742124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110383603","display_name":"Aggeliki Papadopoulou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. Papadopoulou","raw_affiliation_strings":["Molecular and Population Genetics Laboratory, Imperial Cancer\r Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, United\r Kingdom; and Cancer and Immunogenetics Laboratory,\r Imperial Cancer Research Fund, Institute of Molecular Medicine, John\r Radcliffe Hospital, Oxford OX3 9DZ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Population Genetics Laboratory, Imperial Cancer\r Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, United\r Kingdom; and Cancer and Immunogenetics Laboratory,\r Imperial Cancer Research Fund, Institute of Molecular Medicine, John\r Radcliffe Hospital, Oxford OX3 9DZ, United Kingdom","institution_ids":["https://openalex.org/I2802742124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113593461","display_name":"D C Bicknell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D. Bicknell","raw_affiliation_strings":["Molecular and Population Genetics Laboratory, Imperial Cancer\r Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, United\r Kingdom; and Cancer and Immunogenetics Laboratory,\r Imperial Cancer Research Fund, Institute of Molecular Medicine, John\r Radcliffe Hospital, Oxford OX3 9DZ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Population Genetics Laboratory, Imperial Cancer\r Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, United\r Kingdom; and Cancer and Immunogenetics Laboratory,\r Imperial Cancer Research Fund, Institute of Molecular Medicine, John\r Radcliffe Hospital, Oxford OX3 9DZ, United Kingdom","institution_ids":["https://openalex.org/I2802742124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004131652","display_name":"Walter Fred Bodmer","orcid":"https://orcid.org/0000-0001-6244-9792","observed_orcids":["https://orcid.org/0000-0001-6244-9792"]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"W. F. Bodmer","raw_affiliation_strings":["Molecular and Population Genetics Laboratory, Imperial Cancer\r Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, United\r Kingdom; and Cancer and Immunogenetics Laboratory,\r Imperial Cancer Research Fund, Institute of Molecular Medicine, John\r Radcliffe Hospital, Oxford OX3 9DZ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Population Genetics Laboratory, Imperial Cancer\r Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, United\r Kingdom; and Cancer and Immunogenetics Laboratory,\r Imperial Cancer Research Fund, Institute of Molecular Medicine, John\r Radcliffe Hospital, Oxford OX3 9DZ, United Kingdom","institution_ids":["https://openalex.org/I2802742124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040598662","display_name":"Ian P.M. Tomlinson","orcid":"https://orcid.org/0000-0003-3037-1470","observed_orcids":["https://orcid.org/0000-0003-3037-1470","https://orcid.org/0000-0003-3103-6535"]},"institutions":[{"id":"https://openalex.org/I2802742124","display_name":"John Radcliffe Hospital","ror":"https://ror.org/0080acb59","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802742124","https://openalex.org/I4210127145","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"I. P. M. Tomlinson","raw_affiliation_strings":["Molecular and Population Genetics Laboratory, Imperial Cancer\r Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, United\r Kingdom; and Cancer and Immunogenetics Laboratory,\r Imperial Cancer Research Fund, Institute of Molecular Medicine, John\r Radcliffe Hospital, Oxford OX3 9DZ, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Population Genetics Laboratory, Imperial Cancer\r Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, United\r Kingdom; and Cancer and Immunogenetics Laboratory,\r Imperial Cancer Research Fund, Institute of Molecular Medicine, John\r Radcliffe Hospital, Oxford OX3 9DZ, United Kingdom","institution_ids":["https://openalex.org/I2802742124"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2802742124"],"apc_list":null,"apc_paid":null,"fwci":13.9157,"has_fulltext":false,"cited_by_count":496,"citation_normalized_percentile":{"value":0.99224138,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"97","issue":"7","first_page":"3352","last_page":"3357"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apc-gene","display_name":"APC gene","score":0.8389999866485596},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8920000195503235},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.8330000042915344},{"id":"https://openalex.org/keywords/mutation-hotspots","display_name":"mutational hotspots","score":0.6769999861717224},{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.8199999928474426},{"id":"https://openalex.org/keywords/two-hit-model","display_name":"two-hit model","score":0.7480000257492065},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7549999952316284},{"id":"https://openalex.org/keywords/familial-adenomatous-polyposis","display_name":"familial adenomatous polyposis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.7419999837875366},{"id":"https://openalex.org/keywords/ras-erk-pathway","display_name":"Ras/ERK pathway","score":0.6010000109672546},{"id":"https://openalex.org/keywords/truncating-variants","display_name":"truncating mutations","score":0.8450000286102295},{"id":"https://openalex.org/keywords/colorectal-cancer-cell-lines","display_name":"colorectal cancer cell lines","score":0.9210000038146973}],"concepts":[{"id":"https://openalex.org/C2778237340","wikidata":"https://www.wikidata.org/wiki/Q14883378","display_name":"Adenomatous polyposis coli","level":4,"score":0.7336652874946594},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6279414296150208},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5729876160621643},{"id":"https://openalex.org/C2780814781","wikidata":"https://www.wikidata.org/wiki/Q1369011","display_name":"Familial adenomatous polyposis","level":4,"score":0.5509881973266602},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4780200719833374},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.47653302550315857},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.4712046980857849},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.46876853704452515},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4552213251590729},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.42792075872421265},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.4199046194553375},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4132331907749176},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.23309838771820068}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017491","descriptor_name":"Genes, APC","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019656","descriptor_name":"Loss of Heterozygosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.97.7.3352","doi":"https://doi.org/10.1073/pnas.97.7.3352","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.97.7.3352","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:178457","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/16243","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:16243","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/16243","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:10737795","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10737795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:178457","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/16243","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1499807572","https://openalex.org/W1539988273","https://openalex.org/W1544046482","https://openalex.org/W1566456185","https://openalex.org/W1610591498","https://openalex.org/W1942136349","https://openalex.org/W1971856907","https://openalex.org/W1979618971","https://openalex.org/W1982793182","https://openalex.org/W1984439054","https://openalex.org/W1991604385","https://openalex.org/W2006874765","https://openalex.org/W2007127609","https://openalex.org/W2023194603","https://openalex.org/W2024419615","https://openalex.org/W2039800013","https://openalex.org/W2053086049","https://openalex.org/W2065423665","https://openalex.org/W2092691551","https://openalex.org/W2093531978","https://openalex.org/W2134598096","https://openalex.org/W2151365378","https://openalex.org/W2171080110","https://openalex.org/W2244046725"],"related_works":["https://openalex.org/W2171080110","https://openalex.org/W7098880076","https://openalex.org/W2012385890","https://openalex.org/W1499807572","https://openalex.org/W2370912328","https://openalex.org/W2036541245","https://openalex.org/W2604035013","https://openalex.org/W2627073084","https://openalex.org/W2171974881","https://openalex.org/W2134598096"],"abstract_inverted_index":{"Although":[0],"APC":[1,29,84,108,116,136,158,186,196,240,247],"mutations":[2,24,86,117,137,161,197,217],"occur":[3,138],"at":[4,72,129,165,185],"a":[5,15,34,38,92,120],"high":[6],"frequency":[7],"in":[8,37,61,91,125,139,162,187,194,198],"colorectal":[9,96,127,144,189],"cancers,":[10,102,145],"few":[11],"studies":[12],"have":[13],"performed":[14],"comprehensive":[16],"analysis":[17],"by":[18,160],"screening":[19],"the":[20,49,52,56,79,140,146,182,199],"whole":[21],"gene":[22,36],"for":[23,85,122,156,234],"and":[25,64,87,118,237,246],"assessing":[26],"allelic":[27,89,111,212],"loss.":[28,112],"seems":[30],"to":[31,206,222],"act":[32],"as":[33,191,193],"tumor-suppressor":[35],"\"nonclassical\"":[39],"fashion:":[40],"data":[41],"from":[42],"familial":[43],"adenomatous":[44],"polyposis":[45],"(FAP)":[46],"show":[47,176],"that":[48,135,177],"site":[50],"of":[51,58,83,94,107,143,181,228],"germ-line":[53],"mutation":[54,109,124],"determines":[55],"type":[57],"\"second":[59],"hit\"":[60],"FAP":[62],"tumors,":[63,152],"simple":[65],"protein":[66,248],"inactivation":[67],"is":[68,179],"selected":[69],"weakly,":[70],"if":[71],"all.":[73],"In":[74],"this":[75,219,229],"study,":[76],"we":[77],"screened":[78],"entire":[80],"coding":[81],"region":[82,220],"assessed":[88],"loss":[90],"set":[93],"41":[95,101],"cancer":[97],"cell":[98],"lines.":[99],"Of":[100],"32":[103],"(83%)":[104],"showed":[105],"evidence":[106],"and/or":[110,164],"We":[113],"identified":[114],"several":[115],"found":[119],"\"hotspot\"":[121],"somatic":[123],"sporadic":[126,188],"tumors":[128,190,215],"codon":[130,207],"1,554.":[131],"Our":[132],"results":[133,175],"suggest":[134],"great":[141],"majority":[142],"exceptions":[147],"almost":[148],"all":[149],"being":[150],"RER+":[151],"which":[153],"may":[154],"substitute":[155],"altered":[157],"function":[159],"beta-catenin":[163,244],"other":[166],"loci.":[167],"When":[168],"combined":[169],"with":[170,211,216],"previously":[171],"published":[172],"data,":[173],"our":[174],"there":[178],"interdependence":[180],"\"two":[183],"hits\"":[184],"well":[192],"FAP.":[195],"\"mutation":[200],"cluster":[201],"region,\"":[202],"especially":[203],"those":[204],"close":[205],"1,300,":[208],"are":[209,231],"associated":[210],"loss,":[213],"whereas":[214],"outside":[218],"tend":[221],"harbor":[223],"truncating":[224],"mutations.":[225],"The":[226],"causes":[227],"phenomenon":[230],"probably":[232],"selection":[233],"retained":[235],"N-terminal":[236],"lost":[238],"C-terminal":[239],"functions,":[241],"effects":[242],"on":[243],"levels,":[245],"stability.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":27},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":27},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":20},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":18},{"year":2012,"cited_by_count":25}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
