{"id":"https://openalex.org/W2058042345","doi":"https://doi.org/10.1089/neu.2012.2399","title":"Repeated Mild Traumatic Brain Injury: Mechanisms of Cerebral Vulnerability","display_name":"Repeated Mild Traumatic Brain Injury: Mechanisms of Cerebral Vulnerability","publication_year":2012,"publication_date":"2012-10-01","ids":{"openalex":"https://openalex.org/W2058042345","doi":"https://doi.org/10.1089/neu.2012.2399","mag":"2058042345","pmid":"https://pubmed.ncbi.nlm.nih.gov/23025820","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4047842"},"language":"en","primary_location":{"id":"doi:10.1089/neu.2012.2399","doi":"https://doi.org/10.1089/neu.2012.2399","is_oa":false,"landing_page_url":"https://doi.org/10.1089/neu.2012.2399","pdf_url":null,"source":{"id":"https://openalex.org/S85864898","display_name":"Journal of Neurotrauma","issn_l":"0897-7151","issn":["0897-7151","1557-9042"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurotrauma","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2058042345"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4047842/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038971123","display_name":"Mayumi L. Prins","orcid":"https://orcid.org/0000-0001-7694-9739","observed_orcids":["https://orcid.org/0000-0001-7694-9739"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mayumi L. Prins","raw_affiliation_strings":["Department of Neurosurgery, University of California, Los Angeles, School of Medicine, Los Angeles, California","The Interdepartmental Program for Neuroscience, University of California, Los Angeles, School of Medicine, Los Angeles, California","The UCLA Brain Injury Research Center, University of California, Los Angeles, School of Medicine, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, University of California, Los Angeles, School of Medicine, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"The Interdepartmental Program for Neuroscience, University of California, Los Angeles, School of Medicine, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"The UCLA Brain Injury Research Center, University of California, Los Angeles, School of Medicine, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064482235","display_name":"Daya Alexander","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daya Alexander","raw_affiliation_strings":["The Interdepartmental Program for Neuroscience, University of California, Los Angeles, School of Medicine, Los Angeles, California","The UCLA Brain Injury Research Center, University of California, Los Angeles, School of Medicine, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Interdepartmental Program for Neuroscience, University of California, Los Angeles, School of Medicine, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"The UCLA Brain Injury Research Center, University of California, Los Angeles, School of Medicine, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051289030","display_name":"Christopher C. Giza","orcid":"https://orcid.org/0000-0002-5721-2667","observed_orcids":["https://orcid.org/0000-0002-5721-2667"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher C. Giza","raw_affiliation_strings":["Department of Neurology, University of California, Los Angeles, School of Medicine, Los Angeles, California","Department of Neurosurgery, University of California, Los Angeles, School of Medicine, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of California, Los Angeles, School of Medicine, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Neurosurgery, University of California, Los Angeles, School of Medicine, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056220327","display_name":"David Allen Hovda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Hovda","raw_affiliation_strings":["Department of Molecular and Medical Pharmacology, University of California, Los Angeles, School of Medicine, Los Angeles, California","Department of Neurosurgery, University of California, Los Angeles, School of Medicine, Los Angeles, California","The Interdepartmental Program for Neuroscience, University of California, Los Angeles, School of Medicine, Los Angeles, California","The UCLA Brain Injury Research Center, University of California, Los Angeles, School of Medicine, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, University of California, Los Angeles, School of Medicine, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Neurosurgery, University of California, Los Angeles, School of Medicine, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"The Interdepartmental Program for Neuroscience, University of California, Los Angeles, School of Medicine, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"The UCLA Brain Injury Research Center, University of California, Los Angeles, School of Medicine, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5038971123"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":null,"apc_paid":null,"fwci":17.5446,"has_fulltext":false,"cited_by_count":343,"citation_normalized_percentile":{"value":0.99617174,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"30","issue":"1","first_page":"30","last_page":"38"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.5990999937057495,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.5990999937057495,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.39579999446868896,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11487","display_name":"Automotive and Human Injury Biomechanics","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/repetitive-mild-traumatic-brain-injury","display_name":"repetitive mild traumatic brain injury","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cerebral-metabolic-rate-of-glucose","display_name":"cerebral metabolic rate of glucose","score":0.902999997138977},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.6779999732971191},{"id":"https://openalex.org/keywords/brain-vulnerability","display_name":"brain vulnerability","score":0.5109999775886536},{"id":"https://openalex.org/keywords/window-of-vulnerability","display_name":"window of vulnerability","score":0.7519999742507935},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8080000281333923},{"id":"https://openalex.org/keywords/juvenile-brain","display_name":"juvenile brain","score":0.8410000205039978},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.6620000004768372},{"id":"https://openalex.org/keywords/parietal-cortex","display_name":"parietal cortex","score":0.9940000176429749},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.3919999897480011}],"concepts":[{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.8033130168914795},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.5922034978866577},{"id":"https://openalex.org/C3017944768","wikidata":"https://www.wikidata.org/wiki/Q1450463","display_name":"Poison control","level":2,"score":0.49921274185180664},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4743334650993347},{"id":"https://openalex.org/C2777975874","wikidata":"https://www.wikidata.org/wiki/Q2920572","display_name":"Head injury","level":2,"score":0.4636678695678711},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46157822012901306},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.44765788316726685},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35930773615837097},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3439524173736572},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.1881769299507141},{"id":"https://openalex.org/C545542383","wikidata":"https://www.wikidata.org/wiki/Q2751242","display_name":"Medical emergency","level":1,"score":0.09061211347579956},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1089/neu.2012.2399","doi":"https://doi.org/10.1089/neu.2012.2399","is_oa":false,"landing_page_url":"https://doi.org/10.1089/neu.2012.2399","pdf_url":null,"source":{"id":"https://openalex.org/S85864898","display_name":"Journal of Neurotrauma","issn_l":"0897-7151","issn":["0897-7151","1557-9042"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurotrauma","raw_type":"journal-article"},{"id":"pmid:23025820","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23025820","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurotrauma","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:4047842","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4047842/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurotrauma","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4047842","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4047842/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurotrauma","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2117698079","display_name":"Age-Dependent Ketone Metabolism After Brain Injury","funder_award_id":"R01NS052406","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3015335524","display_name":"Using glutamatergic pharmacotherapy to optimize TBI recovery","funder_award_id":"R01NS027544","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":84,"referenced_works":["https://openalex.org/W47045816","https://openalex.org/W176812195","https://openalex.org/W195649217","https://openalex.org/W1480890041","https://openalex.org/W1620750268","https://openalex.org/W1817392531","https://openalex.org/W1936810077","https://openalex.org/W1966191914","https://openalex.org/W1970604028","https://openalex.org/W1974459740","https://openalex.org/W1976244656","https://openalex.org/W1977418950","https://openalex.org/W1979824327","https://openalex.org/W1984707599","https://openalex.org/W1985645068","https://openalex.org/W1986550170","https://openalex.org/W1989378067","https://openalex.org/W1994314634","https://openalex.org/W1995710134","https://openalex.org/W1996614758","https://openalex.org/W1998567152","https://openalex.org/W2001479501","https://openalex.org/W2003540939","https://openalex.org/W2004018261","https://openalex.org/W2004896899","https://openalex.org/W2005606566","https://openalex.org/W2006525554","https://openalex.org/W2007130500","https://openalex.org/W2022697435","https://openalex.org/W2023468397","https://openalex.org/W2023818340","https://openalex.org/W2025009885","https://openalex.org/W2025877279","https://openalex.org/W2026876347","https://openalex.org/W2028697168","https://openalex.org/W2035873736","https://openalex.org/W2037253320","https://openalex.org/W2041204070","https://openalex.org/W2042958071","https://openalex.org/W2046128187","https://openalex.org/W2049428746","https://openalex.org/W2049872156","https://openalex.org/W2056322342","https://openalex.org/W2058080801","https://openalex.org/W2058937984","https://openalex.org/W2063258427","https://openalex.org/W2064725661","https://openalex.org/W2064972676","https://openalex.org/W2068805784","https://openalex.org/W2071109631","https://openalex.org/W2072441360","https://openalex.org/W2073649940","https://openalex.org/W2076554399","https://openalex.org/W2076985921","https://openalex.org/W2083249651","https://openalex.org/W2083863274","https://openalex.org/W2085076209","https://openalex.org/W2085113673","https://openalex.org/W2087021780","https://openalex.org/W2087253152","https://openalex.org/W2087394638","https://openalex.org/W2088085303","https://openalex.org/W2088355838","https://openalex.org/W2088592655","https://openalex.org/W2090306035","https://openalex.org/W2096085373","https://openalex.org/W2099748013","https://openalex.org/W2107114800","https://openalex.org/W2113522285","https://openalex.org/W2116242136","https://openalex.org/W2126652387","https://openalex.org/W2131219948","https://openalex.org/W2132122521","https://openalex.org/W2132185405","https://openalex.org/W2134012733","https://openalex.org/W2137585767","https://openalex.org/W2152619016","https://openalex.org/W2153754654","https://openalex.org/W2254704319","https://openalex.org/W2399758863","https://openalex.org/W2404409455","https://openalex.org/W2410092280","https://openalex.org/W2413809032","https://openalex.org/W2468353405"],"related_works":["https://openalex.org/W1993120818","https://openalex.org/W2191536771","https://openalex.org/W2921179220","https://openalex.org/W2023818340","https://openalex.org/W2094897664","https://openalex.org/W3000399561","https://openalex.org/W2037253320","https://openalex.org/W4382369565","https://openalex.org/W1999043054","https://openalex.org/W2330807792"],"abstract_inverted_index":{"Among":[0],"the":[1,60,67,74,87,104,150,170,174,177,196,202,206,209,225,231,239],"3.5":[2],"million":[3],"annual":[4],"new":[5],"head":[6],"injury":[7,22,237],"cases":[8],"is":[9,64,71,144,167,180,199,213],"a":[10,29,81,91,95,99,140,164,219,246],"subpopulation":[11],"of":[12,26,48,69,76,173,205,227,233,252],"children":[13],"and":[14,34,56,79,153,186,242],"young":[15],"adults":[16],"who":[17],"experience":[18],"repeated":[19],"traumatic":[20],"brain":[21,241],"(TBI).":[23],"The":[24],"duration":[25,68,75,226],"vulnerability":[27,70,89,234,253],"after":[28,54,139,201],"single":[30,82,113,141,220],"TBI":[31,84],"remains":[32,187],"unknown,":[33],"biomarkers":[35],"have":[36],"yet":[37],"to":[38,73,90,133,215,235],"be":[39],"determined.":[40],"Decreases":[41],"in":[42,148,238,249],"glucose":[43,49],"metabolism":[44],"(cerebral":[45],"metabolic":[46,203,228],"rate":[47],"[CMRglc])":[50],"are":[51],"consistently":[52],"observed":[53],"experimental":[55],"human":[57],"TBI.":[58],"In":[59,193],"current":[61],"study,":[62],"it":[63],"hypothesized":[65],"that":[66,80,216,224],"related":[72],"decreased":[77,145],"CMRglc":[78,143,171,179,211],"mild":[83],"(mTBI)":[85],"increases":[86],"brain's":[88],"second":[92,165,197,236],"insult":[93],"for":[94],"period,":[96],"during":[97,169],"which":[98],"subsequent":[100],"mTBI":[101,117,166,198],"will":[102],"worsen":[103],"outcome.":[105],"Postnatal":[106],"day":[107],"35":[108],"rats":[109],"were":[110],"given":[111],"sham,":[112],"mTBI,":[114,142],"or":[115,120,129],"two":[116],"at":[118,127,183,190],"24-h":[119],"120-h":[121],"intervals.":[122],"(14)C-2-deoxy-D-glucose":[123],"autoradiography":[124],"was":[125],"conducted":[126],"1":[128],"3":[130,160,191],"days":[131,161],"post-injury":[132],"calculate":[134],"CMRglc.":[135],"At":[136],"24":[137,184],"h":[138,185],"by":[146,159],"19%":[147],"both":[149],"parietal":[151],"cortex":[152],"hippocampus,":[154],"but":[155],"approached":[156],"sham":[157],"levels":[158],"post-injury.":[162],"When":[163],"introduced":[168,200],"depression":[172,212,229],"first":[175,207],"injury,":[176,208],"consequent":[178,210],"depressed":[181,188],"(36.5%)":[182],"(25%)":[189],"days.":[192],"contrast,":[194],"when":[195],"recovery":[204],"similar":[214],"seen":[217],"with":[218],"injury.":[221],"Results":[222],"suggest":[223],"reflects":[230],"time-course":[232],"juvenile":[240],"could":[243],"serve":[244],"as":[245],"valuable":[247],"biomarker":[248],"establishing":[250],"window":[251],"guidelines.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":25},{"year":2021,"cited_by_count":25},{"year":2020,"cited_by_count":36},{"year":2019,"cited_by_count":28},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":33},{"year":2016,"cited_by_count":31},{"year":2015,"cited_by_count":36},{"year":2014,"cited_by_count":37},{"year":2013,"cited_by_count":14},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}