{"id":"https://openalex.org/W2058036839","doi":"https://doi.org/10.1210/endo-114-2-359","title":"A Possible Role of Prostacyclin to Stimulate Prolactin and Growth Hormone Release by Hypothalamic and Pituitary Actions, Respectively*","display_name":"A Possible Role of Prostacyclin to Stimulate Prolactin and Growth Hormone Release by Hypothalamic and Pituitary Actions, Respectively*","publication_year":1984,"publication_date":"1984-02-01","ids":{"openalex":"https://openalex.org/W2058036839","doi":"https://doi.org/10.1210/endo-114-2-359","mag":"2058036839","pmid":"https://pubmed.ncbi.nlm.nih.gov/6418530"},"language":"en","primary_location":{"id":"doi:10.1210/endo-114-2-359","doi":"https://doi.org/10.1210/endo-114-2-359","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-114-2-359","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018694685","display_name":"Anna Ottlecz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I227486990","display_name":"University of Szeged","ror":"https://ror.org/01pnej532","country_code":"HU","type":"education","lineage":["https://openalex.org/I227486990"]},{"id":"https://openalex.org/I4210094379","display_name":"University of Texas Health Science Center at Dallas","ror":"https://ror.org/00q16t150","country_code":"US","type":"education","lineage":["https://openalex.org/I4210094379"]}],"countries":["HU","US"],"is_corresponding":false,"raw_author_name":"A. OTTLECZ","raw_affiliation_strings":["Department of Physiology, University of Texas Health Science Center at Dallas 5323 Harry Hines Boulevard, Dallas, Texas 75235; Institute of Pathophysiology, University Medical School of Szeged Szeged, H-6701 Hungary","Department of Physiology, University of Texas Health Science Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75235"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Texas Health Science Center at Dallas 5323 Harry Hines Boulevard, Dallas, Texas 75235; Institute of Pathophysiology, University Medical School of Szeged Szeged, H-6701 Hungary","institution_ids":["https://openalex.org/I227486990","https://openalex.org/I4210094379"]},{"raw_affiliation_string":"Department of Physiology, University of Texas Health Science Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75235","institution_ids":["https://openalex.org/I4210094379"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059960680","display_name":"Willis K. Samson","orcid":"https://orcid.org/0000-0003-0560-4447","observed_orcids":["https://orcid.org/0000-0003-0560-4447"]},"institutions":[{"id":"https://openalex.org/I227486990","display_name":"University of Szeged","ror":"https://ror.org/01pnej532","country_code":"HU","type":"education","lineage":["https://openalex.org/I227486990"]},{"id":"https://openalex.org/I4210094379","display_name":"University of Texas Health Science Center at Dallas","ror":"https://ror.org/00q16t150","country_code":"US","type":"education","lineage":["https://openalex.org/I4210094379"]}],"countries":["HU","US"],"is_corresponding":false,"raw_author_name":"W. K. SAMSON","raw_affiliation_strings":["Department of Physiology, University of Texas Health Science Center at Dallas 5323 Harry Hines Boulevard, Dallas, Texas 75235; Institute of Pathophysiology, University Medical School of Szeged Szeged, H-6701 Hungary","Institute of Pathophysiology, University Medical School of Szeged Szeged, H-6701 Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Texas Health Science Center at Dallas 5323 Harry Hines Boulevard, Dallas, Texas 75235; Institute of Pathophysiology, University Medical School of Szeged Szeged, H-6701 Hungary","institution_ids":["https://openalex.org/I227486990","https://openalex.org/I4210094379"]},{"raw_affiliation_string":"Institute of Pathophysiology, University Medical School of Szeged Szeged, H-6701 Hungary","institution_ids":["https://openalex.org/I227486990"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069185819","display_name":"Samuel M. McCann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I227486990","display_name":"University of Szeged","ror":"https://ror.org/01pnej532","country_code":"HU","type":"education","lineage":["https://openalex.org/I227486990"]},{"id":"https://openalex.org/I4210094379","display_name":"University of Texas Health Science Center at Dallas","ror":"https://ror.org/00q16t150","country_code":"US","type":"education","lineage":["https://openalex.org/I4210094379"]}],"countries":["HU","US"],"is_corresponding":false,"raw_author_name":"S. M. MCCANN","raw_affiliation_strings":["Department of Physiology, University of Texas Health Science Center at Dallas 5323 Harry Hines Boulevard, Dallas, Texas 75235; Institute of Pathophysiology, University Medical School of Szeged Szeged, H-6701 Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Texas Health Science Center at Dallas 5323 Harry Hines Boulevard, Dallas, Texas 75235; Institute of Pathophysiology, University Medical School of Szeged Szeged, H-6701 Hungary","institution_ids":["https://openalex.org/I227486990","https://openalex.org/I4210094379"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":2.3809,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.87854909,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"114","issue":"2","first_page":"359","last_page":"363"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.8125,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.8125,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.1615999937057495,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostacyclin","display_name":"prostacyclin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/6-oxo-pgf1-alpha","display_name":"6-oxo-PGF1 alpha","score":0.8659999966621399},{"id":"https://openalex.org/keywords/prolactin-secretion","display_name":"prolactin secretion","score":0.9380000233650208},{"id":"https://openalex.org/keywords/growth-hormone-secretion","display_name":"growth hormone secretion","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hypothalamic-regulation","display_name":"hypothalamic regulation","score":0.8040000200271606},{"id":"https://openalex.org/keywords/anterior-pituitary","display_name":"anterior pituitary","score":0.8560000061988831},{"id":"https://openalex.org/keywords/intraventricular-injection","display_name":"intraventricular injection","score":0.7559999823570251},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.6620000004768372},{"id":"https://openalex.org/keywords/thyroid-stimulating-hormone","display_name":"thyroid-stimulating hormone","score":0.9480000138282776},{"id":"https://openalex.org/keywords/ovariectomized-rats","display_name":"ovariectomized rats","score":0.8999999761581421}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8944493532180786},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8889312148094177},{"id":"https://openalex.org/C8264082","wikidata":"https://www.wikidata.org/wiki/Q7113259","display_name":"Ovariectomized rat","level":3,"score":0.770891547203064},{"id":"https://openalex.org/C2781128415","wikidata":"https://www.wikidata.org/wiki/Q412050","display_name":"Prostacyclin","level":2,"score":0.703278660774231},{"id":"https://openalex.org/C2779064019","wikidata":"https://www.wikidata.org/wiki/Q66590068","display_name":"Prolactin","level":3,"score":0.6691955327987671},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.6292527914047241},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.508677065372467},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.474215030670166},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.4740602374076843},{"id":"https://openalex.org/C176685330","wikidata":"https://www.wikidata.org/wiki/Q857638","display_name":"Radioimmunoassay","level":2,"score":0.4567713439464569},{"id":"https://openalex.org/C2779029589","wikidata":"https://www.wikidata.org/wiki/Q356002","display_name":"Anterior pituitary","level":3,"score":0.4358171224594116},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.37094104290008545},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3230453133583069},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20079371333122253},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007276","descriptor_name":"Injections, Intraventricular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010903","descriptor_name":"Pituitary Gland, Anterior","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011388","descriptor_name":"Prolactin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011388","descriptor_name":"Prolactin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011464","descriptor_name":"Epoprostenol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011464","descriptor_name":"Epoprostenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015121","descriptor_name":"6-Ketoprostaglandin F1 alpha","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015121","descriptor_name":"6-Ketoprostaglandin F1 alpha","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/endo-114-2-359","doi":"https://doi.org/10.1210/endo-114-2-359","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo-114-2-359","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:6418530","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6418530","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1491758502","https://openalex.org/W1967340790","https://openalex.org/W1969167067","https://openalex.org/W1975907272","https://openalex.org/W1979806012","https://openalex.org/W1988885873","https://openalex.org/W1997229407","https://openalex.org/W1997523592","https://openalex.org/W2013046856","https://openalex.org/W2013907154","https://openalex.org/W2029011186","https://openalex.org/W2047543127","https://openalex.org/W2053905609","https://openalex.org/W2054526113","https://openalex.org/W2062070209","https://openalex.org/W2066517867","https://openalex.org/W2066908027","https://openalex.org/W2067655609","https://openalex.org/W2068654437","https://openalex.org/W2071453951","https://openalex.org/W2072708063","https://openalex.org/W2073207573","https://openalex.org/W2092014852","https://openalex.org/W2113579186","https://openalex.org/W2133734605","https://openalex.org/W2305627972","https://openalex.org/W2316731583","https://openalex.org/W2409829782"],"related_works":["https://openalex.org/W2066517867","https://openalex.org/W2063429590","https://openalex.org/W2053905609","https://openalex.org/W2077242263","https://openalex.org/W1975907272","https://openalex.org/W2071453951","https://openalex.org/W1968659912","https://openalex.org/W2066908027","https://openalex.org/W1981380268","https://openalex.org/W1972407445"],"abstract_inverted_index":{"Prostacyclin":[0],"(PGI2)":[1],"(1-5":[2],"micrograms":[3,49],"in":[4,83,106,149,161,179,187,250],"3":[5,43,140],"microliters":[6,44],"0.05":[7],"M":[8,130],"Tris/HCl":[9],"buffer,":[10],"pH":[11],"7.5)":[12],"and":[13,28,33,61,92,109,132],"its":[14,133],"stable":[15],"metabolite,":[16],"6-oxo-PGF1":[17,69,168],"alpha,":[18],"were":[19,36,103,126],"microinjected":[20],"into":[21],"the":[22,65,183,188,208,231,242,255],"third":[23],"ventricle":[24],"of":[25,47,68,114,123,138,167,190,210,217,228,233],"ovariectomized":[26,124],"rats,":[27],"plasma":[29,53,84,107],"FSH,":[30],"GH,":[31],"PRL,":[32],"TSH":[34,110],"levels":[35],"measured":[37],"by":[38,182,201,221,254],"RIA.":[39],"Control":[40],"animals":[41],"received":[42],"buffer.":[45],"Injection":[46],"5":[48,60],"PGI2":[50,89,131,143,197,229,247],"dramatically":[51],"elevated":[52],"PRL":[54,162,180,199],"values":[55],"(4-":[56],"to":[57,98,206,214],"5-fold)":[58],"at":[59,90],"15":[62,136],"min,":[63],"whereas":[64,156],"same":[66],"dose":[67],"alpha":[70,96,169],"produced":[71,144],"a":[72,145,202],"significant":[73,147],"but":[74],"smaller":[75],"(2-fold)":[76],"stimulatory":[77,226],"effect.":[78],"A":[79],"delayed":[80,225],"increase":[81,207],"(1.5-fold)":[82],"GH":[85,100,150,173,234,252],"occurred":[86],"after":[87,111],"intraventricular":[88,112],"30":[91],"60":[93],"min.":[94],"6-Oxo-PGF1":[95],"failed":[97],"alter":[99],"levels.":[101,163],"There":[102,175],"no":[104,159,177],"alterations":[105],"FSH":[108],"injection":[113],"PGI2.":[115,192],"Dispersed,":[116],"overnight":[117],"cultured":[118,184],"cells":[119,185],"from":[120],"anterior":[121,243],"pituitaries":[122],"rats":[125],"tested":[127],"with":[128],"10(-4)-10(-7)":[129],"metabolite.":[134],"After":[135],"min":[137],"incubation,":[139],"X":[141],"10(-5)":[142],"highly":[146],"elevation":[148],"release":[151,181,200,209,216,232,253],"(P":[152],"less":[153],"than":[154],"0.001),":[155],"there":[157],"was":[158,176,248],"alteration":[160,178],"Only":[164],"pharmacological":[165],"doses":[166],"(10(-4)":[170],"M)":[171],"stimulated":[172],"release.":[174],"even":[186],"presence":[189],"10(-4)":[191],"These":[193],"results":[194],"suggest":[195],"that":[196],"stimulates":[198],"hypothalamic":[203],"action":[204],"either":[205],"PRL-releasing":[211],"factor,":[212,219],"or":[213,220],"decrease":[215],"PRL-inhibiting":[218],"both":[222],"mechanisms.":[223],"The":[224],"effect":[227,240],"on":[230,241],"may":[235],"be":[236],"exerted":[237],"via":[238],"an":[239],"lobe":[244],"itself,":[245],"since":[246],"effective":[249],"stimulating":[251],"incubated":[256],"pituitary":[257],"cells.":[258]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}