{"id":"https://openalex.org/W2057993434","doi":"https://doi.org/10.1073/pnas.96.3.800","title":"Disease transmission dynamics and the evolution of antibiotic resistance in hospitals and communal settings","display_name":"Disease transmission dynamics and the evolution of antibiotic resistance in hospitals and communal settings","publication_year":1999,"publication_date":"1999-02-02","ids":{"openalex":"https://openalex.org/W2057993434","doi":"https://doi.org/10.1073/pnas.96.3.800","mag":"2057993434","pmid":"https://pubmed.ncbi.nlm.nih.gov/9927647","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/33521"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.96.3.800","doi":"https://doi.org/10.1073/pnas.96.3.800","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.96.3.800","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC33521","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077712228","display_name":"Simon A. Levin","orcid":"https://orcid.org/0000-0002-8216-5639","observed_orcids":["https://orcid.org/0000-0002-8216-5639","https://orcid.org/0000-0003-0895-0361"]},"institutions":[{"id":"https://openalex.org/I107707843","display_name":"Roskilde University","ror":"https://ror.org/014axpa37","country_code":"DK","type":"education","lineage":["https://openalex.org/I107707843"]},{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Simon A. Levin","raw_affiliation_strings":["Department of Ecology and Evolutionary Biology, Eno Hall, Princeton University, Princeton NJ 08544; and Department of Mathematics, Roskilde University, DK-4000 Roskilde, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolutionary Biology, Eno Hall, Princeton University, Princeton NJ 08544; and Department of Mathematics, Roskilde University, DK-4000 Roskilde, Denmark","institution_ids":["https://openalex.org/I107707843","https://openalex.org/I20089843"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051581382","display_name":"Viggo Andreasen","orcid":"https://orcid.org/0000-0001-8152-3898","observed_orcids":["https://orcid.org/0000-0001-8152-3898"]},"institutions":[{"id":"https://openalex.org/I107707843","display_name":"Roskilde University","ror":"https://ror.org/014axpa37","country_code":"DK","type":"education","lineage":["https://openalex.org/I107707843"]},{"id":"https://openalex.org/I20089843","display_name":"Princeton University","ror":"https://ror.org/00hx57361","country_code":"US","type":"education","lineage":["https://openalex.org/I20089843"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Viggo Andreasen","raw_affiliation_strings":["Department of Ecology and Evolutionary Biology, Eno Hall, Princeton University, Princeton NJ 08544; and Department of Mathematics, Roskilde University, DK-4000 Roskilde, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolutionary Biology, Eno Hall, Princeton University, Princeton NJ 08544; and Department of Mathematics, Roskilde University, DK-4000 Roskilde, Denmark","institution_ids":["https://openalex.org/I107707843","https://openalex.org/I20089843"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.4233,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.88774627,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"96","issue":"3","first_page":"800","last_page":"801"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.6133000254631042,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.6133000254631042,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.11680000275373459,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.10249999910593033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/disease-transmission-dynamics","display_name":"disease transmission dynamics","score":0.8550000190734863},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.7960000038146973},{"id":"https://openalex.org/keywords/hospital-settings","display_name":"hospital settings","score":0.45399999618530273},{"id":"https://openalex.org/keywords/antimicrobial-resistance-evolution","display_name":"antimicrobial resistance evolution","score":0.6930000185966492},{"id":"https://openalex.org/keywords/nosocomial-infections","display_name":"nosocomial infections","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.8908699750900269},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.6707714796066284},{"id":"https://openalex.org/C126142528","wikidata":"https://www.wikidata.org/wiki/Q3771876","display_name":"Nucleic acid structure","level":4,"score":0.6315059661865234},{"id":"https://openalex.org/C2777339483","wikidata":"https://www.wikidata.org/wiki/Q647203","display_name":"Conformational change","level":2,"score":0.473836749792099},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47148963809013367},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4129878580570221},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40394753217697144},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3962639272212982},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3722613751888275},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.28173142671585083},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.23657995462417603}],"mesh":[{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":true},{"descriptor_ui":"D003428","descriptor_name":"Cross Infection","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":true},{"descriptor_ui":"D004352","descriptor_name":"Drug Resistance, Microbial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.96.3.800","doi":"https://doi.org/10.1073/pnas.96.3.800","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.96.3.800","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:192037","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC33521","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:33521","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/33521","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:9927647","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9927647","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Comment"},{"id":"pmh:oai:pure.atira.dk:publications/11b7c910-52bf-11db-a4bc-000ea68e967b","doi":null,"is_oa":false,"landing_page_url":"https://forskning.ruc.dk/da/publications/11b7c910-52bf-11db-a4bc-000ea68e967b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401457","display_name":"RUCforsk (Roskilde University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I107707843","host_organization_name":"Roskilde University","host_organization_lineage":["https://openalex.org/I107707843"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Andreasen, V & Levin, S 1999, 'Disease transmission dynamics and the evolution of antibiotic resistance in hospitals and communal settings', Proceedings of the National Academy of Science of the United States of America, vol. 96, no. 3, pp. 800-801.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:192037","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC33521","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1606697907","https://openalex.org/W1618950725","https://openalex.org/W1628797085","https://openalex.org/W2000753862","https://openalex.org/W2001700040","https://openalex.org/W2026215081","https://openalex.org/W2028849916","https://openalex.org/W2035307958","https://openalex.org/W2067900965","https://openalex.org/W2094949442","https://openalex.org/W2126776457","https://openalex.org/W2159680005","https://openalex.org/W4388299012"],"related_works":["https://openalex.org/W2012999835","https://openalex.org/W2049580143","https://openalex.org/W1976034100","https://openalex.org/W1966196724","https://openalex.org/W2032957122","https://openalex.org/W2067287935","https://openalex.org/W1965403676","https://openalex.org/W2065750764","https://openalex.org/W1963916229","https://openalex.org/W1990028963"],"abstract_inverted_index":{"Fast,":[0],"low-cost,":[1],"accurate":[2],"detection":[3],"of":[4,21,27,56,61],"time-resolved":[5],"dynamic":[6],"nucleic":[7,22],"acid":[8,23],"conformational":[9,37,44],"variation":[10],"in":[11],"response":[12],"to":[13,49],"small":[14,30,41],"molecule":[15],"binding:":[16],"1)":[17],"enriches":[18],"our":[19],"understanding":[20],"structure,":[24],"and":[25,64],"regulation":[26],"structure":[28],"by":[29],"molecules":[31],"as":[32],"...Nucleic":[33],"acids":[34],"can":[35,46,65],"undergo":[36],"changes":[38,45],"upon":[39],"binding":[40],"molecules.":[42],"These":[43],"be":[47,67],"exploited":[48],"develop":[50],"new":[51],"therapeutic":[52],"strategies":[53],"through":[54],"control":[55],"gene":[57],"expression":[58],"or":[59],"triggering":[60],"cellular":[62],"responses":[63],"also":[66],"used":[68],"...":[69]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}