{"id":"https://openalex.org/W2057769045","doi":"https://doi.org/10.1016/s0168-8278(00)00038-6","title":"Inactivation of SSI-1, a JAK/STAT inhibitor, in human hepatocellular carcinomas, as revealed by two-dimensional electrophoresis","display_name":"Inactivation of SSI-1, a JAK/STAT inhibitor, in human hepatocellular carcinomas, as revealed by two-dimensional electrophoresis","publication_year":2001,"publication_date":"2001-03-01","ids":{"openalex":"https://openalex.org/W2057769045","doi":"https://doi.org/10.1016/s0168-8278(00)00038-6","mag":"2057769045","pmid":"https://pubmed.ncbi.nlm.nih.gov/11322203"},"language":"en","primary_location":{"id":"doi:10.1016/s0168-8278(00)00038-6","doi":"https://doi.org/10.1016/s0168-8278(00)00038-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0168-8278(00)00038-6","pdf_url":null,"source":{"id":"https://openalex.org/S83651209","display_name":"Journal of Hepatology","issn_l":"0168-8278","issn":["0168-8278","1600-0641"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056467260","display_name":"Hisaki Nagai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80188885","display_name":"Nippon Medical School","ror":"https://ror.org/00krab219","country_code":"JP","type":"education","lineage":["https://openalex.org/I80188885"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisaki Nagai","raw_affiliation_strings":["Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, Kawasaki, Japan","Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396, Kosugi-cho, Nakahara-ku, Kawasaki 211-8853, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, Kawasaki, Japan","institution_ids":["https://openalex.org/I80188885"]},{"raw_affiliation_string":"Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396, Kosugi-cho, Nakahara-ku, Kawasaki 211-8853, Japan","institution_ids":["https://openalex.org/I80188885"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yong Sung Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58716616","display_name":"Korea Institute of Science and Technology","ror":"https://ror.org/05kzfa883","country_code":"KR","type":"facility","lineage":["https://openalex.org/I27494661","https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I58716616"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yong Sung Kim","raw_affiliation_strings":["Genetic Engineering Research Institute, KIST, Taedok Science Town PO Box 17, Yusung-Ku, Taejon 305-606, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Engineering Research Institute, KIST, Taedok Science Town PO Box 17, Yusung-Ku, Taejon 305-606, South Korea","institution_ids":["https://openalex.org/I58716616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064116866","display_name":"Kyung\u2010Tai Lee","orcid":"https://orcid.org/0000-0003-0990-4818","observed_orcids":["https://orcid.org/0000-0003-0990-4818"]},"institutions":[{"id":"https://openalex.org/I58716616","display_name":"Korea Institute of Science and Technology","ror":"https://ror.org/05kzfa883","country_code":"KR","type":"facility","lineage":["https://openalex.org/I27494661","https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I58716616"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kyung-Tai Lee","raw_affiliation_strings":["Genetic Engineering Research Institute, KIST, Taedok Science Town PO Box 17, Yusung-Ku, Taejon 305-606, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Engineering Research Institute, KIST, Taedok Science Town PO Box 17, Yusung-Ku, Taejon 305-606, South Korea","institution_ids":["https://openalex.org/I58716616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110111192","display_name":"Mi-Young Chu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58716616","display_name":"Korea Institute of Science and Technology","ror":"https://ror.org/05kzfa883","country_code":"KR","type":"facility","lineage":["https://openalex.org/I27494661","https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I58716616"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Mi-Young Chu","raw_affiliation_strings":["Genetic Engineering Research Institute, KIST, Taedok Science Town PO Box 17, Yusung-Ku, Taejon 305-606, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Engineering Research Institute, KIST, Taedok Science Town PO Box 17, Yusung-Ku, Taejon 305-606, South Korea","institution_ids":["https://openalex.org/I58716616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113957380","display_name":"Noboru Konishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noboru Konishi","raw_affiliation_strings":["Department of Pathology, Nara Medical University, 840 Shijo, Kashihara 634, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Nara Medical University, 840 Shijo, Kashihara 634, Japan","institution_ids":["https://openalex.org/I64926303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024088812","display_name":"Jiro Fujimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jiro Fujimoto","raw_affiliation_strings":["Department of Surgery, Hyogo Medical College 1-1, Mukogawa, Nishinomiya 663-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Hyogo Medical College 1-1, Mukogawa, Nishinomiya 663-8501, Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040976202","display_name":"Masaru Baba","orcid":"https://orcid.org/0000-0002-4142-3267","observed_orcids":["https://orcid.org/0000-0002-4142-3267"]},"institutions":[{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaru Baba","raw_affiliation_strings":["Department of Internal Medicine, Mie University School of Medicine, Edobashi Tsu 510, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Mie University School of Medicine, Edobashi Tsu 510, Japan","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114144917","display_name":"Kenichi Matsubara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75917431","display_name":"Nara Institute of Science and Technology","ror":"https://ror.org/05bhada84","country_code":"JP","type":"education","lineage":["https://openalex.org/I75917431"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken-ichi Matsubara","raw_affiliation_strings":["Nara Institute of Science and Technology, 8916-5, Takayama-cho, Ikoma, Nara 630-0101, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nara Institute of Science and Technology, 8916-5, Takayama-cho, Ikoma, Nara 630-0101, Japan","institution_ids":["https://openalex.org/I75917431"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111534430","display_name":"Mitsuru Emi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80188885","display_name":"Nippon Medical School","ror":"https://ror.org/00krab219","country_code":"JP","type":"education","lineage":["https://openalex.org/I80188885"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Mitsuru Emi","raw_affiliation_strings":["Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396, Kosugi-cho, Nakahara-ku, Kawasaki 211-8853, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396, Kosugi-cho, Nakahara-ku, Kawasaki 211-8853, Japan","institution_ids":["https://openalex.org/I80188885"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5111534430"],"corresponding_institution_ids":["https://openalex.org/I80188885"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":1.9868,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.86179118,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"34","issue":"3","first_page":"416","last_page":"421"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.8676999807357788,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.8676999807357788,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.10109999775886536,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.015599999576807022,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/jab1","display_name":"Jab1","score":0.9190000295639038},{"id":"https://openalex.org/keywords/socs1","display_name":"SOCS1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9480000138282776},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.8489999771118164},{"id":"https://openalex.org/keywords/gene-inactivation","display_name":"gene inactivation","score":0.7599999904632568},{"id":"https://openalex.org/keywords/promoter-methylation","display_name":"promoter methylation","score":0.6539999842643738},{"id":"https://openalex.org/keywords/cpg-dinucleotides","display_name":"CpG","score":0.9340000152587891},{"id":"https://openalex.org/keywords/restriction-landmark-genomic-scanning","display_name":"restriction landmark genomic scanning","score":0.7929999828338623},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.8259999752044678},{"id":"https://openalex.org/keywords/cytokine-signaling","display_name":"cytokine signaling","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C2779314089","wikidata":"https://www.wikidata.org/wiki/Q18026830","display_name":"HCCS","level":3,"score":0.9469590187072754},{"id":"https://openalex.org/C112392421","wikidata":"https://www.wikidata.org/wiki/Q903451","display_name":"Janus kinase","level":3,"score":0.7671226263046265},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.6957156658172607},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5915176868438721},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5222540497779846},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5192832350730896},{"id":"https://openalex.org/C2778277574","wikidata":"https://www.wikidata.org/wiki/Q665327","display_name":"stat","level":4,"score":0.5149639248847961},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5002374649047852},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4115731716156006},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3929581642150879},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24295735359191895},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.14812669157981873}],"mesh":[{"descriptor_ui":"D000071222","descriptor_name":"Suppressor of Cytokine Signaling 1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015180","descriptor_name":"Electrophoresis, Gel, Two-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050826","descriptor_name":"Suppressor of Cytokine Signaling Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/s0168-8278(00)00038-6","doi":"https://doi.org/10.1016/s0168-8278(00)00038-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0168-8278(00)00038-6","pdf_url":null,"source":{"id":"https://openalex.org/S83651209","display_name":"Journal of Hepatology","issn_l":"0168-8278","issn":["0168-8278","1600-0641"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hepatology","raw_type":"journal-article"},{"id":"pmid:11322203","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11322203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of hepatology","raw_type":"Journal Article"},{"id":"pmh:oai:http://repository.kribb.re.kr:8080/:201005/5669","doi":null,"is_oa":false,"landing_page_url":"http://doi.org/10.1016/S0168-8278(00)00038-6","pdf_url":null,"source":{"id":"https://openalex.org/S4406922719","display_name":"KRIBB Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"/dspace/upload/original/3751.pdf","raw_type":"Article"},{"id":"pmh:oai:https://repository.kribb.re.kr:201005/5669","doi":null,"is_oa":false,"landing_page_url":"http://doi.org/10.1016/S0168-8278(00)00038-6","pdf_url":null,"source":{"id":"https://openalex.org/S4406922719","display_name":"KRIBB Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"/dspace/upload/original/3751.pdf","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W578050323","https://openalex.org/W597669211","https://openalex.org/W1488478985","https://openalex.org/W1556996865","https://openalex.org/W1668039320","https://openalex.org/W1965265115","https://openalex.org/W1969938956","https://openalex.org/W1973476583","https://openalex.org/W1987714978","https://openalex.org/W1995312920","https://openalex.org/W2001258296","https://openalex.org/W2002239668","https://openalex.org/W2014607365","https://openalex.org/W2030865745","https://openalex.org/W2051020846","https://openalex.org/W2070886703","https://openalex.org/W2073002157","https://openalex.org/W2077005864","https://openalex.org/W2119596771","https://openalex.org/W2139620481","https://openalex.org/W2159871564","https://openalex.org/W2313449389","https://openalex.org/W2324004280","https://openalex.org/W2480372316","https://openalex.org/W4210977380","https://openalex.org/W6757167548"],"related_works":["https://openalex.org/W2023354216","https://openalex.org/W1976665551","https://openalex.org/W2042111923","https://openalex.org/W3011605706","https://openalex.org/W2067224679","https://openalex.org/W2369241429","https://openalex.org/W3186680640","https://openalex.org/W2970813621","https://openalex.org/W2087125953","https://openalex.org/W1458108721"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
