{"id":"https://openalex.org/W2057745867","doi":"https://doi.org/10.1128/aem.01229-14","title":"Host Responses to the Pathogen Mycobacterium avium subsp. paratuberculosis and Beneficial Microbes Exhibit Host Sex Specificity","display_name":"Host Responses to the Pathogen Mycobacterium avium subsp. paratuberculosis and Beneficial Microbes Exhibit Host Sex Specificity","publication_year":2014,"publication_date":"2014-05-10","ids":{"openalex":"https://openalex.org/W2057745867","doi":"https://doi.org/10.1128/aem.01229-14","mag":"2057745867","pmid":"https://pubmed.ncbi.nlm.nih.gov/24814797"},"language":"en","primary_location":{"id":"doi:10.1128/aem.01229-14","doi":"https://doi.org/10.1128/aem.01229-14","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aem.01229-14","pdf_url":"https://aem.asm.org/content/aem/80/15/4481.full.pdf","source":{"id":"https://openalex.org/S158228368","display_name":"Applied and Environmental Microbiology","issn_l":"0099-2240","issn":["0099-2240","1070-6291","1098-5336"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied and Environmental Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aem.asm.org/content/aem/80/15/4481.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052514925","display_name":"Enusha Karunasena","orcid":"https://orcid.org/0000-0002-9069-9681","observed_orcids":["https://orcid.org/0000-0002-9069-9681"]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Enusha Karunasena","raw_affiliation_strings":["Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110158634","display_name":"Kevin Wyatt McMahon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. Wyatt McMahon","raw_affiliation_strings":["Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":null,"display_name":"David Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087683","display_name":"Chenomx (Canada)","ror":"https://ror.org/00344m990","country_code":"CA","type":"company","lineage":["https://openalex.org/I4210087683"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"David Chang","raw_affiliation_strings":["Chenomx Inc., Edmonton, Alberta, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chenomx Inc., Edmonton, Alberta, Canada","institution_ids":["https://openalex.org/I4210087683"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085080204","display_name":"M.M. Brashears","orcid":"https://orcid.org/0000-0002-8016-6769","observed_orcids":["https://orcid.org/0000-0002-8016-6769"]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mindy M. Brashears","raw_affiliation_strings":["Department of Animal and Food Sciences, Texas Tech University, Lubbock, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal and Food Sciences, Texas Tech University, Lubbock, Texas, USA","institution_ids":["https://openalex.org/I12315562"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9389,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.9045083,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"80","issue":"15","first_page":"4481","last_page":"4490"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-avium-subsp-paratuberculosis","display_name":"Mycobacterium avium subsp. paratuberculosis","score":0.972000002861023},{"id":"https://openalex.org/keywords/lactobacillus-animalis","display_name":"Lactobacillus animalis","score":0.9409999847412109},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7870000004768372},{"id":"https://openalex.org/keywords/host-microbe-interactions","display_name":"host-microbe interactions","score":0.8849999904632568},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8840000033378601},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.6949999928474426},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.7419999837875366},{"id":"https://openalex.org/keywords/short-chain-fatty-acids","display_name":"short-chain fatty acids","score":0.828000009059906},{"id":"https://openalex.org/keywords/gut-metabolomics","display_name":"gut metabolomics","score":0.6990000009536743},{"id":"https://openalex.org/keywords/staphylococcus","display_name":"Staphylococcus","score":0.8799999952316284},{"id":"https://openalex.org/keywords/roseburia","display_name":"Roseburia","score":1.0},{"id":"https://openalex.org/keywords/intestinal-inflammation","display_name":"intestinal inflammation","score":0.36399999260902405},{"id":"https://openalex.org/keywords/balb-c-mice","display_name":"BALB/c mice","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.7305938601493835},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.7246636748313904},{"id":"https://openalex.org/C2777849792","wikidata":"https://www.wikidata.org/wiki/Q707388","display_name":"Paratuberculosis","level":4,"score":0.6938316226005554},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6910563111305237},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6896359920501709},{"id":"https://openalex.org/C2780374374","wikidata":"https://www.wikidata.org/wiki/Q194309","display_name":"Mycobacterium","level":3,"score":0.580569863319397},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.4039555490016937},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.33427634835243225},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11903989315032959}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005232","descriptor_name":"Fatty Acids, Volatile","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005232","descriptor_name":"Fatty Acids, Volatile","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005232","descriptor_name":"Fatty Acids, Volatile","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007778","descriptor_name":"Lactobacillus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007778","descriptor_name":"Lactobacillus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007778","descriptor_name":"Lactobacillus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010283","descriptor_name":"Paratuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010283","descriptor_name":"Paratuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010283","descriptor_name":"Paratuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010283","descriptor_name":"Paratuberculosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D010283","descriptor_name":"Paratuberculosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D010283","descriptor_name":"Paratuberculosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016927","descriptor_name":"Mycobacterium avium subsp. paratuberculosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016927","descriptor_name":"Mycobacterium avium subsp. paratuberculosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016927","descriptor_name":"Mycobacterium avium subsp. paratuberculosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019936","descriptor_name":"Probiotics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058507","descriptor_name":"Host Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058507","descriptor_name":"Host Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058507","descriptor_name":"Host Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/aem.01229-14","doi":"https://doi.org/10.1128/aem.01229-14","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aem.01229-14","pdf_url":"https://aem.asm.org/content/aem/80/15/4481.full.pdf","source":{"id":"https://openalex.org/S158228368","display_name":"Applied and Environmental Microbiology","issn_l":"0099-2240","issn":["0099-2240","1070-6291","1098-5336"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied and Environmental Microbiology","raw_type":"journal-article"},{"id":"pmid:24814797","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24814797","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied and environmental microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4148783","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4148783","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Appl Environ Microbiol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1128/aem.01229-14","doi":"https://doi.org/10.1128/aem.01229-14","is_oa":true,"landing_page_url":"https://doi.org/10.1128/aem.01229-14","pdf_url":"https://aem.asm.org/content/aem/80/15/4481.full.pdf","source":{"id":"https://openalex.org/S158228368","display_name":"Applied and Environmental Microbiology","issn_l":"0099-2240","issn":["0099-2240","1070-6291","1098-5336"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied and Environmental Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309537","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93"},{"id":"https://openalex.org/F4320319073","display_name":"Texas Tech University Health Sciences Center","ror":"https://ror.org/033ztpr93"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2057745867.pdf"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W805866823","https://openalex.org/W1483539784","https://openalex.org/W1519117375","https://openalex.org/W1642759093","https://openalex.org/W1651151907","https://openalex.org/W1798139347","https://openalex.org/W1964838915","https://openalex.org/W1968276643","https://openalex.org/W1968293439","https://openalex.org/W1968909959","https://openalex.org/W1970937149","https://openalex.org/W1972739162","https://openalex.org/W1996476032","https://openalex.org/W2005596569","https://openalex.org/W2012490955","https://openalex.org/W2013615583","https://openalex.org/W2013769097","https://openalex.org/W2019419945","https://openalex.org/W2021019773","https://openalex.org/W2029666752","https://openalex.org/W2033829415","https://openalex.org/W2034359028","https://openalex.org/W2036768725","https://openalex.org/W2039960414","https://openalex.org/W2041004038","https://openalex.org/W2045019335","https://openalex.org/W2046753869","https://openalex.org/W2056386675","https://openalex.org/W2069672057","https://openalex.org/W2072548471","https://openalex.org/W2072660904","https://openalex.org/W2077694570","https://openalex.org/W2082285253","https://openalex.org/W2085370071","https://openalex.org/W2094609042","https://openalex.org/W2095164057","https://openalex.org/W2096778064","https://openalex.org/W2097875133","https://openalex.org/W2105924489","https://openalex.org/W2108321732","https://openalex.org/W2109383738","https://openalex.org/W2112314437","https://openalex.org/W2115500551","https://openalex.org/W2118613385","https://openalex.org/W2123209806","https://openalex.org/W2123290361","https://openalex.org/W2130905222","https://openalex.org/W2131484195","https://openalex.org/W2133012172","https://openalex.org/W2140571939","https://openalex.org/W2141708934","https://openalex.org/W2145506897","https://openalex.org/W2146186198","https://openalex.org/W2149459456","https://openalex.org/W2149515881","https://openalex.org/W2152079001","https://openalex.org/W2152398830","https://openalex.org/W2153719950","https://openalex.org/W2163369593","https://openalex.org/W2164063484","https://openalex.org/W2164172900","https://openalex.org/W2166354753","https://openalex.org/W2169706872","https://openalex.org/W2582743722"],"related_works":["https://openalex.org/W1835134368","https://openalex.org/W2091398531","https://openalex.org/W4378528580","https://openalex.org/W2171139833","https://openalex.org/W2343234619","https://openalex.org/W2298099726","https://openalex.org/W2143670527","https://openalex.org/W2791945226","https://openalex.org/W2133052739","https://openalex.org/W2039413187"],"abstract_inverted_index":{"Differences":[0],"between":[1,67],"microbial":[2],"pathogenesis":[3],"in":[4,12,31,81,172,179,184,213],"male":[5,72,236],"and":[6,34,59,70,73,88,111,135,139,155,177,181,208,237,241,249,258],"female":[7,74,189,238],"hosts":[8],"are":[9,261],"well":[10],"characterized":[11],"disease":[13],"conditions":[14],"connected":[15],"to":[16,28,107,116,167,194,216,222,244,266],"sexual":[17],"transmission.":[18],"However,":[19,145],"limited":[20],"biological":[21],"insight":[22],"is":[23,36],"available":[24],"on":[25,142,228],"variances":[26,192],"attributed":[27],"sex":[29,90,159,196,224],"specificity":[30],"host-microbe":[32],"interactions,":[33],"it":[35],"most":[37],"often":[38],"a":[39,60,92,165],"minimized":[40],"variable":[41],"outside":[42],"these":[43],"transmission":[44],"events.":[45],"In":[46],"this":[47],"work,":[48],"we":[49],"studied":[50],"two":[51],"gut":[52,239],"microbes-a":[53],"pathogen,":[54],"Mycobacterium":[55],"avium":[56],"subsp.":[57,109],"paratuberculosis,":[58],"probiotic,":[61],"Lactobacillus":[62],"animalis":[63,113],"NP-51-and":[64],"the":[65,71,267],"interaction":[66],"each":[68,195],"agent":[69],"gastrointestinal":[75],"systems.":[76],"This":[77],"trial":[78],"was":[79],"conducted":[80],"BALB/c":[82],"mice":[83],"(n=5":[84],"per":[85,89],"experimental":[86,143,229],"group":[87],"at":[91,98],"given":[93],"time":[94,100],"point),":[95],"with":[96,199,253],"analysis":[97],"four":[99],"points":[101],"over":[102],"180":[103],"days.":[104],"Host":[105],"responses":[106,257],"M.avium":[108],"paratuberculosis":[110],"L.":[112],"were":[114,120,140,197,210,220],"sensitive":[115],"sex.":[117,269],"Cytokines":[118],"that":[119,235,250],"significantly":[121],"different":[122],"(P":[123],"\u2264":[124],"0.05)":[125],"betweenthe":[126],"sexes":[127],"included":[128],"interleukin-1\u03b1/\u03b2":[129],"(IL-1\u03b1/\u03b2),":[130],"IL-17,":[131],"IL-6,":[132],"IL-10,":[133],"IL-12,":[134],"gamma":[136],"interferon":[137],"(IFN-)":[138],"dependent":[141],"conditions.":[144,230],"granulocyte-macrophage":[146],"colony-stimulating":[147],"factor":[148,153],"(GM-CSF),":[149],"vascular":[150],"endothelial":[151],"growth":[152],"(VEGF),":[154],"IL-13/23":[156],"showed":[157],"no":[158],"specificity.":[160],"A":[161],"metabolomics":[162],"study":[163],"indicated":[164],"0.5-":[166],"2.0-fold":[168],"(log2":[169],"scale)":[170],"increase":[171],"short-chain":[173],"fatty":[174],"acids":[175],"(butyrate":[176],"acetate)":[178],"males":[180],"greater":[182],"increases":[183],"o-phosphocholine":[185],"or":[186,201],"histidine":[187],"from":[188],"colon":[190],"tissues;":[191],"distinct":[193,265],"observed":[198,233],"age":[200],"long-term":[202],"probiotic":[203],"consumption.":[204],"Two":[205],"genera,":[206],"Staphylococcus":[207],"Roseburia,":[209],"consistently":[211],"overrepresented":[212],"females":[214],"compared":[215],"males;":[217],"other":[218],"species":[219],"specific":[221],"one":[223],"but":[225],"fluctuated":[226],"depending":[227],"The":[231],"differences":[232],"suggest":[234],"tissues":[240],"microbiota":[242],"respond":[243],"newly":[245],"introduced":[246],"microorganisms":[247,252],"differently":[248],"gut-associated":[251],"host":[254,268],"immune":[255],"system":[256],"metabolic":[259],"activity":[260],"supported":[262],"by":[263],"biology":[264]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}