{"id":"https://openalex.org/W2057735923","doi":"https://doi.org/10.1186/1471-2156-6-s1-s3","title":"Construction of the model for the Genetic Analysis Workshop 14 simulated data: genotype-phenotype relationships, gene interaction, linkage, association, disequilibrium, and ascertainment effects for a complex phenotype","display_name":"Construction of the model for the Genetic Analysis Workshop 14 simulated data: genotype-phenotype relationships, gene interaction, linkage, association, disequilibrium, and ascertainment effects for a complex phenotype","publication_year":2005,"publication_date":"2005-12-01","ids":{"openalex":"https://openalex.org/W2057735923","doi":"https://doi.org/10.1186/1471-2156-6-s1-s3","mag":"2057735923","pmid":"https://pubmed.ncbi.nlm.nih.gov/16451639","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1866756"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2156-6-s1-s3","doi":"https://doi.org/10.1186/1471-2156-6-s1-s3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2156-6-s1-s3","pdf_url":"https://bmcgenomdata.biomedcentral.com/counter/pdf/10.1186/1471-2156-6-S1-S3","source":{"id":"https://openalex.org/S4394735525","display_name":"BMC Genetics","issn_l":"1471-2156","issn":["1471-2156"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["anvur-scientific","doaj","ki-jl-1","poland-100","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcgenomdata.biomedcentral.com/counter/pdf/10.1186/1471-2156-6-S1-S3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110590031","display_name":"David A. Greenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David A Greenberg","raw_affiliation_strings":["Division of Statistical Genetics, Department of Biostatistics and Psychiatry, Mailman School of Public Health, Columbia-Presbyterian Medical Center, New York, NY 10032, USA. dag2005@columbia.edu","Division of Statistical Genetics, Department of Biostatistics and Psychiatry, Mailman School of Public Health, Columbia-Presbyterian Medical Center, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Statistical Genetics, Department of Biostatistics and Psychiatry, Mailman School of Public Health, Columbia-Presbyterian Medical Center, New York, NY 10032, USA. dag2005@columbia.edu","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]},{"raw_affiliation_string":"Division of Statistical Genetics, Department of Biostatistics and Psychiatry, Mailman School of Public Health, Columbia-Presbyterian Medical Center, New York, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100618936","display_name":"Junying Zhang","orcid":"https://orcid.org/0000-0002-7511-0277","observed_orcids":["https://orcid.org/0000-0002-7511-0277"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junying Zhang","raw_affiliation_strings":["Division of Statistical Genetics, Department of Biostatistics and Psychiatry, Mailman School of Public Health, Columbia-Presbyterian Medical Center, New York, NY, 10032, USA","Division of Statistical Genetics, Department of Biostatistics and Psychiatry, Mailman School of Public Health, Columbia-Presbyterian Medical Center, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Statistical Genetics, Department of Biostatistics and Psychiatry, Mailman School of Public Health, Columbia-Presbyterian Medical Center, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]},{"raw_affiliation_string":"Division of Statistical Genetics, Department of Biostatistics and Psychiatry, Mailman School of Public Health, Columbia-Presbyterian Medical Center, New York, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006609445","display_name":"Dvora Shmulewitz","orcid":"https://orcid.org/0000-0002-8297-6183","observed_orcids":["https://orcid.org/0000-0002-8297-6183"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dvora Shmulewitz","raw_affiliation_strings":["Division of Statistical Genetics, Department of Biostatistics and Psychiatry, Mailman School of Public Health, Columbia-Presbyterian Medical Center, New York, NY, 10032, USA","Division of Statistical Genetics, Department of Biostatistics and Psychiatry, Mailman School of Public Health, Columbia-Presbyterian Medical Center, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Statistical Genetics, Department of Biostatistics and Psychiatry, Mailman School of Public Health, Columbia-Presbyterian Medical Center, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]},{"raw_affiliation_string":"Division of Statistical Genetics, Department of Biostatistics and Psychiatry, Mailman School of Public Health, Columbia-Presbyterian Medical Center, New York, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041161022","display_name":"Lisa J. Strug","orcid":"https://orcid.org/0000-0003-0503-9740","observed_orcids":["https://orcid.org/0000-0003-0503-9740"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa J Strug","raw_affiliation_strings":["Division of Statistical Genetics, Department of Biostatistics and Psychiatry, Mailman School of Public Health, Columbia-Presbyterian Medical Center, New York, NY, 10032, USA","Division of Statistical Genetics, Department of Biostatistics and Psychiatry, Mailman School of Public Health, Columbia-Presbyterian Medical Center, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Statistical Genetics, Department of Biostatistics and Psychiatry, Mailman School of Public Health, Columbia-Presbyterian Medical Center, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]},{"raw_affiliation_string":"Division of Statistical Genetics, Department of Biostatistics and Psychiatry, Mailman School of Public Health, Columbia-Presbyterian Medical Center, New York, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109978602","display_name":"Regina Zimmerman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Regina Zimmerman","raw_affiliation_strings":["Division of Statistical Genetics, Department of Biostatistics and Psychiatry, Mailman School of Public Health, Columbia-Presbyterian Medical Center, New York, NY, 10032, USA","Division of Statistical Genetics, Department of Biostatistics and Psychiatry, Mailman School of Public Health, Columbia-Presbyterian Medical Center, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Statistical Genetics, Department of Biostatistics and Psychiatry, Mailman School of Public Health, Columbia-Presbyterian Medical Center, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]},{"raw_affiliation_string":"Division of Statistical Genetics, Department of Biostatistics and Psychiatry, Mailman School of Public Health, Columbia-Presbyterian Medical Center, New York, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090691779","display_name":"Veena Singh","orcid":"https://orcid.org/0000-0002-6300-7811","observed_orcids":["https://orcid.org/0000-0002-6300-7811"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Veena Singh","raw_affiliation_strings":["Division of Statistical Genetics, Department of Biostatistics and Psychiatry, Mailman School of Public Health, Columbia-Presbyterian Medical Center, New York, NY, 10032, USA","Division of Statistical Genetics, Department of Biostatistics and Psychiatry, Mailman School of Public Health, Columbia-Presbyterian Medical Center, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Statistical Genetics, Department of Biostatistics and Psychiatry, Mailman School of Public Health, Columbia-Presbyterian Medical Center, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]},{"raw_affiliation_string":"Division of Statistical Genetics, Department of Biostatistics and Psychiatry, Mailman School of Public Health, Columbia-Presbyterian Medical Center, New York, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113588803","display_name":"Sudhir V. Marathe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sudhir Marathe","raw_affiliation_strings":["Division of Statistical Genetics, Department of Biostatistics and Psychiatry, Mailman School of Public Health, Columbia-Presbyterian Medical Center, New York, NY, 10032, USA","Division of Statistical Genetics, Department of Biostatistics and Psychiatry, Mailman School of Public Health, Columbia-Presbyterian Medical Center, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Statistical Genetics, Department of Biostatistics and Psychiatry, Mailman School of Public Health, Columbia-Presbyterian Medical Center, New York, NY, 10032, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]},{"raw_affiliation_string":"Division of Statistical Genetics, Department of Biostatistics and Psychiatry, Mailman School of Public Health, Columbia-Presbyterian Medical Center, New York, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110590031"],"corresponding_institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"],"apc_list":{"value":2170,"currency":"USD","value_usd":2170},"apc_paid":{"value":2170,"currency":"USD","value_usd":2170},"fwci":2.3295,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.87958588,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"6","issue":"S1","first_page":"S3","last_page":"S3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/simulated-genetic-data","display_name":"simulated genetic data","score":0.7639999985694885},{"id":"https://openalex.org/keywords/complex-diseases","display_name":"complex diseases","score":0.6890000104904175},{"id":"https://openalex.org/keywords/alcoholism","display_name":"alcoholism","score":0.6740000247955322},{"id":"https://openalex.org/keywords/genotype-phenotype-correlation","display_name":"genotype-phenotype correlation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/gene-gene-interaction","display_name":"gene-gene interaction","score":0.9110000133514404},{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"linkage disequilibrium","score":0.8460000157356262},{"id":"https://openalex.org/keywords/association-mapping","display_name":"association mapping","score":0.5360000133514404},{"id":"https://openalex.org/keywords/disease-definition","display_name":"disease definition","score":0.6140000224113464},{"id":"https://openalex.org/keywords/endophenotypes","display_name":"endophenotypes","score":0.847000002861023},{"id":"https://openalex.org/keywords/microsatellite-markers","display_name":"microsatellite markers","score":0.640999972820282},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9649999737739563},{"id":"https://openalex.org/keywords/multiplex-pedigrees","display_name":"multiplex pedigrees","score":0.7110000252723694},{"id":"https://openalex.org/keywords/disease-heterogeneity","display_name":"disease heterogeneity","score":0.6859999895095825},{"id":"https://openalex.org/keywords/modifier-genes","display_name":"genetic modifiers","score":0.5659999847412109},{"id":"https://openalex.org/keywords/mental-disorders","display_name":"mental illness","score":0.45899999141693115}],"concepts":[{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.8430706858634949},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.7546885013580322},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6596745252609253},{"id":"https://openalex.org/C2778146401","wikidata":"https://www.wikidata.org/wiki/Q10916362","display_name":"Disequilibrium","level":2,"score":0.6241785287857056},{"id":"https://openalex.org/C31266012","wikidata":"https://www.wikidata.org/wiki/Q6554340","display_name":"Linkage (software)","level":3,"score":0.6233687996864319},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.567811131477356},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5461474657058716},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.5278268456459045},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5087080597877502},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.47273221611976624},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.23043319582939148},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14992058277130127},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.14352908730506897},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.14059677720069885},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.0},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003226","descriptor_name":"Congresses as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005190","descriptor_name":"Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056426","descriptor_name":"Genetic Loci","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2156-6-s1-s3","doi":"https://doi.org/10.1186/1471-2156-6-s1-s3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2156-6-s1-s3","pdf_url":"https://bmcgenomdata.biomedcentral.com/counter/pdf/10.1186/1471-2156-6-S1-S3","source":{"id":"https://openalex.org/S4394735525","display_name":"BMC Genetics","issn_l":"1471-2156","issn":["1471-2156"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["anvur-scientific","doaj","ki-jl-1","poland-100","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genetics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1866756","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1866756","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genet","raw_type":"Text"},{"id":"pmid:16451639","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16451639","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC genetics","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.279.8258","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.279.8258","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/08/91/BMC_Genet_2005_Dec_30_6(Suppl_1)_S3.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:bb4e4eceb30540abbc2fc1aa6b0358fe","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/bb4e4eceb30540abbc2fc1aa6b0358fe","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Genetics, Vol 6, Iss Suppl 1, p S3 (2005)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1471-2156-6-s1-s3","doi":"https://doi.org/10.1186/1471-2156-6-s1-s3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2156-6-s1-s3","pdf_url":"https://bmcgenomdata.biomedcentral.com/counter/pdf/10.1186/1471-2156-6-S1-S3","source":{"id":"https://openalex.org/S4394735525","display_name":"BMC Genetics","issn_l":"1471-2156","issn":["1471-2156"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["anvur-scientific","doaj","ki-jl-1","poland-100","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1014027198","display_name":null,"funder_award_id":"DK-31775","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2156111040","display_name":"Two-Locus Models, Heterogeneity and Diabetes","funder_award_id":"R01DK031775","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4545260961","display_name":null,"funder_award_id":"MH65213","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G5191739587","display_name":"A MULTICENTER STUDY OF IDIOPATHIC GENERALIZED EPILEPSY","funder_award_id":"R01NS027941","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6302267532","display_name":"Genetic Analysis: Psychiatric and Other Complex Diseases","funder_award_id":"T32MH065213","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G709123266","display_name":null,"funder_award_id":"NS-27941","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2057735923.pdf","grobid_xml":"https://content.openalex.org/works/W2057735923.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6959493541","https://openalex.org/W7095281533","https://openalex.org/W2165776390","https://openalex.org/W2008053822","https://openalex.org/W2917213312","https://openalex.org/W1975587625","https://openalex.org/W7096238112","https://openalex.org/W1979090539","https://openalex.org/W2012415418","https://openalex.org/W1534122839"],"abstract_inverted_index":{"The":[0,202,222,234,251,270],"Genetic":[1],"Analysis":[2],"Workshop":[3],"14":[4],"simulated":[5,203,292],"dataset":[6],"was":[7,134,205,273,279],"designed":[8,280],"1)":[9],"To":[10,68,88,100,121],"test":[11],"the":[12,45,70,107,111,123,131,188,258,302,318],"ability":[13],"to":[14,18,51,105,141,242,276,281,316],"find":[15,282],"genes":[16,229,237,260,303],"related":[17],"a":[19,26,31,57,79,155,206],"complex":[20,80],"disease":[21,27,55,108,167,184,204,224,309],"(such":[22],"as":[23],"alcoholism).":[24],"Such":[25],"may":[28],"be":[29,52,262],"given":[30],"variety":[32],"of":[33,60,78,82,91,103,113,125,154,187,216,288,301],"definitions":[34],"by":[35,264],"different":[36,126,245,314],"investigators,":[37],"have":[38],"associated":[39,211],"endophenotypes":[40],"that":[41,257],"are":[42],"common":[43],"in":[44,136,220,267,286,306],"general":[46],"population,":[47],"and":[48,75,110,147,169,193,230,304],"is":[49],"likely":[50],"not":[53],"one":[54],"but":[56,63,278],"heterogeneous":[58],"collection":[59],"clinically":[61],"similar,":[62],"genetically":[64],"distinct,":[65],"entities.":[66],"2)":[67],"observe":[69,122],"effect":[71,112,124],"on":[72,130,164,180],"genetic":[73,219],"analysis":[74,266],"gene":[76,83,85,109],"discovery":[77],"set":[81],"x":[84,116,295],"interactions.":[86],"3)":[87],"allow":[89,101],"comparison":[90],"microsatellite":[92,149],"vs.":[93],"large-scale":[94],"single-nucleotide":[95],"polymorphism":[96],"(SNP)":[97],"data.":[98],"4)":[99],"testing":[102],"association":[104,271,285],"identify":[106],"moderate":[114],"marker":[115,117,294,296],"linkage":[118,265,297,319],"disequilibrium.":[119,320],"5)":[120],"ascertainment/disease":[127],"definition":[128],"schemes":[129,178],"analysis.":[132],"Data":[133,139],"distributed":[135,140],"two":[137,231,313],"forms.":[138],"participants":[142],"contained":[143,162,190,226],"about":[144,183],"1,000":[145],"SNPs":[146],"400":[148],"markers.":[150],"Internet-obtainable":[151],"data":[152,163],"consisted":[153],"finer":[156],"10,000":[157],"SNP":[158],"map,":[159],"which":[160,217,247],"also":[161,291,305],"controls.":[165],"While":[166],"characteristics":[168],"parameters":[170,253],"were":[171,218,248,254],"constant,":[172],"four":[173,199,227,235],"\"studies\"":[174],"used":[175],"varying":[176],"ascertainment":[177],"based":[179],"differing":[181],"beliefs":[182],"characteristics.":[185],"One":[186],"studies":[189],"multiplex":[191],"two-":[192],"three-generation":[194],"pedigrees":[195],"with":[196,209,239],"at":[197],"least":[198],"affected":[200],"members.":[201],"psychiatric":[207],"condition":[208],"many":[210],"behaviors":[212],"(endophenotypes),":[213],"almost":[214],"all":[215],"origin.":[221],"underlying":[223],"model":[225],"major":[228,236,259],"modifier":[232],"genes.":[233,310],"interacted":[238],"each":[240],"other":[241],"produce":[243],"three":[244],"phenotypes,":[246],"themselves":[249],"heterogeneous.":[250],"population":[252],"calibrated":[255],"so":[256],"could":[261],"discovered":[263],"most":[268],"datasets.":[269,289],"evidence":[272],"more":[274],"difficult":[275],"calibrate":[277],"statistically":[283],"significant":[284],"50%":[287],"We":[290,311],"some":[293,300],"disequilibrium":[298],"around":[299],"areas":[307],"without":[308],"tried":[312],"methods":[315],"simulate":[317]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}