{"id":"https://openalex.org/W2057614949","doi":"https://doi.org/10.1078/0065-1281-00625","title":"The specificity of the histochemical NADPH diaphorase reaction for nitric oxide synthase-1 in skeletal muscles is increased in the presence of urea","display_name":"The specificity of the histochemical NADPH diaphorase reaction for nitric oxide synthase-1 in skeletal muscles is increased in the presence of urea","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W2057614949","doi":"https://doi.org/10.1078/0065-1281-00625","mag":"2057614949","pmid":"https://pubmed.ncbi.nlm.nih.gov/11993849"},"language":"en","primary_location":{"id":"doi:10.1078/0065-1281-00625","doi":"https://doi.org/10.1078/0065-1281-00625","is_oa":false,"landing_page_url":"https://doi.org/10.1078/0065-1281-00625","pdf_url":null,"source":{"id":"https://openalex.org/S4210188353","display_name":"Acta Histochemica","issn_l":"0065-1281","issn":["0065-1281","1618-0372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Histochemica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001626218","display_name":"Oliver Baum","orcid":"https://orcid.org/0000-0001-5706-0942","observed_orcids":["https://orcid.org/0000-0001-5706-0942"]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Oliver Baum","raw_affiliation_strings":["Department of Anatomy, Universit\u00e4tsklinikum Benjamin Franklin, Freie Universit\u00e4t Berlin, Germany. olibaum@zedat.fu-berlin.de","Department of Anatomy, Universit\u00e4tsklinikum Benjamin Franklin, Freie Universit\u00e4t Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Universit\u00e4tsklinikum Benjamin Franklin, Freie Universit\u00e4t Berlin, Germany. olibaum@zedat.fu-berlin.de","institution_ids":["https://openalex.org/I75951250"]},{"raw_affiliation_string":"Department of Anatomy, Universit\u00e4tsklinikum Benjamin Franklin, Freie Universit\u00e4t Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017669989","display_name":"Alexander Gerhard Miethke","orcid":"https://orcid.org/0000-0003-1395-9475","observed_orcids":["https://orcid.org/0000-0003-1395-9475"]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexander Miethke","raw_affiliation_strings":["Department of Anatomy, Universit\u00e4tsklinikum Benjamin Franklin, Freie Universit\u00e4t Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Universit\u00e4tsklinikum Benjamin Franklin, Freie Universit\u00e4t Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057393976","display_name":"Achim W\u00f6ckel","orcid":"https://orcid.org/0000-0002-6767-9666","observed_orcids":["https://orcid.org/0000-0002-6767-9666"]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Achim W\u00f6ckel","raw_affiliation_strings":["Department of Anatomy, Universit\u00e4tsklinikum Benjamin Franklin, Freie Universit\u00e4t Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Universit\u00e4tsklinikum Benjamin Franklin, Freie Universit\u00e4t Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012728649","display_name":"Gregor D. Willerding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gregor Willerding","raw_affiliation_strings":["Department of Anatomy, Universit\u00e4tsklinikum Benjamin Franklin, Freie Universit\u00e4t Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Universit\u00e4tsklinikum Benjamin Franklin, Freie Universit\u00e4t Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000050748","display_name":"Gerit Planitzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gerit Planitzer","raw_affiliation_strings":["Department of Anatomy, Universit\u00e4tsklinikum Benjamin Franklin, Freie Universit\u00e4t Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Universit\u00e4tsklinikum Benjamin Franklin, Freie Universit\u00e4t Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001626218"],"corresponding_institution_ids":["https://openalex.org/I75951250"],"apc_list":{"value":2940,"currency":"USD","value_usd":2940},"apc_paid":null,"fwci":1.2112,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.77650044,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"104","issue":"1","first_page":"3","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nitric-oxide-synthase-1","display_name":"nitric oxide synthase 1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/nadph-diaphorase","display_name":"NADPH-diaphorase","score":0.9229999780654907},{"id":"https://openalex.org/keywords/urea","display_name":"urea","score":0.6610000133514404},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.8629999756813049},{"id":"https://openalex.org/keywords/sarcolemma","display_name":"sarcolemma","score":0.906000018119812},{"id":"https://openalex.org/keywords/tongue-muscles","display_name":"tongue muscles","score":0.9419999718666077},{"id":"https://openalex.org/keywords/tibialis-anterior","display_name":"tibialis anterior","score":0.9629999995231628},{"id":"https://openalex.org/keywords/enzyme-specificity","display_name":"enzyme specificity","score":0.6309999823570251},{"id":"https://openalex.org/keywords/immunodepletion","display_name":"immunodepletion","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C199096232","wikidata":"https://www.wikidata.org/wiki/Q1545001","display_name":"Sarcolemma","level":3,"score":0.691188633441925},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.6786899566650391},{"id":"https://openalex.org/C2777244444","wikidata":"https://www.wikidata.org/wiki/Q3575572","display_name":"NADPH dehydrogenase","level":4,"score":0.5747942924499512},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.5680840015411377},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5673767328262329},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5066290497779846},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43879130482673645},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4335870146751404},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.40101346373558044},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3024212718009949},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2377043068408966},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009252","descriptor_name":"NADPH Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D018485","descriptor_name":"Muscle Fibers, Skeletal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018485","descriptor_name":"Muscle Fibers, Skeletal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018485","descriptor_name":"Muscle Fibers, Skeletal","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019084","descriptor_name":"Fluorescent Antibody Technique, Indirect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052248","descriptor_name":"Nitric Oxide Synthase Type I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1078/0065-1281-00625","doi":"https://doi.org/10.1078/0065-1281-00625","is_oa":false,"landing_page_url":"https://doi.org/10.1078/0065-1281-00625","pdf_url":null,"source":{"id":"https://openalex.org/S4210188353","display_name":"Acta Histochemica","issn_l":"0065-1281","issn":["0065-1281","1618-0372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Histochemica","raw_type":"journal-article"},{"id":"pmid:11993849","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11993849","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta histochemica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W270022758","https://openalex.org/W1031858249","https://openalex.org/W1417333514","https://openalex.org/W1519638308","https://openalex.org/W1532558315","https://openalex.org/W1849554878","https://openalex.org/W1957992664","https://openalex.org/W1972858099","https://openalex.org/W1977394169","https://openalex.org/W1980000845","https://openalex.org/W1999512514","https://openalex.org/W2009013636","https://openalex.org/W2010469212","https://openalex.org/W2010478333","https://openalex.org/W2020127552","https://openalex.org/W2022276077","https://openalex.org/W2029038770","https://openalex.org/W2035464530","https://openalex.org/W2042054187","https://openalex.org/W2045428478","https://openalex.org/W2063398700","https://openalex.org/W2066244859","https://openalex.org/W2066992356","https://openalex.org/W2073981358","https://openalex.org/W2077045152","https://openalex.org/W2081239833","https://openalex.org/W2084082680","https://openalex.org/W2088928790","https://openalex.org/W2089796673","https://openalex.org/W2104847030","https://openalex.org/W2136895488","https://openalex.org/W2138320382","https://openalex.org/W2170426277","https://openalex.org/W2180195412","https://openalex.org/W2193076987","https://openalex.org/W2255298136","https://openalex.org/W4245482048","https://openalex.org/W6680081741"],"related_works":["https://openalex.org/W2066992356","https://openalex.org/W11574809","https://openalex.org/W2045428478","https://openalex.org/W7100432016","https://openalex.org/W2006405995","https://openalex.org/W250685373","https://openalex.org/W1830065887","https://openalex.org/W2047501234","https://openalex.org/W2050531636","https://openalex.org/W1975753372"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}