{"id":"https://openalex.org/W2057612752","doi":"https://doi.org/10.1021/bi00278a008","title":"Characterization of the complementary deoxyribonucleic acid and gene coding for human prothrombin","display_name":"Characterization of the complementary deoxyribonucleic acid and gene coding for human prothrombin","publication_year":1983,"publication_date":"1983-04-26","ids":{"openalex":"https://openalex.org/W2057612752","doi":"https://doi.org/10.1021/bi00278a008","mag":"2057612752","pmid":"https://pubmed.ncbi.nlm.nih.gov/6305407"},"language":"en","primary_location":{"id":"doi:10.1021/bi00278a008","doi":"https://doi.org/10.1021/bi00278a008","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00278a008","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112252558","display_name":"Sandra J. Friezner Degen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandra J. Friezner Degen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038635870","display_name":"Ross T. A. MacGillivray","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ross T. A. MacGillivray","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5070437574","display_name":"Earl W. Davie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Earl W. Davie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":19.5064,"has_fulltext":false,"cited_by_count":296,"citation_normalized_percentile":{"value":0.99611134,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"22","issue":"9","first_page":"2087","last_page":"2097"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prothrombin","display_name":"prothrombin","score":0.9200000166893005},{"id":"https://openalex.org/keywords/cdna-sequence","display_name":"cDNA sequence","score":0.699999988079071},{"id":"https://openalex.org/keywords/prothrombin-gene","display_name":"prothrombin gene","score":0.8759999871253967},{"id":"https://openalex.org/keywords/signal-peptide","display_name":"signal peptide","score":0.8740000128746033},{"id":"https://openalex.org/keywords/gamma-carboxyglutamic-acid","display_name":"gamma-carboxyglutamic acid","score":0.8569999933242798},{"id":"https://openalex.org/keywords/exons-and-introns","display_name":"introns and exons","score":0.7350000143051147},{"id":"https://openalex.org/keywords/poly-a-tail","display_name":"poly(A) tail","score":0.5740000009536743},{"id":"https://openalex.org/keywords/5-untranslated-region","display_name":"5' untranslated region","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C2778805511","wikidata":"https://www.wikidata.org/wiki/Q1713","display_name":"Citation","level":2,"score":0.6280523538589478},{"id":"https://openalex.org/C2778407487","wikidata":"https://www.wikidata.org/wiki/Q14565201","display_name":"Altmetrics","level":2,"score":0.5607417821884155},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5415123105049133},{"id":"https://openalex.org/C2778447006","wikidata":"https://www.wikidata.org/wiki/Q1156474","display_name":"Icon","level":2,"score":0.4839804172515869},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.47172871232032776},{"id":"https://openalex.org/C518677369","wikidata":"https://www.wikidata.org/wiki/Q202833","display_name":"Social media","level":2,"score":0.4610739052295685},{"id":"https://openalex.org/C179518139","wikidata":"https://www.wikidata.org/wiki/Q5140297","display_name":"Coding (social sciences)","level":2,"score":0.44584643840789795},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.3106076121330261},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10386866331100464},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.10218232870101929},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001482","descriptor_name":"Base Composition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003062","descriptor_name":"Codon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D004262","descriptor_name":"DNA Restriction Enzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011516","descriptor_name":"Prothrombin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi00278a008","doi":"https://doi.org/10.1021/bi00278a008","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00278a008","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:6305407","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6305407","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309622","display_name":"Harvard University","ror":"https://ror.org/03vek6s52"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W68710030","https://openalex.org/W1004388750","https://openalex.org/W1437598086","https://openalex.org/W1482131190","https://openalex.org/W1551709891","https://openalex.org/W1558516755","https://openalex.org/W1596348372","https://openalex.org/W1602844435","https://openalex.org/W1606378510","https://openalex.org/W1965051773","https://openalex.org/W1968266985","https://openalex.org/W1969845182","https://openalex.org/W1969970275","https://openalex.org/W1972795930","https://openalex.org/W1977728729","https://openalex.org/W1982759449","https://openalex.org/W1984889856","https://openalex.org/W1988218731","https://openalex.org/W1995420892","https://openalex.org/W1996099693","https://openalex.org/W1997448407","https://openalex.org/W2001729895","https://openalex.org/W2002935828","https://openalex.org/W2011132187","https://openalex.org/W2013912153","https://openalex.org/W2015971691","https://openalex.org/W2019435196","https://openalex.org/W2027816421","https://openalex.org/W2028030581","https://openalex.org/W2032279957","https://openalex.org/W2032343668","https://openalex.org/W2040276985","https://openalex.org/W2044648543","https://openalex.org/W2044926967","https://openalex.org/W2049280274","https://openalex.org/W2054684040","https://openalex.org/W2063450941","https://openalex.org/W2069062868","https://openalex.org/W2072229642","https://openalex.org/W2074302676","https://openalex.org/W2074559130","https://openalex.org/W2084272192","https://openalex.org/W2086733743","https://openalex.org/W2088940155","https://openalex.org/W2091359755","https://openalex.org/W2094781170","https://openalex.org/W2097993282","https://openalex.org/W2155330016","https://openalex.org/W2463267938"],"related_works":["https://openalex.org/W2029249710","https://openalex.org/W3158293226","https://openalex.org/W2026597197","https://openalex.org/W1997463088","https://openalex.org/W2027877275","https://openalex.org/W2086997327","https://openalex.org/W1995885251","https://openalex.org/W1968682146","https://openalex.org/W2007864656","https://openalex.org/W2030810647"],"abstract_inverted_index":{"The":[0,22,95,126,190],"DNA":[1,143,154,167,198],"sequences":[2,194],"of":[3,12,37,41,59,67,79,107,146,156,171,203],"a":[4,10,38,53,56,64,80,84,134,138,152],"complementary":[5],"deoxyribonucleic":[6],"acid":[7,98,114,187],"(cDNA)":[8],"and":[9,30,63,83,109,164,177,181],"portion":[11],"the":[13,50,75,88,104,116,123,147,172,196],"gene":[14,173],"coding":[15,184],"for":[16,35,87,128,136,174,185],"human":[17,139,153,175],"prothrombin":[18,108,129,176],"have":[19],"been":[20],"determined.":[21],"cDNA":[23,127],"was":[24,31,130,159],"2005":[25],"base":[26,61,69],"pairs":[27],"in":[28,49,93,103,115,195],"length":[29],"found":[32],"to":[33,112],"code":[34],"part":[36],"leader":[39,76],"sequence":[40,77,82,86],"36":[42],"amino":[43,46,186],"acids,":[44],"579":[45],"acids":[47],"present":[48,102],"mature":[51,89,117],"protein,":[52],"stop":[54],"codon,":[55],"noncoding":[57],"region":[58,106],"97":[60],"pairs,":[62],"poly(A)":[65],"tail":[66],"27":[68],"pairs.":[70],"It":[71],"is":[72],"proposed":[73],"that":[74,91,100],"consists":[78],"signal":[81],"pro":[85],"protein":[90,118],"circulates":[92],"plasma.":[94],"10":[96],"glutamic":[97],"residues":[99,188],"are":[101,110,119],"amino-terminal":[105],"converted":[111],"gamma-carboxyglutamic":[113],"coded":[120],"by":[121],"only":[122],"GAG":[124],"codon.":[125],"also":[131],"employed":[132],"as":[133],"probe":[135],"screening":[137],"fetal":[140],"liver":[141],"genomic":[142,197],"library.":[144],"One":[145],"strongly":[148],"positive":[149],"phage":[150],"containing":[151],"insert":[155],"5":[157],"kilobases":[158],"mapped":[160],"with":[161],"restriction":[162],"endonucleases":[163],"sequenced.":[165],"This":[166],"contained":[168,199],"approximately":[169],"half":[170],"included":[178],"six":[179],"introns":[180],"five":[182],"exons":[183],"144-448.":[189],"two":[191,200],"largest":[192],"intervening":[193],"copies":[201],"each":[202],"AluI":[204],"repetitive":[205],"DNA.":[206]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
