{"id":"https://openalex.org/W2057578747","doi":"https://doi.org/10.1089/hyb.1983.2.7","title":"A Comparative Analysis of the Phenotypic Characteristics of Available Fusion Partners for the Construction of Human Hybridomas","display_name":"A Comparative Analysis of the Phenotypic Characteristics of Available Fusion Partners for the Construction of Human Hybridomas","publication_year":1983,"publication_date":"1983-01-01","ids":{"openalex":"https://openalex.org/W2057578747","doi":"https://doi.org/10.1089/hyb.1983.2.7","mag":"2057578747","pmid":"https://pubmed.ncbi.nlm.nih.gov/6332055"},"language":"en","primary_location":{"id":"doi:10.1089/hyb.1983.2.7","doi":"https://doi.org/10.1089/hyb.1983.2.7","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hyb.1983.2.7","pdf_url":null,"source":{"id":"https://openalex.org/S4210200239","display_name":"Hybridoma","issn_l":"0272-457X","issn":["0272-457X","1554-0014","1557-8348","2168-7897"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hybridoma","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019050712","display_name":"Danuta Kozbor","orcid":"https://orcid.org/0000-0003-1927-096X","observed_orcids":["https://orcid.org/0000-0003-1927-096X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"DANUTA KOZBOR","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"DAVID DEXTER","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"DAVID DEXTER","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111715744","display_name":"John Roder","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JOHN C. RODER","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":6.3963,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.96262751,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"2","issue":"1","first_page":"7","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myeloma-cell-lines","display_name":"myeloma cell lines","score":0.7979999780654907},{"id":"https://openalex.org/keywords/b-lymphoblastoid-cell-lines","display_name":"B-lymphoblastoid cell lines","score":0.9409999847412109},{"id":"https://openalex.org/keywords/b-lymphoma-cell-lines","display_name":"B lymphoma cell lines","score":0.781000018119812},{"id":"https://openalex.org/keywords/antibody-secretion","display_name":"immunoglobulin secretion","score":0.6880000233650208},{"id":"https://openalex.org/keywords/cell-morphology","display_name":"cell morphology","score":0.6589999794960022},{"id":"https://openalex.org/keywords/rough-endoplasmic-reticulum","display_name":"rough endoplasmic reticulum","score":0.9810000061988831},{"id":"https://openalex.org/keywords/golgi-apparatus","display_name":"Golgi apparatus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/monoclonal-antibody-production","display_name":"monoclonal antibody production","score":0.8100000023841858},{"id":"https://openalex.org/keywords/cloning-efficiency","display_name":"cloning efficiency","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.7795704007148743},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6790138483047485},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.5807735323905945},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5253167152404785},{"id":"https://openalex.org/C16232356","wikidata":"https://www.wikidata.org/wiki/Q4215980","display_name":"Raji cell","level":3,"score":0.5218823552131653},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5175763368606567},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.5018355846405029},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.48226815462112427},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.46383723616600037},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.46167585253715515},{"id":"https://openalex.org/C92488253","wikidata":"https://www.wikidata.org/wiki/Q56592403","display_name":"Cell fusion","level":3,"score":0.44638606905937195},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42144811153411865},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40682655572891235},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2899180054664612},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1943720281124115},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.11375877261161804}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002459","descriptor_name":"Cell Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006825","descriptor_name":"Hybridomas","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006825","descriptor_name":"Hybridomas","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012270","descriptor_name":"Ribosomes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/hyb.1983.2.7","doi":"https://doi.org/10.1089/hyb.1983.2.7","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hyb.1983.2.7","pdf_url":null,"source":{"id":"https://openalex.org/S4210200239","display_name":"Hybridoma","issn_l":"0272-457X","issn":["0272-457X","1554-0014","1557-8348","2168-7897"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hybridoma","raw_type":"journal-article"},{"id":"pmid:6332055","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6332055","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hybridoma","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W35940881","https://openalex.org/W1969149509","https://openalex.org/W1970748912","https://openalex.org/W1979518464","https://openalex.org/W1982280865","https://openalex.org/W1987055622","https://openalex.org/W1993585891","https://openalex.org/W2021998439","https://openalex.org/W2025646176","https://openalex.org/W2026605790","https://openalex.org/W2073815986","https://openalex.org/W2075787073","https://openalex.org/W2077951663","https://openalex.org/W2084855813","https://openalex.org/W2112968914","https://openalex.org/W2128663983","https://openalex.org/W2574941723","https://openalex.org/W4229801620"],"related_works":["https://openalex.org/W2069608399","https://openalex.org/W1966108334","https://openalex.org/W2062980627","https://openalex.org/W2017714052","https://openalex.org/W1806039838","https://openalex.org/W1659410498","https://openalex.org/W2441524231","https://openalex.org/W77793151","https://openalex.org/W1978605093","https://openalex.org/W2026788309"],"abstract_inverted_index":{"Of":[0],"several":[1],"human":[2,155],"fusion":[3,156,163],"partners":[4],"available":[5],"for":[6,21],"the":[7,48,62,83,136],"production":[8,67],"of":[9,47,59,64,86,128],"monoclonal":[10],"antibodies,":[11],"only":[12],"SKO-007":[13],"and":[14,45,80,91,106,167],"RPMI":[15],"8226":[16],"have":[17],"phenotypic":[18,84],"features":[19],"characteristic":[20],"myeloma":[22],"cells.":[23],"Cells":[24],"from":[25],"both":[26],"lines":[27,89],"exhibited":[28],"abundant":[29],"rough":[30],"endoplasmic":[31],"reticulum":[32],"(RER)":[33],"with":[34,121],"a":[35,101,154],"prominent":[36],"Golgi":[37,104],"apparatus,":[38],"few":[39],"free":[40,99],"ribosomes,":[41],"condensed":[42],"nuclear":[43,52],"chromatin,":[44],"absence":[46],"Epstein-Barr":[49],"virus":[50],"determined":[51],"antigen":[53],"(EBNA).":[54],"However,":[55,118],"following":[56],"prolonged":[57],"passage":[58],"these":[60],"lines,":[61,73],"amount":[63],"immunoglobulin":[65],"(Ig)":[66],"has":[68],"declined.":[69],"The":[70],"other":[71,159],"cell":[72,88],"GM":[74],"1500":[75],"6TG-A11,":[76],"KR-4,":[77],"B6,":[78],"HS-Sultan,":[79],"Raji":[81],"possessed":[82],"characteristics":[85],"B-lymphoblastoid":[87],"(LCLs)":[90],"B-lymphomas":[92],"including":[93],"surface":[94],"Ig":[95,129],"expression,":[96],"sparse":[97],"RER,":[98],"polyribosomes,":[100],"poorly":[102],"developed":[103],"apparatus":[105],"strong":[107],"EBNA":[108],"expression.":[109],"Accordingly,":[110],"they":[111],"secreted":[112],"little":[113],"(nanograms)":[114],"or":[115],"no":[116],"Ig.":[117],"hybrids":[119],"constructed":[120],"two":[122],"LCLs":[123],"secrete":[124],"very":[125],"large":[126],"amounts":[127],"despite":[130],"their":[131],"expressed":[132],"morphologic":[133],"similarity":[134],"to":[135],"parental":[137],"lines.":[138],"These":[139],"data":[140],"indicate":[141],"that":[142],"morphology":[143],"can":[144],"still":[145],"be":[146,171],"used":[147],"as":[148,162],"an":[149],"important":[150],"consideration":[151],"in":[152],"choosing":[153],"partner":[157],"but":[158],"parameters":[160],"such":[161],"frequency,":[164],"cloning":[165],"efficiencies,":[166],"growth":[168],"rates":[169],"may":[170],"equally":[172],"important.":[173]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}