{"id":"https://openalex.org/W2057563641","doi":"https://doi.org/10.1111/j.1474-9726.2007.00318.x","title":"Epidermal stem cells are resistant to cellular aging","display_name":"Epidermal stem cells are resistant to cellular aging","publication_year":2007,"publication_date":"2007-06-07","ids":{"openalex":"https://openalex.org/W2057563641","doi":"https://doi.org/10.1111/j.1474-9726.2007.00318.x","mag":"2057563641","pmid":"https://pubmed.ncbi.nlm.nih.gov/17635170"},"language":"en","primary_location":{"id":"doi:10.1111/j.1474-9726.2007.00318.x","doi":"https://doi.org/10.1111/j.1474-9726.2007.00318.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1474-9726.2007.00318.x","pdf_url":null,"source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020204493","display_name":"Matthew Michael Stern","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew M. Stern","raw_affiliation_strings":["Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, IA 52242, USA","Departments of Anatomy and Cell Biology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Cell Biology, University of Iowa Carver College of Medicine, IA 52242, USA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"Departments of Anatomy and Cell Biology and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108770995","display_name":"Jackie R. Bickenbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jackie R. Bickenbach","raw_affiliation_strings":["Departments of Anatomy and Cell Biology and","Dermatology and Pathology, University of Iowa Carver College of Medicine, IA 52242, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anatomy and Cell Biology and","institution_ids":[]},{"raw_affiliation_string":"Dermatology and Pathology, University of Iowa Carver College of Medicine, IA 52242, USA","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5108770995"],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":4.7794,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.94634623,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"6","issue":"4","first_page":"439","last_page":"452"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.5824999809265137,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.5824999809265137,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.2524000108242035,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.05270000174641609,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epidermal-stem-cells","display_name":"epidermal stem cells","score":1.0},{"id":"https://openalex.org/keywords/cellular-aging","display_name":"cellular aging","score":0.9819999933242798},{"id":"https://openalex.org/keywords/skin-aging","display_name":"skin aging","score":0.5490000247955322},{"id":"https://openalex.org/keywords/epidermal-homeostasis","display_name":"epidermal homeostasis","score":0.8330000042915344},{"id":"https://openalex.org/keywords/basal-cells","display_name":"basal cells","score":0.597000002861023},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.7559999823570251},{"id":"https://openalex.org/keywords/transit-amplifying-cells","display_name":"transit amplifying cells","score":0.9750000238418579},{"id":"https://openalex.org/keywords/mouse-skin","display_name":"mouse skin","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.859520435333252},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7810981273651123},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.756756067276001},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6553155183792114},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5563877820968628},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.4780236482620239},{"id":"https://openalex.org/C14218858","wikidata":"https://www.wikidata.org/wiki/Q7607301","display_name":"Stem cell theory of aging","level":5,"score":0.41159096360206604},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.36248138546943665},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3612525463104248},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.2770586609840393},{"id":"https://openalex.org/C2022786","wikidata":"https://www.wikidata.org/wiki/Q909331","display_name":"Stem cell factor","level":4,"score":0.18707099556922913},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.13347488641738892},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11582392454147339},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08143523335456848},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07394704222679138},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000078404","descriptor_name":"Epidermal Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007633","descriptor_name":"Keratins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039902","descriptor_name":"Multipotent Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053687","descriptor_name":"Adult Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1474-9726.2007.00318.x","doi":"https://doi.org/10.1111/j.1474-9726.2007.00318.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1474-9726.2007.00318.x","pdf_url":null,"source":{"id":"https://openalex.org/S174672550","display_name":"Aging Cell","issn_l":"1474-9718","issn":["1474-9718","1474-9726","1474-9728"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging Cell","raw_type":"journal-article"},{"id":"pmid:17635170","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17635170","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging cell","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2282376839","display_name":"Age-related Responses of Epidermal Stem Cells to Environ","funder_award_id":"R01AG020913","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333120","display_name":"Holden Comprehensive Cancer Center, University of Iowa","ror":"https://ror.org/01jhe7086"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1483167997","https://openalex.org/W1589289370","https://openalex.org/W1632349675","https://openalex.org/W1894632965","https://openalex.org/W1968506175","https://openalex.org/W1970731529","https://openalex.org/W1975609097","https://openalex.org/W1975718597","https://openalex.org/W1976583497","https://openalex.org/W1983673827","https://openalex.org/W1998534168","https://openalex.org/W1999918470","https://openalex.org/W2006531965","https://openalex.org/W2006660996","https://openalex.org/W2007135034","https://openalex.org/W2010474967","https://openalex.org/W2011202983","https://openalex.org/W2015519364","https://openalex.org/W2019818589","https://openalex.org/W2026354624","https://openalex.org/W2029675195","https://openalex.org/W2030338830","https://openalex.org/W2036189250","https://openalex.org/W2037749974","https://openalex.org/W2038085058","https://openalex.org/W2041397939","https://openalex.org/W2042440105","https://openalex.org/W2050166933","https://openalex.org/W2050751211","https://openalex.org/W2051665279","https://openalex.org/W2052260390","https://openalex.org/W2064482166","https://openalex.org/W2073638852","https://openalex.org/W2074371275","https://openalex.org/W2078035943","https://openalex.org/W2080125477","https://openalex.org/W2084891010","https://openalex.org/W2089972187","https://openalex.org/W2094523038","https://openalex.org/W2105886061","https://openalex.org/W2106897784","https://openalex.org/W2107277218","https://openalex.org/W2112364863","https://openalex.org/W2121278044","https://openalex.org/W2125169413","https://openalex.org/W2131263031","https://openalex.org/W2137956382","https://openalex.org/W2140202926","https://openalex.org/W2143384363","https://openalex.org/W2161092951","https://openalex.org/W2315512556"],"related_works":["https://openalex.org/W1966755977","https://openalex.org/W1487588512","https://openalex.org/W7100396978","https://openalex.org/W72333637","https://openalex.org/W6980521058","https://openalex.org/W7140258227","https://openalex.org/W188035239","https://openalex.org/W2033221692","https://openalex.org/W2326241249","https://openalex.org/W2042440105"],"abstract_inverted_index":{"The":[0,49],"epidermis":[1,36,171],"of":[2,26,44,68,87,112,116,139,158,180,206],"the":[3,7,24,35,55,66,84,109,117,153,202],"skin,":[4],"acting":[5],"as":[6,75,172],"primary":[8],"physical":[9],"barrier":[10,119],"between":[11],"self":[12],"and":[13,33,39,60,182],"environment,":[14],"is":[15,21,37,162],"a":[16,42,136],"dynamic":[17],"tissue":[18],"whose":[19],"maintenance":[20],"critical":[22],"to":[23,63,93,127,147,212],"survival":[25],"an":[27,69,113,165,192],"organism.":[28],"Like":[29],"most":[30],"other":[31],"tissues":[32],"organs,":[34],"maintained":[38,95,163],"repaired":[40],"by":[41,142],"population":[43,138],"resident":[45],"somatic":[46],"stem":[47,51,80,133,160,186,208,217],"cells.":[48,187],"epidermal":[50,79,91,118,132,159,185,207,216],"cells":[52,81,134,140,161,218],"reside":[53],"in":[54,201],"proliferative":[56],"basal":[57],"cell":[58,103],"layer":[59],"are":[61,96],"believed":[62],"persist":[64],"for":[65,90,101],"lifetime":[67,111],"individual.":[70,114],"Acting":[71],"through":[72],"intermediaries":[73],"known":[74],"transit":[76],"amplifying":[77],"cells,":[78,209],"ensure":[82],"that":[83,152,214],"enormous":[85],"numbers":[86],"keratinocytes":[88],"required":[89],"homeostasis":[92],"be":[94,106,145],"generated.":[97],"This":[98,124],"continual":[99],"demand":[100],"new":[102],"production":[104],"must":[105],"met":[107],"over":[108,164,191],"entire":[110,166],"Breakdown":[115],"would":[120],"have":[121],"catastrophic":[122],"consequences.":[123],"leads":[125],"us":[126,211],"question":[128],"whether":[129],"or":[130],"not":[131],"represent":[135],"unique":[137],"which,":[141],"necessity,":[143],"might":[144],"resistant":[146],"cellular":[148,220],"aging.":[149,221],"We":[150,188],"hypothesized":[151],"full":[154],"physiologic":[155,203],"functional":[156,204],"capacity":[157,205],"lifetime.":[167],"Using":[168],"murine":[169,215],"skin":[170],"our":[173],"model":[174],"system,":[175],"we":[176],"compared":[177],"several":[178],"properties":[179],"young":[181],"old":[183],"adult":[184],"found":[189],"that,":[190],"average":[193],"mouse's":[194],"lifetime,":[195],"there":[196],"was":[197],"no":[198],"measurable":[199],"loss":[200],"leading":[210],"conclude":[213],"resist":[219]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}