{"id":"https://openalex.org/W2057540845","doi":"https://doi.org/10.1016/s0027-5107(99)00074-3","title":"A genetic effect of altered gravity: mutations induced by simulated hypogravity and hypergravity in microsatellite sequences of human tumor cells","display_name":"A genetic effect of altered gravity: mutations induced by simulated hypogravity and hypergravity in microsatellite sequences of human tumor cells","publication_year":1999,"publication_date":"1999-05-01","ids":{"openalex":"https://openalex.org/W2057540845","doi":"https://doi.org/10.1016/s0027-5107(99)00074-3","mag":"2057540845","pmid":"https://pubmed.ncbi.nlm.nih.gov/10320745"},"language":"en","primary_location":{"id":"doi:10.1016/s0027-5107(99)00074-3","doi":"https://doi.org/10.1016/s0027-5107(99)00074-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0027-5107(99)00074-3","pdf_url":null,"source":{"id":"https://openalex.org/S4394735698","display_name":"Mutation research. Fundamental and molecular mechanisms of mutagenesis","issn_l":"0027-5107","issn":["0027-5107","1386-1964","1873-135X","1879-2871"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100835578","display_name":"Zhen-Bo Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4405285708","display_name":"Radiation Biology Center, Kyoto University","ror":"https://ror.org/0006k6163","country_code":"JP","type":"facility","lineage":["https://openalex.org/I22299242","https://openalex.org/I4405285708"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Zhen-Bo Han","raw_affiliation_strings":["Radiation Biology Center, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Biology Center, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4405285708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110258921","display_name":"Kanji Ishizaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133851","display_name":"Aichi Cancer Center","ror":"https://ror.org/03kfmm080","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210133851"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kanji Ishizaki","raw_affiliation_strings":["Laboratory of Experimental Radiology, Aichi Cancer Center, Kanokoden 1-1, Chikusa-ku, Nagoya 464-8681, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Radiology, Aichi Cancer Center, Kanokoden 1-1, Chikusa-ku, Nagoya 464-8681, Japan","institution_ids":["https://openalex.org/I4210133851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110071797","display_name":"Kimiko Nishizawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133851","display_name":"Aichi Cancer Center","ror":"https://ror.org/03kfmm080","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210133851"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kimiko Nishizawa","raw_affiliation_strings":["Laboratory of Experimental Radiology, Aichi Cancer Center, Kanokoden 1-1, Chikusa-ku, Nagoya 464-8681, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Radiology, Aichi Cancer Center, Kanokoden 1-1, Chikusa-ku, Nagoya 464-8681, Japan","institution_ids":["https://openalex.org/I4210133851"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076886111","display_name":"Tomohisa Kato","orcid":"https://orcid.org/0000-0002-3047-9847","observed_orcids":["https://orcid.org/0000-0002-3047-9847"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4405285708","display_name":"Radiation Biology Center, Kyoto University","ror":"https://ror.org/0006k6163","country_code":"JP","type":"facility","lineage":["https://openalex.org/I22299242","https://openalex.org/I4405285708"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomohisa Kato","raw_affiliation_strings":["Radiation Biology Center, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Biology Center, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4405285708"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102997252","display_name":"Takeshi Todo","orcid":"https://orcid.org/0000-0002-5778-0584","observed_orcids":["https://orcid.org/0000-0002-5778-0584"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4405285708","display_name":"Radiation Biology Center, Kyoto University","ror":"https://ror.org/0006k6163","country_code":"JP","type":"facility","lineage":["https://openalex.org/I22299242","https://openalex.org/I4405285708"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Todo","raw_affiliation_strings":["Radiation Biology Center, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Biology Center, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4405285708"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063751701","display_name":"Mituo Ikenaga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]},{"id":"https://openalex.org/I4405285708","display_name":"Radiation Biology Center, Kyoto University","ror":"https://ror.org/0006k6163","country_code":"JP","type":"facility","lineage":["https://openalex.org/I22299242","https://openalex.org/I4405285708"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Mituo Ikenaga","raw_affiliation_strings":["Radiation Biology Center, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Biology Center, Kyoto University, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan","institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4405285708"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5063751701"],"corresponding_institution_ids":["https://openalex.org/I22299242","https://openalex.org/I4405285708"],"apc_list":{"value":3380,"currency":"USD","value_usd":3380},"apc_paid":null,"fwci":0.6174,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.64605801,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"426","issue":"1","first_page":"1","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12005","display_name":"Spaceflight effects on biology","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/altered-gravity","display_name":"altered gravity","score":0.6940000057220459},{"id":"https://openalex.org/keywords/microsatellite-mutations","display_name":"microsatellite mutations","score":0.8830000162124634},{"id":"https://openalex.org/keywords/mutation-induction","display_name":"mutation induction","score":0.5789999961853027},{"id":"https://openalex.org/keywords/human-cancer-cells","display_name":"human cancer cells","score":0.8040000200271606},{"id":"https://openalex.org/keywords/clinostat","display_name":"clinostat","score":0.8500000238418579},{"id":"https://openalex.org/keywords/mutant-frequency","display_name":"mutant frequency","score":0.6510000228881836},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.9589999914169312},{"id":"https://openalex.org/keywords/protein-kinase-c-signaling","display_name":"protein kinase C signaling","score":0.8830000162124634},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.8769999742507935},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.7300000190734863}],"concepts":[{"id":"https://openalex.org/C128709446","wikidata":"https://www.wikidata.org/wiki/Q5958048","display_name":"Hypergravity","level":2,"score":0.9962457418441772},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.459978312253952},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4151500463485718},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2899825870990753},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21463388204574585},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.13684770464897156}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014965","descriptor_name":"X-Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018470","descriptor_name":"Gravity, Altered","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018895","descriptor_name":"Microsatellite Repeats","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018895","descriptor_name":"Microsatellite Repeats","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018895","descriptor_name":"Microsatellite Repeats","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0027-5107(99)00074-3","doi":"https://doi.org/10.1016/s0027-5107(99)00074-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0027-5107(99)00074-3","pdf_url":null,"source":{"id":"https://openalex.org/S4394735698","display_name":"Mutation research. Fundamental and molecular mechanisms of mutagenesis","issn_l":"0027-5107","issn":["0027-5107","1386-1964","1873-135X","1879-2871"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis","raw_type":"journal-article"},{"id":"pmid:10320745","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10320745","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mutation research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320338077","display_name":"Institute of Space and Astronautical Science","ror":"https://ror.org/034gcgw60"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1593208137","https://openalex.org/W1817423755","https://openalex.org/W1946702933","https://openalex.org/W1953420644","https://openalex.org/W1959610847","https://openalex.org/W1964839077","https://openalex.org/W1966731979","https://openalex.org/W1967004332","https://openalex.org/W1985135628","https://openalex.org/W1990086947","https://openalex.org/W1992052085","https://openalex.org/W2000967656","https://openalex.org/W2004282309","https://openalex.org/W2019298000","https://openalex.org/W2023145566","https://openalex.org/W2023906573","https://openalex.org/W2031600297","https://openalex.org/W2032303041","https://openalex.org/W2038358366","https://openalex.org/W2038465506","https://openalex.org/W2044265591","https://openalex.org/W2044643325","https://openalex.org/W2046545092","https://openalex.org/W2051695225","https://openalex.org/W2059193195","https://openalex.org/W2061941091","https://openalex.org/W2064879624","https://openalex.org/W2069751639","https://openalex.org/W2081378184","https://openalex.org/W2107359522","https://openalex.org/W2138081018","https://openalex.org/W2169264325","https://openalex.org/W2422322308","https://openalex.org/W2494362190"],"related_works":["https://openalex.org/W2912021258","https://openalex.org/W2405573491","https://openalex.org/W2748094222","https://openalex.org/W2795099444","https://openalex.org/W2767404656","https://openalex.org/W358353051","https://openalex.org/W2464857365","https://openalex.org/W2341674686","https://openalex.org/W2418871621","https://openalex.org/W201520611"],"abstract_inverted_index":null,"counts_by_year":[{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}