{"id":"https://openalex.org/W2057528376","doi":"https://doi.org/10.1016/j.febslet.2005.02.011","title":"Genome semantics, in silico multicellular systems and the Central Dogma","display_name":"Genome semantics, in silico multicellular systems and the Central Dogma","publication_year":2005,"publication_date":"2005-02-12","ids":{"openalex":"https://openalex.org/W2057528376","doi":"https://doi.org/10.1016/j.febslet.2005.02.011","mag":"2057528376","pmid":"https://pubmed.ncbi.nlm.nih.gov/15763551"},"language":"en","primary_location":{"id":"doi:10.1016/j.febslet.2005.02.011","doi":"https://doi.org/10.1016/j.febslet.2005.02.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.febslet.2005.02.011","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113574212","display_name":"Eric J. Werner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Eric Werner","raw_affiliation_strings":["Cellnomica, Inc., P.O. Box 1422, Fort Myers, FL 33928-1422, USA. eric.werner@cellnomica.com","Cellnomica, Inc., P.O. Box 1422, Fort Myers, FL 33928-1422, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellnomica, Inc., P.O. Box 1422, Fort Myers, FL 33928-1422, USA. eric.werner@cellnomica.com","institution_ids":[]},{"raw_affiliation_string":"Cellnomica, Inc., P.O. Box 1422, Fort Myers, FL 33928-1422, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5113574212"],"corresponding_institution_ids":[],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":24.6328,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.99177129,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"579","issue":"8","first_page":"1779","last_page":"1782"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10778","display_name":"Philosophy and History of Science","score":0.8550000190734863,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10778","display_name":"Philosophy and History of Science","score":0.8550000190734863,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.03629999980330467,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.028999999165534973,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/central-dogma","display_name":"central dogma","score":0.7680000066757202},{"id":"https://openalex.org/keywords/multicellular-systems","display_name":"multicellular systems","score":0.8420000076293945},{"id":"https://openalex.org/keywords/artificial-genome","display_name":"artificial genome","score":0.9319999814033508},{"id":"https://openalex.org/keywords/top-down-and-bottom-up-approaches","display_name":"top-down and bottom-up approaches","score":0.7910000085830688},{"id":"https://openalex.org/keywords/theory-of-meaning","display_name":"theory of meaning","score":0.6869999766349792},{"id":"https://openalex.org/keywords/genome-function","display_name":"genome function","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.8888951539993286},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.8504488468170166},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.7414047718048096},{"id":"https://openalex.org/C184337299","wikidata":"https://www.wikidata.org/wiki/Q1437428","display_name":"Semantics (computer science)","level":2,"score":0.6265437602996826},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5763349533081055},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5260864496231079},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5148955583572388},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4792185425758362},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.41042694449424744},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3916233777999878},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24508589506149292},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15166795253753662},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0981626808643341},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002477","descriptor_name":"Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012660","descriptor_name":"Semantics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.febslet.2005.02.011","doi":"https://doi.org/10.1016/j.febslet.2005.02.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.febslet.2005.02.011","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:15763551","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15763551","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W93732909","https://openalex.org/W1491095444","https://openalex.org/W1508225465","https://openalex.org/W1583115284","https://openalex.org/W1597226907","https://openalex.org/W1977083937","https://openalex.org/W2023255625","https://openalex.org/W2034269086","https://openalex.org/W2055214702","https://openalex.org/W2143784594","https://openalex.org/W2478224845"],"related_works":["https://openalex.org/W2137124858","https://openalex.org/W4241084279","https://openalex.org/W2160988460","https://openalex.org/W291785704","https://openalex.org/W2032492356","https://openalex.org/W2083200278","https://openalex.org/W1553833389","https://openalex.org/W1531769054","https://openalex.org/W1967119181","https://openalex.org/W2329509798"],"abstract_inverted_index":{"Genomes":[0],"with":[1,89],"their":[2,30],"complexity":[3],"and":[4,29,34,98,122],"size":[5],"present":[6],"what":[7],"appears":[8],"to":[9,64,108,128],"be":[10,51],"an":[11],"impossible":[12],"challenge.":[13],"Scientists":[14],"speak":[15],"in":[16,56,74,110,116],"terms":[17],"of":[18,37,59,82,101,119,132,144],"decades":[19],"or":[20],"even":[21],"centuries":[22],"before":[23],"we":[24,105,125],"will":[25,50],"understand":[26],"how":[27],"genomes":[28,120],"hosts":[31],"the":[32,35,42,67,71,80,95],"cell":[33],"city":[36],"cells":[38,121],"that":[39,48,139],"make":[40,99],"up":[41],"multicellular":[43,123],"context":[44],"function.":[45],"We":[46],"believe":[47],"there":[49],"surprisingly":[52],"quick":[53],"progress":[54],"made":[55],"our":[57],"understanding":[58],"genomes.":[60,83,102,136,145],"The":[61,103],"key":[62],"is":[63,107],"stop":[65],"taking":[66],"Central":[68],"Dogma":[69],"as":[70],"only":[72],"direction":[73],"which":[75],"genome":[76],"research":[77],"can":[78],"scale":[79],"semantics":[81,143],"Instead":[84],"a":[85,90,130,141],"top-down":[86],"approach":[87,92],"coupled":[88],"bottom-up":[91],"may":[93],"snare":[94],"unwieldy":[96],"beast":[97],"sense":[100],"method":[104],"propose":[106],"take":[109],"silico":[111,117],"biology":[112],"seriously.":[113],"By":[114],"developing":[115],"models":[118],"systems,":[124],"position":[126],"ourselves":[127],"develop":[129,140],"theory":[131],"meaning":[133],"for":[134],"artificial":[135],"Then":[137],"using":[138],"natural":[142]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}