{"id":"https://openalex.org/W2057522239","doi":"https://doi.org/10.1210/jcem.85.8.6736","title":"Pteridin-Dependent Hydroxylases as Autoantigens in Autoimmune Polyendocrine Syndrome Type I","display_name":"Pteridin-Dependent Hydroxylases as Autoantigens in Autoimmune Polyendocrine Syndrome Type I","publication_year":2000,"publication_date":"2000-08-01","ids":{"openalex":"https://openalex.org/W2057522239","doi":"https://doi.org/10.1210/jcem.85.8.6736","mag":"2057522239","pmid":"https://pubmed.ncbi.nlm.nih.gov/10946908"},"language":"en","primary_location":{"id":"doi:10.1210/jcem.85.8.6736","doi":"https://doi.org/10.1210/jcem.85.8.6736","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem.85.8.6736","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028168158","display_name":"Olov Ekwall","orcid":"https://orcid.org/0000-0002-4506-9955","observed_orcids":["https://orcid.org/0000-0002-4506-9955"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Olov Ekwall","raw_affiliation_strings":["Departments of Medical Sciences (O.E., H.H., F.R., O.K.), SE-751 85 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medical Sciences (O.E., H.H., F.R., O.K.), SE-751 85 Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013336601","display_name":"H\u00e5kan Hedstrand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"HA\u030akan Hedstrand","raw_affiliation_strings":["Departments of Medical Sciences (O.E., H.H., F.R., O.K.), SE-751 85 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medical Sciences (O.E., H.H., F.R., O.K.), SE-751 85 Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055442295","display_name":"Jan Haavik","orcid":"https://orcid.org/0000-0001-7865-2808","observed_orcids":["https://orcid.org/0000-0001-7865-2808"]},"institutions":[{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Jan Haavik","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology (J.H.), NO-5021 Bergen, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology (J.H.), NO-5021 Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109983784","display_name":"Jaakko Perheentupa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jaakko Perheentupa","raw_affiliation_strings":["the Hospital for Children and Adolescents (J.P.), University of Helsinki, FIN-00014 Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Hospital for Children and Adolescents (J.P.), University of Helsinki, FIN-00014 Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046211779","display_name":"Corrado Betterle","orcid":"https://orcid.org/0000-0002-8996-410X","observed_orcids":["https://orcid.org/0000-0002-8996-410X"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Corrado Betterle","raw_affiliation_strings":["and Institute of Semeiotica Medica (C.B.), Clinical Immunology and Allergy, University of Padova, IT-35128 Padua, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"and Institute of Semeiotica Medica (C.B.), Clinical Immunology and Allergy, University of Padova, IT-35128 Padua, Italy","institution_ids":["https://openalex.org/I138689650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036193907","display_name":"Jan Gustafsson","orcid":"https://orcid.org/0000-0002-7540-438X","observed_orcids":["https://orcid.org/0000-0002-7540-438X"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I1342360035","display_name":"Uppsala University Hospital","ror":"https://ror.org/01apvbh93","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1342360035"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Jan Gustafsson","raw_affiliation_strings":["Women\u2019s and Children\u2019s Health (J.G.), University Hospital, Uppsala University, SE-751 85 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Women\u2019s and Children\u2019s Health (J.G.), University Hospital, Uppsala University, SE-751 85 Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679","https://openalex.org/I1342360035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060877182","display_name":"Eystein S. Husebye","orcid":"https://orcid.org/0000-0002-7886-2976","observed_orcids":["https://orcid.org/0000-0002-7886-2976"]},"institutions":[{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Eystein Husebye","raw_affiliation_strings":["Division of Endocrinology, Institute of Medicine (E.H.), University of Bergen, NO-5021 Bergen, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Institute of Medicine (E.H.), University of Bergen, NO-5021 Bergen, Norway","institution_ids":["https://openalex.org/I4432739"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021512169","display_name":"Fredrik Rorsman","orcid":"https://orcid.org/0000-0003-4023-9617","observed_orcids":["https://orcid.org/0000-0003-4023-9617"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Fredrik Rorsman","raw_affiliation_strings":["Departments of Medical Sciences (O.E., H.H., F.R., O.K.), SE-751 85 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medical Sciences (O.E., H.H., F.R., O.K.), SE-751 85 Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078801536","display_name":"Olle K\u00e4mpe","orcid":"https://orcid.org/0000-0001-6091-9914","observed_orcids":["https://orcid.org/0000-0001-6091-9914"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Olle Ka\u0308mpe","raw_affiliation_strings":["Departments of Medical Sciences (O.E., H.H., F.R., O.K.), SE-751 85 Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medical Sciences (O.E., H.H., F.R., O.K.), SE-751 85 Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":1.4746,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.80478798,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"85","issue":"8","first_page":"2944","last_page":"2950"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.6025000214576721,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.6025000214576721,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.13349999487400055,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11627","display_name":"Autoimmune Neurological Disorders and Treatments","score":0.08479999750852585,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autoantigens","display_name":"autoantigens","score":0.9620000123977661},{"id":"https://openalex.org/keywords/tryptophan-hydroxylase","display_name":"tryptophan hydroxylase","score":0.9190000295639038},{"id":"https://openalex.org/keywords/tyrosine-hydroxylase","display_name":"tyrosine hydroxylase","score":1.0},{"id":"https://openalex.org/keywords/phenylalanine-hydroxylase","display_name":"phenylalanine hydroxylase","score":1.0},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.9700000286102295},{"id":"https://openalex.org/keywords/epitope-cross-reactivity","display_name":"epitope cross-reactivity","score":0.6690000295639038},{"id":"https://openalex.org/keywords/neurotransmitter-synthesis","display_name":"neurotransmitter synthesis","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C207009774","wikidata":"https://www.wikidata.org/wiki/Q420604","display_name":"Phenylalanine hydroxylase","level":4,"score":0.6889137029647827},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6725130081176758},{"id":"https://openalex.org/C2775951788","wikidata":"https://www.wikidata.org/wiki/Q418293","display_name":"Tryptophan hydroxylase","level":5,"score":0.6328808069229126},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.6310943961143494},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6125941872596741},{"id":"https://openalex.org/C159167319","wikidata":"https://www.wikidata.org/wiki/Q420766","display_name":"Tyrosine hydroxylase","level":3,"score":0.5874143838882446},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.5522204041481018},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5229321718215942},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5116065144538879},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3670456111431122},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3448488414287567},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25851041078567505},{"id":"https://openalex.org/C2777431362","wikidata":"https://www.wikidata.org/wiki/Q170545","display_name":"Phenylalanine","level":3,"score":0.19221574068069458},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.13610020279884338},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.09429150819778442},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.07117727398872375},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001324","descriptor_name":"Autoantigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001324","descriptor_name":"Autoantigens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005387","descriptor_name":"Finland","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007558","descriptor_name":"Italy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009664","descriptor_name":"Norway","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010651","descriptor_name":"Phenylalanine Hydroxylase","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D010651","descriptor_name":"Phenylalanine Hydroxylase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013548","descriptor_name":"Sweden","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014365","descriptor_name":"Tryptophan Hydroxylase","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014365","descriptor_name":"Tryptophan Hydroxylase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014446","descriptor_name":"Tyrosine 3-Monooxygenase","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014446","descriptor_name":"Tyrosine 3-Monooxygenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016884","descriptor_name":"Polyendocrinopathies, Autoimmune","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D016884","descriptor_name":"Polyendocrinopathies, Autoimmune","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1210/jcem.85.8.6736","doi":"https://doi.org/10.1210/jcem.85.8.6736","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem.85.8.6736","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},{"id":"doi:10.1210/jc.85.8.2944","doi":"https://doi.org/10.1210/jc.85.8.2944","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.85.8.2944","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},{"id":"pmid:10946908","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10946908","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":181,"referenced_works":["https://openalex.org/W14274566","https://openalex.org/W64278426","https://openalex.org/W256121974","https://openalex.org/W301829811","https://openalex.org/W321094772","https://openalex.org/W1483162601","https://openalex.org/W1527534705","https://openalex.org/W1548757996","https://openalex.org/W1559982705","https://openalex.org/W1565308849","https://openalex.org/W1577992168","https://openalex.org/W1609538723","https://openalex.org/W1624822079","https://openalex.org/W1725663634","https://openalex.org/W1755645448","https://openalex.org/W1826333720","https://openalex.org/W1868339174","https://openalex.org/W1915314899","https://openalex.org/W1942668068","https://openalex.org/W1965983975","https://openalex.org/W1966758596","https://openalex.org/W1966828726","https://openalex.org/W1967167923","https://openalex.org/W1967744736","https://openalex.org/W1968619887","https://openalex.org/W1969614224","https://openalex.org/W1970132947","https://openalex.org/W1971306782","https://openalex.org/W1974439470","https://openalex.org/W1975042320","https://openalex.org/W1975358757","https://openalex.org/W1975455059","https://openalex.org/W1977451393","https://openalex.org/W1980259832","https://openalex.org/W1981932944","https://openalex.org/W1982917969","https://openalex.org/W1983253943","https://openalex.org/W1983653922","https://openalex.org/W1983858481","https://openalex.org/W1984587156","https://openalex.org/W1985432688","https://openalex.org/W1985881712","https://openalex.org/W1986454867","https://openalex.org/W1990792386","https://openalex.org/W1995179449","https://openalex.org/W2003652884","https://openalex.org/W2006881610","https://openalex.org/W2006904341","https://openalex.org/W2009759884","https://openalex.org/W2014597466","https://openalex.org/W2016167513","https://openalex.org/W2016193783","https://openalex.org/W2016283055","https://openalex.org/W2017065556","https://openalex.org/W2017421022","https://openalex.org/W2019638830","https://openalex.org/W2020750439","https://openalex.org/W2020981664","https://openalex.org/W2022723768","https://openalex.org/W2023259605","https://openalex.org/W2023449577","https://openalex.org/W2024603590","https://openalex.org/W2026476364","https://openalex.org/W2026889435","https://openalex.org/W2028222510","https://openalex.org/W2028393908","https://openalex.org/W2029599607","https://openalex.org/W2031111306","https://openalex.org/W2032859645","https://openalex.org/W2034306860","https://openalex.org/W2034877810","https://openalex.org/W2034937079","https://openalex.org/W2036175223","https://openalex.org/W2037061225","https://openalex.org/W2040838085","https://openalex.org/W2041094538","https://openalex.org/W2043213772","https://openalex.org/W2044025957","https://openalex.org/W2044512941","https://openalex.org/W2046036275","https://openalex.org/W2048626660","https://openalex.org/W2049629794","https://openalex.org/W2049723400","https://openalex.org/W2050473688","https://openalex.org/W2051404142","https://openalex.org/W2052207245","https://openalex.org/W2052836649","https://openalex.org/W2054080837","https://openalex.org/W2054670704","https://openalex.org/W2055323045","https://openalex.org/W2058362482","https://openalex.org/W2058844233","https://openalex.org/W2060312395","https://openalex.org/W2061206204","https://openalex.org/W2061507519","https://openalex.org/W2063733110","https://openalex.org/W2064881832","https://openalex.org/W2065508639","https://openalex.org/W2067043949","https://openalex.org/W2070972996","https://openalex.org/W2071863426","https://openalex.org/W2072652145","https://openalex.org/W2073566101","https://openalex.org/W2073688589","https://openalex.org/W2074313357","https://openalex.org/W2076058809","https://openalex.org/W2076727938","https://openalex.org/W2078198072","https://openalex.org/W2079212525","https://openalex.org/W2080956086","https://openalex.org/W2081502384","https://openalex.org/W2082966751","https://openalex.org/W2083737302","https://openalex.org/W2084611222","https://openalex.org/W2086172007","https://openalex.org/W2086661254","https://openalex.org/W2086917665","https://openalex.org/W2087526889","https://openalex.org/W2089749009","https://openalex.org/W2089844380","https://openalex.org/W2091256934","https://openalex.org/W2093058475","https://openalex.org/W2094030933","https://openalex.org/W2096736282","https://openalex.org/W2102348355","https://openalex.org/W2102790920","https://openalex.org/W2103054682","https://openalex.org/W2106669376","https://openalex.org/W2106850730","https://openalex.org/W2109901169","https://openalex.org/W2111344966","https://openalex.org/W2113059823","https://openalex.org/W2116352082","https://openalex.org/W2118352951","https://openalex.org/W2119438647","https://openalex.org/W2119848850","https://openalex.org/W2125540086","https://openalex.org/W2126193485","https://openalex.org/W2128857363","https://openalex.org/W2130043515","https://openalex.org/W2131282155","https://openalex.org/W2137468466","https://openalex.org/W2138174591","https://openalex.org/W2138937703","https://openalex.org/W2142575954","https://openalex.org/W2142582268","https://openalex.org/W2149413915","https://openalex.org/W2150345297","https://openalex.org/W2151468070","https://openalex.org/W2154438445","https://openalex.org/W2154757961","https://openalex.org/W2159665192","https://openalex.org/W2161659922","https://openalex.org/W2163909457","https://openalex.org/W2165638433","https://openalex.org/W2168707268","https://openalex.org/W2170947255","https://openalex.org/W2171408668","https://openalex.org/W2174570609","https://openalex.org/W2195052681","https://openalex.org/W2237902910","https://openalex.org/W2252342479","https://openalex.org/W2313308895","https://openalex.org/W2313467754","https://openalex.org/W2321170381","https://openalex.org/W2324268873","https://openalex.org/W2330826514","https://openalex.org/W2331919277","https://openalex.org/W2336362345","https://openalex.org/W2336464709","https://openalex.org/W2400184104","https://openalex.org/W2402300360","https://openalex.org/W2418137650","https://openalex.org/W2418874383","https://openalex.org/W2421395535","https://openalex.org/W2578150941","https://openalex.org/W2616562178","https://openalex.org/W4235548457","https://openalex.org/W4327766726","https://openalex.org/W6657627873","https://openalex.org/W6811469146"],"related_works":["https://openalex.org/W7014702832","https://openalex.org/W2049629794","https://openalex.org/W2035011133","https://openalex.org/W2119438647","https://openalex.org/W2008963496","https://openalex.org/W4240445316","https://openalex.org/W2138771206","https://openalex.org/W2051404142","https://openalex.org/W2056077259","https://openalex.org/W2110391922"],"abstract_inverted_index":{"Autoimmune":[0],"polyendocrine":[1],"syndrome":[2],"type":[3],"I":[4,38,87,96,119,132],"(APS":[5],"I)":[6],"is":[7],"characterized":[8],"by":[9,80],"autoantibodies,":[10],"often":[11],"directed":[12,197],"towards":[13,155,198],"tissue-specific":[14],"enzymes":[15],"in":[16,36,64,76,107],"the":[17,24,55,65,94,108,113,129,151,181,202],"affected":[18],"organs.":[19],"We":[20],"have":[21],"earlier":[22],"reported":[23],"identification":[25],"of":[26,57,67,117,139,150],"tryptophan":[27],"hydroxylase":[28,32,52],"(TPH)":[29],"and":[30,43,89,102,162,194],"tyrosine":[31],"(TH)":[33],"as":[34],"autoantigens":[35],"APS":[37,86,95,118,131],"associated":[39],"with":[40,50,82,112,122,135,188],"intestinal":[41],"dysfunction":[42],"alopecia,":[44],"respectively.":[45],"These":[46],"two":[47,203],"enzymes,":[48,157],"together":[49],"phenylalanine":[51],"(PAH),":[53],"constitute":[54],"group":[56],"biopterin-dependent":[58],"hydroxylases,":[59],"which":[60],"all":[61,156],"are":[62,196],"involved":[63],"biosynthesis":[66],"neurotransmitters.":[68],"A":[69],"clone":[70],"encoding":[71],"PAH":[72,100,123,184],"was":[73,105,120],"used":[74],"for":[75,201],"vitro":[77],"transcription/translation,":[78],"followed":[79],"immunoprecipitation":[81],"sera":[83,127,152,168],"from":[84,128],"94":[85,130],"patients":[88,133],"70":[90],"healthy":[91],"controls.":[92,109],"Of":[93],"patients,":[97],"25%":[98],"had":[99],"antibodies,":[101],"no":[103,147],"reactivity":[104,182],"detected":[106],"No":[110,167],"association":[111],"main":[114],"clinical":[115],"components":[116],"found":[121],"antibodies.":[124],"Altogether,":[125],"59":[126],"reacted":[134,172],"at":[136],"least":[137],"one":[138],"TPH,":[140,189],"TH,":[141],"or":[142],"PAH,":[143],"whereas":[144,190],"35":[145],"showed":[146,169],"reactivity.":[148],"Nineteen":[149],"contained":[153],"antibodies":[154,170,191],"12":[158,163],"to":[159,164,173],"TPH":[160,193],"only":[161,174],"TH":[165,195],"only.":[166],"that":[171,180],"PAH.":[175],"An":[176],"immunocompetition":[177],"assay":[178],"demonstrated":[179],"against":[183,192],"represents":[185],"a":[186],"cross-reactivity":[187],"epitopes":[199],"unique":[200],"enzymes.":[204]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}