{"id":"https://openalex.org/W2057514545","doi":"https://doi.org/10.1038/ajg.2013.371","title":"Sensitivity Testing in Irritable Bowel Syndrome With Rectal Capsaicin Stimulations: Role of TRPV1 Upregulation and Sensitization in Visceral Hypersensitivity?","display_name":"Sensitivity Testing in Irritable Bowel Syndrome With Rectal Capsaicin Stimulations: Role of TRPV1 Upregulation and Sensitization in Visceral Hypersensitivity?","publication_year":2013,"publication_date":"2013-11-05","ids":{"openalex":"https://openalex.org/W2057514545","doi":"https://doi.org/10.1038/ajg.2013.371","mag":"2057514545","pmid":"https://pubmed.ncbi.nlm.nih.gov/24189713"},"language":"en","primary_location":{"id":"doi:10.1038/ajg.2013.371","doi":"https://doi.org/10.1038/ajg.2013.371","is_oa":false,"landing_page_url":"https://doi.org/10.1038/ajg.2013.371","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088942694","display_name":"Sander van Wanrooij","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Sander J M van Wanrooij","raw_affiliation_strings":["1] Translational Research Center for Gastrointestinal Disorders, Leuven University, Leuven, Belgium [2] These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1] Translational Research Center for Gastrointestinal Disorders, Leuven University, Leuven, Belgium [2] These authors contributed equally to this work","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042940137","display_name":"Mira M. Wouters","orcid":"https://orcid.org/0000-0002-3438-1919","observed_orcids":["https://orcid.org/0000-0002-3438-1919"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Mira M Wouters","raw_affiliation_strings":["1] Translational Research Center for Gastrointestinal Disorders, Leuven University, Leuven, Belgium [2] These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1] Translational Research Center for Gastrointestinal Disorders, Leuven University, Leuven, Belgium [2] These authors contributed equally to this work","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001562615","display_name":"Lukas Van Oudenhove","orcid":"https://orcid.org/0000-0002-6540-3113","observed_orcids":["https://orcid.org/0000-0002-6540-3113"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Lukas Van Oudenhove","raw_affiliation_strings":["Translational Research Center for Gastrointestinal Disorders, Leuven University, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Research Center for Gastrointestinal Disorders, Leuven University, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068109237","display_name":"Winde Vanbrabant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Winde Vanbrabant","raw_affiliation_strings":["Translational Research Center for Gastrointestinal Disorders, Leuven University, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Research Center for Gastrointestinal Disorders, Leuven University, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032566748","display_name":"St\u00e9phanie Mondelaers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"St\u00e9phanie Mondelaers","raw_affiliation_strings":["Translational Research Center for Gastrointestinal Disorders, Leuven University, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Research Center for Gastrointestinal Disorders, Leuven University, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015031921","display_name":"Patrick Kollmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Patrick Kollmann","raw_affiliation_strings":["Department of Human Biology, TU Munchen, Freising, Germany","Department of Human Biology, TU M\u00fcnchen, Freising, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Biology, TU Munchen, Freising, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Department of Human Biology, TU M\u00fcnchen, Freising, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040405142","display_name":"Florian Kreutz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Florian Kreutz","raw_affiliation_strings":["Department of Human Biology, TU Munchen, Freising, Germany","Department of Human Biology, TU M\u00fcnchen, Freising, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Biology, TU Munchen, Freising, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Department of Human Biology, TU M\u00fcnchen, Freising, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044612561","display_name":"Michael Schemann","orcid":"https://orcid.org/0000-0003-1007-9843","observed_orcids":["https://orcid.org/0000-0003-1007-9843","https://orcid.org/0009-0002-4069-2251"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Schemann","raw_affiliation_strings":["Department of Human Biology, TU Munchen, Freising, Germany","Department of Human Biology, TU M\u00fcnchen, Freising, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Biology, TU Munchen, Freising, Germany","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Department of Human Biology, TU M\u00fcnchen, Freising, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051093942","display_name":"Guy E. Boeckxstaens","orcid":"https://orcid.org/0000-0001-8267-5797","observed_orcids":["https://orcid.org/0000-0001-8267-5797"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Guy E Boeckxstaens","raw_affiliation_strings":["Translational Research Center for Gastrointestinal Disorders, Leuven University, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Research Center for Gastrointestinal Disorders, Leuven University, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5051093942"],"corresponding_institution_ids":["https://openalex.org/I99464096"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":9.4052,"has_fulltext":false,"cited_by_count":103,"citation_normalized_percentile":{"value":0.98228421,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"109","issue":"1","first_page":"99","last_page":"109"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irritable-bowel-syndrome","display_name":"irritable bowel syndrome","score":0.9950000047683716},{"id":"https://openalex.org/keywords/visceral-hypersensitivity","display_name":"visceral hypersensitivity","score":0.996999979019165},{"id":"https://openalex.org/keywords/trpv1","display_name":"TRPV1","score":0.972000002861023},{"id":"https://openalex.org/keywords/capsaicin","display_name":"capsaicin","score":0.8420000076293945},{"id":"https://openalex.org/keywords/rectal-distension","display_name":"rectal distension","score":0.9110000133514404},{"id":"https://openalex.org/keywords/visceral-pain-perception","display_name":"visceral pain perception","score":0.8339999914169312},{"id":"https://openalex.org/keywords/nociception","display_name":"nociception","score":0.6389999985694885},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.6880000233650208},{"id":"https://openalex.org/keywords/rectal-mucosa","display_name":"rectal mucosa","score":0.6150000095367432},{"id":"https://openalex.org/keywords/symptom-severity","display_name":"symptom severity","score":0.3619999885559082},{"id":"https://openalex.org/keywords/stool-frequency","display_name":"stool frequency","score":0.5690000057220459},{"id":"https://openalex.org/keywords/abdominal-pain","display_name":"abdominal pain","score":0.8339999914169312},{"id":"https://openalex.org/keywords/loose-stools","display_name":"loose stools","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.920854926109314},{"id":"https://openalex.org/C2778271842","wikidata":"https://www.wikidata.org/wiki/Q838966","display_name":"Irritable bowel syndrome","level":2,"score":0.8432635068893433},{"id":"https://openalex.org/C160145004","wikidata":"https://www.wikidata.org/wiki/Q413209","display_name":"TRPV1","level":4,"score":0.7239087224006653},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.6548157930374146},{"id":"https://openalex.org/C2779794527","wikidata":"https://www.wikidata.org/wiki/Q4116360","display_name":"Visceral pain","level":4,"score":0.6253073811531067},{"id":"https://openalex.org/C2780051329","wikidata":"https://www.wikidata.org/wiki/Q273169","display_name":"Capsaicin","level":3,"score":0.6244388818740845},{"id":"https://openalex.org/C2776625112","wikidata":"https://www.wikidata.org/wiki/Q5282934","display_name":"Distension","level":2,"score":0.6011998653411865},{"id":"https://openalex.org/C172659308","wikidata":"https://www.wikidata.org/wiki/Q412542","display_name":"Nociceptor","level":4,"score":0.5984313488006592},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.5476759672164917},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5050252079963684},{"id":"https://openalex.org/C14184104","wikidata":"https://www.wikidata.org/wiki/Q1362526","display_name":"Visual analogue scale","level":2,"score":0.4933857023715973},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.45035040378570557},{"id":"https://openalex.org/C3673659","wikidata":"https://www.wikidata.org/wiki/Q1098125","display_name":"Threshold of pain","level":2,"score":0.4138965308666229},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.409893274307251},{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.2687656283378601},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12167015671730042},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.10640722513198853}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002211","descriptor_name":"Capsaicin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009619","descriptor_name":"Nociceptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012007","descriptor_name":"Rectum","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":true},{"descriptor_ui":"D012007","descriptor_name":"Rectum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015746","descriptor_name":"Abdominal Pain","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D015746","descriptor_name":"Abdominal Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017288","descriptor_name":"Pain Threshold","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017288","descriptor_name":"Pain Threshold","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D018689","descriptor_name":"Sensory System Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D050916","descriptor_name":"TRPV Cation Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050916","descriptor_name":"TRPV Cation Channels","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D059225","descriptor_name":"Nociception","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/ajg.2013.371","doi":"https://doi.org/10.1038/ajg.2013.371","is_oa":false,"landing_page_url":"https://doi.org/10.1038/ajg.2013.371","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},{"id":"pmid:24189713","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24189713","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of gastroenterology","raw_type":"Journal Article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/486935","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24189713","pdf_url":null,"source":{"id":"https://openalex.org/S4306401954","display_name":"Lirias (KU Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Journal Of Gastroenterology, vol. 109 (1), Art.No. 10.1038/ajg.2013.371, (99-109)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W97582216","https://openalex.org/W1502599914","https://openalex.org/W1542859323","https://openalex.org/W1596758664","https://openalex.org/W1971964695","https://openalex.org/W1980588138","https://openalex.org/W1981639311","https://openalex.org/W2014215730","https://openalex.org/W2020268720","https://openalex.org/W2023226728","https://openalex.org/W2023736621","https://openalex.org/W2027572920","https://openalex.org/W2032901281","https://openalex.org/W2048358400","https://openalex.org/W2051155099","https://openalex.org/W2051242541","https://openalex.org/W2058878920","https://openalex.org/W2064201279","https://openalex.org/W2064441047","https://openalex.org/W2064683282","https://openalex.org/W2073987430","https://openalex.org/W2087717115","https://openalex.org/W2092505454","https://openalex.org/W2096256974","https://openalex.org/W2102865615","https://openalex.org/W2103744963","https://openalex.org/W2104984002","https://openalex.org/W2107026046","https://openalex.org/W2107869127","https://openalex.org/W2107988902","https://openalex.org/W2108244474","https://openalex.org/W2116511946","https://openalex.org/W2124136032","https://openalex.org/W2125214757","https://openalex.org/W2129921159","https://openalex.org/W2130505437","https://openalex.org/W2131790950","https://openalex.org/W2137048847","https://openalex.org/W2141539606","https://openalex.org/W2154410960","https://openalex.org/W2165979101"],"related_works":["https://openalex.org/W2165979101","https://openalex.org/W2203163745","https://openalex.org/W4237737439","https://openalex.org/W2357384565","https://openalex.org/W2909030626","https://openalex.org/W2414974981","https://openalex.org/W1730897712","https://openalex.org/W2347281377","https://openalex.org/W6991075198","https://openalex.org/W4408863522"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Abnormal":[1],"pain":[2,207,245,306,329,361],"perception":[3,66,208,228,246,307,330,362],"or":[4,150,279,310,316],"visceral":[5,65],"hypersensitivity":[6],"(VH)":[7],"is":[8,69],"considered":[9],"to":[10,77,85,109,115,144,159,197,308,324,331,363],"be":[11,349],"an":[12,339],"important":[13,47],"mechanism":[14],"underlying":[15],"symptoms":[16,90,254,312],"in":[17,38,52,64,67,83,91,153,177,211,272,277,287,313],"a":[18,45,169,225,383],"subgroup":[19],"of":[20,41,55,62,73,81,98,113,190,204,229,256,334],"irritable":[21],"bowel":[22],"syndrome":[23],"(IBS)":[24],"patients.":[25],"Increased":[26,244],"TRPV1":[27,63,82,175,283,299,346],"(transient":[28],"receptor":[29,380],"potential":[30],"cation":[31],"channel":[32],"subfamily":[33],"V":[34],"member":[35],"1)":[36],"expression":[37,176,284,297,300],"rectal":[39,86,116,119,127,146,178,198,282,325,332,364],"biopsies":[40,179],"IBS":[42,68,100,192,214,314,320],"patients":[43,92,101,193,215,223,240,274,315,321],"suggests":[44],"potentially":[46],"role":[48,80],"for":[49,345],"this":[50,74],"nociceptor":[51],"the":[53,60,79,145,267,317],"pathophysiology":[54],"IBS.":[56,94],"However,":[57,281],"evidence":[58,344],"underscoring":[59],"involvement":[61],"lacking.":[70],"The":[71],"objective":[72],"study":[75],"was":[76,124,142,180,209,247,270,285],"evaluate":[78],"VH":[84,323,353],"distension":[87,128,138,326],"and":[88,102,118,132,163,184,206,213,219,242,252,261,290,295,354,373],"clinical":[89,311],"with":[93,238,250,305,322,359,378],"METHODS:":[95],"A":[96,188,201],"total":[97,189],"48":[99],"25":[103],"healthy":[104],"volunteers":[105],"(HVs)":[106],"were":[107,166,195],"invited":[108],"undergo":[110],"subsequent":[111],"assessment":[112],"sensitivity":[114,123,381],"distensions":[117,199],"capsaicin":[120,217,235,309,365],"applications.":[121,221],"Visceral":[122,156],"evaluated":[125],"by":[126,182],"at":[129],"3,":[130],"9,":[131],"21":[133],"mm":[134],"Hg":[135],"above":[136],"minimal":[137],"pressure":[139],"(MDP).":[140],"Capsaicin":[141],"applied":[143],"mucosa":[147],"(0.01%,":[148],"0.1%,":[149],"solvent":[151],"only":[152],"random":[154],"order).":[155],"sensations":[157],"(urge":[158],"defecate,":[160],"pain,":[161,230,258],"burning,":[162],"warmth":[164],"sensation)":[165],"scored":[167],"on":[168,292],"100-mm":[170],"visual":[171],"analog":[172],"scale":[173],"(VAS).":[174],"determined":[181],"immunohistochemistry":[183],"real-time":[185],"PCR.":[186],"RESULTS:":[187],"23":[191],"(48%)":[194],"hypersensitive":[196],"(VH-IBS).":[200],"concentration-dependent":[202],"increase":[203],"urge":[205],"present":[210],"HVs":[212,291],"during":[216,234,266],"0.01":[218],"0.1%":[220],"VH-IBS":[222,273],"experienced":[224,265],"significantly":[226,248],"increased":[227,328,340,360,379],"but":[231,275],"not":[232,276,303],"urge,":[233],"applications":[236],"compared":[237],"normosensitive":[239],"(ns-IBS)":[241],"HVs.":[243,280],"associated":[249,358],"anxiety":[251,341,355],"VH,":[253],"scores":[255],"abdominal":[257],"loose":[259],"stools,":[260],"stool":[262],"frequency.":[263],"Anxiety":[264],"experimental":[268],"procedure":[269],"enhanced":[271],"ns-IBS":[278],"similar":[286],"VH-IBS,":[288],"ns-IBS,":[289],"both":[293,352,371],"mRNA":[294],"protein":[296],"levels.":[298],"levels":[301],"did":[302],"correlate":[304],"subgroups.":[318],"CONCLUSIONS:":[319],"reveal":[327],"application":[333],"capsaicin,":[335],"as":[336,338,382],"well":[337],"response.":[342],"No":[343],"upregulation":[347],"could":[348],"demonstrated.":[350],"As":[351],"are":[356,376],"independently":[357],"application,":[366],"our":[367],"data":[368],"suggest":[369],"that":[370],"peripheral":[372],"central":[374],"factors":[375],"involved,":[377],"speculative":[384],"possibility.":[385]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}