{"id":"https://openalex.org/W2057512940","doi":"https://doi.org/10.1007/s00018-002-8447-1","title":"Identification and characterisation of two allelic forms of human alcohol dehydrogenase 2","display_name":"Identification and characterisation of two allelic forms of human alcohol dehydrogenase 2","publication_year":2002,"publication_date":"2002-03-01","ids":{"openalex":"https://openalex.org/W2057512940","doi":"https://doi.org/10.1007/s00018-002-8447-1","mag":"2057512940","pmid":"https://pubmed.ncbi.nlm.nih.gov/11964133","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11337534"},"language":"en","primary_location":{"id":"doi:10.1007/s00018-002-8447-1","doi":"https://doi.org/10.1007/s00018-002-8447-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00018-002-8447-1","pdf_url":null,"source":{"id":"https://openalex.org/S60362788","display_name":"Cellular and Molecular Life Sciences","issn_l":"1420-682X","issn":["1420-682X","1420-9071"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Life Sciences (CMLS)","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11337534/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012631421","display_name":"Patrik Str\u00f6mberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"P. Str\u00f6mberg","raw_affiliation_strings":["Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden","Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm (Sweden), Fax +46 8 338453, e-mail: jan-olov.hoog@mbb.ki.se, , SE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm (Sweden), Fax +46 8 338453, e-mail: jan-olov.hoog@mbb.ki.se, , SE","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109847263","display_name":"Stefan Svensson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"S. Svensson","raw_affiliation_strings":["Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm (Sweden), Fax +46 8 338453, e-mail: jan-olov.hoog@mbb.ki.se, , SE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm (Sweden), Fax +46 8 338453, e-mail: jan-olov.hoog@mbb.ki.se, , SE","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019764141","display_name":"Jesper J. Hedberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"J. J. Hedberg","raw_affiliation_strings":["Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm (Sweden), Fax +46 8 338453, e-mail: jan-olov.hoog@mbb.ki.se, , SE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm (Sweden), Fax +46 8 338453, e-mail: jan-olov.hoog@mbb.ki.se, , SE","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021715811","display_name":"Erik Nordling","orcid":"https://orcid.org/0000-0001-9310-7947","observed_orcids":["https://orcid.org/0000-0001-9310-7947"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"E. Nordling","raw_affiliation_strings":["Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm (Sweden), Fax +46 8 338453, e-mail: jan-olov.hoog@mbb.ki.se, , SE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm (Sweden), Fax +46 8 338453, e-mail: jan-olov.hoog@mbb.ki.se, , SE","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108470484","display_name":"J O H\u00f6\u00f6g","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"J.-O. H\u00f6\u00f6g","raw_affiliation_strings":["Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm (Sweden), Fax +46 8 338453, e-mail: jan-olov.hoog@mbb.ki.se, , SE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm (Sweden), Fax +46 8 338453, e-mail: jan-olov.hoog@mbb.ki.se, , SE","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":{"value":4290,"currency":"USD","value_usd":4290},"apc_paid":null,"fwci":0.6616,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.70034678,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"59","issue":"3","first_page":"552","last_page":"559"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.7666000127792358,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.7666000127792358,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.1941000074148178,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adh2","display_name":"ADH2","score":0.9300000071525574},{"id":"https://openalex.org/keywords/allelic-variants","display_name":"allelic variants","score":0.7820000052452087},{"id":"https://openalex.org/keywords/functional-polymorphisms","display_name":"functional polymorphisms","score":0.6830000281333923},{"id":"https://openalex.org/keywords/protein-thermostability","display_name":"protein thermal stability","score":0.9480000138282776},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.7429999709129333},{"id":"https://openalex.org/keywords/alcohol-metabolism","display_name":"alcohol metabolism","score":0.8199999928474426},{"id":"https://openalex.org/keywords/subunit-interface","display_name":"subunit interface","score":0.5709999799728394},{"id":"https://openalex.org/keywords/active-site-pocket","display_name":"active site pocket","score":0.8610000014305115},{"id":"https://openalex.org/keywords/swedish-population","display_name":"Swedish population","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C2777344606","wikidata":"https://www.wikidata.org/wiki/Q410754","display_name":"Alcohol dehydrogenase","level":3,"score":0.8090101480484009},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.678645670413971},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.654396653175354},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6159876585006714},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4720795154571533},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.46833133697509766},{"id":"https://openalex.org/C96722902","wikidata":"https://www.wikidata.org/wiki/Q17710244","display_name":"ADH1B","level":5,"score":0.4339596629142761},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.37400978803634644},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.26930421590805054},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2666182816028595},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20050904154777527},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1862870156764984},{"id":"https://openalex.org/C151325109","wikidata":"https://www.wikidata.org/wiki/Q22327132","display_name":"Branched-chain alpha-keto acid dehydrogenase complex","level":4,"score":0.059852272272109985},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000426","descriptor_name":"Alcohol Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000426","descriptor_name":"Alcohol Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000426","descriptor_name":"Alcohol Dehydrogenase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004795","descriptor_name":"Enzyme Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s00018-002-8447-1","doi":"https://doi.org/10.1007/s00018-002-8447-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00018-002-8447-1","pdf_url":null,"source":{"id":"https://openalex.org/S60362788","display_name":"Cellular and Molecular Life Sciences","issn_l":"1420-682X","issn":["1420-682X","1420-9071"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Life Sciences (CMLS)","raw_type":"journal-article"},{"id":"pmid:11964133","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11964133","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and molecular life sciences : CMLS","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11337534","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11337534/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Mol Life Sci","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:11337534","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11337534/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Mol Life Sci","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W314352301","https://openalex.org/W1244636074","https://openalex.org/W1428317609","https://openalex.org/W1485839956","https://openalex.org/W1530704185","https://openalex.org/W1545782352","https://openalex.org/W1547353612","https://openalex.org/W1844185706","https://openalex.org/W1919261229","https://openalex.org/W1969774315","https://openalex.org/W1970168533","https://openalex.org/W1972293382","https://openalex.org/W1981491788","https://openalex.org/W1981893445","https://openalex.org/W1985485776","https://openalex.org/W2002551479","https://openalex.org/W2003699602","https://openalex.org/W2004575181","https://openalex.org/W2009310386","https://openalex.org/W2014239620","https://openalex.org/W2021723651","https://openalex.org/W2025311575","https://openalex.org/W2028638028","https://openalex.org/W2030465353","https://openalex.org/W2038109234","https://openalex.org/W2040644205","https://openalex.org/W2046299897","https://openalex.org/W2056872782","https://openalex.org/W2061008984","https://openalex.org/W2061833373","https://openalex.org/W2064712345","https://openalex.org/W2065283382","https://openalex.org/W2083625623","https://openalex.org/W2089224327","https://openalex.org/W2090222771","https://openalex.org/W2110529416","https://openalex.org/W2130479394","https://openalex.org/W2148911584","https://openalex.org/W2259213752","https://openalex.org/W2318048476","https://openalex.org/W4242643049","https://openalex.org/W4246149139"],"related_works":["https://openalex.org/W2412479124","https://openalex.org/W2002283636","https://openalex.org/W1554913569","https://openalex.org/W253679275","https://openalex.org/W2002616593","https://openalex.org/W2149793095","https://openalex.org/W2039562556","https://openalex.org/W7075680390","https://openalex.org/W162258464","https://openalex.org/W1895217811"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}