{"id":"https://openalex.org/W2057472767","doi":"https://doi.org/10.1200/jco.2011.39.1300","title":"Molecular States Underlying Androgen Receptor Activation: A Framework for Therapeutics Targeting Androgen Signaling in Prostate Cancer","display_name":"Molecular States Underlying Androgen Receptor Activation: A Framework for Therapeutics Targeting Androgen Signaling in Prostate Cancer","publication_year":2011,"publication_date":"2011-12-19","ids":{"openalex":"https://openalex.org/W2057472767","doi":"https://doi.org/10.1200/jco.2011.39.1300","mag":"2057472767","pmid":"https://pubmed.ncbi.nlm.nih.gov/22184375"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2011.39.1300","doi":"https://doi.org/10.1200/jco.2011.39.1300","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2011.39.1300","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067800417","display_name":"Peter S. Nelson","orcid":"https://orcid.org/0000-0002-5451-5726","observed_orcids":["https://orcid.org/0000-0002-5451-5726"]},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter S. Nelson","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center, Seattle, WA","Division of Human Biology, Mailstop D4-100, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, Seattle, WA 98109-1024, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center, Seattle, WA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Division of Human Biology, Mailstop D4-100, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, Seattle, WA 98109-1024, USA","institution_ids":["https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5067800417"],"corresponding_institution_ids":["https://openalex.org/I4210089486"],"apc_list":null,"apc_paid":null,"fwci":3.7405,"has_fulltext":false,"cited_by_count":144,"citation_normalized_percentile":{"value":0.93469211,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"30","issue":"6","first_page":"644","last_page":"646"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.9290000200271606},{"id":"https://openalex.org/keywords/androgen-receptor-activation","display_name":"androgen receptor activation","score":0.9470000267028809},{"id":"https://openalex.org/keywords/androgen-signaling","display_name":"androgen signaling","score":0.9380000233650208},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.9929999709129333},{"id":"https://openalex.org/keywords/molecular-states","display_name":"molecular states","score":0.7070000171661377},{"id":"https://openalex.org/keywords/androgen-receptor-antagonists","display_name":"androgen receptor antagonists","score":0.734000027179718},{"id":"https://openalex.org/keywords/therapeutic-targeting","display_name":"therapeutic targeting","score":0.36500000953674316}],"concepts":[{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.8331810235977173},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.7464473843574524},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.68255615234375},{"id":"https://openalex.org/C2778805511","wikidata":"https://www.wikidata.org/wiki/Q1713","display_name":"Citation","level":2,"score":0.5856587290763855},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.533121645450592},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.4907561242580414},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4548807740211487},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40951642394065857},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37744879722595215},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.17999106645584106},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.10195496678352356},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000736","descriptor_name":"Androstenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000737","descriptor_name":"Androstenols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011944","descriptor_name":"Receptors, Androgen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1200/jco.2011.39.1300","doi":"https://doi.org/10.1200/jco.2011.39.1300","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2011.39.1300","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:22184375","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22184375","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1533310838","https://openalex.org/W1975609403","https://openalex.org/W1994047807","https://openalex.org/W2002372801","https://openalex.org/W2003955264","https://openalex.org/W2005658600","https://openalex.org/W2014476883","https://openalex.org/W2028368645","https://openalex.org/W2058596530","https://openalex.org/W2069791479","https://openalex.org/W2077301757","https://openalex.org/W2080134152","https://openalex.org/W2081365151","https://openalex.org/W2085540431","https://openalex.org/W2085847636","https://openalex.org/W2097226696","https://openalex.org/W2108955823","https://openalex.org/W2110534364","https://openalex.org/W2118238803","https://openalex.org/W2119504728","https://openalex.org/W2140855177","https://openalex.org/W2141569270","https://openalex.org/W2147166694","https://openalex.org/W2149131962","https://openalex.org/W2150775704","https://openalex.org/W2156215080","https://openalex.org/W2165782799","https://openalex.org/W2318289184","https://openalex.org/W2401732123","https://openalex.org/W2417902728"],"related_works":["https://openalex.org/W2075014972","https://openalex.org/W4410971284","https://openalex.org/W4240306610","https://openalex.org/W2588824678","https://openalex.org/W3204287984","https://openalex.org/W2789733998","https://openalex.org/W4406960401","https://openalex.org/W3003957700","https://openalex.org/W2317297955","https://openalex.org/W4402161974"],"abstract_inverted_index":{"Article":[0,5],"Tools":[1,6],"UNDERSTANDING":[2],"THE":[3],"PATHWAY":[4],"OPTIONS":[7],"&":[8,18],"TOOLS":[9],"Export":[10],"Citation":[11,13],"Track":[12],"Add":[14],"To":[15],"Favorites":[16],"Rights":[17],"Permissions":[19],"COMPANION":[20],"ARTICLES":[21],"No":[22],"companion":[23],"articles":[24,65],"ARTICLE":[25],"CITATION":[26],"DOI:":[27],"10.1200/JCO.2011.39.1300":[28],"Journal":[29],"of":[30,93],"Clinical":[31,94],"Oncology":[32,95],"-":[33],"published":[34],"online":[35],"before":[36],"print":[37],"December":[38],"19,":[39],"2011":[40,89],"PMID:":[41],"22184375":[42],"Molecular":[43],"States":[44],"Underlying":[45],"Androgen":[46,54],"Receptor":[47],"Activation:":[48],"A":[49],"Framework":[50],"for":[51,64],"Therapeutics":[52],"Targeting":[53],"Signaling":[55],"in":[56],"Prostate":[57],"Cancer":[58,73],"Peter":[59],"S.":[60,62],"NelsonxPeter":[61],"NelsonSearch":[63],"by":[66,90],"this":[67],"author":[68],"Show":[69],"More":[70],"Fred":[71],"Hutchinson":[72],"Research":[74],"Center,":[75],"Seattle,":[76],"WA":[77],"https://doi.org/10.1200/JCO.2011.39.1300":[78],"First":[79],"Page":[80],"Full":[81],"Text":[82],"PDF":[83],"Figures":[84],"and":[85],"Tables":[86],"Supplements":[87],"\u00a9":[88],"American":[91],"Society":[92]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":24},{"year":2013,"cited_by_count":11}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
