{"id":"https://openalex.org/W2057412334","doi":"https://doi.org/10.1126/science.149.3682.432","title":"Adult Thymectomy: Effect on Recovery from Immunologic Depression in Mice","display_name":"Adult Thymectomy: Effect on Recovery from Immunologic Depression in Mice","publication_year":1965,"publication_date":"1965-07-23","ids":{"openalex":"https://openalex.org/W2057412334","doi":"https://doi.org/10.1126/science.149.3682.432","mag":"2057412334","pmid":"https://pubmed.ncbi.nlm.nih.gov/17809411"},"language":"en","primary_location":{"id":"doi:10.1126/science.149.3682.432","doi":"https://doi.org/10.1126/science.149.3682.432","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.149.3682.432","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038938677","display_name":"Anthony P. Monaco","orcid":"https://orcid.org/0000-0001-7480-3197","observed_orcids":["https://orcid.org/0000-0001-7480-3197"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony P. Monaco","raw_affiliation_strings":["Department of Surgery, Massachusetts General Hospital, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Massachusetts General Hospital, Boston","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113573973","display_name":"MARY LEE WOOD","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary L. Wood","raw_affiliation_strings":["Department of Surgery, Massachusetts General Hospital, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Massachusetts General Hospital, Boston","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012790385","display_name":"Paul S. Russell","orcid":"https://orcid.org/0000-0002-1275-7348","observed_orcids":["https://orcid.org/0000-0002-1275-7348"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul S. Russell","raw_affiliation_strings":["Department of Surgery, Massachusetts General Hospital, Boston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Massachusetts General Hospital, Boston","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":11.79,"has_fulltext":false,"cited_by_count":114,"citation_normalized_percentile":{"value":0.99328859,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"149","issue":"3682","first_page":"432","last_page":"435"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thymectomy","display_name":"thymectomy","score":0.8510000109672546},{"id":"https://openalex.org/keywords/lymphopenia","display_name":"lymphopenia","score":0.7979999780654907},{"id":"https://openalex.org/keywords/lymphodepletion","display_name":"lymphocyte depletion","score":0.7059999704360962},{"id":"https://openalex.org/keywords/humoral-antibody-response","display_name":"humoral antibody response","score":0.777999997138977},{"id":"https://openalex.org/keywords/skin-allograft-rejection","display_name":"skin allograft rejection","score":0.8709999918937683},{"id":"https://openalex.org/keywords/allograft-survival","display_name":"allograft survival","score":0.6330000162124634},{"id":"https://openalex.org/keywords/immunologic-recovery","display_name":"immunologic recovery","score":0.5479999780654907},{"id":"https://openalex.org/keywords/a-jax-mice","display_name":"A/Jax mice","score":0.7160000205039978},{"id":"https://openalex.org/keywords/thymus","display_name":"thymus","score":0.6880000233650208}],"concepts":[{"id":"https://openalex.org/C2779615886","wikidata":"https://www.wikidata.org/wiki/Q3090790","display_name":"Thymectomy","level":3,"score":0.8436132669448853},{"id":"https://openalex.org/C91523082","wikidata":"https://www.wikidata.org/wiki/Q420496","display_name":"Antiserum","level":3,"score":0.6592912077903748},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5292315483093262},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.4770885407924652},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.4754894971847534},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42690831422805786},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4126984477043152},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41191989183425903},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3893479108810425},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3884245455265045},{"id":"https://openalex.org/C2778105408","wikidata":"https://www.wikidata.org/wiki/Q8285","display_name":"Myasthenia gravis","level":2,"score":0.10445362329483032},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1126/science.149.3682.432","doi":"https://doi.org/10.1126/science.149.3682.432","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.149.3682.432","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:17809411","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17809411","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:mouseion.jax.org:ssbb1965-1739","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/ssbb1965/740","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Subject Strain Bibliography 1965","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1484980546","https://openalex.org/W1551135499","https://openalex.org/W1914913321","https://openalex.org/W1929691604","https://openalex.org/W1982106777","https://openalex.org/W1983899113","https://openalex.org/W1986150849","https://openalex.org/W2007448975","https://openalex.org/W2023989811","https://openalex.org/W2033429841","https://openalex.org/W2053761503","https://openalex.org/W2062815579","https://openalex.org/W2074982841","https://openalex.org/W2079264541","https://openalex.org/W2080892470","https://openalex.org/W2082203073","https://openalex.org/W2087940114","https://openalex.org/W2134303933","https://openalex.org/W2162795469","https://openalex.org/W2170457801","https://openalex.org/W2414999346","https://openalex.org/W2419322159","https://openalex.org/W2470102268"],"related_works":["https://openalex.org/W1568228149","https://openalex.org/W1557880669","https://openalex.org/W142873737","https://openalex.org/W2409739245","https://openalex.org/W216304861","https://openalex.org/W2059301072","https://openalex.org/W1528050527","https://openalex.org/W6980970424","https://openalex.org/W1996338686","https://openalex.org/W1513881753"],"abstract_inverted_index":{"A/Jax":[0,10,71],"mice":[1,50,72],"treated":[2],"for":[3,21],"I":[4],"week":[5],"with":[6],"rabbit":[7],"antiserum":[8],"to":[9,43,74,79,111],"lymphocytes":[11],"showed":[12,34],"peripheral":[13,84],"lymphopenia":[14,87],"and":[15,41,59,64,85,88],"tissue":[16,60,86],"lymphocyte":[17,61],"depletion":[18],"which":[19,93],"persisted":[20,94,123],"4":[22,48],"weeks":[23,76],"after":[24],"initiation":[25],"of":[26,36,54,70,90],"serum":[27,55,80,104],"treatment.":[28,56],"During":[29],"this":[30],"time,":[31],"such":[32],"animals":[33,102],"depression":[35,89],"the":[37],"humoral":[38],"antibody":[39,91],"response":[40],"inability":[42],"reject":[44],"skin":[45,107],"allografts.":[46],"After":[47],"weeks,":[49],"recovered":[51],"from":[52],"effects":[53],"Normal":[57],"blood":[58],"levels":[62],"returned,":[63],"immunologic":[65],"competence":[66],"was":[67],"restored.":[68],"Thymectomy":[69],"(8":[73],"10":[75],"old)":[77],"prior":[78],"treatment":[81],"resulted":[82],"in":[83,115,120,127],"formation,":[92],"twice":[95],"as":[96,98],"long":[97],"that":[99],"shown":[100],"by":[101],"given":[103],"alone.":[105],"Similarly,":[106],"allografts":[108],"survive":[109],"two":[110],"four":[112],"times":[113],"longer":[114],"serum-treated":[116],"thymectomized":[117],"mice,":[118],"and,":[119],"some":[121],"cases":[122],"over":[124],"100":[125],"days":[126],"perfect":[128],"condition.":[129]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}