{"id":"https://openalex.org/W2057324853","doi":"https://doi.org/10.1111/j.1365-2125.2004.02314.x","title":"Childhood leukaemia: a relationship between intracellular 6\u2010mercaptopurine metabolites and neutropenia","display_name":"Childhood leukaemia: a relationship between intracellular 6\u2010mercaptopurine metabolites and neutropenia","publication_year":2004,"publication_date":"2004-12-01","ids":{"openalex":"https://openalex.org/W2057324853","doi":"https://doi.org/10.1111/j.1365-2125.2004.02314.x","mag":"2057324853","pmid":"https://pubmed.ncbi.nlm.nih.gov/15595985","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1884668"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2125.2004.02314.x","doi":"https://doi.org/10.1111/j.1365-2125.2004.02314.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2125.2004.02314.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.2004.02314.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.2004.02314.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089667999","display_name":"Lynne Lennard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91136226","display_name":"University of Sheffield","ror":"https://ror.org/05krs5044","country_code":"GB","type":"education","lineage":["https://openalex.org/I91136226"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L. Lennard","raw_affiliation_strings":["University of  Sheffield"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of  Sheffield","institution_ids":["https://openalex.org/I91136226"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111515613","display_name":"Corinne Rees","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C.A. Rees","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111379315","display_name":"J S Lilleyman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.S. Lilleyman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110056429","display_name":"John L. Maddocks","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.L. Maddocks","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":4.6922,"has_fulltext":false,"cited_by_count":159,"citation_normalized_percentile":{"value":0.95080259,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"58","issue":"7","first_page":"359","last_page":"63"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/6-mercaptopurine","display_name":"6-mercaptopurine","score":0.9769999980926514},{"id":"https://openalex.org/keywords/6-thioguanine-nucleotides","display_name":"6-thioguanine nucleotides","score":0.9800000190734863},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.7590000033378601},{"id":"https://openalex.org/keywords/myelosuppression","display_name":"myelosuppression","score":0.921999990940094},{"id":"https://openalex.org/keywords/childhood-acute-lymphoblastic-leukemia","display_name":"childhood acute lymphoblastic leukemia","score":0.9139999747276306},{"id":"https://openalex.org/keywords/remission-maintenance-therapy","display_name":"remission maintenance therapy","score":0.9620000123977661},{"id":"https://openalex.org/keywords/bone-marrow-derived-stem-cells","display_name":"bone marrow-derived stem cells","score":0.7540000081062317},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C2777173762","wikidata":"https://www.wikidata.org/wiki/Q418529","display_name":"Mercaptopurine","level":2,"score":0.8866922855377197},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.7318376302719116},{"id":"https://openalex.org/C74133956","wikidata":"https://www.wikidata.org/wiki/Q4669824","display_name":"Absolute neutrophil count","level":4,"score":0.6396507620811462},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6266415119171143},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5304348468780518},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5156902074813843},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.5144053101539612},{"id":"https://openalex.org/C512185932","wikidata":"https://www.wikidata.org/wiki/Q28745","display_name":"Nucleotide","level":3,"score":0.4935339689254761},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4579540491104126},{"id":"https://openalex.org/C2781107101","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Acute lymphocytic leukemia","level":4,"score":0.44892096519470215},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4098746180534363},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.3677269518375397},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36469578742980957},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.2416115403175354},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23787838220596313},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1093091368675232},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.10495427250862122},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009503","descriptor_name":"Neutropenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009503","descriptor_name":"Neutropenia","qualifier_ui":"Q000266","qualifier_name":"history","is_major_topic":true},{"descriptor_ui":"D015122","descriptor_name":"Mercaptopurine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015122","descriptor_name":"Mercaptopurine","qualifier_ui":"Q000266","qualifier_name":"history","is_major_topic":true},{"descriptor_ui":"D015122","descriptor_name":"Mercaptopurine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049673","descriptor_name":"History, 20th Century","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000266","qualifier_name":"history","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1111/j.1365-2125.2004.02314.x","doi":"https://doi.org/10.1111/j.1365-2125.2004.02314.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2125.2004.02314.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.2004.02314.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmid:15595985","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15595985","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of clinical pharmacology","raw_type":"Biography"},{"id":"pmid:6578834","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6578834","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of clinical pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1428034","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1428034/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Clin Pharmacol","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1884668","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1884668/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Clin Pharmacol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/j.1365-2125.2004.02314.x","doi":"https://doi.org/10.1111/j.1365-2125.2004.02314.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2125.2004.02314.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.2004.02314.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2057324853.pdf"},"referenced_works_count":4,"referenced_works":["https://openalex.org/W1535869422","https://openalex.org/W2043201217","https://openalex.org/W2069280442","https://openalex.org/W2096565219"],"related_works":["https://openalex.org/W2146765441","https://openalex.org/W2175441911","https://openalex.org/W4407981195","https://openalex.org/W2041279680","https://openalex.org/W2029476750","https://openalex.org/W2093793436","https://openalex.org/W1970459379","https://openalex.org/W1970856365","https://openalex.org/W2082600916","https://openalex.org/W2333978716"],"abstract_inverted_index":{"6-Mercaptopurine":[0,65],"is":[1,161],"extensively":[2],"used":[3,59],"in":[4,45,52],"the":[5,13,31,93,108,112,131,180,210],"treatment":[6],"of":[7,15,41,63,114,202,226],"childhood":[8],"lymphoblastic":[9,50],"leukaemia":[10,51],"to":[11,23,69,107],"prolong":[12],"duration":[14],"remission":[16,24],"achieved":[17],"with":[18,48,130,163,174,233],"other":[19],"drugs.":[20],"The":[21,54,224],"response":[22],"maintenance":[25],"therapy":[26],"varies":[27],"widely.":[28],"We":[29],"investigated":[30],"relationship":[32],"between":[33,182],"red":[34,245],"blood":[35,246],"cell":[36,247],"6-thioguanine":[37,70,102,126,183,211,227,248],"nucleotide,":[38],"a":[39,164],"metabolite":[40],"6-mercaptopurine,":[42,242],"and":[43,125,147,186,251],"myelosuppression":[44],"22":[46],"children":[47,173,237],"acute":[49],"remission.":[53],"peripheral":[55],"neutrophil":[56,109,132],"count":[57,110,133],"was":[58,67,105,204,216,253],"as":[60],"an":[61],"index":[62],"myelosuppression.":[64],"dose":[66,100,124,241],"related":[68,106],"nucleotide":[71,103,127,184,212,228,249],"concentration":[72,104,128,185,213],"(r":[73,137,189],"=":[74,81,84,138,145,149,156,190,197],"0.4;":[75],"P":[76,140,151,192],"less":[77,141,152,193],"than":[78,142,153,194,218],"0.001;":[79,195],"n":[80,144,155,196],"90;":[82],"y":[83],"18.51":[85],"+":[86],"0.36":[87],"x).":[88],"Large":[89],"individual":[90],"variations":[91],"around":[92],"regression":[94],"line":[95],"are":[96],"observed.":[97,255],"Neither":[98],"6-mercaptopurine":[99,123],"nor":[101],"at":[111,134],"time":[113],"sampling":[115],"(day":[116,214],"0)":[117,215],"or":[118],"7":[119],"days":[120],"later.":[121],"Both":[122],"correlated":[129],"day":[135,207],"14":[136,208],"-0.33;":[139],"0.01;":[143,154],"90":[146,157],"r":[148],"-0.3;":[150],"respectively).":[158],"This":[159],"delay":[160],"compatible":[162],"cytotoxic":[165],"action":[166],"on":[167,238],"bone":[168],"marrow":[169],"stem":[170],"cells.":[171],"Excluding":[172],"other,":[175],"uncontrolled,":[176],"potentially":[177],"myelosuppressive":[178],"influences":[179],"correlation":[181],"neutropenia":[187,203,252],"improved":[188],"-0.6;":[191],"37).":[198],"A":[199],"significant":[200],"degree":[201],"observed":[205],"by":[206],"if":[209],"greater":[217],"210":[219],"pmol/8":[220],"X":[221],"10(8)":[222],"RBCs.":[223],"assay":[225],"may":[229],"highlight":[230],"those":[231],"individuals":[232],"pharmacokinetic":[234],"resistance.":[235],"Two":[236],"continuous":[239],"high":[240],"had":[243],"low":[244],"concentrations":[250],"not":[254]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
