{"id":"https://openalex.org/W2057323738","doi":"https://doi.org/10.1159/000221452","title":"Effects of a New Sulfonamide Combination on Experimental Pyelonephritis","display_name":"Effects of a New Sulfonamide Combination on Experimental Pyelonephritis","publication_year":2009,"publication_date":"2009-05-25","ids":{"openalex":"https://openalex.org/W2057323738","doi":"https://doi.org/10.1159/000221452","mag":"2057323738","pmid":"https://pubmed.ncbi.nlm.nih.gov/4800999"},"language":"en","primary_location":{"id":"doi:10.1159/000221452","doi":"https://doi.org/10.1159/000221452","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000221452","pdf_url":null,"source":{"id":"https://openalex.org/S92531173","display_name":"Chemotherapy","issn_l":"0009-3157","issn":["0009-3157","1421-9794"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025758546","display_name":"A Obek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"A. \u00d6bek","raw_affiliation_strings":["Department of Internal Medicine, Bursa Medical Faculty and Departments of Microbiology, Pharmacology, Histology and Pathological Anatomy, Istanbul Medical Faculty, University of Istanbul, Istanbul"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Bursa Medical Faculty and Departments of Microbiology, Pharmacology, Histology and Pathological Anatomy, Istanbul Medical Faculty, University of Istanbul, Istanbul","institution_ids":["https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109916981","display_name":"\u00d6zdem An\u011f","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u00d6. An\u011f","raw_affiliation_strings":["Department of Internal Medicine, Bursa Medical Faculty and Departments of Microbiology, Pharmacology, Histology and Pathological Anatomy, Istanbul Medical Faculty, University of Istanbul, Istanbul"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Bursa Medical Faculty and Departments of Microbiology, Pharmacology, Histology and Pathological Anatomy, Istanbul Medical Faculty, University of Istanbul, Istanbul","institution_ids":["https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023525153","display_name":"\u0130. Petorak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"I. Petorak","raw_affiliation_strings":["Department of Internal Medicine, Bursa Medical Faculty and Departments of Microbiology, Pharmacology, Histology and Pathological Anatomy, Istanbul Medical Faculty, University of Istanbul, Istanbul"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Bursa Medical Faculty and Departments of Microbiology, Pharmacology, Histology and Pathological Anatomy, Istanbul Medical Faculty, University of Istanbul, Istanbul","institution_ids":["https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036582007","display_name":"Altan Iplik\u00e7i","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"A. \u0130plik\u00e7i","raw_affiliation_strings":["Department of Internal Medicine, Bursa Medical Faculty and Departments of Microbiology, Pharmacology, Histology and Pathological Anatomy, Istanbul Medical Faculty, University of Istanbul, Istanbul"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Bursa Medical Faculty and Departments of Microbiology, Pharmacology, Histology and Pathological Anatomy, Istanbul Medical Faculty, University of Istanbul, Istanbul","institution_ids":["https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028578618","display_name":"Ergene B\u00fcget","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"E. B\u00fcget","raw_affiliation_strings":["Department of Internal Medicine, Bursa Medical Faculty and Departments of Microbiology, Pharmacology, Histology and Pathological Anatomy, Istanbul Medical Faculty, University of Istanbul, Istanbul"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Bursa Medical Faculty and Departments of Microbiology, Pharmacology, Histology and Pathological Anatomy, Istanbul Medical Faculty, University of Istanbul, Istanbul","institution_ids":["https://openalex.org/I67581229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064838454","display_name":"L\u00fctfiye Ero\u01e7lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67581229","display_name":"Istanbul University","ror":"https://ror.org/03a5qrr21","country_code":"TR","type":"education","lineage":["https://openalex.org/I67581229"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"L. Ero\u011flu","raw_affiliation_strings":["Department of Internal Medicine, Bursa Medical Faculty and Departments of Microbiology, Pharmacology, Histology and Pathological Anatomy, Istanbul Medical Faculty, University of Istanbul, Istanbul"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Bursa Medical Faculty and Departments of Microbiology, Pharmacology, Histology and Pathological Anatomy, Istanbul Medical Faculty, University of Istanbul, Istanbul","institution_ids":["https://openalex.org/I67581229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103260727","display_name":"Mehmet G\u00fcng\u00f6r","orcid":"https://orcid.org/0000-0001-6869-4043","observed_orcids":["https://orcid.org/0000-0001-6869-4043"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. G\u00fcng\u00f6r","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"3","first_page":"171","last_page":"178"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.015200000256299973,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sulfamethizole","display_name":"sulfamethizole","score":0.9800000190734863},{"id":"https://openalex.org/keywords/experimental-pyelonephritis","display_name":"experimental pyelonephritis","score":0.9300000071525574},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9819999933242798},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.765999972820282},{"id":"https://openalex.org/keywords/enterococcus","display_name":"Enterococcus","score":0.8960000276565552},{"id":"https://openalex.org/keywords/antibiotic-prophylaxis","display_name":"antibiotic prophylaxis","score":0.8140000104904175},{"id":"https://openalex.org/keywords/renal-lesions","display_name":"renal lesions","score":0.32600000500679016}],"concepts":[{"id":"https://openalex.org/C2781039511","wikidata":"https://www.wikidata.org/wiki/Q3208529","display_name":"Sulfonamide","level":2,"score":0.6717627048492432},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.5805933475494385},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5274519920349121},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4968729317188263},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.25234267115592957},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22838333249092102},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.1774030327796936},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.062099725008010864},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005919","descriptor_name":"Glomerular Filtration Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011704","descriptor_name":"Pyelonephritis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011704","descriptor_name":"Pyelonephritis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D011704","descriptor_name":"Pyelonephritis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013210","descriptor_name":"Staphylococcus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013432","descriptor_name":"Sulfathiazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000221452","doi":"https://doi.org/10.1159/000221452","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000221452","pdf_url":null,"source":{"id":"https://openalex.org/S92531173","display_name":"Chemotherapy","issn_l":"0009-3157","issn":["0009-3157","1421-9794"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemotherapy","raw_type":"journal-article"},{"id":"pmid:4800999","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4800999","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemotherapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2032514192","https://openalex.org/W2461215393","https://openalex.org/W2422408950","https://openalex.org/W2423373007","https://openalex.org/W6997180838","https://openalex.org/W2418238462","https://openalex.org/W168174959","https://openalex.org/W2086802108","https://openalex.org/W2408391328","https://openalex.org/W2410015644"],"abstract_inverted_index":{"Preventive":[0],"effect":[1,83],"of":[2,21,25,55],"a":[3,37,48],"sulfamethizole-sulfaethidole":[4],"combination":[5,31,57],"on":[6,12],"experimental":[7,44,68],"hematogenous":[8,45],"pyelonephritis":[9,69],"was":[10,27,70],"examined":[11],"120":[13],"white":[14],"rats":[15],"weighing":[16],"200\u2013250":[17],"g.":[18],"Two":[19],"strains":[20],"Staphylococcus":[22],"aureus,":[23],"one":[24],"which":[26,67],"resistant":[28,38],"to":[29],"the":[30,33,59,64,77],"and":[32,36],"other":[34,78],"sensitive,":[35],"enterococcus":[39],"strain":[40],"were":[41],"used":[42],"for":[43],"pyelonephritis.":[46],"As":[47],"result,":[49],"we":[50],"observed":[51],"that":[52],"this":[53],"kind":[54],"sulfonamide":[56],"improved":[58],"pathomorphological":[60],"lesions":[61],"only":[62],"in":[63,66],"group":[65],"produced":[71],"by":[72],"sensitive":[73],"S.":[74],"aureus.":[75],"In":[76],"groups,":[79],"practically":[80],"no":[81],"positive":[82],"could":[84],"be":[85],"seen.":[86]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}