{"id":"https://openalex.org/W2057320117","doi":"https://doi.org/10.4161/cib.17140","title":"Membrane traffic as a coordinator of cell migration and junction remodeling","display_name":"Membrane traffic as a coordinator of cell migration and junction remodeling","publication_year":2011,"publication_date":"2011-11-01","ids":{"openalex":"https://openalex.org/W2057320117","doi":"https://doi.org/10.4161/cib.17140","mag":"2057320117","pmid":"https://pubmed.ncbi.nlm.nih.gov/22446532","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3306336"},"language":"en","primary_location":{"id":"doi:10.4161/cib.17140","doi":"https://doi.org/10.4161/cib.17140","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cib.17140","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cib.17140?download=true","source":{"id":"https://openalex.org/S197152527","display_name":"Communicative & Integrative Biology","issn_l":"1942-0889","issn":["1942-0889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communicative & Integrative Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/cib.17140?download=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111389575","display_name":"Chuanshen Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chuanshen Wu","raw_affiliation_strings":["Department of Molecular Cardiology, Cleveland Clinic Lerner College of Medicine; Cleveland, OH USA","Cleveland, OH USA","Department of Molecular Cardiology, Cleveland Clinic Lerner College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cardiology, Cleveland Clinic Lerner College of Medicine; Cleveland, OH USA","institution_ids":["https://openalex.org/I36373038"]},{"raw_affiliation_string":"Cleveland, OH USA","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular Cardiology, Cleveland Clinic Lerner College of Medicine","institution_ids":["https://openalex.org/I36373038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065181198","display_name":"Arie Horowitz","orcid":"https://orcid.org/0000-0001-6239-1287","observed_orcids":["https://orcid.org/0000-0001-6239-1287"]},"institutions":[{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arie Horowitz","raw_affiliation_strings":["Department of Molecular Cardiology, Cleveland Clinic Lerner College of Medicine; Cleveland, OH USA","Cleveland, OH USA","Department of Molecular Cardiology, Cleveland Clinic Lerner College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cardiology, Cleveland Clinic Lerner College of Medicine; Cleveland, OH USA","institution_ids":["https://openalex.org/I36373038"]},{"raw_affiliation_string":"Cleveland, OH USA","institution_ids":[]},{"raw_affiliation_string":"Department of Molecular Cardiology, Cleveland Clinic Lerner College of Medicine","institution_ids":["https://openalex.org/I36373038"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065181198"],"corresponding_institution_ids":["https://openalex.org/I36373038"],"apc_list":{"value":1190,"currency":"GBP","value_usd":1459},"apc_paid":{"value":1190,"currency":"GBP","value_usd":1459},"fwci":0.6139,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.66537834,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"4","issue":"6","first_page":"703","last_page":"705"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/membrane-traffic","display_name":"membrane traffic","score":0.7839999794960022},{"id":"https://openalex.org/keywords/endothelial-cell-migration","display_name":"endothelial cell migration","score":0.9070000052452087},{"id":"https://openalex.org/keywords/rhoa","display_name":"RhoA","score":0.8500000238418579},{"id":"https://openalex.org/keywords/mupp1","display_name":"MUPP1","score":0.9419999718666077},{"id":"https://openalex.org/keywords/rab13","display_name":"Rab13","score":0.9539999961853027},{"id":"https://openalex.org/keywords/vegfr2-phosphorylation","display_name":"VEGFR2 phosphorylation","score":0.800000011920929},{"id":"https://openalex.org/keywords/sprouting-angiogenesis","display_name":"sprouting angiogenesis","score":0.9010000228881836},{"id":"https://openalex.org/keywords/rho-gtpases","display_name":"Rho GTPases","score":0.8130000233650208},{"id":"https://openalex.org/keywords/endocytic-vesicles","display_name":"endocytic vesicles","score":0.781000018119812},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.7799999713897705},{"id":"https://openalex.org/keywords/cell-motility","display_name":"cell motility","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5336253046989441},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.35972869396209717},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35495758056640625},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34159088134765625}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.4161/cib.17140","doi":"https://doi.org/10.4161/cib.17140","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cib.17140","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cib.17140?download=true","source":{"id":"https://openalex.org/S197152527","display_name":"Communicative & Integrative Biology","issn_l":"1942-0889","issn":["1942-0889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communicative & Integrative Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2316598","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3306336","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3306336","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3306336","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Commun Integr Biol","raw_type":"Text"},{"id":"pmid:22446532","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22446532","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communicative & integrative biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4161/cib.17140","doi":"https://doi.org/10.4161/cib.17140","is_oa":true,"landing_page_url":"https://doi.org/10.4161/cib.17140","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/cib.17140?download=true","source":{"id":"https://openalex.org/S197152527","display_name":"Communicative & Integrative Biology","issn_l":"1942-0889","issn":["1942-0889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communicative & Integrative Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2057320117.pdf","grobid_xml":"https://content.openalex.org/works/W2057320117.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1966113252","https://openalex.org/W1969200465","https://openalex.org/W1972547393","https://openalex.org/W1973096186","https://openalex.org/W1974195547","https://openalex.org/W1982517873","https://openalex.org/W1993523135","https://openalex.org/W1993703921","https://openalex.org/W1998083136","https://openalex.org/W2006331214","https://openalex.org/W2006688354","https://openalex.org/W2008588429","https://openalex.org/W2016324935","https://openalex.org/W2035108361","https://openalex.org/W2042127966","https://openalex.org/W2053132501","https://openalex.org/W2064224882","https://openalex.org/W2065221771","https://openalex.org/W2072305777","https://openalex.org/W2074325696","https://openalex.org/W2076265532","https://openalex.org/W2077869706","https://openalex.org/W2087661112","https://openalex.org/W2091550642","https://openalex.org/W2100971189","https://openalex.org/W2107430171","https://openalex.org/W2110616259","https://openalex.org/W2140820666","https://openalex.org/W2141142872","https://openalex.org/W2160025503","https://openalex.org/W2166345281"],"related_works":["https://openalex.org/W1966113252","https://openalex.org/W90377880","https://openalex.org/W3019408971","https://openalex.org/W1997724979","https://openalex.org/W2128875649","https://openalex.org/W2163660564","https://openalex.org/W2040435657","https://openalex.org/W2050788158","https://openalex.org/W152797497","https://openalex.org/W6977362175"],"abstract_inverted_index":{"The":[0,136],"change":[1],"in":[2,45,168],"the":[3,13,20,27,36,39,72,76,84,95,102,107,121,149,163,175,180,212,220,223],"overall":[4],"shape":[5,37],"of":[6,12,19,29,41,79,86,94,152,166,182,196,214,222],"developing":[7],"organs":[8],"is":[9,171,208],"a":[10,87,141,156],"consequence":[11],"cumulative":[14],"movement,":[15],"reshaping,":[16],"and":[17,38,60,106,125,186,228],"proliferation":[18],"individual":[21],"mural":[22,80],"cells":[23,43,55],"that":[24,35,53,74,92,114,126,162,193,205],"make":[25],"up":[26],"walls":[28],"these":[30,54],"organs.":[31],"Recent":[32],"observations":[33],"suggest":[34],"position":[40],"endothelial":[42],"(ECs)":[44],"growing":[46],"blood":[47],"vessels":[48,170],"are":[49],"highly":[50],"dynamic,":[51],"implying":[52],"remodel":[56],"their":[57,64],"junctions":[58,185],"extensively":[59],"do":[61],"not":[62],"preserve":[63],"initial":[65],"relative":[66],"positions.":[67],"In":[68],"order":[69],"to":[70,145,211,219],"determine":[71],"mechanisms":[73],"confer":[75],"dynamic":[77,164],"behavior":[78,165],"ECs,":[81],"we":[82],"tracked":[83],"trafficking":[85],"cell":[88,184,187,226,229],"junction":[89],"protein":[90,104,110,143,177],"complex":[91,119,144,178],"consists":[93],"RhoA-specific":[96],"guanine":[97],"exchange":[98],"factor":[99],"(GEF)":[100],"Syx,":[101],"scaffold":[103],"Mupp1,":[105],"phospholipid":[108],"binding":[109],"Amot.1":[111],"We":[112],"found":[113],"RhoA":[115],"co-trafficked":[116],"with":[117,190],"this":[118],"on":[120],"same":[122,176],"endocytic":[123],"vesicles,":[124],"its":[127],"cellular":[128],"activity":[129],"pattern":[130],"was":[131],"determined":[132],"by":[133,140,173,199],"Rab13-dependent":[134],"trafficking.":[135],"vesicles":[137],"were":[138],"targeted":[139],"Rab13-associated":[142],"Tyr(1175)-phosphorylated":[146],"VEGFR2":[147],"at":[148],"leading":[150],"edge":[151],"ECs":[153,167],"migrating":[154],"under":[155],"VEGF":[157],"gradient.":[158],"These":[159],"results":[160],"indicate":[161],"sprouting":[169],"conferred":[172],"using":[174],"for":[179],"regulation":[181,195,213,221],"both":[183],"motility.":[188],"Together":[189],"previous":[191],"studies":[192],"demonstrated":[194],"Rac":[197],"signaling":[198],"Rab5-dependent":[200],"trafficking,(2)":[201],"it":[202],"appears":[203],"now":[204],"membrane":[206],"traffic":[207],"tightly":[209],"coupled":[210],"Rho":[215],"GTPases,":[216],"and,":[217],"consequently,":[218],"actin":[224],"cytoskeleton,":[225],"junctions,":[227],"migration.":[230]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}