{"id":"https://openalex.org/W2057258396","doi":"https://doi.org/10.1046/j.1365-2141.2003.04639.x","title":"Single agent thalidomide in patients with relapsed or refractory acute myeloid leukaemia","display_name":"Single agent thalidomide in patients with relapsed or refractory acute myeloid leukaemia","publication_year":2003,"publication_date":"2003-10-20","ids":{"openalex":"https://openalex.org/W2057258396","doi":"https://doi.org/10.1046/j.1365-2141.2003.04639.x","mag":"2057258396","pmid":"https://pubmed.ncbi.nlm.nih.gov/14617002"},"language":"en","primary_location":{"id":"doi:10.1046/j.1365-2141.2003.04639.x","doi":"https://doi.org/10.1046/j.1365-2141.2003.04639.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2141.2003.04639.x","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038307470","display_name":"Deborah Ann Thomas","orcid":"https://orcid.org/0000-0002-2656-343X","observed_orcids":["https://orcid.org/0000-0002-2656-343X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Deborah A. Thomas","raw_affiliation_strings":["Department of Leukemia, M D Anderson Cancer Center, University of Texas, Houston, TX 77030, USA. debthomas@mdanderson.org","Department of Leukemia, M.D. Anderson Cancer Center, University of Texas, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, M D Anderson Cancer Center, University of Texas, Houston, TX 77030, USA. debthomas@mdanderson.org","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Leukemia, M.D. Anderson Cancer Center, University of Texas, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057920623","display_name":"Elihu H. Estey","orcid":"https://orcid.org/0000-0002-0987-8077","observed_orcids":["https://orcid.org/0000-0002-0987-8077"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elihu Estey","raw_affiliation_strings":["Departments of Leukemia","University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Leukemia","institution_ids":[]},{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061285204","display_name":"Francis Joseph Giles","orcid":"https://orcid.org/0000-0002-6919-0231","observed_orcids":["https://orcid.org/0000-0002-6919-0231"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francis J. Giles","raw_affiliation_strings":["Departments of Leukemia","University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Leukemia","institution_ids":[]},{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046097970","display_name":"Stefan H Faderl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefan Faderl","raw_affiliation_strings":["Departments of Leukemia","University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Leukemia","institution_ids":[]},{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015101485","display_name":"J\u00f6rge E. Cortes","orcid":"https://orcid.org/0000-0002-8636-1071","observed_orcids":["https://orcid.org/0000-0002-8636-1071"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorge Cortes","raw_affiliation_strings":["Departments of Leukemia","University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Leukemia","institution_ids":[]},{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027575595","display_name":"Michael J. Keating","orcid":"https://orcid.org/0000-0002-9121-6450","observed_orcids":["https://orcid.org/0000-0002-9121-6450"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Keating","raw_affiliation_strings":["Departments of Leukemia","University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Leukemia","institution_ids":[]},{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102743501","display_name":"Susan Mary O'Brien","orcid":"https://orcid.org/0000-0003-3386-6540","observed_orcids":["https://orcid.org/0000-0003-3386-6540"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan O'Brien","raw_affiliation_strings":["Departments of Leukemia","University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Leukemia","institution_ids":[]},{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027800341","display_name":"Maher X. Albitar","orcid":"https://orcid.org/0000-0002-0050-2030","observed_orcids":["https://orcid.org/0000-0002-0050-2030","https://orcid.org/0000-0001-7661-9537"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maher Albitar","raw_affiliation_strings":["Hematopathology, M. D. Anderson Cancer Center, University of Texas, Houston, TX, USA","University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematopathology, M. D. Anderson Cancer Center, University of Texas, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090435894","display_name":"Hagop M. Kantarjian","orcid":"https://orcid.org/0000-0002-1908-3307","observed_orcids":["https://orcid.org/0000-0002-1908-3307"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hagop Kantarjian","raw_affiliation_strings":["Departments of Leukemia","University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Leukemia","institution_ids":[]},{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5038307470"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":1.6511,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.83743667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"123","issue":"3","first_page":"436","last_page":"441"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thalidomide","display_name":"thalidomide","score":1.0},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9649999737739563},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.8740000128746033},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9490000009536743},{"id":"https://openalex.org/keywords/bone-marrow-angiogenesis","display_name":"bone marrow angiogenesis","score":0.8980000019073486},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.828000009059906},{"id":"https://openalex.org/keywords/thalidomide-analogs","display_name":"thalidomide analogues","score":0.9580000042915344},{"id":"https://openalex.org/keywords/salvage-therapy","display_name":"salvage therapy","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C2779609412","wikidata":"https://www.wikidata.org/wiki/Q203174","display_name":"Thalidomide","level":3,"score":0.9648983478546143},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8234889507293701},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.6498268842697144},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6432259678840637},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5518786907196045},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.540941596031189},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5294938683509827},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.49463793635368347},{"id":"https://openalex.org/C2778041864","wikidata":"https://www.wikidata.org/wiki/Q180983","display_name":"Cytarabine","level":3,"score":0.476910799741745},{"id":"https://openalex.org/C2776063141","wikidata":"https://www.wikidata.org/wiki/Q425681","display_name":"Lenalidomide","level":3,"score":0.4672876000404358},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.4508790373802185},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4353219270706177},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4350525736808777},{"id":"https://openalex.org/C2780817109","wikidata":"https://www.wikidata.org/wiki/Q954625","display_name":"Myelodysplastic syndromes","level":3,"score":0.413166344165802},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38551065325737},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3633112907409668},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06552290916442871},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007951","descriptor_name":"Leukemia, Myeloid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012259","descriptor_name":"Ribonuclease, Pancreatic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013792","descriptor_name":"Thalidomide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1365-2141.2003.04639.x","doi":"https://doi.org/10.1046/j.1365-2141.2003.04639.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1365-2141.2003.04639.x","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},{"id":"pmid:14617002","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14617002","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of haematology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8100000023841858}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W12048163","https://openalex.org/W103700203","https://openalex.org/W135651168","https://openalex.org/W1569016295","https://openalex.org/W1970124798","https://openalex.org/W1979998638","https://openalex.org/W1985147506","https://openalex.org/W2018803923","https://openalex.org/W2023561451","https://openalex.org/W2027412145","https://openalex.org/W2034629770","https://openalex.org/W2077946724","https://openalex.org/W2117327010","https://openalex.org/W2137153350","https://openalex.org/W2144531125","https://openalex.org/W2171194005","https://openalex.org/W2316160054","https://openalex.org/W2466569700","https://openalex.org/W4240674955"],"related_works":["https://openalex.org/W2077946724","https://openalex.org/W2166369296","https://openalex.org/W1986130129","https://openalex.org/W10340544","https://openalex.org/W1999753606","https://openalex.org/W2460849336","https://openalex.org/W2023561451","https://openalex.org/W2051913990","https://openalex.org/W1947748380","https://openalex.org/W2044818042"],"abstract_inverted_index":{"Thalidomide":[0,189],"is":[1,175],"a":[2,90,114],"putative":[3],"anti-angiogenesis":[4],"agent":[5,173],"that":[6],"has":[7],"significant":[8],"anti-tumour":[9],"activity":[10],"in":[11,43,56,117,128,137,159],"haematological":[12],"malignancies":[13],"with":[14,40,58,64,72,78,185,191],"increased":[15],"bone":[16],"marrow":[17,118],"angiogenesis,":[18,33],"including":[19],"multiple":[20],"myeloma":[21],"(MM)":[22],"and":[23,110,122,142,150,196],"myelodysplastic":[24],"syndromes":[25],"(MDS).":[26],"Increased":[27],"levels":[28,138],"of":[29,52,69,92,139,169,180],"the":[30],"mitogen":[31],"for":[32,89,107,182],"vascular":[34],"endothelial":[35],"growth":[36],"factor":[37],"(VEGF),":[38],"correlate":[39],"worse":[41],"survival":[42],"acute":[44],"myeloid":[45],"leukaemia":[46],"(AML).":[47],"A":[48,67],"phase":[49],"II":[50],"trial":[51],"thalidomide":[53,79,147,174],"was":[54,132],"conducted":[55],"patients":[57,71,112,184],"relapsed-":[59,186],"or":[60,74,187],"refractory-AML":[61],"previously":[62],"treated":[63,77],"cytarabine-containing":[65],"regimens.":[66],"total":[68],"16":[70],"refractory-":[73],"relapsed-AML":[75],"were":[76,148],"200-800":[80],"mg":[81,87,156],"orally":[82,157],"daily":[83,158],"(median":[84],"dose":[85,152],"400":[86,155],"daily)":[88],"median":[91],"27":[93],"d":[94],"(range,":[95],"3-94":[96],"d).":[97],"Overall,":[98],"one":[99],"patient":[100],"(6%)":[101],"achieved":[102],"complete":[103],"remission":[104],"(CR)":[105],"lasting":[106],"36":[108],"months,":[109],"two":[111],"had":[113],"transient":[115],"reduction":[116,136],"blasts":[119],"from":[120],"8%":[121],"7%":[123],"to":[124,146,165],"less":[125],"than":[126],"5%":[127],"both":[129],"cases.":[130],"There":[131],"no":[133],"correlation":[134],"between":[135],"angiogenesis":[140],"markers":[141],"response.":[143],"Toxicities":[144],"related":[145],"significant,":[149],"precluded":[151],"escalation":[153],"beyond":[154],"most":[160],"patients.":[161],"Although":[162],"there":[163],"appears":[164],"be":[166],"some":[167],"evidence":[168],"biological":[170],"activity,":[171],"single":[172],"not":[176],"an":[177],"optimal":[178],"choice":[179],"therapy":[181],"salvaging":[183],"refractory-AML.":[188],"analogues":[190],"more":[192,197,203],"potent":[193],"immunomodulatory":[194],"activities":[195],"favourable":[198],"toxicity":[199],"profiles":[200],"may":[201],"offer":[202],"promise":[204],"as":[205],"anti-AML":[206],"therapy.":[207]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
