{"id":"https://openalex.org/W2057242539","doi":"https://doi.org/10.1002/ssu.2980070610","title":"Type\u2010oriented therapy for gastric cancer effective for lymph node metastasis: Management of lymph node metastasis using activated carbon particles adsorbing an anticancer agent","display_name":"Type\u2010oriented therapy for gastric cancer effective for lymph node metastasis: Management of lymph node metastasis using activated carbon particles adsorbing an anticancer agent","publication_year":1991,"publication_date":"1991-11-01","ids":{"openalex":"https://openalex.org/W2057242539","doi":"https://doi.org/10.1002/ssu.2980070610","mag":"2057242539","pmid":"https://pubmed.ncbi.nlm.nih.gov/1759087"},"language":"en","primary_location":{"id":"doi:10.1002/ssu.2980070610","doi":"https://doi.org/10.1002/ssu.2980070610","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ssu.2980070610","pdf_url":null,"source":{"id":"https://openalex.org/S179415865","display_name":"Seminars in Surgical Oncology","issn_l":"1098-2388","issn":["1098-2388","8756-0437"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Surgical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Toshio Takahashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshio Takahashi","raw_affiliation_strings":["Department of Surgery, Kyoto Prefectural University of Medicine, Japan","Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Kyoto Prefectural University of Medicine, Japan","institution_ids":["https://openalex.org/I40677808"]},{"raw_affiliation_string":"Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012504165","display_name":"Kiyoshi Sawai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyoshi Sawai","raw_affiliation_strings":["Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102806096","display_name":"Akeo Hagiwara","orcid":"https://orcid.org/0000-0001-7864-7355","observed_orcids":["https://orcid.org/0000-0001-7864-7355"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akeo Hagiwara","raw_affiliation_strings":["Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110113174","display_name":"Shigeru Takahashi","orcid":"https://orcid.org/0009-0001-5673-3559","observed_orcids":["https://orcid.org/0009-0001-5673-3559"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shigeru Takahashi","raw_affiliation_strings":["Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111968656","display_name":"K Seiki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kosuke Seiki","raw_affiliation_strings":["Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"last","author":{"id":null,"display_name":"Hajime Tokuda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hajime Tokuda","raw_affiliation_strings":["Department of Surgery, Kyoto Second Red Cross Hospital, Kyoto, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Kyoto Second Red Cross Hospital, Kyoto, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110113174"],"corresponding_institution_ids":["https://openalex.org/I40677808"],"apc_list":null,"apc_paid":null,"fwci":0.479,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.69281291,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"7","issue":"6","first_page":"378","last_page":"383"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.9829999804496765},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/activated-carbon-particles","display_name":"activated carbon particles","score":0.9879999756813049},{"id":"https://openalex.org/keywords/mitomycin-c","display_name":"mitomycin C","score":0.8579999804496765},{"id":"https://openalex.org/keywords/lymph-node-dissection","display_name":"lymph node dissection","score":0.5899999737739563},{"id":"https://openalex.org/keywords/lymphatic-injection","display_name":"lymphatic injection","score":0.3310000002384186},{"id":"https://openalex.org/keywords/lymph-node-imaging","display_name":"lymph node imaging","score":0.4790000021457672},{"id":"https://openalex.org/keywords/pharmaceutical-adsorption","display_name":"drug adsorption","score":0.5809999704360962},{"id":"https://openalex.org/keywords/survival-rate","display_name":"survival rate","score":0.6290000081062317}],"concepts":[{"id":"https://openalex.org/C2779720271","wikidata":"https://www.wikidata.org/wiki/Q179422","display_name":"Lymph","level":2,"score":0.8360837697982788},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.7466945648193359},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7266135811805725},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.4909704029560089},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4798245429992676},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.4214808940887451},{"id":"https://openalex.org/C2992571226","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node metastasis","level":4,"score":0.41987186670303345},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41004276275634766},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34098631143569946},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3279118537902832},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25574827194213867}],"mesh":[{"descriptor_ui":"D002244","descriptor_name":"Carbon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005743","descriptor_name":"Gastrectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008197","descriptor_name":"Lymph Node Excision","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016685","descriptor_name":"Mitomycin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016685","descriptor_name":"Mitomycin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ssu.2980070610","doi":"https://doi.org/10.1002/ssu.2980070610","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ssu.2980070610","pdf_url":null,"source":{"id":"https://openalex.org/S179415865","display_name":"Seminars in Surgical Oncology","issn_l":"1098-2388","issn":["1098-2388","8756-0437"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Surgical Oncology","raw_type":"journal-article"},{"id":"pmid:1759087","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1759087","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in surgical oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1991708654","https://openalex.org/W2049094430","https://openalex.org/W2056904268","https://openalex.org/W2400174052","https://openalex.org/W2400998862","https://openalex.org/W2403558690","https://openalex.org/W2418147008","https://openalex.org/W2418716483","https://openalex.org/W2944924994"],"related_works":["https://openalex.org/W2369011694","https://openalex.org/W2411388705","https://openalex.org/W2384497590","https://openalex.org/W2372437078","https://openalex.org/W2362249587","https://openalex.org/W2409139000","https://openalex.org/W2335915872","https://openalex.org/W2416641043","https://openalex.org/W2375830769","https://openalex.org/W2134280167"],"abstract_inverted_index":{"Activated":[0],"carbon":[1,22,48,67],"particles":[2,23],"are":[3],"taken":[4],"selectively":[5],"up":[6],"by":[7],"lymphatics":[8],"when":[9],"injected":[10],"into":[11],"the":[12,29,40,73,134,143,157,170],"tissues":[13],"and":[14,38,58,97],"visualize":[15],"regional":[16,69],"lymph":[17,55,61,70,81,109],"nodes":[18,71,82,89,115],"colored":[19,118,144],"black.":[20],"Furthermore,":[21],"adsorb":[24],"a":[25],"large":[26],"amount":[27],"of":[28,46,60,66,72,124,156],"anticancer":[30],"agent":[31],"mitomycin":[32],"C":[33],"(MMC)":[34],"on":[35],"their":[36],"surface":[37],"release":[39],"drug":[41],"reversibly.":[42],"Using":[43],"these":[44],"properties":[45],"activated":[47],"particles,":[49,68],"we":[50],"have":[51],"applied":[52],"it":[53],"for":[54,108,128],"node":[56,62,110],"dissection":[57],"chemotherapy":[59],"metastasis.":[63],"After":[64],"injection":[65],"stomach":[74],"were":[75,90,103,116],"found":[76],"to":[77,87,148],"be":[78],"black;":[79],"blackened":[80],"extending":[83],"widely":[84],"from":[85,92],"perigastric":[86],"para-aortic":[88],"identified":[91],"other":[93],"structures.":[94],"Four":[95],"hundred":[96],"twenty-four":[98],"patients":[99,158],"with":[100,105,160],"gastric":[101],"cancer":[102],"treated":[104,159],"this":[106,161,173],"method":[107],"metastasis":[111],"during":[112],"1984-1988.":[113],"Involved":[114],"generally":[117],"in":[119],"high":[120],"incidence,":[121],"about":[122,149],"70%":[123],"involved":[125],"ones":[126],"except":[127],"highly":[129,140],"positive":[130,141],"nodes,":[131,142],"which":[132,165],"was":[133,146,163,166],"same":[135],"as":[136],"noninvolved":[137],"nodes.":[138],"In":[139],"incidence":[145],"decreased":[147],"48%.":[150],"The":[151],"cumulative":[152],"5-year":[153],"survival":[154],"rate":[155],"series":[162],"74.6%,":[164],"significantly":[167],"higher":[168],"than":[169],"figures":[171],"without":[172],"method.":[174]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}