{"id":"https://openalex.org/W2057210274","doi":"https://doi.org/10.1056/nejmcp065743","title":"In Vitro Fertilization","display_name":"In Vitro Fertilization","publication_year":2007,"publication_date":"2007-01-25","ids":{"openalex":"https://openalex.org/W2057210274","doi":"https://doi.org/10.1056/nejmcp065743","mag":"2057210274","pmid":"https://pubmed.ncbi.nlm.nih.gov/17251534"},"language":"en","primary_location":{"id":"doi:10.1056/nejmcp065743","doi":"https://doi.org/10.1056/nejmcp065743","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejmcp065743","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052683279","display_name":"Bradley J. Van Voorhis","orcid":"https://orcid.org/0000-0002-1455-0164","observed_orcids":["https://orcid.org/0000-0002-1455-0164"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]},{"id":"https://openalex.org/I4210142782","display_name":"University of Iowa Health Care","ror":"https://ror.org/0431j1t39","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bradley J. Van Voorhis","raw_affiliation_strings":["Division of Reproductive Endocrinology and Infertility, University of Iowa School of Medicine, Iowa City 52242, USA. brad-van-voorhis@uiowa.edu","Division of Reproductive Endocrinology and Infertility, University of Iowa School of Medicine, Iowa City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Reproductive Endocrinology and Infertility, University of Iowa School of Medicine, Iowa City 52242, USA. brad-van-voorhis@uiowa.edu","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]},{"raw_affiliation_string":"Division of Reproductive Endocrinology and Infertility, University of Iowa School of Medicine, Iowa City","institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5052683279"],"corresponding_institution_ids":["https://openalex.org/I126307644","https://openalex.org/I4210142782"],"apc_list":null,"apc_paid":null,"fwci":2.1833,"has_fulltext":false,"cited_by_count":165,"citation_normalized_percentile":{"value":0.88592233,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"356","issue":"4","first_page":"379","last_page":"386"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11732","display_name":"Assisted Reproductive Technology and Twin Pregnancy","score":0.03909999877214432,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.01080000028014183,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-vitro-fertilization","display_name":"in vitro fertilization","score":0.996999979019165},{"id":"https://openalex.org/keywords/infertility","display_name":"infertility","score":0.6100000143051147},{"id":"https://openalex.org/keywords/unexplained-infertility","display_name":"unexplained infertility","score":0.6629999876022339},{"id":"https://openalex.org/keywords/male-infertility","display_name":"male infertility","score":0.5370000004768372},{"id":"https://openalex.org/keywords/male-factor-infertility","display_name":"male factor infertility","score":0.4390000104904175},{"id":"https://openalex.org/keywords/assisted-reproductive-technology","display_name":"assisted reproduction","score":0.49399998784065247},{"id":"https://openalex.org/keywords/infertility-counseling","display_name":"infertility counseling","score":0.3720000088214874}],"concepts":[{"id":"https://openalex.org/C512716672","wikidata":"https://www.wikidata.org/wiki/Q200117","display_name":"In vitro fertilisation","level":3,"score":0.7811663150787354},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7723336815834045},{"id":"https://openalex.org/C2777688143","wikidata":"https://www.wikidata.org/wiki/Q179399","display_name":"Infertility","level":3,"score":0.7467939853668213},{"id":"https://openalex.org/C88972607","wikidata":"https://www.wikidata.org/wiki/Q2666904","display_name":"Human fertilization","level":2,"score":0.6192893981933594},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4502633213996887},{"id":"https://openalex.org/C2911058409","wikidata":"https://www.wikidata.org/wiki/Q844342","display_name":"Female Reproductive Tract","level":3,"score":0.43370458483695984},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.41984307765960693},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.3856184482574463},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.36373209953308105},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.35771915316581726},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12420663237571716},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.09359961748123169},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07571402192115784}],"mesh":[{"descriptor_ui":"D000013","descriptor_name":"Congenital Abnormalities","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004624","descriptor_name":"Embryo Transfer","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005298","descriptor_name":"Fertility","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005307","descriptor_name":"Fertilization in Vitro","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D005307","descriptor_name":"Fertilization in Vitro","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007246","descriptor_name":"Infertility","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D007246","descriptor_name":"Infertility","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011256","descriptor_name":"Pregnancy Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011272","descriptor_name":"Pregnancy, Multiple","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017211","descriptor_name":"Treatment Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019836","descriptor_name":"Preimplantation Diagnosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027724","descriptor_name":"Reproductive Techniques, Assisted","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1056/nejmcp065743","doi":"https://doi.org/10.1056/nejmcp065743","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejmcp065743","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:17251534","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17251534","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Journal Article"},{"id":"pmh:oai:ir.uiowa.edu:obgyn_pubs-1832","doi":null,"is_oa":false,"landing_page_url":"https://ir.uiowa.edu/obgyn_pubs/831","pdf_url":null,"source":{"id":"https://openalex.org/S4306401239","display_name":"Iowa Research Online (The University of Iowa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126307644","host_organization_name":"University of Iowa","host_organization_lineage":["https://openalex.org/I126307644"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Obstetrics and Gynecology Publications","raw_type":"article"},{"id":"mag:2184805803","doi":null,"is_oa":false,"landing_page_url":"http://saegre.org.ar/biblioteca/arbol_bibliografico/noviembre2007/379-nejm-fiv.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W195111489","https://openalex.org/W1531487894","https://openalex.org/W1667843617","https://openalex.org/W1764503579","https://openalex.org/W1966334020","https://openalex.org/W1971731466","https://openalex.org/W1973263337","https://openalex.org/W1980680374","https://openalex.org/W1982705804","https://openalex.org/W1988521281","https://openalex.org/W1992593914","https://openalex.org/W1996671888","https://openalex.org/W2011075803","https://openalex.org/W2016992316","https://openalex.org/W2025745794","https://openalex.org/W2033911590","https://openalex.org/W2041490610","https://openalex.org/W2064737420","https://openalex.org/W2065067996","https://openalex.org/W2069463805","https://openalex.org/W2069743515","https://openalex.org/W2075086500","https://openalex.org/W2088496077","https://openalex.org/W2088665709","https://openalex.org/W2093477990","https://openalex.org/W2095296987","https://openalex.org/W2101773718","https://openalex.org/W2106887960","https://openalex.org/W2108478507","https://openalex.org/W2110055479","https://openalex.org/W2112594871","https://openalex.org/W2118702520","https://openalex.org/W2124978752","https://openalex.org/W2129749274","https://openalex.org/W2130119006","https://openalex.org/W2140212151","https://openalex.org/W2147862171","https://openalex.org/W2150601298","https://openalex.org/W2153050474","https://openalex.org/W2158949972","https://openalex.org/W2159003695","https://openalex.org/W2161867232","https://openalex.org/W2167468996","https://openalex.org/W2324042681","https://openalex.org/W2413780100","https://openalex.org/W2466493783"],"related_works":["https://openalex.org/W2184805803","https://openalex.org/W7223233467","https://openalex.org/W6960339288","https://openalex.org/W3095445117","https://openalex.org/W2473111556","https://openalex.org/W2411845339","https://openalex.org/W4254722673","https://openalex.org/W4248960720","https://openalex.org/W7034775270","https://openalex.org/W4299870129"],"abstract_inverted_index":{"A":[0],"37-year-old":[1],"woman":[2],"who":[3],"has":[4,27,50,56],"never":[5],"been":[6,13],"pregnant":[7],"and":[8,38,64],"her":[9,43],"40-year-old":[10],"husband":[11],"have":[12],"attempting":[14],"to":[15,66],"conceive":[16],"a":[17,39,51],"child":[18],"for":[19,31],"the":[20,32],"past":[21],"3":[22],"years.":[23],"An":[24],"infertility":[25],"evaluation":[26],"shown":[28],"no":[29],"cause":[30],"difficulty.":[33],"She":[34],"is":[35,46],"ovulating":[36],"regularly,":[37],"hysterosalpingogram":[40],"shows":[41],"that":[42],"reproductive":[44],"tract":[45],"anatomically":[47],"normal.":[48],"He":[49],"normal":[52],"sperm":[53],"count;":[54],"he":[55],"not":[57],"fathered":[58],"any":[59],"children.":[60],"They":[61],"are":[62],"frustrated":[63],"want":[65],"proceed":[67],"with":[68],"in":[69],"vitro":[70],"fertilization.":[71],"What":[72],"should":[73],"you":[74],"advise?":[75]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}