{"id":"https://openalex.org/W2057200679","doi":"https://doi.org/10.1002/jcp.1041400120","title":"Characterization of the receptor for insulin\u2010like growth factor II in bone cells","display_name":"Characterization of the receptor for insulin\u2010like growth factor II in bone cells","publication_year":1989,"publication_date":"1989-07-01","ids":{"openalex":"https://openalex.org/W2057200679","doi":"https://doi.org/10.1002/jcp.1041400120","mag":"2057200679","pmid":"https://pubmed.ncbi.nlm.nih.gov/2544614"},"language":"en","primary_location":{"id":"doi:10.1002/jcp.1041400120","doi":"https://doi.org/10.1002/jcp.1041400120","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.1041400120","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054497725","display_name":"Subburaman Mohan","orcid":"https://orcid.org/0000-0003-0063-986X","observed_orcids":["https://orcid.org/0000-0003-0063-986X"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Subburaman Mohan","raw_affiliation_strings":["Department of Medicine, Loma Linda University, California","Departments of Medicine, Stanford Medical Center, Palo Alto, California","Pediatrics, Stanford Medical Center, Palo Alto, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Loma Linda University, California","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Departments of Medicine, Stanford Medical Center, Palo Alto, California","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Pediatrics, Stanford Medical Center, Palo Alto, California","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029876277","display_name":"Thomas A. Linkhart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Linkhart","raw_affiliation_strings":["Pediatrics, Stanford Medical Center, Palo Alto, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, Stanford Medical Center, Palo Alto, California","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001402556","display_name":"Ron G. Rosenfeld","orcid":"https://orcid.org/0000-0002-4030-5998","observed_orcids":["https://orcid.org/0000-0002-4030-5998"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ron Rosenfeld","raw_affiliation_strings":["Biochemistry and Physiology Loma Linda University and Pettis V.A. Hospital, Loma Linda, and Department of Pediatrics, Stanford Medical Center, Palo Alto, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Physiology Loma Linda University and Pettis V.A. Hospital, Loma Linda, and Department of Pediatrics, Stanford Medical Center, Palo Alto, California","institution_ids":["https://openalex.org/I26347476","https://openalex.org/I4210137306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102858874","display_name":"David J. Baylink","orcid":"https://orcid.org/0000-0001-9526-7995","observed_orcids":["https://orcid.org/0000-0001-9526-7995"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Baylink","raw_affiliation_strings":["Departments of Medicine, Stanford Medical Center, Palo Alto, California","Pediatrics, Stanford Medical Center, Palo Alto, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine, Stanford Medical Center, Palo Alto, California","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Pediatrics, Stanford Medical Center, Palo Alto, California","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5054497725"],"corresponding_institution_ids":["https://openalex.org/I26347476","https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":{"value":5230,"currency":"USD","value_usd":5230},"apc_paid":null,"fwci":2.1899,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.87125084,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"140","issue":"1","first_page":"169","last_page":"176"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/igf-ii","display_name":"insulin-like growth factor II","score":0.9990000128746033},{"id":"https://openalex.org/keywords/igf-ii-receptor","display_name":"IGF-II receptor","score":0.8450000286102295},{"id":"https://openalex.org/keywords/bone-cells","display_name":"bone cells","score":0.8759999871253967},{"id":"https://openalex.org/keywords/calvaria","display_name":"calvaria","score":0.6179999709129333},{"id":"https://openalex.org/keywords/receptor-binding-kinetics","display_name":"receptor binding kinetics","score":0.75},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7730000019073486},{"id":"https://openalex.org/keywords/mitogenic-signaling","display_name":"mitogenic signaling","score":0.7289999723434448},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C2779918246","wikidata":"https://www.wikidata.org/wiki/Q613203","display_name":"Calvaria","level":3,"score":0.8946028351783752},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6391956210136414},{"id":"https://openalex.org/C2779069268","wikidata":"https://www.wikidata.org/wiki/Q14874349","display_name":"Insulin-like growth factor 2","level":4,"score":0.5794682502746582},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5731817483901978},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5583378076553345},{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.538074791431427},{"id":"https://openalex.org/C133605539","wikidata":"https://www.wikidata.org/wiki/Q913236","display_name":"Bone cell","level":2,"score":0.5282570123672485},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5221612453460693},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.5215668082237244},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48120003938674927},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3827088177204132},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3781013488769531},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14923930168151855},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09159073233604431}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017451","descriptor_name":"Receptors, Somatomedin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jcp.1041400120","doi":"https://doi.org/10.1002/jcp.1041400120","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcp.1041400120","pdf_url":null,"source":{"id":"https://openalex.org/S43643205","display_name":"Journal of Cellular Physiology","issn_l":"0021-9541","issn":["0021-9541","1097-4652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular Physiology","raw_type":"journal-article"},{"id":"pmid:2544614","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2544614","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2494010510","display_name":"Endosteal Bone Volume Regulation and Osteoporosis","funder_award_id":"R01AR031062","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G4901305715","display_name":"SOMATOMEDIN &INSULIN RECEPTORS:  A COMPARATIVE ANALYSIS","funder_award_id":"K04DK001275","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W6602093","https://openalex.org/W13429703","https://openalex.org/W1500990165","https://openalex.org/W1501458107","https://openalex.org/W1508807714","https://openalex.org/W1513516642","https://openalex.org/W1571922057","https://openalex.org/W1606221581","https://openalex.org/W1828467840","https://openalex.org/W1931843124","https://openalex.org/W1967709376","https://openalex.org/W1975491124","https://openalex.org/W1976681877","https://openalex.org/W1977000145","https://openalex.org/W1983649348","https://openalex.org/W1985220842","https://openalex.org/W1994734038","https://openalex.org/W1997748522","https://openalex.org/W2004124848","https://openalex.org/W2008447360","https://openalex.org/W2009928329","https://openalex.org/W2010230690","https://openalex.org/W2014059985","https://openalex.org/W2015248627","https://openalex.org/W2020644093","https://openalex.org/W2031997272","https://openalex.org/W2032221215","https://openalex.org/W2039350440","https://openalex.org/W2052572861","https://openalex.org/W2059554843","https://openalex.org/W2068872959","https://openalex.org/W2073691118","https://openalex.org/W2081780302","https://openalex.org/W2089418707","https://openalex.org/W2090059609","https://openalex.org/W2097257515","https://openalex.org/W2097888058","https://openalex.org/W2108384283","https://openalex.org/W2145481755","https://openalex.org/W2159891671"],"related_works":["https://openalex.org/W2162520620","https://openalex.org/W2014510338","https://openalex.org/W2023293227","https://openalex.org/W2106421204","https://openalex.org/W1992928829","https://openalex.org/W2025831864","https://openalex.org/W1999561771","https://openalex.org/W4301444516","https://openalex.org/W1978842341","https://openalex.org/W2019324407"],"abstract_inverted_index":{"We":[0,27],"have":[1],"previously":[2],"shown":[3],"that":[4,16,97,261,277],"insulin-like":[5],"growth":[6,226],"factor":[7,227],"II":[8,181,203,291],"(IGF-II)":[9],"is":[10,287],"produced":[11],"by":[12,34,116],"bone":[13,25,40,178,193,233,238,265,298],"cells":[14,41,61,75,139,194,199,239],"and":[15,21,47,64,125,136,176,195,224,240],"IGF-II":[17,37,55,98,109,118,262,286],"stimulates":[18],"cell":[19,217,229,253,266],"proliferation":[20,218,230,267],"collagen":[22],"synthesis":[23],"in":[24,31,57,107,153,209,231,268,297],"cells.":[26,179,234,299],"now":[28],"extend":[29],"these":[30],"vitro":[32],"findings":[33,260],"demonstrating":[35],"specific":[36,147],"binding":[38,56,71,113,133,148,173,188,248],"to":[39,72,134,174,191],"derived":[42],"from":[43],"newborn":[44],"mouse":[45,137,177,192,232],"calvaria":[46,60,74,237],"embryonic":[48,58],"chick":[49,59,73,135,175,236,264],"calvaria.":[50],"The":[51,93],"kinetics":[52],"of":[53,69,80,91,114,131,146,149,156,159,171,189,249,271,274,281,285],"[125I]":[54],"showed":[62,76,96,119,163],"time":[63],"temperature":[65],"dependence.":[66],"Scatchard":[67],"analysis":[68],"[125I]IGF-II":[70,115,132,150,172,190,250],"an":[77],"apparent":[78],"Kd":[79],"1.4":[81],"x":[82],"10(-10)":[83],"M,":[84],"with":[85,258],"a":[86,120,210],"calculated":[87],"receptor":[88,182],"site":[89],"concentration":[90],"40,000/cell.":[92],"specificity":[94],"characteristics":[95],"was":[99,140,151],"significantly":[100],"more":[101],"potent":[102],"than":[103,165,293],"IGF-I":[104,162,275],"or":[105],"insulin":[106],"displacing":[108],"tracer.":[110],"Competition":[111],"for":[112,169],"unlabeled":[117,160],"dose-dependent":[121,211],"displacement":[122,130,170],"between":[123],"0.5":[124],"25":[126],"ng/ml.":[127],"Fifty":[128],"percent":[129],"calvarial":[138],"achieved":[141],"at":[142,278],"1-2":[143],"ng/ml;":[144],"90%":[145],"displaceable":[152],"the":[154,187,269,282],"presence":[155,270],"125":[157],"ng/ml":[158],"IGF-II.":[161],"less":[164],"5%":[166],"cross":[167],"reactivity":[168],"Type":[180],"inhibitory":[183],"antibodies,":[184],"R-II-PAB1":[185,213],"inhibited":[186,215,246],"H-35":[196],"rat":[197],"hepatoma":[198],"(which":[200],"contain":[201],"type":[202,206,290,294],"but":[204],"not":[205],"I":[207,295],"receptors)":[208],"manner.":[212],"also":[214],"basal":[216],"as":[219,221],"well":[220],"IGF-II-,":[222],"IGF-I-,":[223],"fibroblast":[225],"(FGF)-induced":[228],"In":[235],"TE89":[241],"human":[242],"osteosarcoma":[243],"cells,":[244],"R-II-PABI":[245],"neither":[247],"nor":[251],"IGF-II-induced":[252],"proliferation.":[254],"These":[255],"results":[256],"together":[257],"our":[259],"increased":[263],"maximal":[272],"doses":[273],"suggest":[276],"least":[279],"part":[280],"mitogenic":[283],"action":[284],"mediated":[288],"through":[289],"rather":[292],"receptors":[296]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
