{"id":"https://openalex.org/W2057121663","doi":"https://doi.org/10.1186/1471-2164-13-195","title":"Genetic variation and metabolic pathway intricacy govern the active compound content and quality of the Chinese medicinal plant Lonicera japonica thunb","display_name":"Genetic variation and metabolic pathway intricacy govern the active compound content and quality of the Chinese medicinal plant Lonicera japonica thunb","publication_year":2012,"publication_date":"2012-05-20","ids":{"openalex":"https://openalex.org/W2057121663","doi":"https://doi.org/10.1186/1471-2164-13-195","mag":"2057121663","pmid":"https://pubmed.ncbi.nlm.nih.gov/22607188","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3443457"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2164-13-195","doi":"https://doi.org/10.1186/1471-2164-13-195","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2164-13-195","pdf_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-13-195","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-13-195","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100334745","display_name":"Yuan Yuan","orcid":"https://orcid.org/0000-0002-1234-6813","observed_orcids":["https://orcid.org/0000-0002-1234-6813","https://orcid.org/0000-0001-7543-5808"]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]},{"id":"https://openalex.org/I4392738151","display_name":"Institute of Chinese Materia Medica","ror":"https://ror.org/04kn56m50","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4392738151"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Yuan","raw_affiliation_strings":["Beijing Key Laboratory of Functional Genomics for Dao-di Herbs, Institute of Chinese Materia Medica, Academy of Chinese Medical Sciences, Beijing, China","Beijing Key Laboratory of Functional Genomics for Dao-di Herbs, Institute of Chinese Materia Medica, Academy of Chinese Medical Sciences, Beijing, 100700, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Functional Genomics for Dao-di Herbs, Institute of Chinese Materia Medica, Academy of Chinese Medical Sciences, Beijing, China","institution_ids":["https://openalex.org/I4210141683","https://openalex.org/I4392738151"]},{"raw_affiliation_string":"Beijing Key Laboratory of Functional Genomics for Dao-di Herbs, Institute of Chinese Materia Medica, Academy of Chinese Medical Sciences, Beijing, 100700, China","institution_ids":["https://openalex.org/I4210141683","https://openalex.org/I4392738151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102085404","display_name":"Lipu Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lipu Song","raw_affiliation_strings":["CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100029, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100675642","display_name":"Minhui Li","orcid":"https://orcid.org/0000-0002-5366-8464","observed_orcids":["https://orcid.org/0000-0002-5366-8464"]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]},{"id":"https://openalex.org/I4210160794","display_name":"Baotou Medical College","ror":"https://ror.org/04t44qh67","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160794"]},{"id":"https://openalex.org/I4392738151","display_name":"Institute of Chinese Materia Medica","ror":"https://ror.org/04kn56m50","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4392738151"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minhui Li","raw_affiliation_strings":["Baotou Medical College, Baotou, 014040, China","Beijing Key Laboratory of Functional Genomics for Dao-di Herbs, Institute of Chinese Materia Medica, Academy of Chinese Medical Sciences, Beijing, 100700, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baotou Medical College, Baotou, 014040, China","institution_ids":["https://openalex.org/I4210160794"]},{"raw_affiliation_string":"Beijing Key Laboratory of Functional Genomics for Dao-di Herbs, Institute of Chinese Materia Medica, Academy of Chinese Medical Sciences, Beijing, 100700, China","institution_ids":["https://openalex.org/I4210141683","https://openalex.org/I4392738151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002945666","display_name":"Guiming Liu","orcid":"https://orcid.org/0000-0002-9292-6198","observed_orcids":["https://orcid.org/0000-0002-9292-6198"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guiming Liu","raw_affiliation_strings":["CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100029, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110703133","display_name":"Yanan Chu","orcid":"https://orcid.org/0000-0002-9349-4307","observed_orcids":["https://orcid.org/0000-0002-9349-4307"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanan Chu","raw_affiliation_strings":["CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100029, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102734079","display_name":"Luyu Ma","orcid":"https://orcid.org/0000-0003-2907-8410","observed_orcids":["https://orcid.org/0000-0003-2907-8410"]},"institutions":[{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Luyu Ma","raw_affiliation_strings":["Shandong Academy of Medical Sciences, Jinan, 250031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shandong Academy of Medical Sciences, Jinan, 250031, China","institution_ids":["https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000255298","display_name":"Yuanyuan Zhou","orcid":"https://orcid.org/0000-0001-5688-9804","observed_orcids":["https://orcid.org/0000-0001-5688-9804"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Zhou","raw_affiliation_strings":["CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100029, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100411530","display_name":"Xiao Dan Wang","orcid":"https://orcid.org/0000-0003-4236-2483","observed_orcids":["https://orcid.org/0000-0003-4236-2483"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]},{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]},{"id":"https://openalex.org/I4392738151","display_name":"Institute of Chinese Materia Medica","ror":"https://ror.org/04kn56m50","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4392738151"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiao Wang","raw_affiliation_strings":["Beijing Key Laboratory of Functional Genomics for Dao-di Herbs, Institute of Chinese Materia Medica, Academy of Chinese Medical Sciences, Beijing, 100700, China","CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100029, China","Shandong Analysis and Test center, Jinan, 250014, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Functional Genomics for Dao-di Herbs, Institute of Chinese Materia Medica, Academy of Chinese Medical Sciences, Beijing, 100700, China","institution_ids":["https://openalex.org/I4210141683","https://openalex.org/I4392738151"]},{"raw_affiliation_string":"CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100029, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]},{"raw_affiliation_string":"Shandong Analysis and Test center, Jinan, 250014, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090642719","display_name":"Wei Gao","orcid":"https://orcid.org/0000-0003-3081-9642","observed_orcids":["https://orcid.org/0000-0003-3081-9642"]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]},{"id":"https://openalex.org/I4392738151","display_name":"Institute of Chinese Materia Medica","ror":"https://ror.org/04kn56m50","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4392738151"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Gao","raw_affiliation_strings":["Beijing Key Laboratory of Functional Genomics for Dao-di Herbs, Institute of Chinese Materia Medica, Academy of Chinese Medical Sciences, Beijing, 100700, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Functional Genomics for Dao-di Herbs, Institute of Chinese Materia Medica, Academy of Chinese Medical Sciences, Beijing, 100700, China","institution_ids":["https://openalex.org/I4210141683","https://openalex.org/I4392738151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108943198","display_name":"Shuangshuang Qin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]},{"id":"https://openalex.org/I4392738151","display_name":"Institute of Chinese Materia Medica","ror":"https://ror.org/04kn56m50","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4392738151"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuangshuang Qin","raw_affiliation_strings":["Beijing Key Laboratory of Functional Genomics for Dao-di Herbs, Institute of Chinese Materia Medica, Academy of Chinese Medical Sciences, Beijing, 100700, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Functional Genomics for Dao-di Herbs, Institute of Chinese Materia Medica, Academy of Chinese Medical Sciences, Beijing, 100700, China","institution_ids":["https://openalex.org/I4210141683","https://openalex.org/I4392738151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100728445","display_name":"Jun Myoung Yu","orcid":"https://orcid.org/0000-0002-2702-055X","observed_orcids":["https://orcid.org/0000-0002-2702-055X"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Yu","raw_affiliation_strings":["CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100029, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088031037","display_name":"Xumin Wang","orcid":"https://orcid.org/0009-0002-4456-322X","observed_orcids":["https://orcid.org/0009-0002-4456-322X","https://orcid.org/0000-0003-0302-8909"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2801577699","display_name":"Beijing Institute of Genomics","ror":"https://ror.org/049gn7z52","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]},{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]},{"id":"https://openalex.org/I4392738151","display_name":"Institute of Chinese Materia Medica","ror":"https://ror.org/04kn56m50","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4392738151"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xumin Wang","raw_affiliation_strings":["Beijing Key Laboratory of Functional Genomics for Dao-di Herbs, Institute of Chinese Materia Medica, Academy of Chinese Medical Sciences, Beijing, 100700, China","CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100029, China","Shandong Analysis and Test center, Jinan, 250014, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Functional Genomics for Dao-di Herbs, Institute of Chinese Materia Medica, Academy of Chinese Medical Sciences, Beijing, 100700, China","institution_ids":["https://openalex.org/I4210141683","https://openalex.org/I4392738151"]},{"raw_affiliation_string":"CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100029, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2801577699"]},{"raw_affiliation_string":"Shandong Analysis and Test center, Jinan, 250014, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101979386","display_name":"Luqi Huang","orcid":"https://orcid.org/0000-0002-2070-4318","observed_orcids":["https://orcid.org/0000-0002-2070-4318"]},"institutions":[{"id":"https://openalex.org/I4210141683","display_name":"China Academy of Chinese Medical Sciences","ror":"https://ror.org/042pgcv68","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210141683"]},{"id":"https://openalex.org/I4392738151","display_name":"Institute of Chinese Materia Medica","ror":"https://ror.org/04kn56m50","country_code":"CN","type":"facility","lineage":["https://openalex.org/I200296433","https://openalex.org/I4392738151"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Luqi Huang","raw_affiliation_strings":["Beijing Key Laboratory of Functional Genomics for Dao-di Herbs, Institute of Chinese Materia Medica, Academy of Chinese Medical Sciences, Beijing, 100700, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Functional Genomics for Dao-di Herbs, Institute of Chinese Materia Medica, Academy of Chinese Medical Sciences, Beijing, 100700, China","institution_ids":["https://openalex.org/I4210141683","https://openalex.org/I4392738151"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5088031037","https://openalex.org/A5100411530","https://openalex.org/A5101979386"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I2801577699","https://openalex.org/I4210141683","https://openalex.org/I4392738151"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":2.0479,"has_fulltext":true,"cited_by_count":96,"citation_normalized_percentile":{"value":0.87111744,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"13","issue":"1","first_page":"195","last_page":"195"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.5830000042915344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.5830000042915344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11237","display_name":"Plant Gene Expression Analysis","score":0.31540000438690186,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.023800000548362732,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lonicera-japonica","display_name":"Lonicera japonica","score":0.9419999718666077},{"id":"https://openalex.org/keywords/lonicerae-japonicae-flos","display_name":"Lonicerae Japonicae Flos","score":0.9890000224113464},{"id":"https://openalex.org/keywords/genetic-variation","display_name":"genetic variation","score":0.5720000267028809},{"id":"https://openalex.org/keywords/drug-quality","display_name":"drug quality","score":0.4490000009536743},{"id":"https://openalex.org/keywords/transcriptome","display_name":"transcriptome","score":0.6549999713897705},{"id":"https://openalex.org/keywords/flower-development","display_name":"flower development","score":0.5540000200271606},{"id":"https://openalex.org/keywords/phenolic-acid-biosynthesis","display_name":"phenolic acid biosynthesis","score":0.7879999876022339},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9570000171661377},{"id":"https://openalex.org/keywords/terpenoids","display_name":"terpenoids","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fatty-acids","display_name":"fatty acids","score":0.9810000061988831},{"id":"https://openalex.org/keywords/gene-family-evolution","display_name":"gene family evolution","score":0.48100000619888306},{"id":"https://openalex.org/keywords/orthologs-and-paralogs","display_name":"orthologs and paralogs","score":0.9670000076293945},{"id":"https://openalex.org/keywords/metabolic-pathways","display_name":"metabolic pathways","score":0.4909999966621399},{"id":"https://openalex.org/keywords/counterfeit-herbal-medicine","display_name":"counterfeit herbal medicine","score":0.49900001287460327},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7777348756790161},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7066935300827026},{"id":"https://openalex.org/C2779409272","wikidata":"https://www.wikidata.org/wiki/Q1757789","display_name":"Japonica","level":2,"score":0.6175180077552795},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.5296440124511719},{"id":"https://openalex.org/C2991655182","wikidata":"https://www.wikidata.org/wiki/Q188840","display_name":"Medicinal herbs","level":2,"score":0.5196434259414673},{"id":"https://openalex.org/C2778711105","wikidata":"https://www.wikidata.org/wiki/Q1767381","display_name":"Flos","level":4,"score":0.4976682960987091},{"id":"https://openalex.org/C2779158651","wikidata":"https://www.wikidata.org/wiki/Q188840","display_name":"Medicinal plants","level":2,"score":0.49655967950820923},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4834781289100647},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.46401891112327576},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.38682520389556885},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3585131764411926},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.311432421207428},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2889322340488434},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2324780821800232},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15597087144851685},{"id":"https://openalex.org/C2775963812","wikidata":"https://www.wikidata.org/wiki/Q407857","display_name":"Rutin","level":3,"score":0.0},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013729","descriptor_name":"Terpenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020224","descriptor_name":"Expressed Sequence Tags","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031239","descriptor_name":"Lonicera","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D031239","descriptor_name":"Lonicera","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D031239","descriptor_name":"Lonicera","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035264","descriptor_name":"Flowers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035264","descriptor_name":"Flowers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059808","descriptor_name":"Polyphenols","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059808","descriptor_name":"Polyphenols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/1471-2164-13-195","doi":"https://doi.org/10.1186/1471-2164-13-195","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2164-13-195","pdf_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-13-195","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2445536","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3443457","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22607188","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22607188","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC genomics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3443457","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3443457/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:b58d66fa88ed4565985c2b4264bdf12f","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/b58d66fa88ed4565985c2b4264bdf12f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Genomics, Vol 13, Iss 1, p 195 (2012)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1471-2164-13-195","doi":"https://doi.org/10.1186/1471-2164-13-195","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2164-13-195","pdf_url":"https://bmcgenomics.biomedcentral.com/counter/pdf/10.1186/1471-2164-13-195","source":{"id":"https://openalex.org/S28614077","display_name":"BMC Genomics","issn_l":"1471-2164","issn":["1471-2164"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Genomics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3716646824","display_name":null,"funder_award_id":"81001605","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320334800","display_name":"Research Committee, Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2057121663.pdf","grobid_xml":"https://content.openalex.org/works/W2057121663.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W100565014","https://openalex.org/W1548077722","https://openalex.org/W1786896381","https://openalex.org/W1962485447","https://openalex.org/W1963930594","https://openalex.org/W1966822396","https://openalex.org/W1971872341","https://openalex.org/W1984430581","https://openalex.org/W1984708728","https://openalex.org/W1990453950","https://openalex.org/W1993329606","https://openalex.org/W1993755424","https://openalex.org/W1994977506","https://openalex.org/W2000391338","https://openalex.org/W2010527250","https://openalex.org/W2034975610","https://openalex.org/W2035273977","https://openalex.org/W2038934471","https://openalex.org/W2039421073","https://openalex.org/W2043488515","https://openalex.org/W2043615442","https://openalex.org/W2046861930","https://openalex.org/W2047765648","https://openalex.org/W2055125610","https://openalex.org/W2056057030","https://openalex.org/W2061994683","https://openalex.org/W2062544327","https://openalex.org/W2064455418","https://openalex.org/W2068787149","https://openalex.org/W2073381739","https://openalex.org/W2107564978","https://openalex.org/W2111700120","https://openalex.org/W2116423958","https://openalex.org/W2119034410","https://openalex.org/W2121070354","https://openalex.org/W2121289999","https://openalex.org/W2125391135","https://openalex.org/W2129746249","https://openalex.org/W2133378187","https://openalex.org/W2134064101","https://openalex.org/W2139760555","https://openalex.org/W2141885858","https://openalex.org/W2148548982","https://openalex.org/W2154267159","https://openalex.org/W2154431984","https://openalex.org/W2155606054","https://openalex.org/W2156752503","https://openalex.org/W2158714788","https://openalex.org/W2159482845","https://openalex.org/W2159742629","https://openalex.org/W2167563606","https://openalex.org/W2168841237","https://openalex.org/W2171030481","https://openalex.org/W2180843619","https://openalex.org/W2314549920","https://openalex.org/W2346977787","https://openalex.org/W2373192935","https://openalex.org/W2416870789","https://openalex.org/W2916540073","https://openalex.org/W4252166161","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W4295234894","https://openalex.org/W4386143192","https://openalex.org/W2410724212","https://openalex.org/W2091956182","https://openalex.org/W2518721893","https://openalex.org/W4400687120","https://openalex.org/W3009331686","https://openalex.org/W7099382466","https://openalex.org/W1977605451","https://openalex.org/W2971594185"],"abstract_inverted_index":{"BACKGROUND:":[0],"Traditional":[1],"Chinese":[2],"medicine":[3],"uses":[4],"various":[5,11],"herbs":[6,98],"for":[7,13,93,154],"the":[8,24,56,72,79,100,120,133,140,157,172,184,199,214,220,230,265,283,321],"treatment":[9],"of":[10,15,28,59,96,156,169,216,234,252,258,297,308,323],"diseases":[12],"thousands":[14],"years":[16],"and":[17,26,36,61,74,85,109,139,190,208,226,237,260,264,294,310],"it":[18],"is":[19,49],"now":[20],"time":[21],"to":[22,77,194,223,272,281,314],"assess":[23,104],"characteristics":[25],"effectiveness":[27],"these":[29],"medicinal":[30,63,81,97,122,292],"plants":[31],"based":[32],"on":[33,180],"modern":[34],"genetic":[35],"molecular":[37],"tools.":[38],"The":[39,144],"herb":[40],"Flos":[41],"Lonicerae":[42],"Japonicae":[43],"(FLJ":[44],"or":[45],"Lonicera":[46],"japonica":[47,111],"Thunb.)":[48],"used":[50,92,271],"as":[51,164,166],"an":[52,249],"anti-inflammatory":[53],"agent":[54],"but":[55],"chemical":[57],"quality":[58],"FLJ":[60,84,108,259,274],"its":[62,238,261],"efficacy":[64],"has":[65],"not":[66],"been":[67],"consistent.":[68],"Here,":[69],"we":[70,187],"analyzed":[71,213],"transcriptomes":[73],"metabolic":[75,196,286],"pathways":[76,182,231,287],"evaluate":[78,273],"active":[80,201,221,291,324],"compounds":[82,222,293],"in":[83,99,256,289,316],"hope":[86],"that":[87,218,268,319],"this":[88],"approach":[89],"can":[90,269],"be":[91,270],"a":[94],"variety":[95],"future.":[101],"RESULTS:":[102],"We":[103,124,211],"transcriptomic":[105,126,145],"differences":[106],"between":[107,183,285],"L.":[110],"Thunb.":[112],"var.":[113],"chinensis":[114],"(Watts)":[115],"(rFLJ),":[116],"which":[117,312],"may":[118],"explain":[119],"variable":[121],"effects.":[123],"acquired":[125],"data":[127],"(over":[128],"100":[129],"million":[130],"reads)":[131],"from":[132,162,171],"two":[134,185],"herbs,":[135],"using":[136],"RNA-seq":[137],"method":[138],"Illumina":[141],"GAII":[142],"platform.":[143],"profiles":[146,193,255],"contain":[147],"over":[148],"6,000":[149],"expressed":[150],"sequence":[151],"tags":[152],"(ESTs)":[153],"each":[155],"three":[158],"flower":[159,174],"development":[160],"stages":[161],"FLJ,":[163],"well":[165],"comparable":[167],"amount":[168],"ESTs":[170],"rFLJ":[173,263],"bud.":[175],"To":[176],"elucidate":[177],"enzymatic":[178],"divergence":[179,307],"biosynthetic":[181],"varieties,":[186],"correlated":[188],"genes":[189,217],"their":[191,298],"expression":[192,254],"known":[195],"activities":[197],"involving":[198],"relevant":[200],"compounds,":[202],"including":[203],"phenolic":[204,235],"acids,":[205],"flavonoids,":[206],"terpenoids,":[207],"fatty":[209],"acids.":[210],"also":[212],"diversification":[215],"process":[219],"distinguish":[224],"orthologs":[225,309],"paralogs":[227],"together":[228],"with":[229,240],"concerning":[232],"biosynthesis":[233],"acid":[236],"connections":[239],"other":[241],"related":[242],"pathways.":[243],"CONCLUSIONS:":[244],"Our":[245,301],"study":[246],"provides":[247],"both":[248],"initial":[250],"description":[251],"gene":[253,295,317],"flowers":[257],"counterfeit":[262],"enzyme":[266],"pool":[267],"quality.":[275],"Detailed":[276],"molecular-level":[277],"analyses":[278],"allow":[279],"us":[280],"decipher":[282],"relationship":[284],"involved":[288],"processing":[290,299],"expressions":[296],"enzymes.":[300],"evolutionary":[302],"analysis":[303],"revealed":[304],"specific":[305],"functional":[306],"paralogs,":[311],"lead":[313],"variation":[315],"functions":[318],"govern":[320],"profile":[322],"compounds.":[325]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}