{"id":"https://openalex.org/W2057093659","doi":"https://doi.org/10.1073/pnas.81.3.974","title":"Quantitative investigation of hepatic genomic response to hormonal and pathophysiological stimuli by multivariate analysis of two-dimensional mRNA activity profiles.","display_name":"Quantitative investigation of hepatic genomic response to hormonal and pathophysiological stimuli by multivariate analysis of two-dimensional mRNA activity profiles.","publication_year":1984,"publication_date":"1984-02-01","ids":{"openalex":"https://openalex.org/W2057093659","doi":"https://doi.org/10.1073/pnas.81.3.974","mag":"2057093659","pmid":"https://pubmed.ncbi.nlm.nih.gov/6366794","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/344962"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.81.3.974","doi":"https://doi.org/10.1073/pnas.81.3.974","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.81.3.974","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/344962","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087721092","display_name":"Frances E. Carr","orcid":"https://orcid.org/0000-0001-7266-8788","observed_orcids":["https://orcid.org/0000-0001-7266-8788"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F E Carr","raw_affiliation_strings":["Department of Medicine, University of Minnesota, Minneapolis, MN 55455; and tDepartment of Applied Statistics,","University of Minnesota, St. Paul, MN 55108"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Minnesota, Minneapolis, MN 55455; and tDepartment of Applied Statistics,","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"University of Minnesota, St. Paul, MN 55108","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111368699","display_name":"C. Raymond Bingham","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Bingham","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111946284","display_name":"Jack H. Oppenheimer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J H Oppenheimer","raw_affiliation_strings":["Department of Medicine, University of Minnesota, Minneapolis, MN 55455; and tDepartment of Applied Statistics,","University of Minnesota, St. Paul, MN 55108"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Minnesota, Minneapolis, MN 55455; and tDepartment of Applied Statistics,","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"University of Minnesota, St. Paul, MN 55108","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":null,"display_name":"C Kistner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Kistner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5051497639","display_name":"Cary N. Mariash","orcid":"https://orcid.org/0000-0002-3675-0263","observed_orcids":["https://orcid.org/0000-0002-3675-0263"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C N Mariash","raw_affiliation_strings":["Department of Medicine, University of Minnesota, Minneapolis, MN 55455; and tDepartment of Applied Statistics,","University of Minnesota, St. Paul, MN 55108"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Minnesota, Minneapolis, MN 55455; and tDepartment of Applied Statistics,","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"University of Minnesota, St. Paul, MN 55108","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2067,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.88695185,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"81","issue":"3","first_page":"974","last_page":"978"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.40310001373291016,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.40310001373291016,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.11749999970197678,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.03700000047683716,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatic-gene-expression","display_name":"hepatic gene expression","score":0.8999999761581421},{"id":"https://openalex.org/keywords/two-dimensional-electrophoresis","display_name":"two-dimensional gel electrophoresis","score":0.925000011920929},{"id":"https://openalex.org/keywords/multivariate-analysis","display_name":"multivariate analysis","score":0.9259999990463257},{"id":"https://openalex.org/keywords/thyroid-function","display_name":"thyroid function","score":0.7699999809265137},{"id":"https://openalex.org/keywords/starvation","display_name":"starvation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/high-carbohydrate-diet","display_name":"high-carbohydrate diet","score":0.8799999952316284},{"id":"https://openalex.org/keywords/experimental-diabetes","display_name":"experimental diabetes","score":0.7960000038146973},{"id":"https://openalex.org/keywords/in-vitro-translation","display_name":"in vitro translation","score":0.6549999713897705},{"id":"https://openalex.org/keywords/rat-liver","display_name":"rat liver","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5990190505981445},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.581636369228363},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5516694784164429},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5427489876747131},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4885800778865814},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4744188189506531},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44273343682289124},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4410057067871094},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2992327809333801},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25230270624160767},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21281540393829346}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004040","descriptor_name":"Dietary Carbohydrates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005215","descriptor_name":"Fasting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013961","descriptor_name":"Thyroid Gland","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013965","descriptor_name":"Thyroidectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014284","descriptor_name":"Triiodothyronine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.81.3.974","doi":"https://doi.org/10.1073/pnas.81.3.974","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.81.3.974","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1294676","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/344962","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:344962","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/344962","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:6366794","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6366794","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1294676","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/344962","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306089","display_name":"American Diabetes Association","ror":"https://ror.org/04f6cgz95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W67170835","https://openalex.org/W142451008","https://openalex.org/W1606423922","https://openalex.org/W1964249630","https://openalex.org/W1970575167","https://openalex.org/W1987717903","https://openalex.org/W2007638374","https://openalex.org/W2017117462","https://openalex.org/W2020076663","https://openalex.org/W2087202250","https://openalex.org/W2089212277","https://openalex.org/W2118587067","https://openalex.org/W2163265131","https://openalex.org/W4289256183","https://openalex.org/W4294570726"],"related_works":["https://openalex.org/W1969588586","https://openalex.org/W2135052059","https://openalex.org/W1540708644","https://openalex.org/W2170179311","https://openalex.org/W2169363902","https://openalex.org/W1784412520","https://openalex.org/W2163265131","https://openalex.org/W1977290650","https://openalex.org/W2058544807","https://openalex.org/W2026901129"],"abstract_inverted_index":{"We":[0,43],"have":[1],"applied":[2],"techniques":[3],"of":[4,12,15,24,57,64,85,89,105,124,160,167,177],"multivariate":[5],"analysis":[6,100,166],"to":[7,115,129],"the":[8,13,22,25,62,78,86,94,116,120,142,158,178,182],"characterization":[9],"and":[10,18,61,122,154],"comparison":[11],"effects":[14],"various":[16,117],"pathophysiological":[17,46,155],"hormonal":[19,153],"stimuli":[20,156],"on":[21],"expression":[23],"rat":[26],"hepatic":[27,125,143,161],"genome":[28],"at":[29,181],"a":[30,110],"pretranslational":[31],"level.":[32,184],"In":[33],"vitro":[34],"translated":[35],"products":[36,90,106],"were":[37],"resolved":[38],"by":[39,50],"two-dimensional":[40,79],"gel":[41],"electrophoresis.":[42],"analyzed":[44],"10":[45],"states":[47],"brought":[48],"about":[49],"variation":[51],"in":[52,77,109,113,136],"thyroidal":[53],"status,":[54],"starvation,":[55],"administration":[56],"high":[58],"carbohydrate":[59],"diet,":[60],"production":[63],"experimentally":[65],"induced":[66],"diabetes":[67],"mellitus.":[68],"Each":[69],"state":[70,76],"differed":[71],"significantly":[72],"from":[73],"every":[74],"other":[75,131],"electrophoretic":[80],"profiles.":[81],"The":[82,99],"set":[83],"consisting":[84],"minimal":[87],"number":[88],"necessary":[91],"for":[92],"maintaining":[93],"distinctive":[95],"patterns":[96],"was":[97],"identified.":[98],"also":[101],"defined":[102],"those":[103],"clusters":[104],"that":[107,141],"behaved":[108],"coordinate":[111],"fashion":[112],"response":[114,180],"stimuli.":[118],"Lastly,":[119],"similarity":[121],"dissimilarity":[123],"mRNA":[126,144],"activity":[127,145],"profiles":[128,169],"each":[130],"could":[132,147],"be":[133,171],"geometrically":[134],"represented":[135],"three-dimensional":[137],"space.":[138],"Our":[139],"finding":[140],"profile":[146],"distinguish":[148],"reliably":[149],"between":[150],"closely":[151],"related":[152],"indicates":[157],"specificity":[159],"genomic":[162],"expression.":[163],"A":[164],"systematic":[165],"such":[168],"may":[170],"useful":[172],"as":[173],"an":[174],"overall":[175],"index":[176],"biologic":[179],"hepatocellular":[183]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}