{"id":"https://openalex.org/W2057092764","doi":"https://doi.org/10.1196/annals.1308.018","title":"Adolescent Development of Forebrain Stimulant Responsiveness: Insights from Animal Studies","display_name":"Adolescent Development of Forebrain Stimulant Responsiveness: Insights from Animal Studies","publication_year":2004,"publication_date":"2004-06-01","ids":{"openalex":"https://openalex.org/W2057092764","doi":"https://doi.org/10.1196/annals.1308.018","mag":"2057092764","pmid":"https://pubmed.ncbi.nlm.nih.gov/15251884"},"language":"en","primary_location":{"id":"doi:10.1196/annals.1308.018","doi":"https://doi.org/10.1196/annals.1308.018","is_oa":false,"landing_page_url":"https://doi.org/10.1196/annals.1308.018","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112340582","display_name":"Frances M. Leslie","orcid":"https://orcid.org/0000-0002-2207-8365","observed_orcids":["https://orcid.org/0000-0002-2207-8365"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"FRANCES M. LESLIE","raw_affiliation_strings":["Department of Pharmacology, College of Medicine, University of California, Irvine, CA 92697-4625, USA. fmleslie@uci.edu","Department of Anatomy & Neurobiology, College of Medicine, University of California, Irvine, California 92697, USA","Department of Pharmacology, University of California, Irvine, California 92697, USA","Transdisciplinary Tobacco Use Research Center, University of California, Irvine, California 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, College of Medicine, University of California, Irvine, CA 92697-4625, USA. fmleslie@uci.edu","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Anatomy & Neurobiology, College of Medicine, University of California, Irvine, California 92697, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Department of Pharmacology, University of California, Irvine, California 92697, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Transdisciplinary Tobacco Use Research Center, University of California, Irvine, California 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064480540","display_name":"Sandra E. Loughlin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SANDRA E. LOUGHLIN","raw_affiliation_strings":["Department of Pharmacology, University of California, Irvine, California 92697, USA","Transdisciplinary Tobacco Use Research Center, University of California, Irvine, California 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of California, Irvine, California 92697, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Transdisciplinary Tobacco Use Research Center, University of California, Irvine, California 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101454420","display_name":"Ruihua Wang","orcid":"https://orcid.org/0000-0003-4809-7262","observed_orcids":["https://orcid.org/0000-0003-4809-7262"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"RUIHUA WANG","raw_affiliation_strings":["Department of Pharmacology, University of California, Irvine, California 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of California, Irvine, California 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":null,"display_name":"LILYANNA PEREZ","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"LILYANNA PEREZ","raw_affiliation_strings":["Department of Anatomy & Neurobiology, College of Medicine, University of California, Irvine, California 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy & Neurobiology, College of Medicine, University of California, Irvine, California 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008628611","display_name":"Shahrdad Lotfipour","orcid":"https://orcid.org/0000-0002-2425-1096","observed_orcids":["https://orcid.org/0000-0002-2425-1096"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SHAHRDAD LOTFIPOUR","raw_affiliation_strings":["Department of Anatomy & Neurobiology, College of Medicine, University of California, Irvine, California 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy & Neurobiology, College of Medicine, University of California, Irvine, California 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024423773","display_name":"JAMES D. BELLUZZIA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JAMES D. BELLUZZIA","raw_affiliation_strings":["Department of Pharmacology, University of California, Irvine, California 92697, USA","Transdisciplinary Tobacco Use Research Center, University of California, Irvine, California 92697, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of California, Irvine, California 92697, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Transdisciplinary Tobacco Use Research Center, University of California, Irvine, California 92697, USA","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112340582"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":0.657,"has_fulltext":false,"cited_by_count":83,"citation_normalized_percentile":{"value":0.54075775,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"1021","issue":"1","first_page":"148","last_page":"159"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.7002000212669373,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.7002000212669373,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.11710000038146973,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.09359999746084213,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adolescent-development","display_name":"adolescent development","score":0.7350000143051147},{"id":"https://openalex.org/keywords/nicotine-reward","display_name":"nicotine reward","score":0.722000002861023},{"id":"https://openalex.org/keywords/cocaine","display_name":"cocaine","score":0.5879999995231628},{"id":"https://openalex.org/keywords/neuronal-activation","display_name":"neuronal activation","score":0.7490000128746033},{"id":"https://openalex.org/keywords/limbic-cortex","display_name":"limbic cortex","score":0.9639999866485596},{"id":"https://openalex.org/keywords/sensory-cortex","display_name":"sensory cortex","score":0.9210000038146973},{"id":"https://openalex.org/keywords/prefrontal-cortex-maturation","display_name":"prefrontal cortex maturation","score":0.925000011920929},{"id":"https://openalex.org/keywords/set-shifting","display_name":"set-shifting","score":0.8640000224113464},{"id":"https://openalex.org/keywords/cognitive-flexibility","display_name":"cognitive flexibility","score":0.9430000185966492},{"id":"https://openalex.org/keywords/psychostimulant-sensitivity","display_name":"psychostimulant sensitivity","score":0.8040000200271606},{"id":"https://openalex.org/keywords/forebrain","display_name":"forebrain","score":0.6050000190734863}],"concepts":[{"id":"https://openalex.org/C2780557958","wikidata":"https://www.wikidata.org/wiki/Q211036","display_name":"Stimulant","level":2,"score":0.9010576009750366},{"id":"https://openalex.org/C2779715522","wikidata":"https://www.wikidata.org/wiki/Q507027","display_name":"Forebrain","level":3,"score":0.8515421748161316},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.43629294633865356},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4224911332130432},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.35709643363952637},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.19016411900520325},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.11027491092681885}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003216","descriptor_name":"Conditioning, Operant","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004193","descriptor_name":"Discrimination Learning","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012201","descriptor_name":"Reward","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012646","descriptor_name":"Self Administration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016548","descriptor_name":"Prosencephalon","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D016548","descriptor_name":"Prosencephalon","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016548","descriptor_name":"Prosencephalon","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D018722","descriptor_name":"Nicotinic Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1196/annals.1308.018","doi":"https://doi.org/10.1196/annals.1308.018","is_oa":false,"landing_page_url":"https://doi.org/10.1196/annals.1308.018","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:15251884","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15251884","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4033277851","display_name":"CENTER ON TOBACCO USE SUSCEPTIBILITY AND INTERVENTION","funder_award_id":"P50DA013332","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W1492515956","https://openalex.org/W1532805410","https://openalex.org/W1566487806","https://openalex.org/W1575705900","https://openalex.org/W1579518684","https://openalex.org/W1603591159","https://openalex.org/W1672681123","https://openalex.org/W1768956672","https://openalex.org/W1964870103","https://openalex.org/W1966266993","https://openalex.org/W1967080377","https://openalex.org/W1967858799","https://openalex.org/W1971487556","https://openalex.org/W1971520272","https://openalex.org/W1974725748","https://openalex.org/W1980890656","https://openalex.org/W1982804225","https://openalex.org/W1985645068","https://openalex.org/W1986540496","https://openalex.org/W1988834155","https://openalex.org/W1994910390","https://openalex.org/W1995599717","https://openalex.org/W2003615600","https://openalex.org/W2007053401","https://openalex.org/W2013122647","https://openalex.org/W2014479855","https://openalex.org/W2017934537","https://openalex.org/W2020497215","https://openalex.org/W2020995685","https://openalex.org/W2026918648","https://openalex.org/W2027458270","https://openalex.org/W2029899001","https://openalex.org/W2032517670","https://openalex.org/W2035631704","https://openalex.org/W2040142797","https://openalex.org/W2041527379","https://openalex.org/W2041827999","https://openalex.org/W2043259970","https://openalex.org/W2045971161","https://openalex.org/W2050233787","https://openalex.org/W2061828239","https://openalex.org/W2063764296","https://openalex.org/W2064635403","https://openalex.org/W2067299901","https://openalex.org/W2069084305","https://openalex.org/W2071416598","https://openalex.org/W2077618560","https://openalex.org/W2079864103","https://openalex.org/W2086582374","https://openalex.org/W2086941401","https://openalex.org/W2088641905","https://openalex.org/W2088753284","https://openalex.org/W2089645365","https://openalex.org/W2090762149","https://openalex.org/W2092842616","https://openalex.org/W2095408844","https://openalex.org/W2102773298","https://openalex.org/W2108634148","https://openalex.org/W2113631648","https://openalex.org/W2117141679","https://openalex.org/W2126085007","https://openalex.org/W2126502833","https://openalex.org/W2128856736","https://openalex.org/W2135601216","https://openalex.org/W2136550122","https://openalex.org/W2136699448","https://openalex.org/W2137587432","https://openalex.org/W2158052449","https://openalex.org/W2161886949","https://openalex.org/W2166670920","https://openalex.org/W2427465207","https://openalex.org/W2764471260"],"related_works":["https://openalex.org/W2288280626","https://openalex.org/W2034401739","https://openalex.org/W1995304320","https://openalex.org/W838590166","https://openalex.org/W2031306868","https://openalex.org/W2027729880","https://openalex.org/W3173345344","https://openalex.org/W2293320962","https://openalex.org/W2103897259","https://openalex.org/W1981574077"],"abstract_inverted_index":{"Although":[0],"initiation":[1,40],"of":[2,16,50,55,59,69,79,89,108,120,122,131,172,184,194,215],"drug":[3,236],"abuse":[4],"occurs":[5],"primarily":[6],"during":[7,22,41,125,151,166,188],"adolescence,":[8],"little":[9],"is":[10,33,135,212],"known":[11],"about":[12],"the":[13,56,80,85,138,163],"central":[14],"effects":[15,58,88,237],"nicotine":[17,90],"and":[18,93,147,179,197],"other":[19,60],"abused":[20,61,222],"drugs":[21],"this":[23,240],"developmental":[24,53,98,139],"period.":[25],"Here":[26],"evidence,":[27],"derived":[28],"from":[29,45,67],"studies":[30],"in":[31,72,91,105,112,144,206,232,239],"rodents,":[32],"presented":[34],"that":[35,37,68,175,210],"suggests":[36,190],"tobacco":[38],"use":[39],"early":[42,82,126,169],"adolescence":[43,167,189,211],"results":[44],"a":[46,118,213],"higher":[47],"reward":[48],"value":[49],"nicotine.":[51,70],"The":[52,182],"profiles":[54],"rewarding":[57],"drugs,":[62],"such":[63],"as":[64],"cocaine,":[65],"differ":[66],"Using":[71],"situ":[73],"hybridization":[74],"to":[75,160,218,228,234],"quantify":[76],"mRNA":[77,110],"levels":[78,107],"immediate":[81],"gene,":[83],"cfos,":[84],"neuronal":[86,133],"activating":[87],"limbic":[92,123,146],"sensory":[94,148],"cortices":[95,124,174],"at":[96,201],"different":[97],"stages":[99],"are":[100,115,226],"evaluated.":[101],"Significant":[102],"age":[103,241],"changes":[104],"basal":[106],"cfos":[109],"expression":[111],"cortical":[113],"regions":[114],"observed,":[116],"with":[117,141],"peak":[119],"responding":[121,150,187],"adolescence.":[127,152],"A":[128],"changing":[129],"pattern":[130],"nicotine-induced":[132],"activation":[134],"seen":[136],"across":[137],"spectrum,":[140],"unique":[142],"differences":[143,165],"both":[145],"cortex":[149],"An":[153],"attentional":[154],"set-shifting":[155],"task":[156],"was":[157],"also":[158],"used":[159],"evaluate":[161,235],"whether":[162],"observed":[164],"reflect":[168],"functional":[170,192],"immaturity":[171],"prefrontal":[173,195],"regulate":[176],"motivated":[177],"behavior":[178],"psychostimulant":[180],"responding.":[181],"finding":[183],"significantly":[185],"better":[186],"apparent":[191],"maturity":[193],"circuits":[196],"greater":[198],"cognitive":[199],"flexibility":[200],"younger":[202],"ages.":[203],"These":[204],"findings":[205],"rodent":[207],"models":[208],"suggest":[209],"period":[214],"altered":[216],"sensitivity":[217],"environmental":[219],"stimuli,":[220],"including":[221],"drugs.":[223],"Further":[224],"efforts":[225],"required":[227],"overcome":[229],"technical":[230],"challenges":[231],"order":[233],"systematically":[238],"group.":[242]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
