{"id":"https://openalex.org/W2057069809","doi":"https://doi.org/10.1159/000201570","title":"The p53 Codon 72 Exon 4 BstUI Polymorphism and Endometrial Cancer in Caucasian Women","display_name":"The p53 Codon 72 Exon 4 BstUI Polymorphism and Endometrial Cancer in Caucasian Women","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2057069809","doi":"https://doi.org/10.1159/000201570","mag":"2057069809","pmid":"https://pubmed.ncbi.nlm.nih.gov/19209008"},"language":"en","primary_location":{"id":"doi:10.1159/000201570","doi":"https://doi.org/10.1159/000201570","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000201570","pdf_url":null,"source":{"id":"https://openalex.org/S198727964","display_name":"Oncology","issn_l":"0030-2414","issn":["0030-2414","1423-0232"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030441119","display_name":"Pavol \u017d\u00fabor","orcid":"https://orcid.org/0009-0003-1423-5556","observed_orcids":["https://orcid.org/0009-0003-1423-5556","https://orcid.org/0000-0003-0244-0125"]},"institutions":[{"id":"https://openalex.org/I74788687","display_name":"Comenius University Bratislava","ror":"https://ror.org/0587ef340","country_code":"SK","type":"education","lineage":["https://openalex.org/I74788687"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Pavol Zubor","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovak Republic. zubor@jfmed.uniba.sk","Departments of Obstetrics and Gynaecology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovak Republic. zubor@jfmed.uniba.sk","institution_ids":["https://openalex.org/I74788687"]},{"raw_affiliation_string":"Departments of Obstetrics and Gynaecology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011600147","display_name":"Andrea \u0160tanclov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrea Stanclova","raw_affiliation_strings":["Pathological Anatomy and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathological Anatomy and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043873828","display_name":"Karol Kajo","orcid":"https://orcid.org/0000-0002-8178-1093","observed_orcids":["https://orcid.org/0000-0002-8178-1093"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karol Kajo","raw_affiliation_strings":["Pathological Anatomy and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathological Anatomy and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007477358","display_name":"Jozef Hatok","orcid":"https://orcid.org/0000-0002-3994-1436","observed_orcids":["https://orcid.org/0000-0002-3994-1436"]},"institutions":[{"id":"https://openalex.org/I74788687","display_name":"Comenius University Bratislava","ror":"https://ror.org/0587ef340","country_code":"SK","type":"education","lineage":["https://openalex.org/I74788687"]}],"countries":["SK"],"is_corresponding":false,"raw_author_name":"Jozef Hatok","raw_affiliation_strings":["Biochemistry, Jessenius Faculty of Medicine, Comenius University, Martin, Slovak Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry, Jessenius Faculty of Medicine, Comenius University, Martin, Slovak Republic","institution_ids":["https://openalex.org/I74788687"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054650832","display_name":"Dasa Klobusiakova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dasa Klobusiakova","raw_affiliation_strings":["Departments of Obstetrics and Gynaecology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Obstetrics and Gynaecology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001931438","display_name":"Jozef Vi\u0161\u0148ovsk\u00fd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jozef Visnovsky","raw_affiliation_strings":["Departments of Obstetrics and Gynaecology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Obstetrics and Gynaecology,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039379906","display_name":"J\u00e1n Danko","orcid":"https://orcid.org/0000-0001-6871-7583","observed_orcids":["https://orcid.org/0000-0001-6871-7583"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan Danko","raw_affiliation_strings":["Departments of Obstetrics and Gynaecology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Obstetrics and Gynaecology,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7386,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.84934109,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"76","issue":"3","first_page":"173","last_page":"183"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.8080999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.8080999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.07850000262260437,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.03460000082850456,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53-arg72pro-polymorphism","display_name":"p53 Arg72Pro polymorphism","score":0.9160000085830688},{"id":"https://openalex.org/keywords/endometrial-cancer","display_name":"endometrial cancer","score":0.949999988079071},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.6940000057220459},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7670000195503235},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.8460000157356262},{"id":"https://openalex.org/keywords/age-at-menarche","display_name":"age at menarche","score":0.7929999828338623},{"id":"https://openalex.org/keywords/age-at-menopause","display_name":"age at menopause","score":0.7329999804496765},{"id":"https://openalex.org/keywords/white-women","display_name":"white women","score":0.5879999995231628},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.5680000185966492},{"id":"https://openalex.org/keywords/type-ii-endometrial-carcinoma","display_name":"type II endometrial carcinoma","score":0.6759999990463257},{"id":"https://openalex.org/keywords/vascular-invasion","display_name":"vascular invasion","score":0.796999990940094},{"id":"https://openalex.org/keywords/tumour-stage-at-diagnosis","display_name":"tumour stage at diagnosis","score":0.5059999823570251}],"concepts":[{"id":"https://openalex.org/C2777088508","wikidata":"https://www.wikidata.org/wiki/Q944777","display_name":"Endometrial cancer","level":3,"score":0.8005639910697937},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.729401171207428},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.7199258208274841},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5958682894706726},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5727636218070984},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5627838969230652},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5078826546669006},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.4908495545387268},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4803972542285919},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.475369393825531},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.46225306391716003},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.4529990553855896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37149038910865784},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3241484761238098},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2877691984176636},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.28093278408050537},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13518354296684265}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003062","descriptor_name":"Codon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008572","descriptor_name":"Menarche","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008593","descriptor_name":"Menopause","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015252","descriptor_name":"Deoxyribonucleases, Type II Site-Specific","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016889","descriptor_name":"Endometrial Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1159/000201570","doi":"https://doi.org/10.1159/000201570","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000201570","pdf_url":null,"source":{"id":"https://openalex.org/S198727964","display_name":"Oncology","issn_l":"0030-2414","issn":["0030-2414","1423-0232"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology","raw_type":"journal-article"},{"id":"pmid:19209008","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19209008","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W121421619","https://openalex.org/W1570030726","https://openalex.org/W1643155728","https://openalex.org/W1966402708","https://openalex.org/W1974018903","https://openalex.org/W1985208675","https://openalex.org/W1994858585","https://openalex.org/W2023736002","https://openalex.org/W2026342938","https://openalex.org/W2026422116","https://openalex.org/W2037379752","https://openalex.org/W2041157195","https://openalex.org/W2044869180","https://openalex.org/W2060421431","https://openalex.org/W2065643866","https://openalex.org/W2068572597","https://openalex.org/W2075230059","https://openalex.org/W2078222310","https://openalex.org/W2094427247","https://openalex.org/W2095627214","https://openalex.org/W2101943966","https://openalex.org/W2102823703","https://openalex.org/W2104940440","https://openalex.org/W2105200249","https://openalex.org/W2108190602","https://openalex.org/W2113190292","https://openalex.org/W2118925298","https://openalex.org/W2119763874","https://openalex.org/W2122969677","https://openalex.org/W2126024803","https://openalex.org/W2138068224","https://openalex.org/W2140847299","https://openalex.org/W2144386753","https://openalex.org/W2167512417"],"related_works":["https://openalex.org/W2147112440","https://openalex.org/W2097901640","https://openalex.org/W2041157195","https://openalex.org/W2226233017","https://openalex.org/W2100175840","https://openalex.org/W1995811689","https://openalex.org/W2327907857","https://openalex.org/W2167512417","https://openalex.org/W2466661793","https://openalex.org/W2154700137"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Studies":[1],"on":[2,30],"the":[3,6,18,25,49,65,115,122,164,235,265,290,293,311],"association":[4,56],"between":[5,297],"p53":[7,66,294],"Arg72Pro":[8,295],"polymorphism":[9,29,69,305],"and":[10,54,86,97,110,125,139,145,149,181,209,228,256,299,316],"endometrial":[11,31,52,314],"cancer":[12,53,77,245,315],"have":[13],"reported":[14],"contrasting":[15],"conclusions.":[16],"With":[17],"exception":[19],"of":[20,27,51,73,163,172,184,215,275,292,313],"Asian":[21],"subjects,":[22],"data":[23,111,282],"demonstrating":[24],"influence":[26],"this":[28,304],"carcinogenesis":[32],"in":[33,48,70,132,161,246,289,319],"other":[34],"races/ethnic":[35],"groups,":[36],"including":[37],"Caucasians,":[38],"are":[39],"scarce.":[40],"Thus,":[41],"we":[42,192],"aimed":[43],"to":[44,104,128],"investigate":[45],"its":[46,55],"role":[47],"development":[50],"with":[57,94,167,213,240,248,310],"prognostic":[58,317],"markers.":[59],"METHODS:":[60],"A":[61],"case-control":[62],"study":[63],"examining":[64],"codon":[67],"72":[68],"a":[71,194,241],"total":[72],"451":[74],"samples":[75],"(121":[76],"patients,":[78],"330":[79],"healthy":[80],"controls)":[81],"using":[82,114],"polymerase":[83],"chain":[84],"reaction":[85],"sequencing":[87],"techniques":[88],"was":[89,238],"conducted.":[90],"Genotypes":[91],"were":[92,102,112,278],"correlated":[93],"clinico-pathological":[95],"factors":[96,318],"age.":[98],"Logistic":[99,152],"regression":[100,153],"analyses":[101],"used":[103],"adjust":[105],"for":[106,159,179,189,196,244,271],"possible":[107],"confounding":[108],"variables,":[109,273],"evaluated":[113],"Pearson":[116],"chi(2)":[117],"test.":[118],"RESULTS:":[119],"We":[120],"found":[121],"Pro":[123,165,236],"allele":[124],"genotype":[126,237,296],"frequency":[127],"be":[129],"insignificantly":[130],"higher":[131],"cases":[133],"than":[134],"controls":[135],"(Pro":[136],"allele:":[137],"24.8":[138],"22.3%,":[140],"respectively;":[141],"genotypes:":[142],"Arg/Pro":[143,197],"36.36":[144],"34.24%,":[146],"Pro/Pro":[147,199],"6.61":[148],"5.15%,":[150],"respectively).":[151],"analysis":[154],"revealed":[155],"an":[156,168,182],"increased":[157,266],"risk":[158,243,269,312],"disease":[160],"carriers":[162],"allele,":[166],"odds":[169],"ratio":[170],"(OR)":[171],"1.13":[173],"[95%":[174],"confidence":[175],"interval":[176],"(CI)":[177],"0.73-1.76]":[178],"heterozygotes":[180],"OR":[183],"1.36":[185],"(95%":[186,217,221,225,230],"CI":[187,218,222,226,231,254,262],"0.56-3.30)":[188],"homozygotes.":[190],"Furthermore,":[191],"noted":[193],"trend":[195],"+":[198],"towards":[200],"poor":[201],"tumour":[202],"differentiation,":[203],"angioinvasion,":[204],"pelvic":[205],"lymph":[206],"node":[207],"spread":[208],"type":[210],"II":[211],"carcinomas,":[212],"ORs":[214],"1.27":[216],"0.60-2.66),":[219],"1.24":[220],"0.67-2.30),":[223],"1.21":[224],"0.53-2.75)":[227],"1.69":[229],"0.70-4.10),":[232],"respectively.":[233],"Additionally,":[234],"associated":[239,309],"lower":[242],"women":[247],"early":[249],"menarche":[250],"(OR":[251,259],"1.17,":[252],"95%":[253,261],"0.60-2.28)":[255],"late":[257],"menopause":[258],"0.70,":[260],"0.30-1.63).":[263],"Despite":[264],"or":[267],"decreased":[268],"observed":[270],"some":[272],"none":[274],"these":[276],"trends":[277],"significant.":[279],"CONCLUSIONS:":[280],"Our":[281],"did":[283],"not":[284],"demonstrate":[285],"any":[286],"significant":[287],"difference":[288],"prevalence":[291],"patients":[298],"controls,":[300],"providing":[301],"evidence":[302],"that":[303],"is":[306],"only":[307],"weakly":[308],"Caucasian":[320],"women.":[321]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
