{"id":"https://openalex.org/W2057060295","doi":"https://doi.org/10.2174/157016007781669178","title":"Pharmacogenomics of Non-Small Cell Lung Cancer","display_name":"Pharmacogenomics of Non-Small Cell Lung Cancer","publication_year":2007,"publication_date":"2007-08-28","ids":{"openalex":"https://openalex.org/W2057060295","doi":"https://doi.org/10.2174/157016007781669178","mag":"2057060295"},"language":"en","primary_location":{"id":"doi:10.2174/157016007781669178","doi":"https://doi.org/10.2174/157016007781669178","is_oa":false,"landing_page_url":"https://doi.org/10.2174/157016007781669178","pdf_url":null,"source":{"id":"https://openalex.org/S19792597","display_name":"Current Pharmacogenomics","issn_l":"1570-1603","issn":["1570-1603","1875-6204"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmacogenomics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034748028","display_name":"James F. Spicer","orcid":"https://orcid.org/0000-0003-3732-8491","observed_orcids":["https://orcid.org/0000-0003-3732-8491","https://orcid.org/0009-0005-6890-2128"]},"institutions":[{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James Spicer","raw_affiliation_strings":["King \u2018s College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King \u2018s College London","institution_ids":["https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067102201","display_name":"P. Andrew Futreal","orcid":"https://orcid.org/0000-0001-8663-2671","observed_orcids":["https://orcid.org/0000-0001-8663-2671"]},"institutions":[{"id":"https://openalex.org/I2802476451","display_name":"Wellcome Sanger Institute","ror":"https://ror.org/05cy4wa09","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2802476451","https://openalex.org/I87048295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew Futreal","raw_affiliation_strings":["Wellcome Sanger Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellcome Sanger Institute","institution_ids":["https://openalex.org/I2802476451"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072378199","display_name":"Johann Sebastian De Bono","orcid":"https://orcid.org/0000-0002-2034-595X","observed_orcids":["https://orcid.org/0000-0002-2034-595X"]},"institutions":[{"id":"https://openalex.org/I142947616","display_name":"Institute of Cancer Research","ror":"https://ror.org/043jzw605","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I142947616"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Johann De Bono","raw_affiliation_strings":["The Institute of Cancer Research London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Cancer Research London","institution_ids":["https://openalex.org/I142947616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.208559,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"3","first_page":"228","last_page":"234"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9810000061988831},{"id":"https://openalex.org/keywords/pharmacogenomics","display_name":"pharmacogenomics","score":0.9990000128746033},{"id":"https://openalex.org/keywords/egfr-mutation","display_name":"EGFR mutation","score":0.7160000205039978},{"id":"https://openalex.org/keywords/gefitinib","display_name":"gefitinib","score":0.9950000047683716},{"id":"https://openalex.org/keywords/bcr-abl-fusion","display_name":"BCR-ABL fusion gene","score":0.9940000176429749},{"id":"https://openalex.org/keywords/chemotherapy-response","display_name":"chemotherapy response","score":0.7820000052452087},{"id":"https://openalex.org/keywords/germline-genetic-variation","display_name":"germline genetic variation","score":0.8119999766349792},{"id":"https://openalex.org/keywords/molecular-heterogeneity","display_name":"molecular heterogeneity","score":0.7739999890327454},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.7829999923706055},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.7889999747276306}],"concepts":[{"id":"https://openalex.org/C170734499","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenomics","level":2,"score":0.7625339031219482},{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.6945422887802124},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6661774516105652},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6603623628616333},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6180024147033691},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5597072243690491},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5029255747795105},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.487002432346344},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4529820382595062},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43550994992256165},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.37872764468193054},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22489136457443237},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.12073555588722229}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2174/157016007781669178","doi":"https://doi.org/10.2174/157016007781669178","is_oa":false,"landing_page_url":"https://doi.org/10.2174/157016007781669178","pdf_url":null,"source":{"id":"https://openalex.org/S19792597","display_name":"Current Pharmacogenomics","issn_l":"1570-1603","issn":["1570-1603","1875-6204"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmacogenomics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2024934599","https://openalex.org/W1981246896","https://openalex.org/W2120512254","https://openalex.org/W3148881633","https://openalex.org/W2004088207","https://openalex.org/W2356274630","https://openalex.org/W1980529851","https://openalex.org/W7168137165","https://openalex.org/W1022449723","https://openalex.org/W2024585537"],"abstract_inverted_index":{"Despite":[0],"the":[1,11,23,32,68,82,85,99,108],"availabilty":[2],"of":[3,25,34,71,84,91,110],"active":[4],"chemotherapy":[5],"combinations":[6],"and":[7,94,117],"novel":[8],"targeted":[9,118],"agents,":[10],"prognosis":[12],"in":[13,57,137],"advanced":[14],"non-small":[15],"cell":[16],"cancer":[17,86,101],"(NSCLC)":[18],"remains":[19,43],"poor.":[20],"Similarly,":[21],"although":[22],"efficacy":[24],"adjuvant":[26],"chemotherpy":[27],"has":[28],"recently":[29],"been":[30],"established,":[31],"risk":[33],"disease":[35,42],"recurrence":[36],"after":[37],"surgery":[38],"for":[39,112,141],"early":[40],"stage":[41],"high.":[44],"Some":[45],"patients":[46,111],"enjoy":[47],"sustained":[48],"benefit":[49],"from":[50],"currently":[51],"available":[52],"drugs,":[53],"but":[54],"overall":[55],"results":[56],"unselected":[58],"patient":[59],"groups":[60],"are":[61],"modest.":[62],"This":[63],"marked":[64],"inter-patient":[65],"variation":[66],"reflects":[67],"molecular":[69],"heterogeneity":[70,74],"NSCLC,":[72],"a":[73],"which":[75],"is":[76,103,122],"increasingly":[77],"understood":[78],"to":[79,106,132],"arise":[80],"at":[81],"level":[83],"genome.":[87],"The":[88],"wide":[89],"range":[90],"somatic":[92],"genetic":[93],"epigenetic":[95],"events":[96],"that":[97,125],"drive":[98],"lung":[100],"phenotype":[102],"now":[104],"beginning":[105],"inform":[107],"selection":[109],"treatment":[113,139],"with":[114],"both":[115],"cytotoxic":[116],"therapies.":[119],"Furthermore,":[120],"it":[121],"becoming":[123],"apparent":[124],"germline":[126],"genomic":[127],"variability":[128],"may":[129],"also":[130],"need":[131],"be":[133],"taken":[134],"into":[135],"account":[136],"making":[138],"decisions":[140],"NSCLC":[142],"patients.":[143],"Keywords:":[144],"epidermal":[145],"growth":[146],"factor":[147],"receptor":[148],"mutations,":[149],"Gefitinib,":[150],"BCR-ABL":[151],"fusion,":[152],"chemotherapy,":[153],"ERCC1":[154],"expression":[155]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
