{"id":"https://openalex.org/W2057049893","doi":"https://doi.org/10.1016/0165-4608(87)90156-7","title":"Cytogenetic studies of a human medullary thyroid carcinoma cell line","display_name":"Cytogenetic studies of a human medullary thyroid carcinoma cell line","publication_year":1987,"publication_date":"1987-03-01","ids":{"openalex":"https://openalex.org/W2057049893","doi":"https://doi.org/10.1016/0165-4608(87)90156-7","mag":"2057049893","pmid":"https://pubmed.ncbi.nlm.nih.gov/3467830"},"language":"en","primary_location":{"id":"doi:10.1016/0165-4608(87)90156-7","doi":"https://doi.org/10.1016/0165-4608(87)90156-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0165-4608(87)90156-7","pdf_url":null,"source":{"id":"https://openalex.org/S4210175027","display_name":"Cancer Genetics and Cytogenetics","issn_l":"0165-4608","issn":["0165-4608","1873-4456"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Genetics and Cytogenetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103532579","display_name":"Kimio J. Tanaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4390039317","display_name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center","ror":"https://ror.org/01vft3j45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I14285509","https://openalex.org/I4390039317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimio Tanaka","raw_affiliation_strings":["Section of Cancer Genetics, University of Maryland Cancer Center, University of Maryland School of Medicine, Baltimore, MD USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cancer Genetics, University of Maryland Cancer Center, University of Maryland School of Medicine, Baltimore, MD USA","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I4390039317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058612163","display_name":"Stephen B. Baylin","orcid":"https://orcid.org/0000-0003-3697-3798","observed_orcids":["https://orcid.org/0000-0003-3697-3798"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen B. Baylin","raw_affiliation_strings":["Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD USA","Oncology Center, The Johns Hopkins Medical Institutions, Baltimore, MD USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Oncology Center, The Johns Hopkins Medical Institutions, Baltimore, MD USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010169788","display_name":"Barry D. Nelkin","orcid":"https://orcid.org/0000-0002-1552-6377","observed_orcids":["https://orcid.org/0000-0002-1552-6377"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barry D. Nelkin","raw_affiliation_strings":["Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD USA","Oncology Center, The Johns Hopkins Medical Institutions, Baltimore, MD USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Oncology Center, The Johns Hopkins Medical Institutions, Baltimore, MD USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014868247","display_name":"Joseph R. Testa","orcid":"https://orcid.org/0000-0003-1301-5175","observed_orcids":["https://orcid.org/0000-0003-1301-5175"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4390039317","display_name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center","ror":"https://ror.org/01vft3j45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I14285509","https://openalex.org/I4390039317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joseph R. Testa","raw_affiliation_strings":["Section of Cancer Genetics, University of Maryland Cancer Center, University of Maryland School of Medicine, Baltimore, MD USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cancer Genetics, University of Maryland Cancer Center, University of Maryland School of Medicine, Baltimore, MD USA","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I4390039317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5014868247"],"corresponding_institution_ids":["https://openalex.org/I126744593","https://openalex.org/I4390039317"],"apc_list":null,"apc_paid":null,"fwci":3.494,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.92901049,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"1","first_page":"27","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medullary-thyroid-carcinoma","display_name":"medullary thyroid carcinoma","score":1.0},{"id":"https://openalex.org/keywords/tt-cell-line","display_name":"TT cell line","score":0.9430000185966492},{"id":"https://openalex.org/keywords/karyotype","display_name":"karyotype","score":0.9169999957084656},{"id":"https://openalex.org/keywords/hypodiploidy","display_name":"hypodiploidy","score":0.8569999933242798},{"id":"https://openalex.org/keywords/chromosomal-rearrangements","display_name":"chromosomal rearrangements","score":0.906000018119812},{"id":"https://openalex.org/keywords/chromosome-11","display_name":"chromosome 11","score":0.878000020980835},{"id":"https://openalex.org/keywords/calcitonin-gene","display_name":"calcitonin gene","score":0.9879999756813049},{"id":"https://openalex.org/keywords/chromosome-11-deletion","display_name":"chromosome 11 deletion","score":0.9549999833106995},{"id":"https://openalex.org/keywords/sporadic-medullary-thyroid-carcinoma","display_name":"sporadic medullary thyroid carcinoma","score":0.8059999942779541},{"id":"https://openalex.org/keywords/karyotype-stability","display_name":"karyotype stability","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8024168014526367},{"id":"https://openalex.org/C53226629","wikidata":"https://www.wikidata.org/wiki/Q189967","display_name":"Karyotype","level":4,"score":0.7387528419494629},{"id":"https://openalex.org/C2779627488","wikidata":"https://www.wikidata.org/wiki/Q315860","display_name":"Calcitonin","level":2,"score":0.7141016721725464},{"id":"https://openalex.org/C2776667971","wikidata":"https://www.wikidata.org/wiki/Q6807316","display_name":"Medullary carcinoma","level":4,"score":0.6416107416152954},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.5612690448760986},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.5374913811683655},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.5140656232833862},{"id":"https://openalex.org/C130773972","wikidata":"https://www.wikidata.org/wiki/Q904181","display_name":"Marker chromosome","level":5,"score":0.4293172359466553},{"id":"https://openalex.org/C174475383","wikidata":"https://www.wikidata.org/wiki/Q246128","display_name":"Cytogenetics","level":4,"score":0.42527538537979126},{"id":"https://openalex.org/C195121873","wikidata":"https://www.wikidata.org/wiki/Q1131385","display_name":"Medullary cavity","level":2,"score":0.4109065532684326},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36162716150283813},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32343894243240356},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2763257622718811},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.26063859462738037},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.201048344373703},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.12929373979568481},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06294512748718262}],"mesh":[{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011003","descriptor_name":"Ploidies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/0165-4608(87)90156-7","doi":"https://doi.org/10.1016/0165-4608(87)90156-7","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0165-4608(87)90156-7","pdf_url":null,"source":{"id":"https://openalex.org/S4210175027","display_name":"Cancer Genetics and Cytogenetics","issn_l":"0165-4608","issn":["0165-4608","1873-4456"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Genetics and Cytogenetics","raw_type":"journal-article"},{"id":"pmid:3467830","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3467830","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer genetics and cytogenetics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W110182977","https://openalex.org/W1490026085","https://openalex.org/W1496458703","https://openalex.org/W1519519905","https://openalex.org/W1525850954","https://openalex.org/W1594043562","https://openalex.org/W1906167831","https://openalex.org/W1966030630","https://openalex.org/W1966406203","https://openalex.org/W1977508321","https://openalex.org/W1980710371","https://openalex.org/W1981447883","https://openalex.org/W1990516512","https://openalex.org/W2001509055","https://openalex.org/W2009575342","https://openalex.org/W2012500896","https://openalex.org/W2017164036","https://openalex.org/W2030480699","https://openalex.org/W2032972450","https://openalex.org/W2044366071","https://openalex.org/W2050586989","https://openalex.org/W2051902571","https://openalex.org/W2058943713","https://openalex.org/W2059132989","https://openalex.org/W2061950562","https://openalex.org/W2062927712","https://openalex.org/W2082030057","https://openalex.org/W2085074491","https://openalex.org/W2092186919","https://openalex.org/W2111486924","https://openalex.org/W2114999054","https://openalex.org/W2117241454","https://openalex.org/W2144462623","https://openalex.org/W2147650665","https://openalex.org/W2151428293","https://openalex.org/W2152848856","https://openalex.org/W2165740658","https://openalex.org/W2339359539","https://openalex.org/W4249652143","https://openalex.org/W6629385271","https://openalex.org/W6658906401","https://openalex.org/W6665312715","https://openalex.org/W6682049019"],"related_works":["https://openalex.org/W2013187343","https://openalex.org/W1591420500","https://openalex.org/W2091303227","https://openalex.org/W1969019434","https://openalex.org/W2005981287","https://openalex.org/W2052241202","https://openalex.org/W2005906273","https://openalex.org/W1786948330","https://openalex.org/W2023936355","https://openalex.org/W2444319118"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}