{"id":"https://openalex.org/W2057040504","doi":"https://doi.org/10.1089/10430349950017338","title":"Basic Study on Gene Therapy of Human Malignant Glioma by Use of the Cationic Multilamellar Liposome-Entrapped Human Interferon beta Gene","display_name":"Basic Study on Gene Therapy of Human Malignant Glioma by Use of the Cationic Multilamellar Liposome-Entrapped Human Interferon beta Gene","publication_year":1999,"publication_date":"1999-08-10","ids":{"openalex":"https://openalex.org/W2057040504","doi":"https://doi.org/10.1089/10430349950017338","mag":"2057040504","pmid":"https://pubmed.ncbi.nlm.nih.gov/10466631"},"language":"en","primary_location":{"id":"doi:10.1089/10430349950017338","doi":"https://doi.org/10.1089/10430349950017338","is_oa":false,"landing_page_url":"https://doi.org/10.1089/10430349950017338","pdf_url":null,"source":{"id":"https://openalex.org/S39730559","display_name":"Human Gene Therapy","issn_l":"1043-0342","issn":["1043-0342","1557-7422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108209336","display_name":"Kunio Yagi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210159482","display_name":"Institute of Applied Biochemistry","ror":"https://ror.org/05d4dac15","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210159482"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kunio Yagi","raw_affiliation_strings":["Institute of Applied Biochemistry, Yagi Memorial Park, Mitake, Gifu, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Applied Biochemistry, Yagi Memorial Park, Mitake, Gifu, Japan","institution_ids":["https://openalex.org/I4210159482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113732540","display_name":"Nobuko Ohishi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nobuko Ohishi","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111771725","display_name":"Ayako Hamada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ayako Hamada","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080125337","display_name":"Masayo Shamoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masayo Shamoto","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113482808","display_name":"Masaharu Ohbayashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masaharu Ohbayashi","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110517331","display_name":"Naoko Ishida","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naoko Ishida","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110945585","display_name":"Akiko Nagata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akiko Nagata","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113512678","display_name":"Susumu Kanazawa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susumu Kanazawa","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061398713","display_name":"Morimitsu Nishikimi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Morimitsu Nishikimi","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5748,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.57827911,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"10","issue":"12","first_page":"1975","last_page":"1982"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.6542999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.6542999744415283,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.18799999356269836,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.13089999556541443,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.8029999732971191},{"id":"https://openalex.org/keywords/high-grade-glioma","display_name":"high-grade glioma","score":0.996999979019165},{"id":"https://openalex.org/keywords/interferon-beta","display_name":"interferon-beta","score":0.9509999752044678},{"id":"https://openalex.org/keywords/liposome-gene-delivery","display_name":"liposome gene delivery","score":0.6299999952316284},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.6510000228881836},{"id":"https://openalex.org/keywords/paracrine-signaling","display_name":"paracrine signaling","score":0.6209999918937683},{"id":"https://openalex.org/keywords/ifn-alpha-beta-receptor","display_name":"IFN-alpha/beta receptor","score":0.9430000185966492},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.8370000123977661}],"concepts":[{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.7079267501831055},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.6356145739555359},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.6264232397079468},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.6204727292060852},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6113429665565491},{"id":"https://openalex.org/C155887181","wikidata":"https://www.wikidata.org/wiki/Q5053552","display_name":"Cationic liposome","level":4,"score":0.5732806921005249},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5472486019134521},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5022847652435303},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.4993107318878174},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48695147037506104},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.46077579259872437},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.41483891010284424},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3358926773071289},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3192252218723297},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.195896178483963},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1670360267162323},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12772497534751892},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D002412","descriptor_name":"Cations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/10430349950017338","doi":"https://doi.org/10.1089/10430349950017338","is_oa":false,"landing_page_url":"https://doi.org/10.1089/10430349950017338","pdf_url":null,"source":{"id":"https://openalex.org/S39730559","display_name":"Human Gene Therapy","issn_l":"1043-0342","issn":["1043-0342","1557-7422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy","raw_type":"journal-article"},{"id":"pmid:10466631","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10466631","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human gene therapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1967372897","https://openalex.org/W1971290197","https://openalex.org/W1990195483","https://openalex.org/W1992225885","https://openalex.org/W1993608993","https://openalex.org/W1999568195","https://openalex.org/W1999952184","https://openalex.org/W2019359568","https://openalex.org/W2049725501","https://openalex.org/W2057160975","https://openalex.org/W2057358205","https://openalex.org/W2060202806","https://openalex.org/W2062023486","https://openalex.org/W2078474155","https://openalex.org/W2082590590","https://openalex.org/W2131379869","https://openalex.org/W2182551711","https://openalex.org/W2270859981","https://openalex.org/W2408522910"],"related_works":["https://openalex.org/W2131379869","https://openalex.org/W2090737037","https://openalex.org/W855819694","https://openalex.org/W2182551711","https://openalex.org/W2332123736","https://openalex.org/W2386034111","https://openalex.org/W2363266132","https://openalex.org/W2170692060","https://openalex.org/W2329994491","https://openalex.org/W1641333833"],"abstract_inverted_index":{"For":[0,168],"gene":[1,42,105,111],"therapy":[2],"of":[3,25,45,50,61,72,88,133,175,208],"human":[4,15,26],"malignant":[5,27],"glioma,":[6],"we":[7,90],"adopted":[8],"positively":[9],"charged":[10],"multilamellar":[11],"liposomes":[12,39,202],"entrapping":[13,40,203],"the":[14,23,38,41,58,62,79,85,109,124,137,139,152,156,171,180,186,193,204],"interferon":[16],"beta":[17],"(hIFN-beta)":[18],"gene.":[19,205],"One":[20],"week":[21],"after":[22],"transplantation":[24,64],"glioma":[28,33],"U251-SP":[29],"cells":[30,158],"to":[31,136],"produce":[32],"in":[34,93,113,155,164,185],"nude":[35],"mouse":[36],"brain,":[37],"(500":[43],"ng":[44],"DNA":[46],"per":[47,52],"25":[48],"nmol":[49],"lipids":[51],"2":[53],"microl)":[54],"were":[55,219],"injected":[56,195],"into":[57,123],"same":[59,181],"site":[60],"cell":[63,147],"once":[65],"every":[66],"second":[67],"day":[68],"for":[69],"a":[70,97,100,165],"total":[71],"five":[73],"injections;":[74],"and":[75,106,126,162,201,215],"by":[76,179],"this":[77,146],"means":[78],"tumor":[80],"completely":[81],"disappeared.":[82],"To":[83],"confirm":[84],"antiproliferative":[86],"effect":[87,142],"hIFN-beta,":[89],"performed":[91],"an":[92],"vitro":[94],"study":[95],"using":[96],"plasmid":[98,199],"containing":[99,108],"secretion":[101],"signal":[102],"sequence-deleted":[103],"hIFN-beta":[104,110,121,153],"one":[107],"inserted":[112],"reverse.":[114],"In":[115,206],"both":[116],"cases,":[117],"there":[118],"was":[119,143,189],"no":[120,127],"release":[122],"medium":[125],"growth":[128,140],"inhibition":[129,141],"effect.":[130],"On":[131],"addition":[132],"anti-hIFN-beta":[134],"antibody":[135],"medium,":[138],"abolished.":[144],"As":[145],"line":[148],"expresses":[149],"IFN-alpha/beta":[150],"receptor,":[151],"produced":[154],"transfected":[157],"could":[159],"be":[160],"released":[161],"acted":[163],"paracrine":[166],"manner.":[167],"120":[169],"days":[170],"body":[172],"weight":[173],"change":[174],"normal":[176],"mice":[177],"treated":[178],"procedure":[182],"as":[183],"used":[184],"curing":[187],"experiment":[188],"not":[190,220],"significant":[191,216],"among":[192],"groups":[194],"with":[196],"empty":[197],"liposomes,":[198],"only,":[200],"all":[207],"these":[209],"three":[210],"groups,":[211],"death,":[212],"abnormal":[213],"behavior,":[214],"histological":[217],"changes":[218],"observed.":[221]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}