{"id":"https://openalex.org/W2056956271","doi":"https://doi.org/10.1210/en.130.3.1180","title":"Gonadotropin-releasing hormone-induced accumulation of follicle- stimulating hormone beta-subunit messenger ribonucleic acid in adenohypophysial cells developing in an ectopic position","display_name":"Gonadotropin-releasing hormone-induced accumulation of follicle- stimulating hormone beta-subunit messenger ribonucleic acid in adenohypophysial cells developing in an ectopic position","publication_year":1992,"publication_date":"1992-03-01","ids":{"openalex":"https://openalex.org/W2056956271","doi":"https://doi.org/10.1210/en.130.3.1180","mag":"2056956271","pmid":"https://pubmed.ncbi.nlm.nih.gov/1537284"},"language":"en","primary_location":{"id":"doi:10.1210/en.130.3.1180","doi":"https://doi.org/10.1210/en.130.3.1180","is_oa":false,"landing_page_url":"http://doi.org/10.1210/en.130.3.1180","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109221683","display_name":"Gary T. Campbell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G T Campbell","raw_affiliation_strings":["Department of Anatomy, Cell Biology and Neurosciences, University of South Carolina, School of Medicine, Columbia 29208"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Cell Biology and Neurosciences, University of South Carolina, School of Medicine, Columbia 29208","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110052867","display_name":"J N Southard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J N Southard","raw_affiliation_strings":["Department of Anatomy, Cell Biology and Neurosciences, University of South Carolina, School of Medicine, Columbia 29208"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Cell Biology and Neurosciences, University of South Carolina, School of Medicine, Columbia 29208","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033066814","display_name":"Frank J. Talamantes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F Talamantes","raw_affiliation_strings":["Department of Anatomy, Cell Biology and Neurosciences, University of South Carolina, School of Medicine, Columbia 29208"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Cell Biology and Neurosciences, University of South Carolina, School of Medicine, Columbia 29208","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"last","author":{"id":null,"display_name":"C A Blake","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C A Blake","raw_affiliation_strings":["Department of Anatomy, Cell Biology and Neurosciences, University of South Carolina, School of Medicine, Columbia 29208"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Cell Biology and Neurosciences, University of South Carolina, School of Medicine, Columbia 29208","institution_ids":["https://openalex.org/I155781252"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I155781252"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.7884,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.714307,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"130","issue":"3","first_page":"1180","last_page":"1184"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gonadotropin-releasing-hormone","display_name":"gonadotropin-releasing hormone","score":0.9909999966621399},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone-beta-subunit","display_name":"follicle-stimulating hormone beta subunit","score":0.9120000004768372},{"id":"https://openalex.org/keywords/anterior-pituitary","display_name":"anterior pituitary","score":0.7139999866485596},{"id":"https://openalex.org/keywords/pituitary-development","display_name":"pituitary development","score":0.6420000195503235},{"id":"https://openalex.org/keywords/hamster","display_name":"hamster","score":0.4090000092983246},{"id":"https://openalex.org/keywords/pituitary-cell-differentiation","display_name":"pituitary cell differentiation","score":0.44699999690055847},{"id":"https://openalex.org/keywords/gonadotropin-secretion","display_name":"gonadotropin secretion","score":0.5139999985694885},{"id":"https://openalex.org/keywords/developmental-gene-expression","display_name":"developmental gene expression","score":0.38100001215934753},{"id":"https://openalex.org/keywords/pituitary-hormones","display_name":"pituitary hormones","score":0.37299999594688416},{"id":"https://openalex.org/keywords/gonadotrophs","display_name":"gonadotrophs","score":0.47999998927116394}],"concepts":[{"id":"https://openalex.org/C2778575167","wikidata":"https://www.wikidata.org/wiki/Q6573","display_name":"Hamster","level":2,"score":0.898009181022644},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7804720401763916},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7650440335273743},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5942937731742859},{"id":"https://openalex.org/C2779525107","wikidata":"https://www.wikidata.org/wiki/Q389919","display_name":"Mesocricetus","level":3,"score":0.5299333930015564},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.48079410195350647},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.444989413022995},{"id":"https://openalex.org/C2778782382","wikidata":"https://www.wikidata.org/wiki/Q409770","display_name":"Gonadotropin","level":3,"score":0.41203773021698},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11831921339035034},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09690150618553162},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002828","descriptor_name":"Choristoma","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008647","descriptor_name":"Mesocricetus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010903","descriptor_name":"Pituitary Gland, Anterior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037201","descriptor_name":"Follicle Stimulating Hormone, beta Subunit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1210/en.130.3.1180","doi":"https://doi.org/10.1210/en.130.3.1180","is_oa":false,"landing_page_url":"http://doi.org/10.1210/en.130.3.1180","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"doi:10.1210/endo.130.3.1537284","doi":"https://doi.org/10.1210/endo.130.3.1537284","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.130.3.1537284","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:1537284","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1537284","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1938708144","display_name":null,"funder_award_id":"HD 22687","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G2106710450","display_name":null,"funder_award_id":"HD-14966","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G2314504472","display_name":null,"funder_award_id":"RR-08132","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5152037231","display_name":"MECHANISMS OF CYCLIC LH AND FSH RELEASE","funder_award_id":"5r01hd022687-09","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W2002526474","https://openalex.org/W2010635897","https://openalex.org/W2052855324","https://openalex.org/W2065667368","https://openalex.org/W2066951718","https://openalex.org/W2074182138","https://openalex.org/W2088560939","https://openalex.org/W2093955230","https://openalex.org/W2111286539","https://openalex.org/W2148866023","https://openalex.org/W2162190352"],"related_works":["https://openalex.org/W2085360551","https://openalex.org/W2052855324","https://openalex.org/W1985059052","https://openalex.org/W2162190352","https://openalex.org/W2138340979","https://openalex.org/W2093955230","https://openalex.org/W2170722648","https://openalex.org/W2085444275","https://openalex.org/W2023686067","https://openalex.org/W2028287008"],"abstract_inverted_index":{"We":[0],"investigated":[1],"the":[2,7,31,64,67,89,108,120,124,129,136,193,268,308,314,339,368,386],"influence":[3],"of":[4,9,34,66,69,111,123,135,139,145,175,231,278,280,287,297,326,332,344,373,391],"LHRH":[5,51,112],"on":[6,88,119,154,185],"accumulation":[8],"FSH":[10,203,210,327],"beta":[11,204,211,328],"messenger":[12],"RNA":[13,219,230],"(mRNA)":[14],"in":[15,43,63,97,223,244,320,330,342,356,358,371,389],"anterior":[16],"pituitary":[17],"glands":[18],"removed":[19,151],"from":[20,162,179,235,246,259,276,284,295,318],"hamster":[21,163,206,236],"pups":[22,164],"less":[23,165,299,346,352,362,377],"than":[24,166,300,338,347,353,363,367,378],"36":[25,167,285,301,348],"h":[26,80,87,127,168,286,302,349],"old":[27,169,303,350],"and":[28,54,73,78,84,143,152,170,172,205,265,355,380,394],"transplanted":[29],"beneath":[30],"renal":[32],"capsules":[33],"adult":[35,99,147,395],"male":[36,100,148,396],"hamsters":[37,101,116,140,279,298,345,360,375,393],"(hosts).":[38],"Three":[39],"experiments":[40],"were":[41,47,56,61,74,105,117,150,160,183,195,263],"performed":[42,96],"which":[44,98],"some":[45,180],"hosts":[46,334],"injected":[48,57,106],"sc":[49],"with":[50,58,107],"(1":[52],"microgram/injection)":[53],"others":[55],"vehicle.":[59,114],"Injections":[60],"begun":[62],"afternoon":[65],"day":[68,122],"transplantation":[70],"(day":[71],"1)":[72,336],"given":[75],"at":[76,85],"0800":[77,86],"1700":[79],"for":[81,201,255,270],"6":[82],"days":[83,174],"eighth":[90,121],"day.":[91],"An":[92],"additional":[93],"experiment":[94],"was":[95,311],"not":[102,382],"bearing":[103],"allografts":[104,319,331,357],"same":[109,305],"regimen":[110],"or":[113],"The":[115,132,208,252,272,291,323],"decapitated":[118],"study,":[125],"2":[126],"after":[128],"last":[130],"injection.":[131],"allografts,":[133,142],"adenohypophyses":[134,138,144,159,277,296,343,372,390],"hosts,":[137],"without":[141],"normal":[146],"rats":[149],"frozen":[153],"dry":[155],"ice":[156],"immediately.":[157],"Additionally,":[158],"collected":[161],"8":[171],"15":[173],"age.":[176],"Total":[177],"RNAs":[178,194,242],"pooled":[181],"specimens":[182],"electrophoresed":[184],"a":[186,217],"formaldehyde-agarose":[187],"gel.":[188],"After":[189],"transfer":[190],"to":[191,198,216,229,241,249,267,289,313,385],"Nytran,":[192],"hybridized":[196,215,228,240],"sequentially":[197],"complementary":[199,212],"DNAs":[200],"rat":[202,209,224],"beta-actin.":[207,271],"DNA":[213],"probe":[214],"single":[218],"(approximately":[220],"1.7":[221,233,250],"Kb)":[222],"adenohypophyses.":[225,237],"It":[226],"predominantly":[227],"approximately":[232],"Kb":[234,248],"Sometimes":[238],"it":[239],"ranging":[243],"size":[245],"0.5":[247],"kb.":[251],"hybridization":[253,273,292,315],"signals":[254,269,274],"all":[256],"samples":[257],"obtained":[258,275,294,317],"dot":[260],"blot":[261],"analyses":[262],"quantitated":[264],"normalized":[266],"different":[281,383],"ages":[282],"increased":[283],"age":[288,306],"adulthood.":[290],"signal":[293,316],"(the":[304],"as":[307],"donor":[309],"hamsters)":[310],"similar":[312],"vehicle-treated":[321,359],"hamsters.":[322],"relative":[324,340,369,387],"levels":[325,341,370,388],"mRNA":[329],"LHRH-treated":[333],"were:":[335],"greater":[337,366],"(P":[351,361,376],"0.05)":[354],"0.05),":[364,379],"2)":[365],"8-day-old":[374],"3)":[381],"compared":[384],"15-day-old":[392],"hamsters.(ABSTRACT":[397],"TRUNCATED":[398],"AT":[399],"400":[400],"WORDS)":[401]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}