{"id":"https://openalex.org/W2056939714","doi":"https://doi.org/10.1097/01253092-200603001-00153","title":"CD8+ T Cells Have a Decreased Requirement for Activation Late After Burn Injury","display_name":"CD8+ T Cells Have a Decreased Requirement for Activation Late After Burn Injury","publication_year":2006,"publication_date":"2006-03-01","ids":{"openalex":"https://openalex.org/W2056939714","doi":"https://doi.org/10.1097/01253092-200603001-00153","mag":"2056939714"},"language":"en","primary_location":{"id":"doi:10.1097/01253092-200603001-00153","doi":"https://doi.org/10.1097/01253092-200603001-00153","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01253092-200603001-00153","pdf_url":null,"source":{"id":"https://openalex.org/S57131103","display_name":"Journal of Burn Care & Research","issn_l":"1559-047X","issn":["1559-047X","1559-0488"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Burn Care &amp; Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007601702","display_name":"Robert Maile","orcid":"https://orcid.org/0000-0002-9126-4188","observed_orcids":["https://orcid.org/0000-0002-9126-4188"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Maile","raw_affiliation_strings":["University of North Carolina Chapel Hill, Chapel Hill, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina Chapel Hill, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029252868","display_name":"Carie M. Barnes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C M. Barnes","raw_affiliation_strings":["University of North Carolina Chapel Hill, Chapel Hill, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina Chapel Hill, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008183954","display_name":"Jeffrey A. Frelinger","orcid":"https://orcid.org/0000-0002-2503-6267","observed_orcids":["https://orcid.org/0000-0002-2503-6267"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J A. Frelinger","raw_affiliation_strings":["University of North Carolina Chapel Hill, Chapel Hill, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina Chapel Hill, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041245842","display_name":"Anthony A. Meyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A A. Meyer","raw_affiliation_strings":["University of North Carolina Chapel Hill, Chapel Hill, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina Chapel Hill, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113584482","display_name":"Bruce A. Cairns","orcid":"https://orcid.org/0000-0003-2360-2840","observed_orcids":["https://orcid.org/0000-0003-2360-2840"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B A. Cairns","raw_affiliation_strings":["University of North Carolina Chapel Hill, Chapel Hill, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina Chapel Hill, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":3698,"currency":"USD","value_usd":3698},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"Supplement","first_page":"S125","last_page":"S125"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.5351999998092651,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.5351999998092651,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11422","display_name":"Burn Injury Management and Outcomes","score":0.45829999446868896,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.921999990940094},{"id":"https://openalex.org/keywords/burns","display_name":"burns","score":0.9900000095367432},{"id":"https://openalex.org/keywords/costimulation","display_name":"costimulation","score":0.7900000214576721},{"id":"https://openalex.org/keywords/cd28","display_name":"CD28","score":0.8569999933242798},{"id":"https://openalex.org/keywords/memory-t-cells","display_name":"memory T cells","score":0.8830000162124634},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.7680000066757202},{"id":"https://openalex.org/keywords/h-y-antigen","display_name":"H-Y antigen","score":0.7720000147819519},{"id":"https://openalex.org/keywords/anti-cd3-antibody","display_name":"anti-CD3 antibody","score":0.8510000109672546},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.43299999833106995}],"concepts":[{"id":"https://openalex.org/C148125776","wikidata":"https://www.wikidata.org/wiki/Q1622348","display_name":"CD28","level":4,"score":0.7964367866516113},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.664820671081543},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.56330406665802},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5275618433952332},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.45647555589675903},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45644810795783997},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4213699698448181},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3862975835800171},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32649892568588257},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30996716022491455},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.265113890171051},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.176974356174469},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11460596323013306}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/01253092-200603001-00153","doi":"https://doi.org/10.1097/01253092-200603001-00153","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01253092-200603001-00153","pdf_url":null,"source":{"id":"https://openalex.org/S57131103","display_name":"Journal of Burn Care & Research","issn_l":"1559-047X","issn":["1559-047X","1559-0488"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Burn Care &amp; Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2077225762","https://openalex.org/W2083555304","https://openalex.org/W2025439103","https://openalex.org/W2055509777","https://openalex.org/W2071913639","https://openalex.org/W2015055687","https://openalex.org/W2060806856","https://openalex.org/W7100633001","https://openalex.org/W1979966185","https://openalex.org/W7097314261"],"abstract_inverted_index":{"Burn":[0],"injury":[1,10,110],"initially":[2],"suppresses":[3],"T":[4,12,29,45,50,62,86,115,137,161],"cell":[5,63],"responses":[6],"but":[7],"later":[8],"after":[9,66,109],"CD8+":[11,28,61,85,114,136],"cells":[13,46,116,144,162,173],"are":[14],"hyper-responsive":[15],"to":[16,23,99,133,159],"specific":[17],"and":[18,111,126,196],"non-specific":[19],"stimuli,":[20],"possibly":[21],"due":[22],"the":[24,33,93,181],"generation":[25],"of":[26,80,177,185],"memory":[27,44],"cells.":[30,87,128,138],"Given":[31],"that":[32,57],"requirement":[34],"for":[35,60,92],"costimulation":[36,58],"(e.g.":[37],"B7-CD28":[38],"interactions)":[39],"is":[40,157],"much":[41],"less":[42],"in":[43,48,52,82,180],"than":[47],"na\u00efve":[49],"cells,":[51],"this":[53,70,74],"study":[54],"we":[55,72,167],"hypothesize":[56],"requirements":[59],"activity":[64],"late":[65],"burn":[67],"injury.":[68],"In":[69],"study,":[71],"test":[73],"hypothesis":[75],"with":[76,147,174,202],"two":[77,131],"different":[78],"models":[79],"costimulation-dependency":[81],"purified":[83,112,135],"murine":[84],"Female":[88],"C57BL/6":[89],"mice":[90,106],"transgenic":[91],"HY":[94,154],"male":[95],"antigen":[96],"were":[97,145],"subjected":[98],"20%":[100],"TBSA":[101],"contact":[102],"burn.":[103],"We":[104,129],"sacrificed":[105],"14":[107],"days":[108],"viable":[113],"using":[117],"negative":[118],"magnetic":[119],"separation":[120],"eliminating":[121],"CD4+,":[122],"MHC":[123,149],"Class":[124,150],"II+,":[125],"CD11b+":[127],"used":[130],"methods":[132],"stimulate":[134],"First,":[139],"1":[140,169],"\u00d7":[141,170],"10":[142,171],"6":[143,172],"stimulated":[146],"soluble":[148],"I":[151],"tetramer":[152],"bearing":[153],"peptide,":[155],"which":[156],"known":[158],"activate":[160],"without":[163],"signal":[164],"two.":[165],"Next":[166],"incubated":[168],"limiting":[175],"amounts":[176],"anti-CD3":[178],"antibody":[179],"presence":[182],"or":[183],"absence":[184],"costimulatory":[186],"anti-CD28":[187],"antibody.":[188],"Proliferation":[189],"was":[190],"measured":[191],"by":[192,199],"standard":[193],"[3H]-thymidine":[194],"uptake":[195],"data":[197],"compared":[198],"Student's":[200],"t-test":[201],"significance":[203],"defined":[204],"as":[205],"p<0.05.":[206]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}