{"id":"https://openalex.org/W2056936324","doi":"https://doi.org/10.1158/1078-0432.ccr-13-3346","title":"Inhibition of Bromodomain Proteins for the Treatment of Human Diffuse Large B-cell Lymphoma","display_name":"Inhibition of Bromodomain Proteins for the Treatment of Human Diffuse Large B-cell Lymphoma","publication_year":2014,"publication_date":"2014-07-10","ids":{"openalex":"https://openalex.org/W2056936324","doi":"https://doi.org/10.1158/1078-0432.ccr-13-3346","mag":"2056936324","pmid":"https://pubmed.ncbi.nlm.nih.gov/25009295","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4286476"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-13-3346","doi":"https://doi.org/10.1158/1078-0432.ccr-13-3346","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-13-3346","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4286476","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009917980","display_name":"Sally E. Trabucco","orcid":"https://orcid.org/0000-0002-8836-1542","observed_orcids":["https://orcid.org/0000-0002-8836-1542"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sally E. Trabucco","raw_affiliation_strings":["1Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, Massachusetts","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057150258","display_name":"Rachel M. Gerstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel M. Gerstein","raw_affiliation_strings":["2Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064091455","display_name":"Andrew M. Evens","orcid":"https://orcid.org/0000-0002-6900-1824","observed_orcids":["https://orcid.org/0000-0002-6900-1824"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew M. Evens","raw_affiliation_strings":["3Division of Hematology and Oncology, Tufts Medical Center, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Division of Hematology and Oncology, Tufts Medical Center, Boston, Massachusetts","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110274677","display_name":"James E. Bradner","orcid":"https://orcid.org/0000-0002-2718-4415","observed_orcids":["https://orcid.org/0000-0002-2718-4415","https://orcid.org/0000-0003-1422-5318"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James E. Bradner","raw_affiliation_strings":["4Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036394378","display_name":"Leonard D. Shultz","orcid":"https://orcid.org/0000-0002-4868-1031","observed_orcids":["https://orcid.org/0000-0002-4868-1031"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonard D. Shultz","raw_affiliation_strings":["5The Jackson Laboratory, Bar Harbor, Maine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5The Jackson Laboratory, Bar Harbor, Maine","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022634163","display_name":"Dale L. Greiner","orcid":"https://orcid.org/0000-0002-5923-339X","observed_orcids":["https://orcid.org/0000-0002-5923-339X"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dale L. Greiner","raw_affiliation_strings":["6Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100430269","display_name":"Hong Zhang","orcid":"https://orcid.org/0000-0002-1844-799X","observed_orcids":["https://orcid.org/0000-0002-1844-799X"]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hong Zhang","raw_affiliation_strings":["1Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, Massachusetts","institution_ids":["https://openalex.org/I166722992"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100430269"],"corresponding_institution_ids":["https://openalex.org/I166722992"],"apc_list":null,"apc_paid":null,"fwci":7.3298,"has_fulltext":false,"cited_by_count":146,"citation_normalized_percentile":{"value":0.98355279,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":100},"biblio":{"volume":"21","issue":"1","first_page":"113","last_page":"122"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.8960000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.8960000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.09179999679327011,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/bromodomain-proteins","display_name":"bromodomain proteins","score":0.8320000171661377},{"id":"https://openalex.org/keywords/bet-proteins","display_name":"BET proteins","score":0.7689999938011169},{"id":"https://openalex.org/keywords/jq1","display_name":"JQ1","score":0.996999979019165},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9150000214576721},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.8100000023841858},{"id":"https://openalex.org/keywords/cell-proliferation-inhibition","display_name":"cell proliferation inhibition","score":0.8799999952316284},{"id":"https://openalex.org/keywords/g1-cell-cycle-arrest","display_name":"G1 cell cycle arrest","score":0.9160000085830688},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9490000009536743},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.7699999809265137},{"id":"https://openalex.org/keywords/myc-amplification","display_name":"MYC amplification","score":0.5979999899864197},{"id":"https://openalex.org/keywords/myc-translocation","display_name":"MYC translocation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/chemotherapy-refractory-lymphoma","display_name":"chemotherapy-refractory lymphoma","score":0.6539999842643738}],"concepts":[{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.6970676779747009},{"id":"https://openalex.org/C74401373","wikidata":"https://www.wikidata.org/wiki/Q1829843","display_name":"Bromodomain","level":4,"score":0.6245549917221069},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5497036576271057},{"id":"https://openalex.org/C2778559949","wikidata":"https://www.wikidata.org/wiki/Q2626074","display_name":"Diffuse large B-cell lymphoma","level":3,"score":0.41963890194892883},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4195924401283264},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41191181540489197},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4070463478565216},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3805435597896576},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3755599856376648},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2725120782852173},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17299038171768188},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.16418471932411194},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.155271977186203}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001381","descriptor_name":"Azepines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016403","descriptor_name":"Lymphoma, Large B-Cell, Diffuse","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1158/1078-0432.ccr-13-3346","doi":"https://doi.org/10.1158/1078-0432.ccr-13-3346","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-13-3346","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:25009295","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25009295","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4286476","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4286476","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Cancer Res","raw_type":"Text"},{"id":"pmh:oai:escholarship.umassmed.edu:gsbs_sp-2881","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.umassmed.edu/gsbs_sp/1861","pdf_url":null,"source":{"id":"https://openalex.org/S7407064370","display_name":"eScholarship@UMassChan","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Morningside Graduate School of Biomedical Sciences Student Publications","raw_type":"text"},{"id":"pmh:oai:mouseion.jax.org:stfb2015-1014","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/stfb2015/14","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Research 2015","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4286476","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4286476","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4526430440","display_name":"Genetic pathways of replicative senescence and its function in tumorigenesis","funder_award_id":"R01CA131210","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6543545613","display_name":"Viral Infection Influence on Transplantation Tolerance","funder_award_id":"P01AI046629","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000917281","display_name":"Cancer Center Support (CORE) Grant","funder_award_id":"P30CA034196","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W52050551","https://openalex.org/W171679570","https://openalex.org/W296713146","https://openalex.org/W1482784375","https://openalex.org/W1523117612","https://openalex.org/W1970400561","https://openalex.org/W1971659434","https://openalex.org/W1976564639","https://openalex.org/W1976590012","https://openalex.org/W1978959944","https://openalex.org/W1979816280","https://openalex.org/W1989069691","https://openalex.org/W1997765594","https://openalex.org/W2002395443","https://openalex.org/W2003262666","https://openalex.org/W2006070956","https://openalex.org/W2006342636","https://openalex.org/W2006436290","https://openalex.org/W2009949436","https://openalex.org/W2018071905","https://openalex.org/W2024373518","https://openalex.org/W2026214119","https://openalex.org/W2031855605","https://openalex.org/W2035135710","https://openalex.org/W2041535798","https://openalex.org/W2044352858","https://openalex.org/W2045399297","https://openalex.org/W2045832601","https://openalex.org/W2057239580","https://openalex.org/W2059567581","https://openalex.org/W2063988572","https://openalex.org/W2064208261","https://openalex.org/W2071500044","https://openalex.org/W2082780518","https://openalex.org/W2095924801","https://openalex.org/W2116382435","https://openalex.org/W2120572492","https://openalex.org/W2128605424","https://openalex.org/W2129129812","https://openalex.org/W2131382859","https://openalex.org/W2135676046","https://openalex.org/W2138428661","https://openalex.org/W2139954541","https://openalex.org/W2142766411","https://openalex.org/W2147246240","https://openalex.org/W2152006714","https://openalex.org/W2158102062","https://openalex.org/W2159862107","https://openalex.org/W2162696088","https://openalex.org/W2166337170","https://openalex.org/W2172003817"],"related_works":["https://openalex.org/W255626605","https://openalex.org/W2341820900","https://openalex.org/W4292682665","https://openalex.org/W2588240037","https://openalex.org/W6983483615","https://openalex.org/W2566037995","https://openalex.org/W143166624","https://openalex.org/W3174570086","https://openalex.org/W2750819425","https://openalex.org/W4409979857"],"abstract_inverted_index":{"PURPOSE:":[0],"Approximately":[1],"50%":[2],"of":[3,51,63,70,93,100,110,131,140,148,172,179,196,205,214,218,230],"patients":[4,71],"with":[5,18,72],"diffuse":[6],"large":[7],"B-cell":[8],"lymphoma":[9],"(DLBCL)":[10],"enter":[11],"long-term":[12],"remission":[13],"after":[14],"standard":[15],"chemotherapy.":[16],"Patients":[17],"DLBCL":[19,56,82,111,133,161,197],"who":[20],"do":[21],"not":[22],"respond":[23],"to":[24,35],"chemotherapy":[25],"have":[26,47],"few":[27],"treatment":[28,159,181,192,229],"options.":[29],"There":[30],"remains":[31],"a":[32,78,136,145,177],"critical":[33],"need":[34],"identify":[36],"effective":[37],"and":[38,57,66,96,115,202],"targeted":[39],"therapeutics":[40],"for":[41,81],"DLBCL.":[42,151,231],"EXPERIMENTAL":[43],"DESIGN:":[44],"Recent":[45],"studies":[46],"highlighted":[48],"the":[49,58,94,183,215,228],"incidence":[50],"increased":[52],"c-MYC":[53,64,76,89,173],"protein":[54,65],"in":[55,113,118,135,150,160,200,227],"correlation":[59],"between":[60],"high":[61],"levels":[62],"poor":[67],"survival":[68,204],"prognosis":[69],"DLBCL,":[73],"suggesting":[74,144],"that":[75,123,212],"is":[77],"compelling":[79],"target":[80],"therapy.":[83],"The":[84,152,170],"small":[85],"molecule":[86],"JQ1":[87,106,124,149,158,180,191,222],"suppresses":[88],"expression":[90,171],"through":[91],"inhibition":[92,213],"bromodomain":[95,101,219],"extra-terminal":[97],"(BET)":[98],"family":[99,217],"proteins.":[102],"We":[103,121],"investigated":[104],"whether":[105],"can":[107],"inhibit":[108],"proliferation":[109,130],"cells":[112,134,162,198],"culture":[114],"xenograft":[116],"models":[117],"vivo.":[119],"RESULTS:":[120],"show":[122],"at":[125],"nanomolar":[126],"concentrations":[127],"efficiently":[128],"inhibited":[129],"human":[132],"dose-dependent":[137],"manner":[138],"regardless":[139],"their":[141],"molecular":[142],"subtypes,":[143],"broad":[146],"effect":[147],"initial":[153],"G1":[154],"arrest":[155],"induced":[156],"by":[157,165,221],"was":[163,174],"followed":[164],"either":[166],"apoptosis":[167],"or":[168,187],"senescence.":[169],"suppressed":[175,194],"as":[176],"result":[178],"from":[182],"natural,":[184],"chromosomally":[185],"translocated,":[186],"amplified":[188],"loci.":[189],"Furthermore,":[190],"significantly":[193],"growth":[195],"engrafted":[199,206],"mice":[201],"improved":[203],"mice.":[207],"CONCLUSION:":[208],"Our":[209],"results":[210],"demonstrate":[211],"BET":[216],"proteins":[220],"has":[223],"potential":[224],"clinical":[225],"use":[226]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":17},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":26},{"year":2014,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}