{"id":"https://openalex.org/W2056895025","doi":"https://doi.org/10.1371/journal.pone.0028804","title":"AMP-Activated Protein Kinase (AMPK) Mediates Nutrient Regulation of Thioredoxin-Interacting Protein (TXNIP) in Pancreatic Beta-Cells","display_name":"AMP-Activated Protein Kinase (AMPK) Mediates Nutrient Regulation of Thioredoxin-Interacting Protein (TXNIP) in Pancreatic Beta-Cells","publication_year":2011,"publication_date":"2011-12-14","ids":{"openalex":"https://openalex.org/W2056895025","doi":"https://doi.org/10.1371/journal.pone.0028804","mag":"2056895025","pmid":"https://pubmed.ncbi.nlm.nih.gov/22194917","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3237554"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0028804","doi":"https://doi.org/10.1371/journal.pone.0028804","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0028804","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0028804&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0028804&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021571847","display_name":"Maayan Shaked","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Maayan Shaked","raw_affiliation_strings":["Endocrinology and Metabolism Service, Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrinology and Metabolism Service, Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081992000","display_name":"Mali Ketzinel\u2010Gilad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Mali Ketzinel-Gilad","raw_affiliation_strings":["Endocrinology and Metabolism Service, Department of Medicine, Hadassah - Hebrew University Medical Center, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrinology and Metabolism Service, Department of Medicine, Hadassah - Hebrew University Medical Center, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076271317","display_name":"Erol Cerasi","orcid":"https://orcid.org/0000-0002-8234-3618","observed_orcids":["https://orcid.org/0000-0002-8234-3618"]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Erol Cerasi","raw_affiliation_strings":["Endocrinology and Metabolism Service, Department of Medicine, Hadassah - Hebrew University Medical Center, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrinology and Metabolism Service, Department of Medicine, Hadassah - Hebrew University Medical Center, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110124347","display_name":"Nurit Kaiser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Nurit Kaiser","raw_affiliation_strings":["Endocrinology and Metabolism Service, Department of Medicine, Hadassah - Hebrew University Medical Center, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrinology and Metabolism Service, Department of Medicine, Hadassah - Hebrew University Medical Center, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017696201","display_name":"Gil Leibowitz","orcid":"https://orcid.org/0000-0002-6915-4361","observed_orcids":["https://orcid.org/0000-0002-6915-4361"]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Gil Leibowitz","raw_affiliation_strings":["Endocrinology and Metabolism Service, Department of Medicine, Hadassah - Hebrew University Medical Center, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endocrinology and Metabolism Service, Department of Medicine, Hadassah - Hebrew University Medical Center, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5017696201"],"corresponding_institution_ids":["https://openalex.org/I2799899409"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.6703,"has_fulltext":true,"cited_by_count":72,"citation_normalized_percentile":{"value":0.89397891,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"6","issue":"12","first_page":"e28804","last_page":"e28804"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.8988999724388123,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.8988999724388123,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.08910000324249268,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.9120000004768372},{"id":"https://openalex.org/keywords/txnip","display_name":"TXNIP","score":0.9810000061988831},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.8450000286102295},{"id":"https://openalex.org/keywords/palmitate","display_name":"palmitate","score":0.9399999976158142},{"id":"https://openalex.org/keywords/oleate","display_name":"oleate","score":0.972000002861023},{"id":"https://openalex.org/keywords/glucose","display_name":"glucose","score":0.8560000061988831},{"id":"https://openalex.org/keywords/chrebp","display_name":"ChREBP","score":0.8619999885559082},{"id":"https://openalex.org/keywords/glucolipotoxicity","display_name":"glucolipotoxicity","score":0.7639999985694885},{"id":"https://openalex.org/keywords/beta-cell-apoptosis","display_name":"beta-cell apoptosis","score":0.9169999957084656},{"id":"https://openalex.org/keywords/fatty-acid-signaling","display_name":"fatty acid signaling","score":0.47600001096725464},{"id":"https://openalex.org/keywords/nutrient-regulation","display_name":"nutrient regulation","score":0.5789999961853027},{"id":"https://openalex.org/keywords/gene-transcription","display_name":"gene transcription","score":0.5450000166893005},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C2779076967","wikidata":"https://www.wikidata.org/wiki/Q21122281","display_name":"TXNIP","level":4,"score":0.9958287477493286},{"id":"https://openalex.org/C2908690268","wikidata":"https://www.wikidata.org/wiki/Q21122281","display_name":"Thioredoxin-Interacting Protein","level":5,"score":0.7949257493019104},{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.7898179888725281},{"id":"https://openalex.org/C2853687","wikidata":"https://www.wikidata.org/wiki/Q18039976","display_name":"Carbohydrate-responsive element-binding protein","level":4,"score":0.6463756561279297},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5542937517166138},{"id":"https://openalex.org/C2776828364","wikidata":"https://www.wikidata.org/wiki/Q1767180","display_name":"Beta cell","level":4,"score":0.47175082564353943},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43506479263305664},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.42295169830322266},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4031932055950165},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3552590012550354},{"id":"https://openalex.org/C3623737","wikidata":"https://www.wikidata.org/wiki/Q421219","display_name":"Thioredoxin","level":3,"score":0.3541053831577301},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34475576877593994},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3057135343551636},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.2809222340583801},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.263608455657959},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.11636549234390259},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.09117823839187622},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08023384213447571},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.06114780902862549},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003847","descriptor_name":"Deoxyglucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008687","descriptor_name":"Metformin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019301","descriptor_name":"Oleic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019308","descriptor_name":"Palmitic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020536","descriptor_name":"Enzyme Activators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051778","descriptor_name":"Basic Helix-Loop-Helix Leucine Zipper Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0028804","doi":"https://doi.org/10.1371/journal.pone.0028804","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0028804","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0028804&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3237554","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3237554","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:22194917","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22194917","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.287.6309","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.287.6309","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/33/94/PLoS_One_2011_Dec_14_6(12)_e28804.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:0724204292ea43bfb81c059b31e6e05e","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/0724204292ea43bfb81c059b31e6e05e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 6, Iss 12, p e28804 (2011)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/130513","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/AMP_Activated_Protein_Kinase_AMPK_Mediates_Nutrient_Regulation_of_Thioredoxin_Interacting_Protein_TXNIP_in_Pancreatic_Beta_Cells/130513","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0028804","doi":"https://doi.org/10.1371/journal.pone.0028804","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0028804","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0028804&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9074000120162964,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309434","display_name":"University of Wisconsin-Madison","ror":"https://ror.org/01y2jtd41"},{"id":"https://openalex.org/F4320320946","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306"},{"id":"https://openalex.org/F4320321950","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017"},{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2056895025.pdf","grobid_xml":"https://content.openalex.org/works/W2056895025.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1598254642","https://openalex.org/W1704389558","https://openalex.org/W1800546974","https://openalex.org/W1966339676","https://openalex.org/W1969071520","https://openalex.org/W1970205234","https://openalex.org/W1976268751","https://openalex.org/W1978213355","https://openalex.org/W2001865488","https://openalex.org/W2006313405","https://openalex.org/W2018932672","https://openalex.org/W2022975427","https://openalex.org/W2025651276","https://openalex.org/W2031710562","https://openalex.org/W2037657431","https://openalex.org/W2044801671","https://openalex.org/W2044842369","https://openalex.org/W2048930008","https://openalex.org/W2052491988","https://openalex.org/W2054799199","https://openalex.org/W2056378761","https://openalex.org/W2059216373","https://openalex.org/W2059791010","https://openalex.org/W2061741332","https://openalex.org/W2073315259","https://openalex.org/W2079840768","https://openalex.org/W2082515526","https://openalex.org/W2083819344","https://openalex.org/W2088990035","https://openalex.org/W2100465511","https://openalex.org/W2117444367","https://openalex.org/W2117812417","https://openalex.org/W2125425314","https://openalex.org/W2128473384","https://openalex.org/W2129192121","https://openalex.org/W2131155467","https://openalex.org/W2140683982","https://openalex.org/W2142640187","https://openalex.org/W2145869245","https://openalex.org/W2150127982","https://openalex.org/W2152791345","https://openalex.org/W2154267159","https://openalex.org/W2155139714","https://openalex.org/W2158951820","https://openalex.org/W2160905895","https://openalex.org/W2168180935"],"related_works":["https://openalex.org/W7100733549","https://openalex.org/W2806266122","https://openalex.org/W2150127982","https://openalex.org/W2611287386","https://openalex.org/W2010142306","https://openalex.org/W2035394565","https://openalex.org/W1978213355","https://openalex.org/W1976100963","https://openalex.org/W2117026649","https://openalex.org/W2146019031"],"abstract_inverted_index":{"Thioredoxin-interacting":[0],"protein":[1,90,175],"(TXNIP)":[2],"regulates":[3],"critical":[4,20],"biological":[5],"processes":[6],"including":[7],"inflammation,":[8],"stress":[9],"and":[10,17,53,66,75,101,145,152,183,214,271],"apoptosis.":[11],"TXNIP":[12,42,57,69,80,137,157,167,218,237,263],"is":[13,18,168,197],"upregulated":[14],"by":[15,131,171,243],"glucose":[16,52,118,143,213],"a":[19,71],"mediator":[21],"of":[22,51,79,83,103,114,126,141,164,201,206,212,232,236,262,273],"hyperglycemia-induced":[23],"beta-cell":[24,73,239],"apoptosis":[25],"in":[26,47,70,97,111,139,160,221,238],"diabetes.":[27,274],"In":[28,230],"contrast,":[29],"the":[30,39,48,186,233,269],"saturated":[31],"long-chain":[32],"fatty":[33,54,84,129,153,215,244],"acid":[34,85],"palmitate,":[35,147],"although":[36],"toxic":[37],"to":[38,185,253],"beta-cell,":[40],"inhibits":[41],"expression.":[43],"The":[44,209,255],"mechanisms":[45],"involved":[46],"opposing":[49,225],"effects":[50,155,211,226],"acids":[55,130,216,245],"on":[56,156,217,227],"expression":[58,138,219],"are":[59,158],"unknown.":[60],"We":[61,193],"found":[62],"that":[63,149,195,257],"both":[64],"palmitate":[65,121],"oleate":[67],"inhibited":[68,119,178],"rat":[72],"line":[74],"islets.":[76],"Palmitate":[77,177],"inhibition":[78,242],"was":[81],"independent":[82],"beta-oxidation":[86],"or":[87],"esterification.":[88],"AMP-activated":[89],"kinase":[91],"(AMPK)":[92],"has":[93],"an":[94,198,250],"important":[95,199,234,266],"role":[96,235],"cellular":[98],"energy":[99],"sensing":[100],"control":[102],"metabolic":[104],"homeostasis;":[105],"therefore":[106],"we":[107],"investigated":[108],"its":[109,241],"involvement":[110],"nutrient":[112,150,260],"regulation":[113,261],"TXNIP.":[115,133],"As":[116],"expected,":[117],"whereas":[120],"stimulated":[122],"AMPK.":[123],"Pharmacologic":[124],"activators":[125],"AMPK":[127,134,165,196,228,258],"mimicked":[128],"inhibiting":[132,190],"knockdown":[135],"increased":[136],"presence":[140],"high":[142],"with":[144],"without":[146],"indicating":[148],"(glucose":[151],"acids)":[154],"mediated":[159],"part":[161,222],"via":[162,204],"modulation":[163,205],"activity.":[166,208,229],"transcriptionally":[169],"regulated":[170],"carbohydrate":[172],"response":[173,252],"element-binding":[174],"(ChREBP).":[176],"glucose-stimulated":[179],"ChREBP":[180,207],"nuclear":[181],"entry":[182],"recruitment":[184],"Txnip":[187,191,202],"promoter,":[188],"thereby":[189],"transcription.":[192],"conclude":[194],"regulator":[200],"transcription":[203],"divergent":[210],"result":[220],"from":[223],"their":[224],"light":[231],"apoptosis,":[240],"can":[246],"be":[247],"regarded":[248],"as":[249],"adaptive/protective":[251],"glucolipotoxicity.":[254],"finding":[256],"mediates":[259],"may":[264],"have":[265],"implications":[267],"for":[268],"pathophysiology":[270],"treatment":[272]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}