{"id":"https://openalex.org/W2056890176","doi":"https://doi.org/10.1517/13543784.2011.583236","title":"Tumor treating fields: concept, evidence and future","display_name":"Tumor treating fields: concept, evidence and future","publication_year":2011,"publication_date":"2011-05-09","ids":{"openalex":"https://openalex.org/W2056890176","doi":"https://doi.org/10.1517/13543784.2011.583236","mag":"2056890176","pmid":"https://pubmed.ncbi.nlm.nih.gov/21548832"},"language":"en","primary_location":{"id":"doi:10.1517/13543784.2011.583236","doi":"https://doi.org/10.1517/13543784.2011.583236","is_oa":false,"landing_page_url":"https://doi.org/10.1517/13543784.2011.583236","pdf_url":null,"source":{"id":"https://openalex.org/S131064935","display_name":"Expert Opinion on Investigational Drugs","issn_l":"1354-3784","issn":["1354-3784","1744-7658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Investigational Drugs","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011868198","display_name":"Miklos Pless","orcid":"https://orcid.org/0000-0001-5121-4402","observed_orcids":["https://orcid.org/0000-0001-5121-4402"]},"institutions":[{"id":"https://openalex.org/I4210099681","display_name":"Kantonsspital Winterthur","ror":"https://ror.org/014gb2s11","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210099681"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Miklos Pless","raw_affiliation_strings":["Medical Oncology, Department of Internal Medicine, and Tumor Center, Kantonsspital Winterthur, Brauerstrasse, Switzerland. miklos.pless@ksw.ch","+41 52 266 45 20","Kantonsspital Winterthur, Brauerstrasse 15, 8400 Winterthur, Switzerland +41 52 266 25 52","Medical Oncology, Department of Internal Medicine","Tumor Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology, Department of Internal Medicine, and Tumor Center, Kantonsspital Winterthur, Brauerstrasse, Switzerland. miklos.pless@ksw.ch","institution_ids":["https://openalex.org/I4210099681"]},{"raw_affiliation_string":"+41 52 266 45 20","institution_ids":[]},{"raw_affiliation_string":"Kantonsspital Winterthur, Brauerstrasse 15, 8400 Winterthur, Switzerland +41 52 266 25 52","institution_ids":["https://openalex.org/I4210099681"]},{"raw_affiliation_string":"Medical Oncology, Department of Internal Medicine","institution_ids":[]},{"raw_affiliation_string":"Tumor Center","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021783438","display_name":"Uri Weinberg","orcid":"https://orcid.org/0009-0000-6908-620X","observed_orcids":["https://orcid.org/0009-0000-6908-620X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Uri Weinberg","raw_affiliation_strings":["NovoCure Ltd, Matam Advanced Technology Centre, 31905, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NovoCure Ltd, Matam Advanced Technology Centre, 31905, Haifa, Israel","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.568,"has_fulltext":false,"cited_by_count":78,"citation_normalized_percentile":{"value":0.42307692,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"20","issue":"8","first_page":"1099","last_page":"1106"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10874","display_name":"Electromagnetic Fields and Biological Effects","score":0.4041000008583069,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10874","display_name":"Electromagnetic Fields and Biological Effects","score":0.4041000008583069,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.218299999833107,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":0.17309999465942383,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-treating-fields","display_name":"tumor treating fields","score":0.9909999966621399},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9409999847412109},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9010000228881836},{"id":"https://openalex.org/keywords/pemetrexed","display_name":"pemetrexed","score":0.9490000009536743},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.4690000116825104},{"id":"https://openalex.org/keywords/mitotic-inhibition","display_name":"mitosis inhibition","score":0.7570000290870667},{"id":"https://openalex.org/keywords/local-tumor-control","display_name":"local tumor control","score":0.7089999914169312},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.6679999828338623},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.781000018119812},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.8289999961853027},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.6620000004768372},{"id":"https://openalex.org/keywords/salvage-therapy","display_name":"salvage therapy","score":0.9850000143051147}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8171311616897583},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6016881465911865},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5916017889976501},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5138859748840332},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5064953565597534},{"id":"https://openalex.org/C2777240266","wikidata":"https://www.wikidata.org/wiki/Q415220","display_name":"Pemetrexed","level":4,"score":0.4859119951725006},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.48098480701446533},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.450031042098999},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.427432656288147},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.1976432502269745},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004574","descriptor_name":"Electromagnetic Fields","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004599","descriptor_name":"Electric Stimulation Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004599","descriptor_name":"Electric Stimulation Therapy","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1517/13543784.2011.583236","doi":"https://doi.org/10.1517/13543784.2011.583236","is_oa":false,"landing_page_url":"https://doi.org/10.1517/13543784.2011.583236","pdf_url":null,"source":{"id":"https://openalex.org/S131064935","display_name":"Expert Opinion on Investigational Drugs","issn_l":"1354-3784","issn":["1354-3784","1744-7658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Investigational Drugs","raw_type":"journal-article"},{"id":"pmid:21548832","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21548832","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on investigational drugs","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1630180746","https://openalex.org/W1968590286","https://openalex.org/W1975130399","https://openalex.org/W1975702241","https://openalex.org/W1979512319","https://openalex.org/W1995972041","https://openalex.org/W2000905326","https://openalex.org/W2002144685","https://openalex.org/W2051578169","https://openalex.org/W2061055915","https://openalex.org/W2061947498","https://openalex.org/W2068898429","https://openalex.org/W2077340768","https://openalex.org/W2078796617","https://openalex.org/W2098950184","https://openalex.org/W2113088508","https://openalex.org/W2115578580","https://openalex.org/W2128756950","https://openalex.org/W2134667653","https://openalex.org/W2146039417","https://openalex.org/W2146972602","https://openalex.org/W2156826863","https://openalex.org/W2168283594","https://openalex.org/W2170281556","https://openalex.org/W2233650883","https://openalex.org/W2267405374","https://openalex.org/W2416187705","https://openalex.org/W2484955881","https://openalex.org/W2496401776","https://openalex.org/W2500821485"],"related_works":["https://openalex.org/W3137395572","https://openalex.org/W1875003163","https://openalex.org/W4388616910","https://openalex.org/W2523123787","https://openalex.org/W2764165846","https://openalex.org/W2386326640","https://openalex.org/W2969394978","https://openalex.org/W2990962759","https://openalex.org/W3010361310","https://openalex.org/W3109192163"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Local":[1],"control":[2],"is":[3,302,313],"fundamental,":[4],"both":[5,93],"for":[6,155,283],"the":[7,12,43,46,59,89,109,156,169,205,210,213,219,221,240,244,268],"curative":[8],"as":[9,11,94,97,99,289,294],"well":[10,98,237],"palliative":[13],"treatment":[14,319],"of":[15,48,61,91,163,201,212,231,233,256,264,274],"cancer.":[16],"Tumor":[17],"treating":[18],"fields":[19,36],"(TTFields)":[20],"are":[21,271,309],"low":[22],"intensity":[23],"(1":[24],"?":[25,31],"2":[26],"V/cm),":[27],"intermediate":[28],"frequency":[29],"(100":[30],"200":[32],"kHz)":[33],"alternating":[34],"electric":[35],"administered":[37,189],"using":[38],"insulated":[39],"electrodes":[40],"placed":[41],"on":[42,73],"skin":[44,265],"surrounding":[45],"region":[47],"a":[49,95,124,176,272,290,295],"malignant":[50],"tumor.":[51],"TTFields":[52,69,92,131,140,170,187,214,220,234,257,278,312],"were":[53,258],"shown":[54],"to":[55,267],"destroy":[56],"cells":[57],"within":[58,209],"process":[60],"mitosis":[62],"via":[63],"apoptosis,":[64],"thereby":[65],"inhibiting":[66],"tumor":[67,251],"growth.":[68],"have":[70],"no":[71],"effect":[72],"non-dividing":[74],"cells.":[75],"AREAS":[76],"COVERED:":[77],"This":[78,193],"article":[79],"reviews":[80],"in":[81,84,100,115,119,123,168,180,196,239,249,261,276,285],"vitro":[82],"and":[83,243,260,316],"vivo":[85],"preclinical":[86,241],"studies,":[87],"demonstrating":[88],"activity":[90],"monotherapy":[96],"combination":[101,194,286],"with":[102,112,134,148,191,287],"several":[103],"cytotoxic":[104],"agents.":[105],"Furthermore,":[106],"it":[107],"summarizes":[108],"clinical":[110,245,307],"experience":[111],"TTFields,":[113],"mainly":[114],"two":[116],"indications:":[117],"one":[118],"recurrent":[120],"glioblastoma":[121],"multiforme:":[122],"large":[125],"prospective":[126],"randomized":[127],"Phase":[128,177],"III":[129],"trial":[130],"was":[132,165,175,188,215,223],"compared":[133,147],"best":[135],"standard":[136,149],"care":[137],"(including":[138],"chemotherapy):":[139],"significantly":[141],"improved":[142],"median":[143,199],"overall":[144],"survival":[145,207],"(OS)":[146],"therapy":[150,297],"(7.8":[151],"vs":[152],"6.1":[153],"months)":[154],"patients":[157],"treated":[158],"per":[159],"protocol.":[160],"Importantly,":[161],"quality":[162],"life":[164],"also":[166],"better":[167],"group.":[171],"The":[172,229,253],"second":[173],"indication":[174],"II":[178],"study":[179],"second-line":[181],"non-small":[182],"cell":[183],"lung":[184],"cancer,":[185],"where":[186],"concomitantly":[190],"pemetrexed.":[192],"resulted":[195],"an":[197,314],"excellent":[198],"OS":[200],"13.8":[202],"months.":[203],"Interestingly,":[204],"progression-free":[206],"(PFS)":[208],"area":[211],"28,":[216],"however,":[217],"outside":[218],"PFS":[222],"only":[224],"22":[225],"weeks.":[226],"EXPERT":[227],"OPINION:":[228],"proof":[230],"concept":[232],"has":[235],"been":[236],"demonstrated":[238],"setting,":[242],"data":[246,308],"seem":[247],"promising":[248,317],"various":[250],"types.":[252],"side":[254],"effects":[255],"minimal":[259],"general":[262],"consisted":[263],"reaction":[266],"electrodes.":[269],"There":[270],"number":[273],"ways":[275],"which":[277],"could":[279],"be":[280],"further":[281],"evaluated,":[282],"example,":[284],"chemotherapy,":[288],"maintenance":[291],"treatment,":[292],"or":[293,300],"salvage":[296],"if":[298],"radiotherapy":[299],"surgery":[301],"not":[303],"possible.":[304],"While":[305],"more":[306],"clearly":[310],"needed,":[311],"emerging":[315],"novel":[318],"concept.":[320]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}