{"id":"https://openalex.org/W2056865532","doi":"https://doi.org/10.1073/pnas.82.17.5598","title":"Quantitative structural analysis of eukaryotic ribosomal RNA by scanning transmission electron microscopy.","display_name":"Quantitative structural analysis of eukaryotic ribosomal RNA by scanning transmission electron microscopy.","publication_year":1985,"publication_date":"1985-09-01","ids":{"openalex":"https://openalex.org/W2056865532","doi":"https://doi.org/10.1073/pnas.82.17.5598","mag":"2056865532","pmid":"https://pubmed.ncbi.nlm.nih.gov/3862084","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/390598"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.82.17.5598","doi":"https://doi.org/10.1073/pnas.82.17.5598","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.82.17.5598","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/390598","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023671584","display_name":"Gert T. Oostergetel","orcid":"https://orcid.org/0000-0001-6816-136X","observed_orcids":["https://orcid.org/0000-0001-6816-136X"]},"institutions":[{"id":"https://openalex.org/I200870766","display_name":"Brookhaven National Laboratory","ror":"https://ror.org/02ex6cf31","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I200870766","https://openalex.org/I39565521","https://openalex.org/I4210142672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G T Oostergetel","raw_affiliation_strings":["Brookhaven National Laboratory, Upton, NY 11973","Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110; and tBiology Department,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brookhaven National Laboratory, Upton, NY 11973","institution_ids":["https://openalex.org/I200870766"]},{"raw_affiliation_string":"Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110; and tBiology Department,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113873033","display_name":"J.S. Wall","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J S Wall","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103093436","display_name":"James F. Hainfeld","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J F Hainfeld","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5114259319","display_name":"Miloslav Boubl\u00edk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200870766","display_name":"Brookhaven National Laboratory","ror":"https://ror.org/02ex6cf31","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I200870766","https://openalex.org/I39565521","https://openalex.org/I4210142672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Boublik","raw_affiliation_strings":["Brookhaven National Laboratory, Upton, NY 11973","Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110; and tBiology Department,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brookhaven National Laboratory, Upton, NY 11973","institution_ids":["https://openalex.org/I200870766"]},{"raw_affiliation_string":"Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110; and tBiology Department,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6052,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.65418772,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"82","issue":"17","first_page":"5598","last_page":"5602"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.8618000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.8618000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10857","display_name":"Advanced Electron Microscopy Techniques and Applications","score":0.12359999865293503,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/28s-rrna","display_name":"28S rRNA","score":0.9919999837875366},{"id":"https://openalex.org/keywords/scanning-transmission-electron-microscopy","display_name":"scanning transmission electron microscopy","score":0.6290000081062317},{"id":"https://openalex.org/keywords/buffer-conditions","display_name":"buffer conditions","score":0.6079999804496765},{"id":"https://openalex.org/keywords/ionic-strength","display_name":"ionic strength","score":0.9129999876022339},{"id":"https://openalex.org/keywords/molecular-weight-distribution","display_name":"molecular weight distribution","score":0.7599999904632568},{"id":"https://openalex.org/keywords/radius-of-gyration","display_name":"radius of gyration","score":0.9480000138282776},{"id":"https://openalex.org/keywords/60s-ribosomal-subunit","display_name":"60S ribosomal subunit","score":0.8949999809265137},{"id":"https://openalex.org/keywords/nucleic-acid-structure","display_name":"nucleic acid structure","score":0.7369999885559082},{"id":"https://openalex.org/keywords/bhk-cells","display_name":"BHK cells","score":0.847000002861023}],"concepts":[{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.7974172830581665},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5760629773139954},{"id":"https://openalex.org/C193016168","wikidata":"https://www.wikidata.org/wiki/Q874835","display_name":"Scanning transmission electron microscopy","level":3,"score":0.4917738735675812},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.48509204387664795},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.4401059150695801},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38348549604415894},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37698930501937866},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3647475242614746},{"id":"https://openalex.org/C146088050","wikidata":"https://www.wikidata.org/wiki/Q744818","display_name":"Transmission electron microscopy","level":2,"score":0.36196404695510864},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2809121906757355},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.20518764853477478},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002942","descriptor_name":"Circular Dichroism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008855","descriptor_name":"Microscopy, Electron, Scanning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009690","descriptor_name":"Nucleic Acid Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012335","descriptor_name":"RNA, Ribosomal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.82.17.5598","doi":"https://doi.org/10.1073/pnas.82.17.5598","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.82.17.5598","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:390598","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/390598","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:3862084","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3862084","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:390598","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/390598","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6","score":0.75}],"study_designs":[],"awards":[{"id":"https://openalex.org/G869871382","display_name":null,"funder_award_id":"RR-01777","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W296378309","https://openalex.org/W1481074838","https://openalex.org/W1504260229","https://openalex.org/W1512885643","https://openalex.org/W1966161204","https://openalex.org/W1968052992","https://openalex.org/W1973017007","https://openalex.org/W1975532934","https://openalex.org/W1979381429","https://openalex.org/W1980056776","https://openalex.org/W1987832764","https://openalex.org/W1988776401","https://openalex.org/W1991824274","https://openalex.org/W2007534712","https://openalex.org/W2012742079","https://openalex.org/W2018308587","https://openalex.org/W2019400001","https://openalex.org/W2025675183","https://openalex.org/W2025962789","https://openalex.org/W2026614206","https://openalex.org/W2027561066","https://openalex.org/W2034917271","https://openalex.org/W2072908872","https://openalex.org/W2087211462","https://openalex.org/W2093543259","https://openalex.org/W2119490364","https://openalex.org/W2121234754","https://openalex.org/W2129277820","https://openalex.org/W2142393243","https://openalex.org/W2156546767","https://openalex.org/W2163977585","https://openalex.org/W2335292472","https://openalex.org/W2461699057"],"related_works":["https://openalex.org/W3036539005","https://openalex.org/W1966457666","https://openalex.org/W2086983986","https://openalex.org/W2003730733","https://openalex.org/W3036044588","https://openalex.org/W941106411","https://openalex.org/W2069405720","https://openalex.org/W3036668571","https://openalex.org/W3036744205","https://openalex.org/W3036517914"],"abstract_inverted_index":{"The":[0,81],"conformation":[1,42,51],"of":[2,32,40,43,52,68,79,142],"28S":[3,53,82],"ribosomal":[4,130],"RNA":[5],"isolated":[6],"from":[7],"baby":[8],"hamster":[9],"kidney":[10],"cells":[11],"was":[12],"studied":[13],"by":[14],"scanning":[15],"transmission":[16],"electron":[17],"microscopy":[18],"(STEM)":[19],"and":[20,65,75,90,145],"circular":[21],"dichroic":[22],"spectroscopy":[23],"to":[24,127],"establish":[25],"the":[26,41,50,59,62,66,72,76,100,112,121,128],"conditions":[27],"under":[28,55],"which":[29,120],"STEM":[30],"images":[31],"unstained":[33],"freeze-dried":[34],"rRNA":[35,44,54,83,122],"are":[36],"a":[37,117,135],"meaningful":[38],"representation":[39],"in":[45,88,99,119,138],"solution.":[46],"We":[47],"have":[48],"determined":[49],"various":[56],"buffer":[57],"conditions,":[58],"molecular":[60],"mass,":[61],"mass":[63],"distribution,":[64],"number":[67],"polynucleotide":[69],"strands":[70],"within":[71],"individual":[73],"molecules,":[74],"apparent":[77],"radii":[78],"gyration.":[80],"molecule":[84,123],"is":[85],"highly":[86],"extended":[87],"water":[89],"becomes":[91],"compact":[92],"with":[93],"increasing":[94],"ionic":[95],"strength.":[96],"However,":[97],"even":[98],"\"reconstitution":[101],"buffer\"":[102],"(30":[103],"mM":[104,106,108],"Tris/HCl/20":[105],"MgCl2/360":[107],"KCl,":[109],"pH":[110],"7.6)":[111],"compactness":[113],"does":[114],"not":[115],"reach":[116],"state":[118],"appears":[124],"structurally":[125],"similar":[126],"60S":[129],"subunit.":[131],"Our":[132],"approach":[133],"has":[134],"broad":[136],"application":[137],"high-resolution":[139],"structural":[140],"studies":[141],"nucleic":[143,146],"acids":[144],"acid-protein":[147],"interactions.":[148]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
