{"id":"https://openalex.org/W2056854444","doi":"https://doi.org/10.1001/jama.1939.02800360026008","title":"GRANULOCYTOPENIA IN SULFAPYRIDINE THERAPY","display_name":"GRANULOCYTOPENIA IN SULFAPYRIDINE THERAPY","publication_year":1939,"publication_date":"1939-09-09","ids":{"openalex":"https://openalex.org/W2056854444","doi":"https://doi.org/10.1001/jama.1939.02800360026008","mag":"2056854444"},"language":"en","primary_location":{"id":"doi:10.1001/jama.1939.02800360026008","doi":"https://doi.org/10.1001/jama.1939.02800360026008","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jama.1939.02800360026008","pdf_url":null,"source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Association","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053258754","display_name":"Vera B. Dolgopol","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"VERA B. DOLGOPOL","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5041092195","display_name":"HAROLD M. HOBART","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"HAROLD M. HOBART","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.4875,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.97988827,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"113","issue":"11","first_page":"1012","last_page":"1012"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.4713999927043915,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.4713999927043915,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.22339999675750732,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.16500000655651093,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sulfapyridine","display_name":"sulfapyridine","score":0.949999988079071},{"id":"https://openalex.org/keywords/granulocytopenia","display_name":"granulocytopenia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/bone-marrow-depression","display_name":"bone marrow depression","score":0.75},{"id":"https://openalex.org/keywords/sulfonamide-toxicity","display_name":"sulfonamide toxicity","score":0.6959999799728394},{"id":"https://openalex.org/keywords/white-blood-cell-count","display_name":"white blood cell count","score":0.7609999775886536},{"id":"https://openalex.org/keywords/pneumococcal-disease","display_name":"pneumococcal infection","score":0.7889999747276306},{"id":"https://openalex.org/keywords/streptococcal-infection","display_name":"streptococcal infection","score":0.9580000042915344},{"id":"https://openalex.org/keywords/gonorrhea","display_name":"gonorrhea","score":0.9860000014305115},{"id":"https://openalex.org/keywords/chemotherapy-side-effects","display_name":"chemotherapy side effects","score":0.6169999837875366}],"concepts":[{"id":"https://openalex.org/C2777031107","wikidata":"https://www.wikidata.org/wiki/Q3976827","display_name":"Sulfapyridine","level":2,"score":0.9258567094802856},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42068976163864136},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.11692541837692261},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1001/jama.1939.02800360026008","doi":"https://doi.org/10.1001/jama.1939.02800360026008","is_oa":false,"landing_page_url":"https://doi.org/10.1001/jama.1939.02800360026008","pdf_url":null,"source":{"id":"https://openalex.org/S172573765","display_name":"JAMA","issn_l":"0002-9955","issn":["0002-9955","0098-7484","1538-3598","2376-8118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Medical Association","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1978106230","https://openalex.org/W2020147333","https://openalex.org/W2040526412","https://openalex.org/W2061058834","https://openalex.org/W2073185009","https://openalex.org/W2090526213","https://openalex.org/W2337382171","https://openalex.org/W2588198818"],"related_works":["https://openalex.org/W2023084370","https://openalex.org/W4243142999","https://openalex.org/W2414239627","https://openalex.org/W1972430158","https://openalex.org/W1531336805","https://openalex.org/W2048900613","https://openalex.org/W1517056547","https://openalex.org/W2153698451","https://openalex.org/W2040526412","https://openalex.org/W1578403625"],"abstract_inverted_index":{"The":[0,140],"recent":[1],"introduction":[2],"of":[3,12,15,22,37,83,86,97,99,107,115,126],"sulfapyridine":[4,59,110],"as":[5,90],"a":[6,95],"chemotherapeutic":[7],"agent":[8],"offered":[9],"the":[10,19,35,84,87,124],"possibility":[11],"successful":[13],"treatment":[14,36],"infections":[16,40],"caused":[17],"by":[18],"pneumococcus,":[20],"irrespective":[21],"its":[23],"type.":[24],"This":[25],"drug":[26,77],"was":[27,70],"also":[28],"found":[29,58],"to":[30,60,118],"give":[31],"encouraging":[32],"results":[33],"in":[34,94,112,123],"miscellaneous":[38],"other":[39,65],"(streptococcic,":[41],"gonococcic":[42],"and":[43,45,68,101,131,137],"others)":[44],"is":[46],"consequently":[47],"being":[48],"used":[49],"quite":[50],"extensively.":[51],"Whitby1and":[53],"Wien,2in":[54],"their":[55],"animal":[56],"experiments,":[57],"be":[61],"less":[62],"toxic":[63],"than":[64],"sulfonamide":[66],"preparations,":[67],"it":[69],"thought":[71],"for":[72],"some":[73],"time":[74],"that":[75],"this":[76],"would":[78],"not":[79],"cause":[80],"any":[81,120],"depression":[82],"function":[85],"bone":[88],"marrow":[89],"had":[91],"been":[92],"observed":[93],"number":[96,125],"cases":[98],"neoprontosil":[100],"sulfanilamide":[102],"therapy.":[103],"Several":[105],"series":[106],"observations":[108],"on":[109],"therapy":[111],"large":[113],"groups":[114],"patients":[116],"failed":[117],"reveal":[119],"grave":[121],"drop":[122],"white":[127],"blood":[128],"cells":[129],"(Evans":[130],"Gainsford3100":[132],"cases,":[133,135],"Rosenthal4150":[134],"Anderson":[136],"Dowdeswell550":[138],"cases).":[139],"lowest":[141]},"counts_by_year":[],"updated_date":"2026-07-28T07:46:37.118299","created_date":"2016-06-24T00:00:00"}