{"id":"https://openalex.org/W2056833048","doi":"https://doi.org/10.1200/edbook_am.2013.33.e91","title":"Cellular Composition of the Tumor Microenvironment","display_name":"Cellular Composition of the Tumor Microenvironment","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2056833048","doi":"https://doi.org/10.1200/edbook_am.2013.33.e91","mag":"2056833048","pmid":"https://pubmed.ncbi.nlm.nih.gov/23714465"},"language":"en","primary_location":{"id":"doi:10.1200/edbook_am.2013.33.e91","doi":"https://doi.org/10.1200/edbook_am.2013.33.e91","is_oa":true,"landing_page_url":"https://doi.org/10.1200/edbook_am.2013.33.e91","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.14694/EdBook_AM.2013.33.e91","source":{"id":"https://openalex.org/S4210215109","display_name":"American Society of Clinical Oncology Educational Book","issn_l":"1548-8748","issn":["1548-8748","1548-8756","1930-7020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","medline","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320068","host_organization_name":"American Society of Clinical Oncology","host_organization_lineage":["https://openalex.org/P4310320068"],"host_organization_lineage_names":["American Society of Clinical Oncology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Society of Clinical Oncology Educational Book","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ascopubs.org/doi/pdfdirect/10.14694/EdBook_AM.2013.33.e91","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059729547","display_name":"Stephen Maxted Ansell","orcid":"https://orcid.org/0000-0003-1244-6758","observed_orcids":["https://orcid.org/0000-0003-1244-6758"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen M. Ansell","raw_affiliation_strings":["Division of Hematology , Mayo Clinic , 200 First St. SW , Rochester , MN 55905 ;","From the Division of Hematology, Mayo Clinic, Rochester, MN; Abrahamson Cancer Center of the University of Pennsylvania, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology , Mayo Clinic , 200 First St. SW , Rochester , MN 55905 ;","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"From the Division of Hematology, Mayo Clinic, Rochester, MN; Abrahamson Cancer Center of the University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040750947","display_name":"Robert H. Vonderheide","orcid":"https://orcid.org/0000-0002-7252-954X","observed_orcids":["https://orcid.org/0000-0002-7252-954X"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4390039297","display_name":"Abramson Cancer Center","ror":"https://ror.org/01hvpjq66","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210143392","https://openalex.org/I4390039297"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert H. Vonderheide","raw_affiliation_strings":["Abrahamson Cancer Center of the University of Pennsylvania, Philadelphia, PA","Division of Hematology , Mayo Clinic , Rochester , MN ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abrahamson Cancer Center of the University of Pennsylvania, Philadelphia, PA","institution_ids":["https://openalex.org/I4390039297","https://openalex.org/I79576946"]},{"raw_affiliation_string":"Division of Hematology , Mayo Clinic , Rochester , MN ;","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5805,"has_fulltext":true,"cited_by_count":94,"citation_normalized_percentile":{"value":0.81686028,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"33","issue":"33","first_page":"e91","last_page":"e97"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":1.0},{"id":"https://openalex.org/keywords/hematologic-malignancies","display_name":"hematologic malignancies","score":0.8820000290870667},{"id":"https://openalex.org/keywords/b-cell-lymphoma","display_name":"B-cell lymphoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.5490000247955322},{"id":"https://openalex.org/keywords/tumor-vasculature","display_name":"tumor vasculature","score":0.6729999780654907},{"id":"https://openalex.org/keywords/tumor-microenvironment-heterogeneity","display_name":"tumor microenvironment heterogeneity","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.9021874666213989},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.49930644035339355},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.44372496008872986},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.4338027238845825},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3948698043823242},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38899514079093933},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.352233350276947},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.206169992685318},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06039753556251526}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008221","descriptor_name":"Lymphoid Tissue","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008221","descriptor_name":"Lymphoid Tissue","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016176","descriptor_name":"T-Lymphocyte Subsets","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018655","descriptor_name":"Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019337","descriptor_name":"Hematologic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D020566","descriptor_name":"Dendritic Cells, Follicular","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D022423","descriptor_name":"Myeloid Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1200/edbook_am.2013.33.e91","doi":"https://doi.org/10.1200/edbook_am.2013.33.e91","is_oa":true,"landing_page_url":"https://doi.org/10.1200/edbook_am.2013.33.e91","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.14694/EdBook_AM.2013.33.e91","source":{"id":"https://openalex.org/S4210215109","display_name":"American Society of Clinical Oncology Educational Book","issn_l":"1548-8748","issn":["1548-8748","1548-8756","1930-7020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","medline","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320068","host_organization_name":"American Society of Clinical Oncology","host_organization_lineage":["https://openalex.org/P4310320068"],"host_organization_lineage_names":["American Society of Clinical Oncology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Society of Clinical Oncology Educational Book","raw_type":"journal-article"},{"id":"doi:10.14694/edbook_am.2013.33.e91","doi":"https://doi.org/10.14694/edbook_am.2013.33.e91","is_oa":false,"landing_page_url":"https://doi.org/10.14694/edbook_am.2013.33.e91","pdf_url":null,"source":{"id":"https://openalex.org/S4210215109","display_name":"American Society of Clinical Oncology Educational Book","issn_l":"1548-8748","issn":["1548-8748","1548-8756","1930-7020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","medline","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320068","host_organization_name":"American Society of Clinical Oncology","host_organization_lineage":["https://openalex.org/P4310320068"],"host_organization_lineage_names":["American Society of Clinical Oncology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Society of Clinical Oncology Educational Book","raw_type":"journal-article"},{"id":"pmid:23714465","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23714465","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1200/edbook_am.2013.33.e91","doi":"https://doi.org/10.1200/edbook_am.2013.33.e91","is_oa":true,"landing_page_url":"https://doi.org/10.1200/edbook_am.2013.33.e91","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.14694/EdBook_AM.2013.33.e91","source":{"id":"https://openalex.org/S4210215109","display_name":"American Society of Clinical Oncology Educational Book","issn_l":"1548-8748","issn":["1548-8748","1548-8756","1930-7020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","medline","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320068","host_organization_name":"American Society of Clinical Oncology","host_organization_lineage":["https://openalex.org/P4310320068"],"host_organization_lineage_names":["American Society of Clinical Oncology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Society of Clinical Oncology Educational Book","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2056833048.pdf","grobid_xml":"https://content.openalex.org/works/W2056833048.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W1507503772","https://openalex.org/W1525800821","https://openalex.org/W1671259416","https://openalex.org/W1699798481","https://openalex.org/W1894436773","https://openalex.org/W1947079675","https://openalex.org/W1969267175","https://openalex.org/W1971425687","https://openalex.org/W1978020435","https://openalex.org/W1986969439","https://openalex.org/W1987255100","https://openalex.org/W1991361673","https://openalex.org/W1995663931","https://openalex.org/W1997849135","https://openalex.org/W1998673571","https://openalex.org/W2002726823","https://openalex.org/W2006608981","https://openalex.org/W2010105078","https://openalex.org/W2013575415","https://openalex.org/W2017186967","https://openalex.org/W2021379322","https://openalex.org/W2021603971","https://openalex.org/W2029995825","https://openalex.org/W2030341765","https://openalex.org/W2031352878","https://openalex.org/W2032115660","https://openalex.org/W2033866193","https://openalex.org/W2034156891","https://openalex.org/W2034401200","https://openalex.org/W2037061225","https://openalex.org/W2040770569","https://openalex.org/W2049426330","https://openalex.org/W2049910239","https://openalex.org/W2052749202","https://openalex.org/W2060275053","https://openalex.org/W2081915365","https://openalex.org/W2085257327","https://openalex.org/W2090739244","https://openalex.org/W2097090220","https://openalex.org/W2097811455","https://openalex.org/W2101327682","https://openalex.org/W2107235439","https://openalex.org/W2107598346","https://openalex.org/W2110956453","https://openalex.org/W2124655619","https://openalex.org/W2132598458","https://openalex.org/W2135737755","https://openalex.org/W2139605769","https://openalex.org/W2145476394","https://openalex.org/W2145761792","https://openalex.org/W2146604395","https://openalex.org/W2149142217","https://openalex.org/W2150040388","https://openalex.org/W2150201242","https://openalex.org/W2158853057","https://openalex.org/W2162080418","https://openalex.org/W2162413627","https://openalex.org/W2162819001","https://openalex.org/W2163240418","https://openalex.org/W2171775292","https://openalex.org/W2172223853","https://openalex.org/W4234533101","https://openalex.org/W4313324526"],"related_works":["https://openalex.org/W4415837294","https://openalex.org/W4243726115","https://openalex.org/W2581032328","https://openalex.org/W2064610182","https://openalex.org/W2039130367","https://openalex.org/W1972825083","https://openalex.org/W3110012019","https://openalex.org/W3087164679","https://openalex.org/W4213199705","https://openalex.org/W4394835013"],"abstract_inverted_index":{"In":[0],"addition":[1],"to":[2],"malignant":[3],"cells,":[4,11],"the":[5,21,24,28,32,41,44,48,63,79,84],"tumor":[6,33,37,54,64,85],"microenvironment":[7,34,49,65,86],"also":[8],"includes":[9],"nonmalignant":[10],"secreted":[12],"proteins,":[13],"and":[14,19,46,56,60,72,81],"blood":[15],"vessels":[16],"that":[17],"surround":[18],"support":[20],"growth":[22],"of":[23,31,43,62,70,83],"tumor.":[25],"Interactions":[26],"between":[27,73],"various":[29],"components":[30],"are":[35],"significant;":[36],"cells":[38],"can":[39,50],"change":[40],"nature":[42],"microenvironment,":[45],"conversely,":[47],"affect":[51],"how":[52],"a":[53,91],"grows":[55],"spreads.":[57],"The":[58],"structure":[59],"composition":[61,80],"varies":[66],"among":[67],"different":[68],"types":[69],"cancers":[71],"patients.":[74],"This":[75],"paper":[76],"focuses":[77],"on":[78,94],"function":[82],"in":[87],"hematologic":[88],"malignancies":[89],"with":[90],"specific":[92],"focus":[93],"B-cell":[95],"lymphomas.":[96]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}