{"id":"https://openalex.org/W2056788686","doi":"https://doi.org/10.1093/nar/gkn874","title":"TcSNP: a database of genetic variation in Trypanosoma cruzi","display_name":"TcSNP: a database of genetic variation in Trypanosoma cruzi","publication_year":2008,"publication_date":"2008-10-31","ids":{"openalex":"https://openalex.org/W2056788686","doi":"https://doi.org/10.1093/nar/gkn874","mag":"2056788686","pmid":"https://pubmed.ncbi.nlm.nih.gov/18974180","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2686512"},"language":"en","primary_location":{"id":"doi:10.1093/nar/gkn874","doi":"https://doi.org/10.1093/nar/gkn874","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkn874","pdf_url":"https://academic.oup.com/nar/article-pdf/37/suppl_1/D544/3332415/gkn874.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/nar/article-pdf/37/suppl_1/D544/3332415/gkn874.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078264955","display_name":"Alejandro A Ackermann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"A. A. Ackermann","raw_affiliation_strings":["Instituto de Investigaciones Biotecnol\u00f3gicas, Universidad de San Mart\u00edn - CONICET, San Mart\u00edn, 1650, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Biotecnol\u00f3gicas, Universidad de San Mart\u00edn - CONICET, San Mart\u00edn, 1650, Argentina","institution_ids":["https://openalex.org/I151201029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009921267","display_name":"Santiago J. Carmona","orcid":"https://orcid.org/0000-0002-2495-0671","observed_orcids":["https://orcid.org/0000-0002-2495-0671"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"S. J. Carmona","raw_affiliation_strings":["Instituto de Investigaciones Biotecnol\u00f3gicas, Universidad de San Mart\u00edn - CONICET, San Mart\u00edn, 1650, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Biotecnol\u00f3gicas, Universidad de San Mart\u00edn - CONICET, San Mart\u00edn, 1650, Argentina","institution_ids":["https://openalex.org/I151201029"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077801542","display_name":"Fern\u00e1n Ag\u00fcero","orcid":"https://orcid.org/0000-0003-1331-5741","observed_orcids":["https://orcid.org/0000-0003-1331-5741"]},"institutions":[{"id":"https://openalex.org/I151201029","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59","country_code":"AR","type":"government","lineage":["https://openalex.org/I151201029","https://openalex.org/I4210123736","https://openalex.org/I4387155568"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"F. Aguero","raw_affiliation_strings":["Instituto de Investigaciones Biotecnol\u00f3gicas, Universidad de San Mart\u00edn - CONICET, San Mart\u00edn, 1650, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Biotecnol\u00f3gicas, Universidad de San Mart\u00edn - CONICET, San Mart\u00edn, 1650, Argentina","institution_ids":["https://openalex.org/I151201029"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5077801542"],"corresponding_institution_ids":["https://openalex.org/I151201029"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":{"value":3992,"currency":"USD","value_usd":3992},"fwci":1.237,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.80529883,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"37","issue":"Database","first_page":"D544","last_page":"D549"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trypanosoma-cruzi","display_name":"Trypanosoma cruzi","score":0.996999979019165},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8880000114440918},{"id":"https://openalex.org/keywords/genetic-variation","display_name":"genetic variation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/chagas-disease","display_name":"Chagas disease","score":0.8679999709129333},{"id":"https://openalex.org/keywords/snp-database","display_name":"SNP database","score":0.7009999752044678},{"id":"https://openalex.org/keywords/small-indels","display_name":"small indels","score":0.8069999814033508},{"id":"https://openalex.org/keywords/multiple-sequence-alignment","display_name":"multiple sequence alignment","score":0.7749999761581421},{"id":"https://openalex.org/keywords/coding-sequences","display_name":"coding sequences","score":0.546999990940094},{"id":"https://openalex.org/keywords/reference-genome","display_name":"reference genome","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.967864990234375},{"id":"https://openalex.org/C2777625466","wikidata":"https://www.wikidata.org/wiki/Q150162","display_name":"Trypanosoma cruzi","level":3,"score":0.8677040338516235},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.5280735492706299},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.48182860016822815},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.3587522506713867},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.16709917783737183},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14399608969688416},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014349","descriptor_name":"Trypanosoma cruzi","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018503","descriptor_name":"Genome, Protozoan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054643","descriptor_name":"INDEL Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/nar/gkn874","doi":"https://doi.org/10.1093/nar/gkn874","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkn874","pdf_url":"https://academic.oup.com/nar/article-pdf/37/suppl_1/D544/3332415/gkn874.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2686512","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2686512","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"},{"id":"pmid:18974180","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18974180","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/nar/gkn874","doi":"https://doi.org/10.1093/nar/gkn874","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/gkn874","pdf_url":"https://academic.oup.com/nar/article-pdf/37/suppl_1/D544/3332415/gkn874.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321594","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2056788686.pdf","grobid_xml":"https://content.openalex.org/works/W2056788686.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1499500424","https://openalex.org/W1528782506","https://openalex.org/W1566107011","https://openalex.org/W1995498227","https://openalex.org/W1998006729","https://openalex.org/W2045038692","https://openalex.org/W2045346667","https://openalex.org/W2049290286","https://openalex.org/W2053235121","https://openalex.org/W2064278849","https://openalex.org/W2070309039","https://openalex.org/W2089753630","https://openalex.org/W2106181586","https://openalex.org/W2122261141","https://openalex.org/W2125757584","https://openalex.org/W2145772607","https://openalex.org/W2150607432","https://openalex.org/W2152015607","https://openalex.org/W2155159495","https://openalex.org/W2160265473","https://openalex.org/W4211252435"],"related_works":["https://openalex.org/W7099940829","https://openalex.org/W2089306260","https://openalex.org/W2123527663","https://openalex.org/W2014720502","https://openalex.org/W130557408","https://openalex.org/W2043196378","https://openalex.org/W2053235121","https://openalex.org/W7120495185","https://openalex.org/W189657792","https://openalex.org/W4411076577"],"abstract_inverted_index":{"The":[0,27],"TcSNP":[1,65,98,119],"database":[2,28],"(http://snps.tcruzi.org)":[3],"integrates":[4],"information":[5],"on":[6,81],"genetic":[7],"variation":[8],"(polymorphisms":[9],"and":[10,16,40,50,53],"mutations)":[11],"for":[12],"different":[13],"stocks,":[14],"strains":[15],"isolates":[17],"of":[18,24,78,84,97,109],"Trypanosoma":[19],"cruzi,":[20],"the":[21,33,107,129],"causative":[22],"agent":[23],"Chagas":[25],"disease.":[26],"incorporates":[29],"sequences":[30],"(genes":[31],"from":[32,47,106],"T.":[34],"cruzi":[35],"reference":[36,130],"genome,":[37],"mRNAs,":[38],"ESTs":[39],"genomic":[41],"sequences);":[42],"multiple":[43,60],"sequence":[44,61,115],"alignments":[45],"obtained":[46],"these":[48,59,122],"sequences;":[49],"single-nucleotide":[51],"polymorphisms":[52],"small":[54],"indels":[55],"identified":[56],"by":[57],"scanning":[58],"alignments.":[62],"Information":[63],"in":[64],"can":[66],"be":[67],"readily":[68],"interrogated":[69],"to":[70],"arrive":[71],"at":[72],"gene":[73],"sets,":[74],"or":[75],"SNP":[76],"sets":[77],"interest":[79],"based":[80],"a":[82],"number":[83],"attributes.":[85],"Sequence":[86],"similarity":[87],"searches":[88],"using":[89],"BLAST":[90],"are":[91],"also":[92],"supported.":[93],"This":[94],"first":[95],"release":[96],"contains":[99],"nearly":[100],"170,000":[101],"high-confidence":[102],"candidate":[103,126],"SNPs,":[104],"derived":[105],"analysis":[108],"annotated":[110],"coding":[111],"sequences.":[112,132],"As":[113],"new":[114,125],"data":[116],"become":[117],"available,":[118],"will":[120],"incorporate":[121],"data,":[123],"mapping":[124],"SNPs":[127],"onto":[128],"genome":[131]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}