{"id":"https://openalex.org/W2056780277","doi":"https://doi.org/10.1038/clpt.1990.77","title":"Pharmacokinetic-pharmacodynamic relationships of methadone infusions in patients with cancer pain","display_name":"Pharmacokinetic-pharmacodynamic relationships of methadone infusions in patients with cancer pain","publication_year":1990,"publication_date":"1990-05-01","ids":{"openalex":"https://openalex.org/W2056780277","doi":"https://doi.org/10.1038/clpt.1990.77","mag":"2056780277","pmid":"https://pubmed.ncbi.nlm.nih.gov/2188771"},"language":"en","primary_location":{"id":"doi:10.1038/clpt.1990.77","doi":"https://doi.org/10.1038/clpt.1990.77","is_oa":false,"landing_page_url":"https://doi.org/10.1038/clpt.1990.77","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology and Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067118176","display_name":"Charles E. Inturrisi","orcid":"https://orcid.org/0000-0002-0890-6275","observed_orcids":["https://orcid.org/0000-0002-0890-6275"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Charles E Inturrisi","raw_affiliation_strings":["Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY","Pain Research Program of the Department of Neurology, Memorial Sloan-Kettering Cancer Center, the Departments of Neurology and Pharmacology Cornell University Medical College New York","Pharmacokinetics/Drug Metabolism Department Warner\u2010Lambert/Parke\u2010Davis Ann Arbor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Pain Research Program of the Department of Neurology, Memorial Sloan-Kettering Cancer Center, the Departments of Neurology and Pharmacology Cornell University Medical College New York","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I205783295"]},{"raw_affiliation_string":"Pharmacokinetics/Drug Metabolism Department Warner\u2010Lambert/Parke\u2010Davis Ann Arbor","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090628353","display_name":"Russell K. Portenoy","orcid":"https://orcid.org/0000-0001-9637-9577","observed_orcids":["https://orcid.org/0000-0001-9637-9577"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russell K Portenoy","raw_affiliation_strings":["Pain Research Program of the Department of Neurology, Memorial Sloan-Kettering Cancer Center, the Departments of Neurology and Pharmacology, Cornell University Medical College, New York","Pharmacokinetics/Drug Metabolism Department, Warner-Lambert/Parke-Davis, Ann Arbor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pain Research Program of the Department of Neurology, Memorial Sloan-Kettering Cancer Center, the Departments of Neurology and Pharmacology, Cornell University Medical College, New York","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I205783295"]},{"raw_affiliation_string":"Pharmacokinetics/Drug Metabolism Department, Warner-Lambert/Parke-Davis, Ann Arbor","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111628764","display_name":"Mitchell B. Max","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitchell B Max","raw_affiliation_strings":["Pain Research Program of the Department of Neurology, Memorial Sloan-Kettering Cancer Center, the Departments of Neurology and Pharmacology, Cornell University Medical College, New York","Pharmacokinetics/Drug Metabolism Department, Warner-Lambert/Parke-Davis, Ann Arbor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pain Research Program of the Department of Neurology, Memorial Sloan-Kettering Cancer Center, the Departments of Neurology and Pharmacology, Cornell University Medical College, New York","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I205783295"]},{"raw_affiliation_string":"Pharmacokinetics/Drug Metabolism Department, Warner-Lambert/Parke-Davis, Ann Arbor","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041467390","display_name":"Wayne A. Colburn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wayne A Colburn","raw_affiliation_strings":["Pain Research Program of the Department of Neurology, Memorial Sloan-Kettering Cancer Center, the Departments of Neurology and Pharmacology, Cornell University Medical College, New York","Pharmacokinetics/Drug Metabolism Department, Warner-Lambert/Parke-Davis, Ann Arbor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pain Research Program of the Department of Neurology, Memorial Sloan-Kettering Cancer Center, the Departments of Neurology and Pharmacology, Cornell University Medical College, New York","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I205783295"]},{"raw_affiliation_string":"Pharmacokinetics/Drug Metabolism Department, Warner-Lambert/Parke-Davis, Ann Arbor","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083219961","display_name":"Kathleen M. Foley","orcid":"https://orcid.org/0000-0001-9707-007X","observed_orcids":["https://orcid.org/0000-0001-9707-007X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathleen M Foley","raw_affiliation_strings":["Pain Research Program of the Department of Neurology, Memorial Sloan-Kettering Cancer Center, the Departments of Neurology and Pharmacology, Cornell University Medical College, New York","Pharmacokinetics/Drug Metabolism Department, Warner-Lambert/Parke-Davis, Ann Arbor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pain Research Program of the Department of Neurology, Memorial Sloan-Kettering Cancer Center, the Departments of Neurology and Pharmacology, Cornell University Medical College, New York","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I205783295"]},{"raw_affiliation_string":"Pharmacokinetics/Drug Metabolism Department, Warner-Lambert/Parke-Davis, Ann Arbor","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5067118176"],"corresponding_institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I205783295"],"apc_list":{"value":4410,"currency":"USD","value_usd":4410},"apc_paid":null,"fwci":6.424,"has_fulltext":false,"cited_by_count":111,"citation_normalized_percentile":{"value":0.96752904,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"47","issue":"5","first_page":"565","last_page":"577"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11199","display_name":"Pain Management and Opioid Use","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methadone","display_name":"methadone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pharmacokinetic-pharmacodynamic-relationship","display_name":"pharmacokinetic-pharmacodynamic relationship","score":0.8669999837875366},{"id":"https://openalex.org/keywords/cancer-pain","display_name":"cancer pain","score":0.9639999866485596},{"id":"https://openalex.org/keywords/continuous-infusion","display_name":"continuous infusion","score":0.7210000157356262},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.824999988079071},{"id":"https://openalex.org/keywords/sedation","display_name":"sedation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/steady-state-concentration","display_name":"steady-state concentration","score":0.6499999761581421},{"id":"https://openalex.org/keywords/hysteresis","display_name":"hysteresis","score":0.7129999995231628},{"id":"https://openalex.org/keywords/opioid-analgesics","display_name":"opioid analgesics","score":0.8450000286102295},{"id":"https://openalex.org/keywords/pharmacodynamic-modeling","display_name":"pharmacodynamic modeling","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C2778767360","wikidata":"https://www.wikidata.org/wiki/Q179996","display_name":"Methadone","level":2,"score":0.8638542294502258},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.8467651605606079},{"id":"https://openalex.org/C2776814716","wikidata":"https://www.wikidata.org/wiki/Q574801","display_name":"Sedation","level":2,"score":0.8425367474555969},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.7382568717002869},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7280779480934143},{"id":"https://openalex.org/C2778904085","wikidata":"https://www.wikidata.org/wiki/Q3712728","display_name":"Cancer pain","level":3,"score":0.650905966758728},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6215158104896545},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.517373263835907},{"id":"https://openalex.org/C63433958","wikidata":"https://www.wikidata.org/wiki/Q1774688","display_name":"Clinical pharmacology","level":2,"score":0.47858500480651855},{"id":"https://openalex.org/C2993247534","wikidata":"https://www.wikidata.org/wiki/Q621261","display_name":"Pain relief","level":2,"score":0.47832155227661133},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33890441060066223},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.21517160534858704},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14983263611793518},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008691","descriptor_name":"Methadone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008691","descriptor_name":"Methadone","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D008691","descriptor_name":"Methadone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/clpt.1990.77","doi":"https://doi.org/10.1038/clpt.1990.77","is_oa":false,"landing_page_url":"https://doi.org/10.1038/clpt.1990.77","pdf_url":null,"source":{"id":"https://openalex.org/S159852663","display_name":"Clinical Pharmacology & Therapeutics","issn_l":"0009-9236","issn":["0009-9236","1085-8733","1532-6535"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Pharmacology and Therapeutics","raw_type":"journal-article"},{"id":"pmid:2188771","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2188771","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical pharmacology and therapeutics","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G310631625","display_name":null,"funder_award_id":"CA32897","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2072255226","https://openalex.org/W1964540228","https://openalex.org/W1971505591","https://openalex.org/W2081558294","https://openalex.org/W2033285615","https://openalex.org/W2079969352","https://openalex.org/W2070257919","https://openalex.org/W2141701918","https://openalex.org/W2032137996","https://openalex.org/W2103888546"],"abstract_inverted_index":{"To":[0],"determine":[1],"the":[2,26,86,100,103,115,144,155,167,177,182,188,197,201],"relationship":[3],"between":[4,162],"changes":[5],"in":[6,36,46,51,55],"plasma":[7,13,47,163],"methadone":[8,14,30,48,164,186],"concentration":[9,49],"and":[10,16,19,24,73,127,146,166,203],"pharmacodynamic":[11,183],"effects,":[12],"profiles":[15],"pharmacodynamics":[17],"(analgesia":[18],"sedation)":[20],"were":[21],"measured":[22],"during":[23,143,187],"after":[25,152],"continuous":[27],"infusion":[28,145,156],"of":[29,62,64,66,137,140,154,176,179,185,200,206],"for":[31,70,90,107,120,147,195],"180":[32],"to":[33,82,149,181],"270":[34],"minutes":[35],"15":[37],"patients":[38],"with":[39,76],"pain":[40,56,71,91,121,170],"caused":[41],"by":[42],"cancer.":[43],"An":[44],"increase":[45,54],"resulted":[50],"a":[52,77,158,193],"rapid":[53,160],"relief":[57,72,92,122],"or":[58],"sedation.":[59],"The":[60],"estimates":[61],"values":[63,165],"50%":[65],"maximum":[67],"effect":[68],"(Css50)":[69],"sedation":[74,108,128],"obtained":[75,142],"pharmacokinetic-pharmacodynamic":[78,198],"model":[79],"varied":[80],"tenfold":[81],"twentyfold":[83],"among":[84],"patients;":[85],"mean":[87,104,116],"Css50":[88,105],"value":[89,106],"(0.359":[93],"+/-":[94,110,124,130],"0.158":[95],"[SD]":[96,112],"micrograms/ml)":[97],"was":[98,173],"virtually":[99],"same":[101],"as":[102],"(0.336":[109],"0.205":[111],"micrograms/ml).":[113],"Similarly,":[114],"gamma":[117],"(slope":[118],"function)":[119],"(4.4":[123],"3.8":[125],"[SD])":[126,132],"(5.8":[129],"5.4":[131],"did":[133],"not":[134],"differ.":[135],"Examination":[136],"hysteresis":[138],"plots":[139],"data":[141],"4":[148],"5":[150],"hours":[151],"cessation":[153],"revealed":[157],"very":[159],"equilibration":[161],"sites":[168],"mediating":[169],"relief.":[171],"There":[172],"no":[174],"indication":[175],"development":[178],"tolerance":[180],"effects":[184,205],"study.":[189],"This":[190],"report":[191],"describes":[192],"method":[194],"quantitating":[196],"relationships":[199],"desirable":[202],"undesirable":[204],"opioid":[207],"analgesics.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}