{"id":"https://openalex.org/W2056772980","doi":"https://doi.org/10.1186/1476-5926-6-6","title":"Regeneration in pig livers by compensatory hyperplasia induces high levels of telomerase activity","display_name":"Regeneration in pig livers by compensatory hyperplasia induces high levels of telomerase activity","publication_year":2007,"publication_date":"2007-07-02","ids":{"openalex":"https://openalex.org/W2056772980","doi":"https://doi.org/10.1186/1476-5926-6-6","mag":"2056772980","pmid":"https://pubmed.ncbi.nlm.nih.gov/17605788","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1920532"},"language":"en","primary_location":{"id":"doi:10.1186/1476-5926-6-6","doi":"https://doi.org/10.1186/1476-5926-6-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1476-5926-6-6","pdf_url":"https://comparative-hepatology.biomedcentral.com/track/pdf/10.1186/1476-5926-6-6","source":{"id":"https://openalex.org/S203092637","display_name":"Comparative Hepatology","issn_l":"1476-5926","issn":["1476-5926"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comparative Hepatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://comparative-hepatology.biomedcentral.com/track/pdf/10.1186/1476-5926-6-6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086026527","display_name":"Henning Wege","orcid":"https://orcid.org/0000-0002-5924-796X","observed_orcids":["https://orcid.org/0000-0002-5924-796X"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Henning Wege","raw_affiliation_strings":["Department of Gastroenterology and Hepatology with Sections Infectious Disease and Tropical Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany. hwege@uke.uni-hamburg.de","Department of Gastroenterology and Hepatology with Sections Infectious Disease and Tropical Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology with Sections Infectious Disease and Tropical Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany. hwege@uke.uni-hamburg.de","institution_ids":["https://openalex.org/I4210108711"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology with Sections Infectious Disease and Tropical Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112376689","display_name":"Anett M\u00fcller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anett M\u00fcller","raw_affiliation_strings":["Department of Hepatobiliary Surgery and Visceral Transplantation, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany","Department of Hepatobiliary Surgery and Visceral Transplantation; University Medical Center Hamburg-Eppendorf; Hamburg Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery and Visceral Transplantation, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]},{"raw_affiliation_string":"Department of Hepatobiliary Surgery and Visceral Transplantation; University Medical Center Hamburg-Eppendorf; Hamburg Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042429732","display_name":"L. P. M\u00fcller","orcid":"https://orcid.org/0000-0003-3501-0367","observed_orcids":["https://orcid.org/0000-0003-3501-0367"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lars M\u00fcller","raw_affiliation_strings":["Department of Hepatobiliary Surgery and Visceral Transplantation, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany","Department of Hepatobiliary Surgery and Visceral Transplantation; University Medical Center Hamburg-Eppendorf; Hamburg Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery and Visceral Transplantation, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]},{"raw_affiliation_string":"Department of Hepatobiliary Surgery and Visceral Transplantation; University Medical Center Hamburg-Eppendorf; Hamburg Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038367631","display_name":"Susan Petri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Susan Petri","raw_affiliation_strings":["Department of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany","Department of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]},{"raw_affiliation_string":"Department of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113556175","display_name":"J\u00f6rg Petersen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00f6rg Petersen","raw_affiliation_strings":["Department of Gastroenterology and Hepatology with Sections Infectious Disease and Tropical Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany","Department of Gastroenterology and Hepatology with Sections Infectious Disease and Tropical Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology and Hepatology with Sections Infectious Disease and Tropical Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]},{"raw_affiliation_string":"Department of Gastroenterology and Hepatology with Sections Infectious Disease and Tropical Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035143560","display_name":"Christian Hillert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Hillert","raw_affiliation_strings":["Department of Hepatobiliary Surgery and Visceral Transplantation, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany","University Medical Center Hamburg- Eppendorf"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hepatobiliary Surgery and Visceral Transplantation, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany","institution_ids":["https://openalex.org/I4210108711"]},{"raw_affiliation_string":"University Medical Center Hamburg- Eppendorf","institution_ids":["https://openalex.org/I4210108711"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5086026527"],"corresponding_institution_ids":["https://openalex.org/I4210108711"],"apc_list":null,"apc_paid":null,"fwci":1.4131,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.81869858,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"6","issue":"1","first_page":"6","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.8604000210762024,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.8604000210762024,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.13539999723434448,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telomerase-activity","display_name":"telomerase activity","score":0.9419999718666077},{"id":"https://openalex.org/keywords/compensatory-hyperplasia","display_name":"compensatory hyperplasia","score":0.8970000147819519},{"id":"https://openalex.org/keywords/liver-regeneration","display_name":"liver regeneration","score":0.9959999918937683},{"id":"https://openalex.org/keywords/partial-hepatectomy","display_name":"partial hepatectomy","score":0.972000002861023},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.6510000228881836},{"id":"https://openalex.org/keywords/telomere-length","display_name":"telomere length","score":0.7820000052452087},{"id":"https://openalex.org/keywords/porcine-liver","display_name":"porcine liver","score":0.7749999761581421},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6399999856948853},{"id":"https://openalex.org/keywords/telomere-shortening","display_name":"telomere shortening","score":0.8759999871253967}],"concepts":[{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.983787477016449},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.9021074771881104},{"id":"https://openalex.org/C125593758","wikidata":"https://www.wikidata.org/wiki/Q15315135","display_name":"Telomerase reverse transcriptase","level":4,"score":0.8652496337890625},{"id":"https://openalex.org/C2776795407","wikidata":"https://www.wikidata.org/wiki/Q19597761","display_name":"Liver regeneration","level":3,"score":0.7111523747444153},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.5668988823890686},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5183433294296265},{"id":"https://openalex.org/C66640590","wikidata":"https://www.wikidata.org/wiki/Q4296711","display_name":"Mitotic index","level":3,"score":0.5182737708091736},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49194595217704773},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.48925352096557617},{"id":"https://openalex.org/C75934600","wikidata":"https://www.wikidata.org/wiki/Q419245","display_name":"Ribonucleoprotein","level":4,"score":0.48855194449424744},{"id":"https://openalex.org/C2776909242","wikidata":"https://www.wikidata.org/wiki/Q1514021","display_name":"Hepatectomy","level":3,"score":0.4722385108470917},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.45090335607528687},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4094707667827606},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37803924083709717},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3533676266670227},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3486306369304657},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3280217945575714},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.22567614912986755},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.13305681943893433},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1170518696308136},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.08533573150634766},{"id":"https://openalex.org/C159110652","wikidata":"https://www.wikidata.org/wiki/Q17078201","display_name":"Resection","level":2,"score":0.07922658324241638},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06726926565170288},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/1476-5926-6-6","doi":"https://doi.org/10.1186/1476-5926-6-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1476-5926-6-6","pdf_url":"https://comparative-hepatology.biomedcentral.com/track/pdf/10.1186/1476-5926-6-6","source":{"id":"https://openalex.org/S203092637","display_name":"Comparative Hepatology","issn_l":"1476-5926","issn":["1476-5926"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comparative Hepatology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1920532","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1920532","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comp Hepatol","raw_type":"Text"},{"id":"pmid:17605788","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17605788","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comparative hepatology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/1476-5926-6-6","doi":"https://doi.org/10.1186/1476-5926-6-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1476-5926-6-6","pdf_url":"https://comparative-hepatology.biomedcentral.com/track/pdf/10.1186/1476-5926-6-6","source":{"id":"https://openalex.org/S203092637","display_name":"Comparative Hepatology","issn_l":"1476-5926","issn":["1476-5926"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Comparative Hepatology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320323381","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2056772980.pdf","grobid_xml":"https://content.openalex.org/works/W2056772980.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W36961956","https://openalex.org/W176224146","https://openalex.org/W1562053774","https://openalex.org/W1579661837","https://openalex.org/W1966574826","https://openalex.org/W1971061718","https://openalex.org/W1982389534","https://openalex.org/W1991827974","https://openalex.org/W1995868560","https://openalex.org/W1999434307","https://openalex.org/W2000971601","https://openalex.org/W2001566280","https://openalex.org/W2004862304","https://openalex.org/W2008320117","https://openalex.org/W2010947710","https://openalex.org/W2012573722","https://openalex.org/W2024619097","https://openalex.org/W2032064526","https://openalex.org/W2036289995","https://openalex.org/W2036425626","https://openalex.org/W2042781066","https://openalex.org/W2048338090","https://openalex.org/W2049861836","https://openalex.org/W2053820570","https://openalex.org/W2054145511","https://openalex.org/W2064482102","https://openalex.org/W2070205084","https://openalex.org/W2074126915","https://openalex.org/W2081926396","https://openalex.org/W2083141185","https://openalex.org/W2085533487","https://openalex.org/W2086545203","https://openalex.org/W2090979450","https://openalex.org/W2093948249","https://openalex.org/W2096565432","https://openalex.org/W2117824620","https://openalex.org/W2122740168","https://openalex.org/W2135340623","https://openalex.org/W2143384363","https://openalex.org/W2159954692","https://openalex.org/W2335772131","https://openalex.org/W2414596392","https://openalex.org/W2463346311","https://openalex.org/W4254164242"],"related_works":["https://openalex.org/W2051342289","https://openalex.org/W1967765276","https://openalex.org/W2048338090","https://openalex.org/W2324700059","https://openalex.org/W2028967675","https://openalex.org/W2588452543","https://openalex.org/W2398112683","https://openalex.org/W2894478264","https://openalex.org/W7098888861","https://openalex.org/W2805936840"],"abstract_inverted_index":{"BACKGROUND:":[0],"Several":[1],"highly":[2],"proliferative":[3,42],"human":[4,26],"cells":[5,187],"transiently":[6],"activate":[7],"telomerase,":[8],"a":[9,40,74,167,181],"ribonucleoprotein":[10],"with":[11,57,137,171],"reverse":[12],"transcriptase":[13],"activity,":[14],"to":[15,21,69,84,101,148,175,183],"counterbalance":[16],"replication-associated":[17],"telomere":[18,91,172,189],"erosion":[19],"and":[20,93,140,191],"increase":[22],"stress":[23],"resistance.":[24],"Quiescent":[25],"hepatocytes":[27,38,110],"exhibit":[28],"very":[29],"low":[30],"or":[31],"undetectable":[32],"levels":[33,131],"of":[34,122,151],"telomerase":[35,58,62,94,144,158],"activity.":[36],"However,":[37],"display":[39],"remarkable":[41],"capability":[43],"following":[44],"liver":[45,50,161,186],"injury.":[46],"To":[47],"investigate":[48],"whether":[49],"regeneration":[51,162],"by":[52,163],"compensatory":[53,114,164],"hyperplasia":[54,165],"is":[55],"associated":[56],"activation,":[59],"we":[60],"measured":[61],"activity":[63,95,125,145],"in":[64,96,134,160,166],"pig":[65],"livers":[66],"after":[67],"70":[68],"80%":[70],"partial":[71,105,138],"hepatectomy":[72,139],"using":[73],"fully":[75],"quantitative":[76],"real-time":[77],"telomeric":[78],"repeat":[79],"amplification":[80],"protocol.":[81],"In":[82],"contrast":[83],"commonly":[85],"studied":[86],"inbred":[87],"laboratory":[88],"mouse":[89],"strains,":[90],"length":[92],"porcine":[97],"tissues":[98],"are":[99],"comparable":[100,174],"humans.":[102,176],"RESULTS:":[103],"Following":[104],"hepatectomy,":[106],"histology":[107],"revealed":[108],"mitotic":[109,152],"as":[111],"marker":[112],"for":[113],"hyperplasia.":[115],"As":[116],"expected,":[117],"there":[118],"was":[119],"no":[120],"induction":[121],"inflammation.":[123],"Telomerase":[124,177],"increased":[126],"significantly":[127,146],"showing":[128],"the":[129,149],"highest":[130],"(5-fold":[132],"upregulation)":[133],"pigs":[135],"treated":[136],"hepatic":[141],"decompression.":[142],"Moreover,":[143],"correlated":[147],"number":[150],"hepatocytes.":[153],"CONCLUSION:":[154],"Our":[155],"data":[156],"demonstrate":[157],"activation":[159,178],"large":[168],"animal":[169],"model":[170],"biology":[173],"may":[179],"constitute":[180],"mechanism":[182],"protect":[184],"proliferating":[185],"against":[188],"shortening":[190],"oxidative":[192],"stress.":[193]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
