{"id":"https://openalex.org/W2056763231","doi":"https://doi.org/10.1002/(sici)1099-081x(199705)18:4<335::aid-bdd22>3.0.co;2-w","title":"DISTRIBUTION OF ANTIHISTAMINES INTO THE CSF FOLLOWING INTRANASAL DELIVERY","display_name":"DISTRIBUTION OF ANTIHISTAMINES INTO THE CSF FOLLOWING INTRANASAL DELIVERY","publication_year":1997,"publication_date":"1997-05-01","ids":{"openalex":"https://openalex.org/W2056763231","doi":"https://doi.org/10.1002/(sici)1099-081x(199705)18:4<335::aid-bdd22>3.0.co;2-w","mag":"2056763231","pmid":"https://pubmed.ncbi.nlm.nih.gov/9158881"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1099-081x(199705)18:4<335::aid-bdd22>3.0.co;2-w","doi":"https://doi.org/10.1002/(sici)1099-081x(199705)18:4<335::aid-bdd22>3.0.co;2-w","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1099-081x(199705)18:4<335::aid-bdd22>3.0.co;2-w","pdf_url":null,"source":{"id":"https://openalex.org/S57691945","display_name":"Biopharmaceutics & Drug Disposition","issn_l":"0142-2782","issn":["0142-2782","1099-081X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biopharmaceutics &amp; Drug Disposition","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002869939","display_name":"Kang-Jye Chou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"KANG-JYE CHOU","raw_affiliation_strings":["College of Pharmacy, University of Iowa, Iowa City 52242, USA","College of Pharmacy, The University of Iowa, Iowa City, IA 52242, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, University of Iowa, Iowa City 52242, USA","institution_ids":["https://openalex.org/I126307644"]},{"raw_affiliation_string":"College of Pharmacy, The University of Iowa, Iowa City, IA 52242, U.S.A","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109307287","display_name":"Maureen D. Donovan","orcid":"https://orcid.org/0000-0002-9508-0060","observed_orcids":["https://orcid.org/0000-0002-9508-0060"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"MAUREEN D. DONOVAN*","raw_affiliation_strings":["College of Pharmacy, The University of Iowa, Iowa City, IA 52242, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, The University of Iowa, Iowa City, IA 52242, U.S.A","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109307287"],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":4.1672,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.95349615,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"18","issue":"4","first_page":"335","last_page":"346"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antihistamines","display_name":"antihistamines","score":0.8600000143051147},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.8309999704360962},{"id":"https://openalex.org/keywords/intranasal-drug-delivery","display_name":"intranasal drug delivery","score":0.9789999723434448},{"id":"https://openalex.org/keywords/nasal-absorption","display_name":"nasal absorption","score":0.5189999938011169},{"id":"https://openalex.org/keywords/hydroxyzine","display_name":"hydroxyzine","score":0.8069999814033508},{"id":"https://openalex.org/keywords/chlorpheniramine","display_name":"chlorpheniramine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/triprolidine","display_name":"triprolidine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chlorcyclizine","display_name":"chlorcyclizine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/drug-distribution","display_name":"drug distribution","score":0.3610000014305115}],"concepts":[{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.899433970451355},{"id":"https://openalex.org/C2776246316","wikidata":"https://www.wikidata.org/wiki/Q421937","display_name":"Hydroxyzine","level":2,"score":0.8301348686218262},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7181751132011414},{"id":"https://openalex.org/C2776880894","wikidata":"https://www.wikidata.org/wiki/Q324089","display_name":"Antihistamine","level":2,"score":0.6584475040435791},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6539478898048401},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5543182492256165},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.48522210121154785},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.44866523146629333},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.4421229362487793},{"id":"https://openalex.org/C2776093070","wikidata":"https://www.wikidata.org/wiki/Q621636","display_name":"Route of administration","level":2,"score":0.43997693061828613},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.4299100935459137},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3727814555168152},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1631772220134735},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002744","descriptor_name":"Chlorpheniramine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002744","descriptor_name":"Chlorpheniramine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002744","descriptor_name":"Chlorpheniramine","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D002744","descriptor_name":"Chlorpheniramine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D006634","descriptor_name":"Histamine H1 Antagonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006634","descriptor_name":"Histamine H1 Antagonists","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006634","descriptor_name":"Histamine H1 Antagonists","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D006634","descriptor_name":"Histamine H1 Antagonists","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D006919","descriptor_name":"Hydroxyzine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006919","descriptor_name":"Hydroxyzine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006919","descriptor_name":"Hydroxyzine","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D006919","descriptor_name":"Hydroxyzine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D007269","descriptor_name":"Injections, Intra-Arterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009296","descriptor_name":"Nasal Cavity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014311","descriptor_name":"Triprolidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014311","descriptor_name":"Triprolidine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014311","descriptor_name":"Triprolidine","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D014311","descriptor_name":"Triprolidine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/(sici)1099-081x(199705)18:4<335::aid-bdd22>3.0.co;2-w","doi":"https://doi.org/10.1002/(sici)1099-081x(199705)18:4<335::aid-bdd22>3.0.co;2-w","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1099-081x(199705)18:4<335::aid-bdd22>3.0.co;2-w","pdf_url":null,"source":{"id":"https://openalex.org/S57691945","display_name":"Biopharmaceutics & Drug Disposition","issn_l":"0142-2782","issn":["0142-2782","1099-081X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biopharmaceutics &amp; Drug Disposition","raw_type":"journal-article"},{"id":"pmid:9158881","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9158881","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biopharmaceutics & drug disposition","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.75,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308402","display_name":"American Association of Colleges of Pharmacy","ror":"https://ror.org/031v2vc59"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1970882712","https://openalex.org/W2006349109","https://openalex.org/W1996838227","https://openalex.org/W2068306536","https://openalex.org/W2109317576","https://openalex.org/W2115100688","https://openalex.org/W1957313516","https://openalex.org/W2037942687","https://openalex.org/W2358699957","https://openalex.org/W2035726141"],"abstract_inverted_index":{"The":[0,28,57,82,142,161,178],"preferential":[1],"absorption":[2,121],"of":[3,31,107,180,196,207],"certain":[4],"drug":[5,23,83],"compounds":[6,110],"from":[7,73,182,224],"the":[8,12,19,43,51,74,78,108,117,126,166,183,187,204],"nasal":[9,46,123,184],"cavity":[10],"into":[11,42,186],"cerebrospinal":[13],"fluid":[14],"(CSF)":[15],"raises":[16],"questions":[17],"regarding":[18],"transport":[20],"processes":[21],"controlling":[22],"disposition":[24,29],"following":[25,45,122,131,139],"intranasal":[26,132,152,205],"delivery.":[27],"characteristics":[30,212],"several":[32],"structurally":[33],"similar":[34],"antihistamine":[35,168],"compounds,":[36],"hydroxyzine,":[37],"chlorpheniramine,":[38],"triprolidine,":[39,165],"and":[40,65,68,77,87,97,147,153,158,175],"chlorcyclizine,":[41],"CSF":[44,67,86,98,130,146,171,188],"administration":[47,133,155],"were":[48,59,71,89,99,134,156,173],"studied":[49],"using":[50],"rat":[52],"as":[53],"an":[54,216,225],"animal":[55],"model.":[56],"antihistamines":[58,181],"administered":[60],"either":[61],"intranasally":[62],"or":[63],"intra-arterially,":[64],"serial":[66],"plasma":[69,88,96,148],"samples":[70],"collected":[72],"cisterna":[75],"magna":[76],"femoral":[79],"artery,":[80],"respectively.":[81,160,177],"levels":[84,128],"in":[85,95,129,215],"assayed":[90],"by":[91,193],"HPLC.":[92],"Hydroxyzine":[93],"concentrations":[94],"found":[100],"to":[101,190,221],"be":[102,191],"significantly":[103,135],"greater":[104],"than":[105,137],"most":[106,118],"other":[109,167],"tested.":[111],"In":[112],"addition,":[113],"hydroxyzine":[114,127,150],"also":[115,201],"showed":[116],"rapid":[119],"systemic":[120],"administration.":[124,141],"Interestingly,":[125],"higher":[136],"those":[138,222],"intra-arterial":[140,154],"AUC":[143,162],"ratios":[144,163],"between":[145],"for":[149,164],"after":[151],"4.0":[157],"0.4,":[159],"with":[169,209],"measurable":[170],"concentrations,":[172],"0.5":[174],"0.7,":[176],"distribution":[179],"membrane":[185],"appears":[189,202],"controlled":[192],"a":[194],"combination":[195],"their":[197],"molecular":[198],"properties.":[199],"It":[200],"that":[203],"delivery":[206],"drugs":[208],"optimal":[210],"physicochemical":[211],"can":[213],"result":[214],"improved":[217],"CNS":[218],"bioavailability":[219],"compared":[220],"achieved":[223],"equivalent":[226],"parenteral":[227],"dose.":[228]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
